Array ( [0] => Array ( [articleID] => 4039 [articleIDUniqueCode] => 250305198 [titleOfPaper] => HIF-PHI for Management of Anaemia of Chronic Kidney Disease: An Overview [keywords] => Chronic kidney disease, Anaemia, HIF-PHI [abstract] => Anaemia is a common consequence of chronic renal disease, which affects 10% of the global population. The primary cause of it is the kidneys' diminished capacity to produce enough EPO in response to hypoxia or anemia. The management of anemia and quality of life have improved with the use of ESAs and iron therapy in current treatment. This treatment raises safety concerns as it attempts to bring the hemoglobin level close to normal. HIF-PHIs, or hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) inhibitors, were created as a substitute method and oral treatment for anemia in chronic kidney disease in order to address these issues. Clinical trial data demonstrated no inferiority in correcting anemia when compared to ESAs or a placebo. Improved iron mobilization and utilization, a reduction in LDL cholesterol, and a reduction in major cardiovascular events were among the other benefits for inflammatory patients. [titleOfPaperOne] => HIFPHI for Management of Anaemia of Chronic Kidney Disease An Overview [authorName] => Sona Toji ) [1] => Array ( [articleID] => 5935 [articleIDUniqueCode] => 250310282 [titleOfPaper] => A Review on Herbal Ointment for Anti-inflammatory Activity [keywords] => Herbal Drugs, Tridax Procumbers, Turmeric, Flavonoids, Anti-Inflammatory Activity [abstract] => Examining the phytochemical components and in vitro anti-inflammatory qualities of Tridax procumbens L. aerial parts was the aim of the current investigation. Qualitative phytochemical study revealed the presence of tannins, alkaloids, saponins, flavonoids, phlorotannin’s, quinines, phenols, coumarins, steroids, and phytosterol terpenoids, but not glycosides or anthraquinones. The spectral response at different wavelengths is shown by analysis in the UV-visible region. FT-IR analysis was used to find organic substances such as alcohol, alkanes, alkyl halides, alkenes, and aromatic groups. Five distinct concentrations of plant aerial parts (20, 40, 60, 80, and 100 g/ml) were also tested for their anti-inflammatory properties utilizing a range of methods, such as protein denaturation inhibition and HRBC membrane stabilization and the inhibitory effects of proteinases. The highest anti-inflammatory benefits were shown by plant extract at a concentration of 100 g/ml for all three animals. The outcomes were compared to those of taking aspirin normally. In conclusion, the aerial part of Tridax procumbens L. shows a strong anti-inflammatory effect, which could be explained by the presence of flavonoid and phenolic chemicals. For over two millennia, curcumin, a naturally occurring polyphenolic compound, has been recognized for its potent anti-inflammatory properties in relation to a variety of conditions, including arthritis. Curcumin's limited water solubility, which results in reduced intestine absorption, is its primary disadvantage. as well as low bioavailability. We compared the anti-arthritic in vivo effects of several curcumin formulations in this work, including micellar curcumin, basic curcumin extract, curcumin combination with piperine, and microencapsulated curcumin. Methods: Complete Freund's adjuvant was used to cause arthritis in Wistar rats, and the arthritis scoring system was used every day to gauge the severity of the condition. Animals received formulations of curcumin once a day for 20. [titleOfPaperOne] => A Review on Herbal Ointment for Antiinflammatory Activity [authorName] => Prajakta Thombare ) [2] => Array ( [articleID] => 5100 [articleIDUniqueCode] => 250307394 [titleOfPaper] => Design and Evaluation of Fluconazole loaded In-Situ Gel for Ocular Keratitis [keywords] => Ocular keratitis, Fluconazole, In-situ gel, Poloxamer 407, Thermosensitive polymers, Mucoadhesion, Fungal keratitis [abstract] => Ocular keratitis, particularly fungal keratitis, remains a significant cause of visual impairment globally, especially in tropical and subtropical regions. Conventional ophthalmic formulations like eye drops often suffer from poor ocular bioavailability due to rapid precorneal elimination, tear turnover, and blinking. To address these limitations, the