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  • An In Depth Exploration of Ginkgo Biloba: A Review
  • 1Assistant Professor (Academics & Research) Lucknow Model College of Pharmacy, Lucknow, UP, India
    2Director (Academics & Research) Lucknow Model College of Pharmacy, Lucknow, UP, India

Abstract

Ginkgo biloba, commonly known as the ginkgo tree, is one of the oldest living tree species on Earth and holds significant importance in traditional medicine and modern research. This research paper provides a comprehensive review of the botanical properties, medicinal benefits, and therapeutic potential of Ginkgo biloba. We explore its historical usage, phytochemical composition, and various pharmacological activities, including antioxidant, anti-inflammatory, neuroprotective, and cardiovascular effects. Additionally, we discuss its potential applications in cognitive enhancement and neurological disorders. Furthermore, this paper presents a critical analysis of the safety and potential adverse effects associated with Ginkgo biloba use.

Keywords

Ginkgo Biloba

Reference

  1. Toghueo, R.M.K. Endophytes from Gingko biloba: The current status. Phytochem. Rev. 2020, 19, 743–759.
  2. Boateng, I.D. A critical review of ginkgolic acids in Ginkgo biloba leaf extract (EGb): Toxicity and technologies to remove ginkgolic acids and their promising bioactivities. Food Funct. 2022, 13, 9226–9242
  3. Liu, L.; Wang, Y.; Zhang, J.; Wang, S. Advances in the chemical constituents and chemical analysis of Ginkgo biloba leaf, extract, and phytopharmaceuticals. J. Pharm. Biomed. Anal. 2021, 193, 113704. 
  4. Tiwari, Dr & Talreja, Shreya. (2020). A Pharmaceutical Importance of Murraya Koenigii-A Complete Study. Indian Journal of Public Health Research and Development. 11. 276-284.
  5. Han, S.; Chio, C.; Ma, T.; Kognou, A.L.M.; Shrestha, S.; Chen, F.; Qin, W. Extracting flavonoid from Ginkgo biloba using lignocellulolytic bacteria Paenarthrobacter sp. and optimized via response surface methodology. Biotechnol. Appl. Microbiol. 2021, 15, 867–878. 
  6. Shu, P.; Sun, M.; Li, J.; Zhang, L.; Xu, H.; Lou, Y.; Ju, Z.; Wei, X.; Wu, W.; Sun, N. Chemical constituents from Ginkgo biloba leaves and their cytotoxicity activity. J. Nat. Med. 2020, 74, 269–274.
  7. Dong, K.-L.; Lin, S.; Wu, Q.-L.; Su, R.-X.; Wu, Z.-L.; Dong, H.-Y.; Li, H.-L.; Zhang, W.-D. A new bilobalide isomer and two cis-coumaroylated flavonol glycosides from Ginkgo biloba leaves. Fitoterapia 2020, 142, 104516. 
  8. Tabassum, N.-E.; Das, R.; Lami, M.S.; Chakraborty, A.J.; Mitra, S.; Tallei, T.E.; Idroes, R.; Mogamed, A.A.-R.; Hossain, J.; Dhama, K.; et al. Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications. Evid.-Based Complement. Altern. Med. 2022, 2022, 8288818. 
  9. Bhupathyraaj, Mullaicharam. (2013). A Review on Evidence Based Practice of Ginkgo biloba in Brain Health. International Journal of Chemical and Pharmaceutical Analysis. Volume 1, Issue 1, 2013, PP.24-30.
  10. Kalisz, O.; Wolski, T.; Gerkowicz, M. Terapia zaburze? kr??enia obwodowego i mózgowego przy u?yciu preparatów z mi?orz?bu dwuklapowego (Ginkgo biloba). Post?py Fitoter. 2005, 3–4, 91–97. 
  11. Chen, D.; Sun, S.; Cai, D.; Kong, G. Induction of mitochondrial-dependent apoptosis in T24 cells by a selenium (Se)-containing polysaccharide from Ginkgo biloba L. leaves. Int. J. Biol. Macromol. 2017, 101, 126–130. 
