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  • Formulation Development And In Vitro Evaluation Of Metformin Hydrocholoride And Glibenclamide Buccal Patch
  • 1Professor and Head Department of Pharmaceutics, Dr Vithalrao Vikhe Patil foundation's College of Pharmacy, Vilad Ghat, Ahmednagar-414111 
    2Department of pharmaceutics, Dr Vithalrao Vikhe Patil Foundation's College of Pharmacy, Vilad ghat, Ahmednagar-414111
     

Abstract

In the present study, attempt has been done to develop a novel mucoadhesive drug system in the form of the buccal patches for the release of metformin HCl and glibenclamide in a unidirectional manner, to maintain constant therapeutic levels of the drug for long time. Buccal formulation of metformin HCl and glibenclamide in the form of mucoadhesive patches were developed to a satisfactory level in term of drug release, drug permeation, content uniformity, swelling index, surface pH, thickness and folding endurances. Although all buccal patches exhibited satisfactory results, but best results were obtained from Mf4 and Gf5. the above study concluded that the possibility of the making of mucoadhesive drug delivery system for metformin hcl and glibenclamide which will be more efficacious and acceptable than conventional drug delivery of drug and also having satisfactory controlled release profile which may provide an increased therapeutic efficacy.

Keywords

Buccal film, unidirectional buccal patch, Ex-vivo permeation, mucoadhesive drug delivery, antihyperglycemic agent

Reference

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Shruti P. Gosavi
Corresponding author

Department of pharmaceutics, Dr Vithalrao Vikhe Patil Foundation's College of Pharmacy, Vilad ghat, Ahmednagar-414111

Photo
S. Z. Chemate
Co-author

Professor and Head Department of Pharmaceutics, Dr Vithalrao Vikhe Patil foundation's College of Pharmacy, Vilad Ghat, Ahmednagar-414111

S. Z. Chemate, Shruti P. Gosavi, Formulation development and in-vitro evaluation of metformin hydrocholoride and glibenclamide buccal patch, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 482-512. https://doi.org/10.5281/zenodo.10556884

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