Research Scholar, Carrier Point University (CPU), Hamirpur (H.P.)
Associate Professor, Carrier Point University (CPU), Hamirpur (H.P.)
For the estimation of aspirin in bulk form, a straightforward, sensitive, and focused liquid chromatographic approach has been established. Chromatographic conditions included Column C-18 (250 x 4.6 mm, 5 m particle size), water at pH 3.0, 0.1% orthophosphoric acid (v/v), and acetonitrile (45:55), flow rate of 1 ml, and a running time of 20 minutes. The wavelength of interest was 237 nm. The average recovery percentage was found to be 99.9%, while the retention duration was 4.01 minutes. ICH guidelines were determined to be followed by the suggested procedure and can be used for the analysis of aspirin as a bulk drug and also in combination with other drugs.
Monika Puri, Yogesh Walia, Analytical Method Development and Validation for Analysis of Aspirin: A Component of Anti-hypertensive Drugs by using RP-HPLC Method, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 217-226. https://doi.org/10.5281/zenodo.8332355