Many medicinal plants are claimed to be useful in skin diseases in all traditional systems of medicine and folklore. At the same time, these herbal remedies are used orally and by topical application. Looking at the scope of the herbal drug and the increasing demand, especially for liver disease, cancer, diabetes, hypertension, kidney disease, inflammation, infectious disease, skin disease, etc. Plumeria obtusa is a deciduous tree with a thick, widely spread, common rather wet garden; in lawns and open plantations, the tree is unusual in appearance. The plant loses leaves for a short time during the winter. This study aims to determine phytochemical components using different solvents and to study the antibacterial effect of methanol extract to varying concentrations against these bacteria. Phytochemical analysis of Plumeria obtusa leaves extracts indicate the presence of various medicinally valuable components, including alkaloids, glycosides, carbohydrates, phytosterols, phenolic compounds, tannins, saponins, flavonoids, proteins, and amino acids. Current findings indicate that methanol is a good solvent for extracting antibacterial agents. Further studies are needed to investigate the individual phytochemical compounds of Plumeria obtusa Leaves can be considered as effective as the most effective artificial antibiotics.


Antibiotics, Antibacterial activity, Methanol extract, Plumeria obtusa Linn, Phytochemical analysis, etc


  1. Harborne JB, Baxter H and Moss GP. A handbook of bioactive compounds from plants. Phytochemical dictionary. 1993; 35:36-7.
  2. Edema MO and Alaga TO. Comparative evaluation of bioactive compounds in Hibiscus sabdariffa and Syzygium samarangense juice extracts. African Crop Science Journal. 2012;20(3):179-88.
  3. Sobhy EA, Abd Elaleem KG and Abd Elaleem HG. Potential antibacterial activity of Hibiscus rosa-sinensis Linn flowers extracts. International Journal of Current Microbiology Applications. 2017;6(4):1066-72.
  4. Koehn FE and Carter GT. The evolving role of natural products in drug discovery. Nature Reviews Drug discovery. 2005 Mar 1;4(3):206-20.
  5. Newman DJ, Gragg GM and Sander KM. Medicinal plants and their benefits. Journal of Natural Products. 2003; 66:1022-45.
  6. Akinmoladun AC, Ibukun EO, Afor E, Obuotor EM and Farombi EO. Phytochemical constituent and antioxidant activity of extract from the leaves of Ocimum gratissimum. Scientific Research Essay. 2007 May 1;2(5):163-6.
  7. Edeoga HO, Okwu DE and Mbaebie BO. Phytochemical constituents of some Nigerian medicinal plants. African Journal of Biotechnology. 2005 Aug 19;4(7):685-8.
  8. Krishnaiah D, Sarbatly R and Bono A. Phytochemical antioxidants for health and medicine: A move towards nature. Biotechnology and Molecular Biology Reviews. 2007;1(4):97-104.
  9. Patel R, Patel A, Vaghasiya D and Nagee A. Antimicrobial evaluation of Hibiscus rosa-sinensis plant extracts against some pathogenic bacteria. Bulletin of Environmental and Scientific Research. 2012;1(3-4):14-7.
  10. Abate TA and Belay AN. Assessment of antibacterial and antioxidant activity of aqueous crude flower, leaf, and bark extracts of Ethiopian Hibiscus rosa-sinensis Linn: geographical effects and Co2Res2/Glassy carbon electrode. International Journal of Food Properties. 2022;25(1):1875-89.
  11. Dwivedi SJ and Dubey R. Pharmacological, phytochemical, and traditional uses of Plumeria obtusa Linn. alba Linn. An Indian medicinal plant. Journal of Pharmaceutical Biosciences. 2018; 1:14–7
  12. Shinde PR, Patil PS and Bairagi VA. Phytopharmacological review of Plumeria obtusa Linn. species. Scholar Academics Journal of Pharmacy. 2014; 3:217–27.
  13. Kaur J, Sanghavi AD, Chopra A, Lobo R and Saha S. Antimicrobial and cytotoxicity properties of Plumeria obtusa Linn. alba flower extract against oral and periodontal pathogens: A comparative in vitro study. Journal of Indian Society of Periodontology. 2022;26(4):334-341. 
  14. Prajapati ND and Purohit SS. Handbook of Medicinal Plants. Jodhpur, India: Agrobios; 2004. pp. 336–8.
  15. Raju RA. A Textbook of Wild Plants of Indian Subcontinent and Their Economic Use. New Delhi: CBS Publ; 2000. p. 145.
  16. Kumari S, Mazumdera A and Bhattacharya S. In-vitro antifungal activity of the essential oil of flowers of Plumeria obtusa Linn. alba Linn. (Apocynaceae) International Journal of PharmTech Research. 2012; 4:208–12.
  17. Radha R, Sriram L and Narayanan N. Antibacterial and antifungal activities of methanolic extract and the isolated fraction of Plumeria obtusa Linn. alba Linn. Natural Products. 2008; 4:13–26.
  18. Akhtar N, Malik A and Ali S. A new antibacterial triterpenoid from Plumeria obtusa Linn. alba. Fitoterapia. 1993; 2:162–6.
  19. Zahid Z, Khan SW, Patel KA and Konale AG. Antimicrobial activity of essential Linn., oil of flowers of Plumeria obtusa Linn. alba. Journal of Pharmaceutical and Phytochemical Sciences. 2010; 2:155–7.
  20. Syakira MH, Brenda L. Antibacterial capacity of Plumeria obtusa Linn. alba petals. World Academic Sciences, Engineering and Technology. 2010; 44:1473–6.
  21. The wealth of India, CSIR New Delhi, 1sted, Shree Saraswati Press Ltd, Calcutta, CSIR. 1959; 5:164-165. 
  22. Prusti AB and Behera KK. Ethno-medico botanical study of Sundargarh district, Orissa, India. Ethnobotanical Leaflets, 2007; 11:148-163.
  23. Aguoru CU, Abah OP and Olasan JO. Systematic Descriptions and Taxonomic Studies on Three (3) Species of Plumeria obtusa Linn. in North Central Nigeria. International Journal of Innovation and Scientific Research. 2015; 2:403-411.
  24. Manisha K and Aher AN. Review on the traditional medicinal plant: Plumeria obtusa Linn. rubra. Journal of Medicinal Plants Studies. 2016;4(6):204-7.
  25. Bihani T. Plumeria obtusa Linn. rubra L.–A review of its ethnopharmacological, morphological, phytochemical, pharmacological and toxicological studies. Journal of Ethnopharmacology. 2021; 264:113291.
  26. https://www.floridacolorsPlumeria obtusa obtusa Linn.-fertilization nutrition/#:~:text=Nitrogen (N), phosphorus (,) and Chlorine (Ci)
  27. Vasudeva N, Sharma SK. Post-coital antifertility activity of Hibiscus rosa-sinensis Linn roots. Evidence-Based Complement Alternative Method. 2008;5(1):91-94.
  28. Kokate CK. Practical Pharmacognosy. 4th Ed. New Delhi: Vallabh Prakashan; 2005.  124.

