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  • A Review on: Formulation and Evaluation of Herbal Cold Cream Using Hibiscus Rosa Sinesis, Neem and Aloe Vera Extract

  • Department of pharmaceutics, Samarth institute of pharmacy, Belhe, Pune, 412410, Maharashtra, India

Abstract

Herbal cold creams are topical formulations designed to provide hydration, soothe the skin, and protect against environmental stressors such as cold weather, unlike conventional cold creams that may contain synthetic ingredients, herbal cold creams are enriched with natural extracts derived from plants, offering therapeutic benefits. The active ingredients typically include herbal oils and plant-based compounds like Aloe vera, neem extract. These ingredients are known for their anti-inflammatory, antibacterial, antioxidant, and moisturizing properties.Aloe vera is a widely used ingredient in herbal cold creams due to its diverse skin benefits. This plant extract is known for its powerful moisturizing properties, which help maintain skin hydration and softness. Aloe vera’s anti-inflammatory compounds reduce redness, irritation, and discomfort, making it suitable for sensitive or damaged skin. It also promotes skin healing and regeneration, aiding in the treatment of burns, wounds, and dry skin. Additionally, its natural cooling effect provides relief from sunburn and inflammation. Rich in essential vitamins (A, C, E, B12) and minerals, aloe vera nourishes the skin while offering therapeutic and cosmetic advantages. Its inclusion in herbal cold creams enhances the overall effectiveness of the product, making it a popular and beneficial choice for skin care.

Keywords

Cold Cream, Aloe Vera,Neem extract,Rose water,stability

Introduction

Cold cream is a type of emulsion-based cosmetic product primarily used for skin hydration, cleansing, and protection. Traditionally, cold creams have been used to moisturize dry skin, especially during colder months when environmental factors such as low humidity and wind can strip the skin of its natural moisture. The term "cold" in cold cream originates from the cooling sensation it provides when applied to the skin, due to the presence of water in the formula that evaporates, leaving a soothing and refreshing feeling. The formulation of cold creams typically includes a blend of water, oils (like mineral or almond oil), emulsifiers (such as beeswax), and other ingredients that offer soothing and protective effects. The water-in-oil emulsion structure makes cold creams thicker than other moisturizers, forming a protective layer on the skin that locks in moisture and shields against harsh environmental conditions.

HISTORY

Cold cream was first invented by Galen, a famous Greek physician- pharmacist in the Roman Empire (who practiced in Rome) of the 1" Century AD. The Galen formula of cold cream has changed but little in proportions or method of preparation throughout many centuries. The term "cold cream” refers to the numbing sensation the cream left behind on the skin. Water in oil (w/o) emulsions were typically used to create cold creams. Much of the water in the creams evaporates after they are applied to the skin, leaving the residual oil to function as a solvent, clearing the skin of makeup and other impurities. Additionally, surfactant activity might exist. According to some chemists, the cooling effect of the water evaporation on the skin is the reason why these creams are referred to as “cold creams.”An other argument Is that the creams required to be stored in a cool environment to prevent them from growing rancid in the days before mineral oil or Petrolatum were utilised. They acquired their moniker because of how frigid they felt to the touch.

ADVANTAGES OF COLD CREAM:

  1. Hydration: Deeply moisturizes and hydrates the skin, preventing dryness.
  2. Cleansing: Effectively removes makeup, dirt, and impurities.
  3. Soothing: Calms and soothes irritated or inflamed skin.
  4. Cooling Effect: Provides a refreshing, cooling sensation.
  5. Non-Greasy: Leaves skin feeling soft and supple without a greasy residue.
  6. Versatility: Suitable for all skin types, including sensitive skin.
  7. Anti-aging: Helps maintain skin elasticity and reduces fine lines.
  8. Protective Barrier: Shields skin from environmental stressors.
  9. Easy Application: Smooth, creamy texture spreads easily.

DISADVANTAGES OF COLD CREAM:

    1. Comedogenic Potential: Some formulations may clog pores, causing acne.
    2. Heavy Texture: Can feel too heavy or greasy for oily skin types.
    3. Residue: This may leave a residue that some users find uncomfortable.
    4. Artificial Ingredients: Some cold creams contain synthetic fragrances and preservatives that can irritate sensitive skin.
    5. Limited Penetration: Might not penetrate deeply enough for some skin concerns.
    6. Short Shelf Life: Natural formulations may have a shorter shelf life without preservatives.
    7. Allergic Reactions: Risk of allergic reactions to certain ingredients.

