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Abstract

Infertility is one of the major health problems in life. More factors such as drug treatment, chemotherapy, toxins, air pollutants, and insufficient vitamins intake have harmful effects on spermatogenesis and sperm normal production.Previous phytochemical investigations of the Commelina genus were reported on C. undulata.,C. benghalensis L. and C. communis L. from which several types of compounds such as alkaloids, steroids, terpenoids, iridoids, flavonoids, lignans, aliphatic alcohols, polyols, and phenolic acids were obtained1.The objective of the study is evaluating the effect of the Commelina benghalensis extract on male rats by evaluating some andrological parameters of the Wistar rat such as sperm volume, motility, count, liveability and morphology which are some of the indices that determine the ability of a male rats to produce viable spermatozoa and it is used as a sex stimulant in rural areas.

Keywords

Infertility, Commelina benghalensis, Spermatogenesis, Cyclophosphamide, Testosterone

Reference

  1. Leseilane J. Mampuru et al.,( 2008) Alteration of Bax-to-Bcl-2 ratio modulates the anticancer activity of methanolic extract of Commelina benghalensis (Commelinaceae) in Jurkat T cells African Journal of Biotechnology Vol. 7 (20), pp. 3569–3576, 20 October.
  2. Isidori AM, et al.,(2006) A. Medical treatment to improve sperm quality. J Reprod Biomed;12:704 -714.
  3. Subramoniam A, et al.,(1997).Aphrodisiac property of Trichopus zeylanicus extract in male mice. J Ethnopharmacol.;57: 21–27.
  4. Fairley, et al., (1972) Sterility and testicular atrophy related to cyclophosphamide therapy. Lancet; 1:568.
  5. Acevedo-Rodriguez, et al., (2005), "Monocotyledons and Gymnosperms of Puerto Rico and Virgin Islands", Contributions of the United States Faden, Robert B. "The misconstrued and rare species of Commelina (Commelinaceae) in the eastern United States", Annals of the Missouri Botanical Garden 80 (1): 208–218

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Umamaheswari
Corresponding author

Department of Pharmacology, Varadaraja Institute of Pharmaceutical Education & Research, Tumkur, Karnataka

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Dr. Bheemachari
Co-author

Department of Pharmacology, Varadaraja Institute of Pharmaceutical Education & Research, Tumkur, Karnataka

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Firdos Sultana
Co-author

Department of Pharmacology, Varadaraja Institute of Pharmaceutical Education & Research, Tumkur, Karnataka

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Raziya begum
Co-author

Department of Pharmacology, Varadaraja Institute of Pharmaceutical Education & Research, Tumkur, Karnataka

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Niveditha
Co-author

Department of Pharmacology, Varadaraja Institute of Pharmaceutical Education & Research, Tumkur, Karnataka

Umamaheswari*, Dr. Bheemachari, Firdos Sultana, Raziya begum, Niveditha, Evaluation Of Spermatogenic Activity Of Commelina Benghalensis Against Cyclophosphamide Induced Reproductive Changes In Male Albino Rats, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 145-151. https://doi.org/10.5281/zenodo.10073402

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