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  • Formulation And Evaluation of Erythromycin Delayed Release Tablets
  • 1Department of Pharmaceutics, Mallareddy college of Pharmacy, Dhulapally, Secunderabad.
    2Department of Pharmaceutics, JNTU, Kakinada.
    3Department of Pharmacognosy, Mallareddy college of Pharmacy, Dhulapally, Secunderabad

Abstract

The present study is to formulate and evaluate Erythromycin enteric coated tablets prepared by wet granulation method by using Povidone k30 as polymer, Tricetin as plasticizer ,titanium dioxide as opacifer ,aqueous coating Eudragit 100-55 as coating agent and opadry red as coloring agent .The physico - chemical incompatibity was studied by using Hplc and physical parameters of prepared enteric coated tablets were evaluated as pharmacopeia standards .The dissolution studies of prepared enteric coated tablets was evaluated as pharmacopeia standards .The dissolution studies were performed by using ph 4 acetate buffer for 2hrs and then transfer to phosphate buffer 6.8 for 1 hr. The release order kinetics was studied for the best formulation and was found zero order. The stability studies were performed as per ICH guidelines and results was found satisfactory.

Keywords

Hypermellose, Eudragit 100-55, HPLC, Tricetin, titanium dioxide

Reference

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Photo
Surisetty Sridevi
Corresponding author

Department of Pharmaceutics, Mallareddy college of Pharmacy, Dhulapally, Secunderabad

Photo
D. Vinay Kumar
Co-author

Department of Pharmaceutics, JNTU, Kakinada

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SNVL Sirisha
Co-author

Department of Pharmacognosy, Mallareddy college of Pharmacy, Dhulapally, Secunderabad.

Surisetty Sridevi*, D. Vinay Kumar, SNVL Sirisha, Formulation And Evaluation Of Erythromycin Delayed Release Tablets, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 152-161. https://doi.org/10.5281/zenodo.8330907

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