Benefits of herbal cosmetics

  • Natural elements have the least detrimental effects on the skin or other bodily components.
  • Comparatively safer.
  • Due to its use in customs and culture, consumers have a greater placebo effect.
  • Formulation flexibility.
  • Population data demonstrate ancient consequences.
    • Simple accessibility.
    • It helps to beautify and cleanse the body without causing any negative side effects.

Emulsification technique

Emulsification is the process of combining two immiscible liquids such as oil and water on to a stable and uniform mixture. Cold cream is emulsion of oil in water with the oil being the primary ingredient.There are several technique for emulsifying cold cream but one common method is to use an emulsifying agent, such as beeswax or borax which helps to stabilize the emulsion and prevent separation of the oil and water phases. Here is a basic recipe for making cold cream using the emulsification techniques

Benefits of Emulsification Technique

  1. Enhanced Texture
  2. Improved Moisturizer
  3. Controlled Release of Ingredients
  4. Customizable Stability
  5. Formulations
  6. Compatibility with Additional Ingredie

Sr.No.

INGREDIENTS

Role of ingredients

1

Hibiscus Flowers extract

Improve Skin tone, Hyper pigmentation, discolouration, dark spots

2

Aloe vera gel

Anti-ageing, Anti Inflammatory, moisturizer, reduce acne and pimples

3

Neem extract

Anti-inflammatory, moisturizer, reduce pimples

4

Rose water

Fragrance

5

Borax

With emulsifying agent to form soap

6

Beeswax

It gives thickness to the cream.

7

Methyl paraben

Preservative

8

Liquid paraffin

Lubricating agent, alkaline agent

METHOD AND MATERIALS

Making of herbal Cold Cream Formulation: -

 In a borosilicate glass beaker, heat the liquid paraffin and beeswax to 75°C and keep it there. Phase of oil. Borax and methyl paraben should be dissolved in distilled water in a different beaker, and the mixture should be heated to 75°C to produce a transparent solution. (Phase of water). Next, gradually incorporate this aqueous phase into the heated oil phase A smooth cream will then form after adding a measured amount of Aloe vera gel and mixing. After adding a few drops of rose oil for fragrance, gradually add the powdered hibiscus extract and thoroughly. Transfer this cream to a plate, stir it geometrically in order to ensure that all the ingredients are well combined and the cream has a smooth texture, and add a few drops of distilled water if needed

Evaluation of Polyherbal Cold Cream: -

Determination of Physical appearance

The physical appearance of cold cream was inspected visually against dark background. The average of three reading is recorded. 

Homogeneity

Homogeneity is the formulated cold creamwas tested for the homogeneity y visual appearance and by touch. After feel Emolliency, slipperiness and amount of residue left after the application of fixed amount of cream was checked. After application of cream, the type of film or smear formed on the skin were checked. The ease of removal of the cream applied was examined by washing the applied part with tap water.

Sensitivity test: -

The cream which was prepared has applied on 1cm skin of hand and exposed to sunlight for 4-5mins.

Spread ability:

The spread ability was expressed in terms of time in seconds taken by two slides to slip off from the cream, placed in between the slides, under certain load. Lesser the time taken for separation of the two slides better the spread ability. Two sets of glass slides of standard dimension were taken8 . Then one slide of suitable dimension was taken and the cream formulation was placed on that slide. Then other slide was placed on the top of the formulation. Then a weight or certain load was placed on the upper slide so that the cream between the two slides was pressed uniformly to form a thin layer. Then the weight was removed and excess of formulation adhering to the slides was scrapped off. The upper slide was allowed to slip off freely by the force of weight tied to it. The time taken by the upper slide to slip off was noted9.

