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  • Formulation And In Vitro Release Kinetic Of Aceclofenac Through Polymeric Film System Using Modified Polymers

  • Photo Chethana R * Photo Shiva Kumar S Photo Manoj R V

  • 1Department of Pharmaceutics, St. John's Pharmacy College, #6, 9th cross, 2nd main, Vijayanagar 2nd stage, Hampinagar, Bangalore India-560104
    2Department of Pharmaceutics, National College of Pharmacy, Balaraj urs road, Shivamoga India-577201
    3St. John’s Pharmacy college, #6, 9th cross, 2nd main, Vijayanagar 2nd stage, Hampinagar, Bangalore -560104
     

Abstract

Transdermal films of aceclofenac using chitosan, modified chitosan, HPMC, and sodium alginate were developed by solvent casting technique and evaluated with respect to various physical parameters. As a plasticizer, glycerin was utilized in a variety of weight ratios. The article also discusses conjugating chitosan with thioglycolic acid and the modification of chitosan with acetaldehyde and propionaldehyde, respectively for creating Schiff's bases (polymers-I and II). Modification and compatibility were confirmed by differential scanning calorimetry (DSC) and FTIR analysis respectively. The produced films were assessed for a number of characteristics, including thickness, folding resistance, swelling index, bursting strength, tensile strength, moisture content, water vapour transfer (WVT) rate, and in vitro drug permeation studies. All of the formulations for physical and mechanical characterization were observed, and it was found that the formulations produced the best results and the membranes were stable

Keywords

Transdermal drug delivery, Aceclofenac, Modified Chitosan, Polymer-I, Polymer-II, Conjugated Chitosan, Sodium alginate, HPMC, EDAC

Reference

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Photo
Chethana R
Corresponding author

Department of Pharmaceutics, St. John's Pharmacy College, #6, 9th cross, 2nd main, Vijayanagar 2nd stage, Hampinagar, Bangalore India-560104

Photo
Shiva Kumar S
Co-author

Department of Pharmaceutics, National College of Pharmacy, Balaraj urs road, Shivamoga India-577201

Photo
Manoj R V
Co-author

St. John’s Pharmacy college, #6, 9th cross, 2nd main, Vijayanagar 2nd stage, Hampinagar, Bangalore -560104

Chethana R., Shiva Kumar S., Manoj R. V., Formulation And In-Vitro Release Kinetic Of Aceclofenac Through Polymeric Film System Using Modified Polymers, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 717-737. https://doi.org/10.5281/zenodo.10579099

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