  12. DeFeudis, F.V.; Papadopoulos, V.; Drieu, K. Ginkgo biloba extracts and cancer: A research area in its infancy. Fundam. Clin. Pharmacol. 2003, 17, 405–417.
  13. Sun, S.; Li, Y.; Chu, L.; Kuanhg, X.; Song, J.; Sun, C. Full-length sequencing of ginkgo transcriptomes for an in-depth understanding of flavonoid and terpenoid trilactone biosynthesis. Gene 2020, 758, 144961.
  14. Lu, Z.; Jiang, B.; Zhao, B.; Mau, X.; Lu, J.; Jin, B.; Wang, L. Liquid profiling in plants: Identification and analysis of extracellular metabolites and miRNAs in pollination drops of Ginkgo biloba. Tress Physiol. 2020, 40, 1420–1436. 
  15. Cao, J.; Wang, H.; Zhang, W.; Cao, F.; Ma, G.; Su, E. Tailor-Made Deep Eutectic Solvents for Simultaneous Extraction of Five Aromatic Acids from Ginkgo biloba Leaves. Molecules 2018, 23, 3214. 
  16. Zhang, S.; Gong, X.; Qu, H. Near-infrared spectroscopy and HPLC combined with chemometrics for comprehensive evaluation of six organic acids in Ginkgo biloba leaf extract. J. Pharm. Pharmacol. 2022, 74, 1040–1050. 
  17. Tiwari, Dr & Talreja, Shreya. (2020). Medicinal and Pharmacological importance of Vitex trifolia: A Review. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 11. 9-13. 10.33887/rjpbcs/2020.11.5.2.
  18. Liu, L.L.; Ke, Z.; Xu, W.; Sun, L.; Ma, A.-C. A strategy for quality control of ginkgo biloba preparations based on UPLC fingerprint analysis and multi-component separation combined with quantitative analysis. Chin. Med. 2022, 17, 72.
  19. Pereira, E.; Barros, L.; Ferreira, I.C.F.R. Chemical characterization of Ginkgo biloba L. and antioxidant properties of its extracts and dietary supplements. Ind. Crops Prod. 2013, 51, 244–248. 
  20. Zhang, L.; Zhu, C.; Liu, X.; Su, E.; Cau, F.; Zhao, L. Study on Synergistic Antioxidant Effect of Typical Functional Components of Hydroethanolic Leaf Extract from Ginkgo Biloba In Vitro. Molecules 2022, 27, 439.
  21. Jiang, B.; Chen, H.; Zhao, H.; Wu, W.; Jin, Y. Structural features and antioxidant behavior of lignins successively extracted from ginkgo shells (Ginkgo biloba L). Int. J. Biol. Macromol. 2020, 163, 694–701.
  22. Kuli?, Ž.; Ritter, T.; Röck, B.; Elsäßer, J.; Schneider, H.; Germen, S. A Detailed View on the Proanthocyanidins in Ginkgo Extract EGb 761. Nat. Prod. Chem. Anal. Stud. 2022, 88, 398–404. 
  23. Boateng, I.D.; Yang, X.-M. Effect of different drying methods on product quality, bioactive and toxic components of Ginkgo biloba L. seed. J. Sci. Food Agric. 2021, 101, 3290–3297. 
  24. Tiwari, Dr & Talreja, Shreya. (2020). Insomnia: A Study on Sleeping Disorder with the Reference of Ayurvedic Herbs. Journal of Pharmaceutical Sciences and Research. 12. 1375-1379.
  25. Zhang, C.H.-W.; Li, M.-F.; Qi, Z.W.; Tao, R.; Ye, J.-Z.; Xue, X.-Y.; Wang, C.H.-Z. The construction of a green and efficient system for the separation of polyprenols from Ginkgo biloba leaves. Process Biochem. 2021, 100, 252–259. 
  26. Zhang, C.H.-W.; Wang, C.H.-Z.; Tao, R.; Ye, J.-Z. Separation of polyprenols from Ginkgo biloba leaves by a nano silica-based adsorbent containing silver ions. J. Chromatogr. A 2019, 1590, 58–64. 
  27. Fang, J.; Wang, Z.; Wang, P.; Wang, M. Extraction, structure and bioactivities of the polysaccharides from Ginkgo biloba: A review. Int. J. Biol. Macromol. 2020, 162, 1897–1905. 
  28. Li, H.; Zhou, G.-Y.; Xu, J.-P.; Liu, J.-A.; Zhang, H.-Y.; Tan, Y. Research progress on polysaccharides from Ginkgo biloba. J. Med. Plants Res. 2012, 6, 171–176.