              Spread ability= m × l/t

Where,

m= Standard weight which is tied to or placed over the upper slide (30g)

l= length of a glass slide (5 cm)

t= time taken in seconds.

pH

The pH of aloe cold cream was determined using pH meter. The most accurate common means of measuring pH is through a lab device called a probe and meter, or simply a pH meter. The probe consists of a glass electrode through which a small voltage is passed. The meter is a voltmeter, measures the electronic impedance in the glass electrode and displays pH units instead of volts. Measurement is made by submerging the probe in the semisolid until a reading is registered by the meter

Washability

Washability test was carried out by applying a small amount of cream on the hand and then washing it with tap water. Result: Washing the formulations was simple.

Irritancy study observations

On the dorsal surface of the left hand, mark the area (1 cm2). After that, the region was treated with the cream, and the time was recorded. No redness, edema, inflammation, and irritation was found during irritancy study. Thus, the prepared formulation was safe to use for skin. Result: Nil Irritant, erythema and edema effect.

Sensitivity test

The cream which was prepared has applied on Skin of handand exposed to sunlightfor 4- 5mins

CONCLUSION

By using neem extract, hibiscus flowers extract and aloe vera the cream showed a multipurposeeffect and all these aloeingredients showed significant different activities. Based on results and discussion, the formulations F1, and F2 were stable at room temperature and can be safely used onthe skin.Howeverthe formula 1 showed the best results in all aspects. From the above results it is concluded that the formulated cream showed good consistency and spread ability, homogeneity, pH, non-greasy and there is no phase separation during study period ofresearch. From the above study it can be concluded that the cold cream is safe to use as it is developed from extract. Natural remedies are more acceptable in the belief that they are safer with fewer side effects than the synthetic ones. So,the values of herbs in the cosmeceutical has been extensively improved in personal care system and there is a great demand for the herbal cosmetics nowadays. An herbal cream which is non-toxic, safe, effective and improves patient compliance by the utilization of herbal extracts would be highly acceptable than synthetic ones.