present research aimed to develop a fluconazole-loaded in-situ gel (ISG) using temperature-sensitive polymers for sustained ocular drug delivery. The study utilized Poloxamer 407, in combination with mucoadhesive agents such as xanthan gum and carbopol 934, to formulate a sol-to-gel system that undergoes gelation upon contact with physiological temperature. A 3² factorial design was employed to optimize the formulation based on critical parameters including gelation temperature, viscosity, and drug release profile. The optimized ISG formulation was characterized for clarity, pH, viscosity, gelation time and temperature, mucoadhesive strength, in vitro diffusion, and release kinetics. The antifungal efficacy of the optimized formulation was tested against Candida albicans and confirmed via agar diffusion studies. Additionally, the formulation exhibited sustained drug release, improved ocular residence time, and was found to be non-irritating in the HET-CAM test. Stability studies further validated the physical and chemical integrity of the formulation over a defined period. This study successfully demonstrates the potential of fluconazole-loaded thermosensitive ISGs as an effective, patient-compliant strategy for the targeted treatment of fungal keratitis, enhancing both therapeutic efficacy and drug bioavailability. [titleOfPaperOne] => Design and Evaluation of Fluconazole loaded InSitu Gel for Ocular Keratitis [authorName] => Ashwinkumar Budhanale ) [3] => Array ( [articleID] => 986 [articleIDUniqueCode] => 240205159 [titleOfPaper] => Review on Licorice Plant (Jaist Madhu) [keywords] => Glycyrrhiza glabra pharmacology phytochemistry toxicology traditional use . [abstract] => Since natural compounds are generally thought to be safe, consumers have become much more aware of natural medicines and principles in recent years. However, the industry is becoming more and more interested in using plants that are used in traditional medicine in foods, nutraceuticals, cosmetics, and even medications. Glycyrrhiza glabra Linn. is a member of the Fabaceae family and has been valued for its ethnopharmacological properties since ancient times. This plant contains a variety of phytocompounds with diverse pharmacological activities, including glycyrrhizin, 18?-glycyrrhetinic acid, glabrin A and B, and isoflavones. Numerous extracts and pure compounds from this species have been shown through pharmacological experiments to exhibit a wide range of biological properties, such as antibacterial, anti-inflammatory, antiviral, antioxidant, and antidiabetic activities. Certain toxicological studies have raised some red flags. All of those concerns are covered in this review, which also concentrates on the pharmacological actions associated with G. glabra. To explore G. glabra's therapeutic potential and future challenges for use in the formulation of new products that will improve human well-being, an extensive, critical, and up-to-date overview of the current knowledge about its composition and biological activities is presented here. [titleOfPaperOne] => Review on Licorice Plant Jaist Madhu [authorName] => Jayesh Dnyaneshwar Phalake ) [4] => Array ( [articleID] => 2434 [articleIDUniqueCode] => 240212284 [titleOfPaper] => Formulation And Evaluation of Polyherbal Shampoo Powder [keywords] => Formulation And Evaluation, Polyherbal Shampoo Powder. [abstract] => The aim of the present work is to formulate and evaluate Polyherbal Shampoo powder. Herbs and herbal medications have been shown in studies to promote hair growth. Comparing herbal hair shampoo to synthetic formulation, which can have adverse effects like itching and localized irritation has drawn attention to these alternatives. There are several synthetic formulation available for hair loss, but they have serious adverse effects and don't provide permanent relief. Graying of the Hair is the natural phenomenon which attributes to the ageing and frequent use of shampoos which leads to use of synthetic shampoos with the increase of hazardous chemicals in the process of manufacturing. Polyherbal hair shampoo is preferred due to their advantages in contrast to synthetic one which has adverse effect on human health because of harsh chemicals. Polyherbal shampoos are prepared by using Fenugreek, Soap Nuts, Neem, Amla, Shikakai, Rose