UV Method Of Development For Estimation Of Losartan In Bulk & Marketed Formulation

Abstract

Attempts were made to develope UV method for simultaneous estimation of losartan from tablet. the mobile phase methanol:water(70:30 ratio).pKa was found drug 5.5.pH of drug was found to be 3.Selection of wavelength found to 208nm.The linearity,accuracy,precision,range,LOD,LOQ was within the limit as specified by the ICH guidelines.Hence these method simple economic precise accurate and reproducible.

Keywords

Introduction

       
           
       
Table 6.1: List of chemicals

       
           
       
Table 6.2: List of Equipment

FORMULATION –

       
           
       
Validation of UV Method –

       
           
       
Linearity curve for Losartan

       
           
       
Precision –

       
           
       
Intra – Day precision parameter with % RSD

       
           
       
Inter– Day precision parameter with % RSD

       
           
       
 CONCLUSION

The simple spectrophotometric method for determination of Losartan has been developed and validated as per ICH guidelines. The developed method is found to be sensitive, accurate and reproducible and can be used for the routine quality control analysis of Losartan in bulk and pharmaceutical formulations. Attempts were made to develop spectrophotometric for estimation of Losartan. The spectrophotometric methods were developed for estimation. For the spectrophotometric methods, Methanol was used as solvent. The wavelength used for Losartan 208nm. The spectrophotometric methods were validated according to the ICH guidelines. The linearity, precisions, LOD, LOQ by the spectrophotometric method were within the limit as specified by the ICH guidelines. Hence the methods were found to be simple, accurate, precise, economic and reproducible. so the proposed methods can be used for the routine quality control analysis of Venlafaxine in bulk drug as well as in formulations.

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