REFERENCES

  1. Manisha Yogesh Sonalkar, Sachin Annasaheb Nitave.Formulation and evaluation ofpolyherbal cosmetic cream. World JPharm Pharm Sci 2016; 5:772-9.
  2. N. Shah, B.M.Methal, (2006) A Handbook of Cosmetic, Vallabh Prakashan.
  3. Mishra B, Pandit JK and Bhattacharya SK, Recent trends indrug delivery systems - transdermal drug delivery, Indian Journal of Experimental Biology, 28, 1990, 1001-1007.
  4. Anuradha Keshwar, Unmesh Keshwar, Ashwini Deogirkar,S. S. Dhurde, Veena Deo and B. K. Shrikhande, Formulation Development and Evaluation of Cream Containing Natural Essential Oils having Mosquito Repellent Property, World Journal of Pharmacy And Pharmaceutical Sciences, Volume 5, Issue 8, 1586-1593.
  5. Storm JE, Collier SW, Stewart S, Metabolisam of Xenobiotics During Percutaneous Penetration: Role of Absorption Rate and Cutaneous Enzyme Activity, Fundam.Appl.Toxicol, 1990;4:132? 41.
  6. Clewell, M. Barnes, J. R. Endres, M. Ahmed, and D. K.S. Ghambeer, “Efficacy and tolerability assessment of a topical formulation containing copper sulfate and Hypericumperforatum on patients with herpes skin lesions: a comparative, randomized controlled trial,” Journal of Drugs in Dermatology, vol. 11, no. 2, pp. 209–215, 2012.
  7. Martin BA, Lemos CN, Dalmolin LF, Arruda C, Brait ÍSC, Cazarim MdS, da Cruz-Cazarim ELC, Bueno PCP, Júnior MP,Pereira LRL, Cardili RN, Fonseca Vianna Lopez R. A New Approach to Atopic Dermatitis Control with Low- Concentration Propolis-Loaded Cold Cream. Pharmaceutics.2021;13(9):1346.
  8. R.M. Mehta, pharmaceutics-II, fourth Edition, Vallabh Prakashan 2015;222.
  9. Dr. Sweta Srivastava Koka ; MS. Supriya Shidhaye , Handbook of Experimental – Herbal Drug Technology , S.Vikas and
  10. Company – Medical Publishers, Editiol 2020; 15:17.
  11. N. Shah, B.M.Methal, (2006) A Handbook of Cosmetic, Vallabh Prakash an.
  12. Tejswini Devidas Navgire, Madhuri Baburao Pawar Formulation and Evaluation of Cold Cream.
  13. Mishra B, Pandit JK and Bhattacharya SK, Recent trends in drug delivery systems – transdermal Drug delivery, Indian Journal of Experimental Biology, 28, 1990, 1001-1007.
  14. Nikhil Nitin Navindgikar, K.A. Kamalapurkar, Prashant S. chavan. Formulation and Evaluation of Multipurpose herbal cream. Int J Curr Pharm Res, Volume 12, Issue 3, 25-30.
  15. Saraf, S., &Kaur, C. D. (2010). Phyto constituents as photo protective novel cosmetic formulations. Pharmacognosy reviews, 4(7), 1.
  16. R. Patel, H. U. Momin, R.L. Dhumal, K, L. Mohite, (2017), Prepara preparation and evaluation of multipurpose Herbal cream, Adv Pharm Life sci Res;5(1);27-32.
  17. Solangi A, Siddiqui A, Junejo s, Younisarain M, Aslam Ansari M, Talpur A, et al. Roselle (Hibiscus Sabdariffa L.) A Multipurpose Medicinal Plant And Its Uses: A Review. Int J Biol Res. 2017 ;5(1):21– 24.
  18. Ismail A, Hainida E, Ikram K, Saadiah H, Nazri M. Roselle (Hibiscus sabdariffa L.) Seeds-Nutritional Composition, Protein Quality and Health Benefits Global Science Books Roselle (Hibiscus sabdariffa L.) Seeds-Nutritional Composition, Protein Quality and Health Benefits. 2008; 2(1):1-16
  19. Puro K, Sunjukta R, Samir S, Ghatak S, Shakuntala I, Sen A. Medicinal Uses of Roselle Plant (Hibiscus sabdariffa L.): A Mini Review. Issue 1 Indian J of Hill Farming. 2014 ;27(1):47-51.
  20. H. D. V. Prendergast, Pollination of Hibiscus rosa-sinensis, Biotropica 14(4) (1982), 287.
  21. Jadhav VM, Thorat RM, Kadam VJ, Sathe NS. Hibiscus Rosa sinesis Linn–‘‘Rudrapuspa’’: A Review. J Pharm Res. 2009; 2(7):1168-73.
