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1Professor and Head Department of Pharmaceutics, Dr Vithalrao Vikhe Patil foundation's College of Pharmacy, Vilad Ghat, Ahmednagar-414111
2Department of pharmaceutics, Dr Vithalrao Vikhe Patil Foundation's College of Pharmacy, Vilad ghat, Ahmednagar-414111
In the present study, attempt has been done to develop a novel mucoadhesive drug system in the form of the buccal patches for the release of metformin HCl and glibenclamide in a unidirectional manner, to maintain constant therapeutic levels of the drug for long time. Buccal formulation of metformin HCl and glibenclamide in the form of mucoadhesive patches were developed to a satisfactory level in term of drug release, drug permeation, content uniformity, swelling index, surface pH, thickness and folding endurances. Although all buccal patches exhibited satisfactory results, but best results were obtained from Mf4 and Gf5. the above study concluded that the possibility of the making of mucoadhesive drug delivery system for metformin hcl and glibenclamide which will be more efficacious and acceptable than conventional drug delivery of drug and also having satisfactory controlled release profile which may provide an increased therapeutic efficacy.
S. Z. Chemate, Shruti P. Gosavi, Formulation development and in-vitro evaluation of metformin hydrocholoride and glibenclamide buccal patch, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 482-512. https://doi.org/10.5281/zenodo.10556884
10.5281/zenodo.10556884