  29. Li, Y.; Sheng, Y.; Liu, J.; Xu, G.; Yu, W.; Cui, Q.; Lu, X.; Du, P.; An, L. Hair-growth promoting effect and anti-inflammatory mechanism of Ginkgo biloba polysaccharides. Carbohydr. Polym. 2022, 278, 118811. 
  30. Tewari, G.; Mohan, B.; Kishor, K.; Tewari, L.M.; Nailwal, T.K. Volatile constituents of Ginkgo biloba L. leaves from Kumaun: A source of (E)-nerolidol and phytol. J. Indian Chem. Soc. 2015, 92, 1583–1586. 
  31. Nwosu, O.; Okaka, A.N.C.; Ubaoji, K.I. Evaluation of Nutritional and Anti-nutritional Compositions of Leaves of (Maiden Hair) Tree Found in Nigeria. J. Exp. Res. 2018, 6, 66–72. 
  32. Tomowa, T.; Slavova, I.; Tomov, D.; Kirova, G.; Argirova, M.D. Ginkgo biloba Seeds—An Environmental Pollutant or a Functional Food. Horticulturae 2021, 7, 218. 
  33. ChemSpider Search and Share Chemistry. Available online: http://www.chemspider.com/ (accessed on 14 June 2023).
  34. Sarkar, C.; Quispe, C.; Jamaddar, S.; Hossain, R.; Ray, P.; Mondal, M.; Mohamed, Z.A.; Sani, M.; Salehi, B.; Islam, M.T.; et al. Therapeutic promises of ginkgolide A: A literature-based review. Biomed. Pharmacother. 2020, 132, 110908.
  35. Zhao, Y.; Xiong, S.; Liu, P.; Liu, W.; Wang, Q.; Liu, Y.; Tan, H.; Chen, X.; Shi, X.; Wang, Q.; et al. Polymeric Nanoparticles-Based Brain Delivery with Improved Therapeutic Efficacy of Ginkgolide B in Parkinson’s Disease. Int. J. Nanomed. 2020, 15, 10453–10467. 
  36. Yang, M.H.; Baek, S.H.; Um, J.-Y.; Ahn, K.S. Anti-neoplastic Effect of Ginkgolide C through Modulating c-Met Phosphorylation in Hepatocellular Carcinoma Cells. Int. J. Mol. Sci. 2020, 21, 8303.
  37. Bolshakov, S.; Dzyuba, S.V.; Decatur, J.; Nakanishi, K. A Concise Synthesis of Ginkgolide M, a Minor Component of a Terpene Trilactone Fraction from Ginkgo biloba Roots. J. Nat. Prod. 2006, 69, 429–431.
  38. Taillandier J, Ammar A, Rabourdin JP et al. Treatment of cerebral aging disorders with Ginkgo biloba extract. A longtitudinal multicenter doubleblind drug vs. placebo study. Presse Med. 1986; 15:1583-1587.
  39. Grasse E, Effect of Ginkgo-biloba extract on mental performance. Double-blind study using computerized measurement conditions in patients with cerebral insufficiency. Fortschr Med. 1992; 110(5):73-76. 
  40. Hofenmuller W. Evidence for a therapeutic effect of Ginkgo biloba special extract. Metaanalysis of 11 clinical studies in patients with cerebrovascular insufficiency in old age. Arzneimittelforschung 1994; 44(9):1005-1013. 
  41. Allain et al. Effect of two doses of ginkgo biloba extract (EGb 761) on the dual-coding test in elderly subjects. Clin Ther. 1993; 15:549-558. 
  42. Hindmarch I. Activity of Ginkgo biloba extract on short-term memory. Presse Med1986; 15:1592- 1594.
  43. Le Bars PL, Katz MM, Berman N, et al. A placebocontrolled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. JAMA. 1997; 278:1327-1332

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Shreya Talreja
Corresponding author

Assistant Professor (Academics & Research) Lucknow Model College of Pharmacy, Lucknow, UP, India

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Dr Shashank Tiwari
Co-author

Director (Academics & Research) Lucknow Model College of Pharmacy, Lucknow, UP, India

Shreya Talreja*, Dr Shashank Tiwari, An In-Depth Exploration of Ginkgo Biloba: A Review, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 7, 326-334. https://doi.org/10.5281/zenodo.8190129

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