  22. Kassakul W, Praznik W, Hongwiset D, Article O, Viernstein H, Phrutivorapongkul A, et al. Characterisation Of The Mucilage’s Extracted From Hibiscus Rosa Sinesis Linn And Hibiscus Mutabilis Linn And Their Skin Moisturizing Effect. Art in InterJ of Pharma and PharmaceuSci . 2014;6(11).
  23. Ojulari V, Lee G, Nam O. Beneficial Effects of Natural Bioactive Compounds from Hibiscus sabdariffa L. on Obesity. 2019; 24(210):1-14
  24. Itrat M and Zarnigar K: Aloe vera: A review of its clinical Effectiveness. Int. Res. J. Pharm. 2013; 4: 79. 20.
  25. Wynn RL: Aloe vera gel: update for dentistry. Gen. Dent. 2005; 53: 6-9
  26. Joseph B and Raj SJ: Pharmacognostic and phytochemical Properties of Aloe vera Linn-an overview. Int. J. Pharmaceut. Sci. Rev. Res. 2010; 4: 106-110.
  27. Franco R, Sammarco E, Calvanese MG, De Natale F, Falivene S and Lecce A: Preventing the acute skin side Effects in patients treated with radiotherapy for breast Cancer: The use of corneometry in order to evaluate the Protective effect of moisturizing creams. Radiation Oncol. 2013; 8: 48-57.
  28. Shahzad MN and Ahmed N: Effectiveness of Aloe vera Gel compared with one percent silver sulphadiazine cream As burn wound dressing in second degree burns. J. Pak. Medical Asso. 2014; 21: 663-670. 24.
  29. Joseph B and Justin RS: Pharmacognostic and Phyto-chemical properties of Aloe vera Linn. - An overview. Int. J. Pharmaceut. Sci. Review Res. 2010; 2: 106-110. 25.
  30. da Silva SF, Cardoso JR, Mendes JV, Pinto MV (2014) Pharmacognostic study of Rosa alba L. RevistaEletrônica FMB 7:136–150 26.
  31. Allen LV Jr (2010) Cooling ointment for dry skin. US Pharm 35:38–39 27.
  32. Saraf, S., & Kaur, C. D. (2010). Phytoconstituents as photoprotective novel cosmetic Frmulations. Pharmacognosy reviews, 4(7), 1. 28.
  33. Sujith S Nair, Molly Mathew and Sreena K, Formulation and Evaluation of Herbal Cream co1ntaining Curcuma Longa, International Journal of Pharmaceutical and Chemical Sciences Vol. 1 (4) Oct-Dec 2012. 29.
  34. Madalene CY Heng*, Topical Curcumin: A Review of Mechanisms and uses in Dermatology International Journal of Dermatology and Clinical Research 2017. 30.
  35. UddanduSaheb*, Aduri Prakash Reddy, K. Rajitha, B. Sravani, B. Vanitha, (2018). Formulation and Evaluation of Cream from containing plant extracts, World Journal of Pharmacy and Pharmaceutical Sciences, 7(5) :851-862. 31.
  36. Singh J, Sahu RK, Prasad DN, Jangde R, Gupta R. Evaluation of antidiabetic potential of Ougeiniaoojeinensis Leaves in streptozotocin-induced-diabetic rats. Pharmacologyonline, 2 (2011) 1046-1052. 32.
  37. 12.Osmani OH, Sekar DS, Senthil Kumar KL, Sahu RK, Roy A. In- vivo antidiabetic potential of Artocarpusheterophyllus plant seeds in streptozotocin-induced- diabetic rats. Biomedical and Pharmacological Journal,2 (2009) 339-343. 33.
  38. A. Clewell, M. Barnes, J. R. Endres, M. Ahmed, and D. K. S. Ghambeer, “Efficacy and tolerability assessment of a topical formulation containing copper sulfate and Hypericumperforatum on patients with herpes skin lesions: a comparative, randomized controlled trial,” Journal of Drugs in Dermatology, 11(2) (2012) 209215 34.
  39. Maurya AK, Tripathi S, Kahrana M, Ahmed Z, Sahu RK. Evaluation of antidiabetic effects of FicusRacemosa extracts in diabetic induced rats. Pharmacologyonline,3(2011) 907-914. 35.
  40. Mei X. Chen, Kenneth S. Alexander, and Gabriella Baki, Formulation and Evaluation of Antibacterial Creams and Gels Containing Metal Ions for Topical Application, Journal of Pharmaceutics Volume 2016 (2016), Article ID 5754349, 10 pages 36.