Mary, Henna. [titleOfPaperOne] => Formulation And Evaluation of Polyherbal Shampoo Powder [authorName] => Suvarna Kasi ) [5] => Array ( [articleID] => 1070 [articleIDUniqueCode] => 240205401 [titleOfPaper] => Formulation and Evaluation of Herbal Antiseptic Oil from the Phyllanthus Niruri Extract [keywords] => Bioactive compounds, Evaluation, Extraction, Formulation, Therapeutic properties [abstract] => Objective: The study focuses on the formulation and evaluation of an herbal Antiseptic oil from the Phyllanthus niruri extract. This study discusses the preparation of herbal antiseptic preparation for wound-healing activity purpose. In studies, it has shown antibacterial and antimicrobial properties. Methodology: Traditional extraction methods (Percolation, Decoction, Soxhlet extraction) are used to extract the bioactive compounds from the plant. The ethanolic and aqueous solvent is used to obtain the extract from the plant. Results: The presence of bioactive compound is evaluated using chemical tests, The Physical parameter (Appearance,pH, Appearance, odour, density, viscosity, TLC) of the formulation are evaluated. Conclusion: This study concludes the presence of bioactive compounds and physical parametric evaluation study of formulation. [titleOfPaperOne] => Formulation and Evaluation of Herbal Antiseptic Oil from the Phyllanthus Niruri Extract [authorName] => Swati Pawar ) [6] => Array ( [articleID] => 4776 [articleIDUniqueCode] => 250306512 [titleOfPaper] => Formulation and Evaluation of Moringa Oil-Enriched Anti-Aging Cream [keywords] => Moringa oleifera, Camellia sinensis, Rose, Anti-aging, Antioxidant [abstract] => The rising demand for natural skincare has spurred interest in harnessing plant-based ingredients known for their antioxidant and rejuvenating properties. This research paper explores the formulation and evaluation of a moringa oil-based along with green tea oil and rose oil anti-aging cream, aimed at counteracting the visible effects of aging such as wrinkles and skin elasticity loss. This study aimed to develop and assess the efficacy of a synergistic blend of these botanical oils, each contributing unique bioactive properties: moringa oil for its nutrient-rich profile and potent fatty acids; green tea oil for its high antioxidant content and anti-inflammatory benefits; and rose oil for its soothing, cell-regenerative, and hydrating effects. An optimized oil-in-water emulsion technique was employed to integrate these oils into a stable cream formulation. Comprehensive evaluations were conducted to determine the formulation's physicochemical stability, including assessments of viscosity, pH, spread-ability etc. Overall, the results underscore the potential of combining moringa, green tea, and rose oils into an anti-aging cream, presenting a alternative in cosmetic formulations aimed at combating the effects of aging. [titleOfPaperOne] => Formulation and Evaluation of Moringa OilEnriched AntiAging Cream [authorName] => Kunjal Ghadge ) [7] => Array ( [articleID] => 5187 [articleIDUniqueCode] => 250307517 [titleOfPaper] => Recent Advances in Diagnostic and Therapeutic Strategies for Diabetes Mellitus: A Comprehensive Review [keywords] => Diabetes mellitus, diagnostics, therapeutics, biosensors, phytotherapy, nanotechnology, personalized medicine [abstract] => Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Its global burden continues to escalate, affecting over 540 million individuals as of 2024. This comprehensive review highlights recent developments in the diagnosis and management of diabetes, focusing on both conventional and emerging approaches. Diagnostic innovations include continuous glucose monitoring systems, lab-on-a-chip devices, wearable biosensors, and novel biomarkers such as microRNAs and adipokines, which offer enhanced sensitivity and real-time glycemic profiling. Therapeutically, advancements extend beyond traditional pharmacological interventions—such as insulin, metformin, and sulfonylureas—to include incretin-based therapies, SGLT2 inhibitors, and cardio-renal protective agents. In parallel, plant-based interventions and phytochemicals derived from Momordica charantia, Gymnema sylvestre, Tinospora cordifolia, and others have shown significant antidiabetic activity via multifaceted mechanisms including ?