Ganesh D. Barkade
Corresponding author

Assistant Professor, Department of Pharmaceutical Chemistry, Dr. Vitthalrao Vikhe Patil Foundation’s College of Pharmacy, Vilad Ghat, Ahmednagar – 414111

Akshata B. Sinare

Research Scholar, Dr Vitthalrao Vikhe Patil Foundation's College of Pharmacy, Vilad Ghat, Ahmednagar – 414111

Mayur G. Tandale

Research Scholar, Dr Vitthalrao Vikhe Patil Foundation's College of Pharmacy, Vilad Ghat, Ahmednagar – 414111

Rutuja B. Sonawane

Research Scholar, Dr Vitthalrao Vikhe Patil Foundation's College of Pharmacy, Vilad Ghat, Ahmednagar – 414111

Rutuja R. Sumbe

Research Scholar, Dr Vitthalrao Vikhe Patil Foundation's College of Pharmacy, Vilad Ghat, Ahmednagar – 414111

Akshata B. Sinare, Mayur G. Tandale, Rutuja B. Sonawane, Rutuja R. Sumbe, Vaibhav D. Talekar, Ganesh D. Barkade*, Extraction, Phytochemical Investigation and Antimicrobial Activity of Plumeria Obtusa, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 6, 39-46.

More related articles
Formulation And In vitro Evaluation Of Bilayer Tab...
Mayur Aware, Sheetal Gondkar, Rishikesh Bachhav, ...
A Comprehensive Review On Herbal Plants Showing An...
Saurabh Dumbre, Gaurav Gawade, Swati Jadhav, Pravin Khamkar, ...
Development And Validation Of UV HPLC Method For T...
Amol Amrutkar, Smita Aher, Rishikesh Bachhav, ...
Related Articles
Ayurvedic Remedies of Bacterial Meningitis...
Komal Ushir, Dinesh Rishipathak, Pragati Bhosale, Manisha Raut, ...
More related articles
A Comprehensive Review On Herbal Plants Showing Anti Diabetic Activity...
Saurabh Dumbre, Gaurav Gawade, Swati Jadhav, Pravin Khamkar, ...