Reference

  1. Manisha Yogesh Sonalkar, Sachin Annasaheb Nitave.Formulation and evaluation ofpolyherbal cosmetic cream. World JPharm Pharm Sci 2016; 5:772-9.
  2. N. Shah, B.M.Methal, (2006) A Handbook of Cosmetic, Vallabh Prakashan.
  3. Mishra B, Pandit JK and Bhattacharya SK, Recent trends indrug delivery systems - transdermal drug delivery, Indian Journal of Experimental Biology, 28, 1990, 1001-1007.
  4. Anuradha Keshwar, Unmesh Keshwar, Ashwini Deogirkar,S. S. Dhurde, Veena Deo and B. K. Shrikhande, Formulation Development and Evaluation of Cream Containing Natural Essential Oils having Mosquito Repellent Property, World Journal of Pharmacy And Pharmaceutical Sciences, Volume 5, Issue 8, 1586-1593.
  5. Storm JE, Collier SW, Stewart S, Metabolisam of Xenobiotics During Percutaneous Penetration: Role of Absorption Rate and Cutaneous Enzyme Activity, Fundam.Appl.Toxicol, 1990;4:132? 41.
  6. Clewell, M. Barnes, J. R. Endres, M. Ahmed, and D. K.S. Ghambeer, “Efficacy and tolerability assessment of a topical formulation containing copper sulfate and Hypericumperforatum on patients with herpes skin lesions: a comparative, randomized controlled trial,” Journal of Drugs in Dermatology, vol. 11, no. 2, pp. 209–215, 2012.
  7. Martin BA, Lemos CN, Dalmolin LF, Arruda C, Brait ÍSC, Cazarim MdS, da Cruz-Cazarim ELC, Bueno PCP, Júnior MP,Pereira LRL, Cardili RN, Fonseca Vianna Lopez R. A New Approach to Atopic Dermatitis Control with Low- Concentration Propolis-Loaded Cold Cream. Pharmaceutics.2021;13(9):1346.
  8. R.M. Mehta, pharmaceutics-II, fourth Edition, Vallabh Prakashan 2015;222.
  9. Dr. Sweta Srivastava Koka ; MS. Supriya Shidhaye , Handbook of Experimental – Herbal Drug Technology , S.Vikas and
  10. Company – Medical Publishers, Editiol 2020; 15:17.
  11. N. Shah, B.M.Methal, (2006) A Handbook of Cosmetic, Vallabh Prakash an.
  12. Tejswini Devidas Navgire, Madhuri Baburao Pawar Formulation and Evaluation of Cold Cream.
  13. Mishra B, Pandit JK and Bhattacharya SK, Recent trends in drug delivery systems – transdermal Drug delivery, Indian Journal of Experimental Biology, 28, 1990, 1001-1007.
  14. Nikhil Nitin Navindgikar, K.A. Kamalapurkar, Prashant S. chavan. Formulation and Evaluation of Multipurpose herbal cream. Int J Curr Pharm Res, Volume 12, Issue 3, 25-30.
  15. Saraf, S., &Kaur, C. D. (2010). Phyto constituents as photo protective novel cosmetic formulations. Pharmacognosy reviews, 4(7), 1.
  16. R. Patel, H. U. Momin, R.L. Dhumal, K, L. Mohite, (2017), Prepara preparation and evaluation of multipurpose Herbal cream, Adv Pharm Life sci Res;5(1);27-32.
  17. Solangi A, Siddiqui A, Junejo s, Younisarain M, Aslam Ansari M, Talpur A, et al. Roselle (Hibiscus Sabdariffa L.) A Multipurpose Medicinal Plant And Its Uses: A Review. Int J Biol Res. 2017 ;5(1):21– 24.
  18. Ismail A, Hainida E, Ikram K, Saadiah H, Nazri M. Roselle (Hibiscus sabdariffa L.) Seeds-Nutritional Composition, Protein Quality and Health Benefits Global Science Books Roselle (Hibiscus sabdariffa L.) Seeds-Nutritional Composition, Protein Quality and Health Benefits. 2008; 2(1):1-16
  19. Puro K, Sunjukta R, Samir S, Ghatak S, Shakuntala I, Sen A. Medicinal Uses of Roselle Plant (Hibiscus sabdariffa L.): A Mini Review. Issue 1 Indian J of Hill Farming. 2014 ;27(1):47-51.
  20. H. D. V. Prendergast, Pollination of Hibiscus rosa-sinensis, Biotropica 14(4) (1982), 287.
  21. Jadhav VM, Thorat RM, Kadam VJ, Sathe NS. Hibiscus Rosa sinesis Linn–‘‘Rudrapuspa’’: A Review. J Pharm Res. 2009; 2(7):1168-73.
  22. Kassakul W, Praznik W, Hongwiset D, Article O, Viernstein H, Phrutivorapongkul A, et al. Characterisation Of The Mucilage’s Extracted From Hibiscus Rosa Sinesis Linn And Hibiscus Mutabilis Linn And Their Skin Moisturizing Effect. Art in InterJ of Pharma and PharmaceuSci . 2014;6(11).