-cell preservation, insulin mimetic action, and antioxidative stress modulation. The incorporation of nanotechnology, gene therapy, and stem cell approaches represents a transformative frontier in diabetes care, aiming at disease modification rather than symptomatic control. Despite these promising strides, challenges remain in the form of affordability, health system integration, regulatory oversight, and the need for robust clinical validation, particularly for herbal and nanomedicine-based strategies. This review underscores the importance of a multidisciplinary, patient-centered approach to diabetes management, integrating evidence-based innovations with public health strategies to curb the global impact of the disease. [titleOfPaperOne] => Recent Advances in Diagnostic and Therapeutic Strategies for Diabetes Mellitus A Comprehensive Review [authorName] => Dr. Shivakumar Ladde ) [8] => Array ( [articleID] => 1061 [articleIDUniqueCode] => 240205380 [titleOfPaper] => A Review Of The UV-Visible Spectroscopy's Method Development And Validation [keywords] => Method development, validation, UV-visible spectroscopy, spectroscopy, analytical approach. [abstract] => The creation and verification of analytical methodologies are crucial to the production, development, and progression of pharmaceuticals. Pharmaceutical analysis significantly affects the quality assurance and control of both bulk drugs and pharmaceutical formulations. UV spectroscopy has been utilised in the pharmaceutical industry for the past three-and-a-half decades; it is an effective and significant analytical instrument. The processes that are required to determine the "identity, strength, quality, or purity" of these compounds are all part of the pharmaceutical analysis. The methodology for analysis involves the utilisation of colourless substances to measure how they absorb of light that is monochromatic in the near-ultraviolet (200–400 nm) range. In order to obtain the absorbance spectrum of a chemical in solution or solid form, UV-visible spectroscopy is utilised. The creation and verification of a spectroscopy using ultraviolet light method for the precise quantification of a substance are detailed in this study. The procedure was refined by means of distinct stages, and exhaustive evaluation validated its accuracy and dependability. The outcomes demonstrate its prospective utility in various domains for accurate substance quantification. [titleOfPaperOne] => A Review Of The UVVisible Spectroscopys Method Development And Validation [authorName] => Shraddha Khokrale ) [9] => Array ( [articleID] => 3793 [articleIDUniqueCode] => 250305237 [titleOfPaper] => Formulation and Evaluation of Nasal Microspheres [keywords] => Montelukast; Mucoadhesion; Intranasal; Chitosan; Nasal Microspheres [abstract] => Montelukast, a leukotriene antagonist, anti-asthmatic drug, and anti-arrhythmia drug, was approved for clinical use by the US FDA in 1998 under the brand name Singulair. It is a conjugate acid of montelukast and belongs to the leukotriene receptor antagonist (LTRA) category. Although effective, it is typically used alongside inhaled corticosteroids in asthma step therapy. FDA-led investigations in 2008-2009 investigated the possibility of montelukast eliciting neuropsychiatric effects like agitation, hallucinations, and suicidal behavior in users. Although these effects are now included in the official prescribing information, the drug continues to be used worldwide through millions of prescriptions annually and is available as a generic and brand name product. The study aims to develop and evaluate nasal microspheres containing Montelukast for targeted drug delivery, improving bioavailability, patient compliance, reducing dosing frequency, minimizing side effects, and optimizing size and shape. It also evaluates drug release profiles, develops a stable manufacturing process, and compares with existing systems. The microspheres were found to be favorable for intranasal absorption, with particle sizes ranging from 7.90 ± 1.01 to 8.10 ± 0.93 µm. All batches showed good in vitro mucoadhesion (88-96%). The study also found no aggregation between drug and polymer in the microspheres, suggesting promising potential for delivering Montelukast intranasal. [titleOfPaperOne] => Formulation and Evaluation of Nasal Microspheres [authorName] => Payal Raut ) )