  23. Ojulari V, Lee G, Nam O. Beneficial Effects of Natural Bioactive Compounds from Hibiscus sabdariffa L. on Obesity. 2019; 24(210):1-14
  24. Itrat M and Zarnigar K: Aloe vera: A review of its clinical Effectiveness. Int. Res. J. Pharm. 2013; 4: 79. 20.
  25. Wynn RL: Aloe vera gel: update for dentistry. Gen. Dent. 2005; 53: 6-9
  26. Joseph B and Raj SJ: Pharmacognostic and phytochemical Properties of Aloe vera Linn-an overview. Int. J. Pharmaceut. Sci. Rev. Res. 2010; 4: 106-110.
  27. Franco R, Sammarco E, Calvanese MG, De Natale F, Falivene S and Lecce A: Preventing the acute skin side Effects in patients treated with radiotherapy for breast Cancer: The use of corneometry in order to evaluate the Protective effect of moisturizing creams. Radiation Oncol. 2013; 8: 48-57.
  28. Shahzad MN and Ahmed N: Effectiveness of Aloe vera Gel compared with one percent silver sulphadiazine cream As burn wound dressing in second degree burns. J. Pak. Medical Asso. 2014; 21: 663-670. 24.
  29. Joseph B and Justin RS: Pharmacognostic and Phyto-chemical properties of Aloe vera Linn. - An overview. Int. J. Pharmaceut. Sci. Review Res. 2010; 2: 106-110. 25.
  30. da Silva SF, Cardoso JR, Mendes JV, Pinto MV (2014) Pharmacognostic study of Rosa alba L. RevistaEletrônica FMB 7:136–150 26.
  31. Allen LV Jr (2010) Cooling ointment for dry skin. US Pharm 35:38–39 27.
  32. Saraf, S., & Kaur, C. D. (2010). Phytoconstituents as photoprotective novel cosmetic Frmulations. Pharmacognosy reviews, 4(7), 1. 28.
  33. Sujith S Nair, Molly Mathew and Sreena K, Formulation and Evaluation of Herbal Cream co1ntaining Curcuma Longa, International Journal of Pharmaceutical and Chemical Sciences Vol. 1 (4) Oct-Dec 2012. 29.
  34. Madalene CY Heng*, Topical Curcumin: A Review of Mechanisms and uses in Dermatology International Journal of Dermatology and Clinical Research 2017. 30.
  35. UddanduSaheb*, Aduri Prakash Reddy, K. Rajitha, B. Sravani, B. Vanitha, (2018). Formulation and Evaluation of Cream from containing plant extracts, World Journal of Pharmacy and Pharmaceutical Sciences, 7(5) :851-862. 31.
  36. Singh J, Sahu RK, Prasad DN, Jangde R, Gupta R. Evaluation of antidiabetic potential of Ougeiniaoojeinensis Leaves in streptozotocin-induced-diabetic rats. Pharmacologyonline, 2 (2011) 1046-1052. 32.
  37. 12.Osmani OH, Sekar DS, Senthil Kumar KL, Sahu RK, Roy A. In- vivo antidiabetic potential of Artocarpusheterophyllus plant seeds in streptozotocin-induced- diabetic rats. Biomedical and Pharmacological Journal,2 (2009) 339-343. 33.
  38. A. Clewell, M. Barnes, J. R. Endres, M. Ahmed, and D. K. S. Ghambeer, “Efficacy and tolerability assessment of a topical formulation containing copper sulfate and Hypericumperforatum on patients with herpes skin lesions: a comparative, randomized controlled trial,” Journal of Drugs in Dermatology, 11(2) (2012) 209215 34.
  39. Maurya AK, Tripathi S, Kahrana M, Ahmed Z, Sahu RK. Evaluation of antidiabetic effects of FicusRacemosa extracts in diabetic induced rats. Pharmacologyonline,3(2011) 907-914. 35.
  40. Mei X. Chen, Kenneth S. Alexander, and Gabriella Baki, Formulation and Evaluation of Antibacterial Creams and Gels Containing Metal Ions for Topical Application, Journal of Pharmaceutics Volume 2016 (2016), Article ID 5754349, 10 pages 36.

Photo
Gajare Prajakta
Corresponding author

Department of pharmaceutics, Samarth institute of pharmacy, Belhe, Pune, 412410, Maharashtra, India

Photo
Khaladkar shraddha
Co-author

Department of pharmaceutics, Samarth institute of pharmacy, Belhe, Pune, 412410, Maharashtra, India

Gajare Prajakta*, Khaladkar shraddha, A Review on: Formulation and Evaluation of Herbal Cold Cream Using Hibiscus Rosa Sinesis, Neem and Aloe Vera Extract, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 4, 1772-1778. https://doi.org/10.5281/zenodo.15213391

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