View Article

  • Formulation Development and Evaluation Of Wax Incorporated Floating Beads Of Dalfampridine
  • 1Department of Pharmaceutics, R. G, Sapkal College of Pharmacy, Anjaneri, Nashik-422212
    2Department of Pharmacology, R. G, Sapkal College of Pharmacy, Anjaneri, Nashik-422212

Abstract

In this study, the Dalfampridine multi-unit sustained release gastric drug delivery system was developed from a purely aqueous medium, avoiding the use of any organic solvents, thereby releasing the drug over a short period of time. time. The emulsion gelation technique is used to prepare the beads. Edible oil pearls are made by mixing and homogenizing olive oil and water containing pectin and molten wax, then extruding them into a solution of calcium chloride. The effects of carnauba wax on smoking efficacy, variation in delay, morphology, and drug release have been studied. Carnauba wax was found to be sufficient to promote drug release at gastric pH. The results show that these particles can trap drugs in large enough quantities and can also successfully deliver drugs to the stomach for a long time without the use of organic solvents.

Keywords

Gastroretentive, Floating Wax Beads, Dalfampridine

Reference

  1. Khavare NB, Dasankoppa FS, Najundaswamy NG. A Review on Key Parameters and Components in Designing of Osmotic Controlled Oral Drug Delivery Systems. Indian Journal of Novel Drug Delivery 2010; 2(4): 122 – 31.
  2. Sungthongjeen S, Paeratakul O, Limmatvapirat S, Puttipupathachorn S. Preparation and in-vitro evaluation of multiple-unit floating drug delivery system based on gas formation technique. Int J Pharm 2006; 324: 136-43.
  3. Sato Y, Kawashima Y, Takenchi H, Yamamoto H. Physicochemical properties to determine the buoyancy of hollow microspheres (microballoons) prepared by the emulsion solvent diffusion method. Eur J Pharm Biopharm 2003; 55: 297-304.
  4.  Bairagi PD. et. al. (2018),Formulation development and evaluation of floating wax microspheres of Tizanidine Hydrochloride: Asian Journal of Pharmacy and Pharmacology 2018,4(5),pp. 673-679.
  5. Patel RP, Baria AH. 2009. Stomach-specific Drug Delivery of Famotidine Alginate beads. International Journal of Pharma Tech Research, 1:288-291.
  6. Unites State Pharmacopoeia. 2008. Water solid interaction of Pharmaceutical systems, the official standard, Volume 1: pp.177-179, 710, 1460-1462.
  7. Tekade BW, Jadhao UT, 2014, Formulation and Evaluation of Metclopramide Hydrochloride Sustained Release Microsphere, Research and Reviews. Journal of Pharmacy and Pharmaceutical and Pharmaceutical Science, 1:22-31.
  8. Fursale RA, Patil GB. 2009. Study of Multiparticulate Floating Drug Delivery System prepared by Emulsion Gelation Technique. International Journal of Chem Tech Research, 1:162-167.
  9. Khan AD, Bajpai M. 2011. Formulation and Evaluation of Floating Beads of Verapamil Hydrochloride. International Journal of Pharma Tech Research, 3:pp.1537-1546.
  10. Gupta R, Meenakshi B. 2013. Influence of formulation parameter on Tizanidine hydrochloride nanoparticle. International Journal of Pharma and Bio Sciences, 4(2):1056- 1078.
  11. Pavia DL, Lampan GM. 2007. Spectroscopy, 9 Ed. Cennage th Learning Pvt. Ltd.; pp.23-93.
  12. ICH Harmonised Tripartite Guidelines, International Conference on Harmonisation, Stability Testing of new drug substances and products Q1A(R2) and evaluation for stability data Q1E, Current step version. 6th February 2003.
  13. Nevine Malak (2012), Formulation of Coated polymer reinforced gellan gum beads of Tizanidine HCl using Fractional Factorial Design, International Journal of Pharmacy and Pharmaceutical Sciences;4(5).pp.369-379.
  14. Adimoolam Senthl et.al.(2011), Formulation and Evaluation of floating tablets of Tizanidine Hydrochloride, International Research Journal of Pharmacy,2(8),pp.124-129.
  15. Pornsak Sriamornsak et.al.(2008), Wax-incorporated Emulsion Gel Beads of Calcium Pectinate for Intragastric Floating Drug Delivery, AAPS PharmaSciTech; 9(2),pp.571-578.
  16. Gowda D.V., Shivkumar H.G. (2007), Preparation and Evaluation of Waxes/Fat Microspheres Loaded with Lithium Carbonate for Controlled Release, Indian Journal of Pharmaceutical Sciences; 69(2),pp.251-256.

Photo
Amol Ghare
Corresponding author

Department of Pharmaceutics, R. G, Sapkal College of Pharmacy, Anjaneri, Nashik-422212

Photo
Sheetal Gondkar
Co-author

Department of Pharmaceutics, R. G, Sapkal College of Pharmacy, Anjaneri, Nashik-422212

Photo
Rishikesh Bachhav
Co-author

Department of Pharmacology, R. G, Sapkal College of Pharmacy, Anjaneri, Nashik-422212

Amol Ghare, Sheetal Gondkar, Rishikesh Bachhav, Formulation Development and Evaluation Of Wax Incorporated Floating Beads Of Dalfampridine, Int. J. in Pharm. Sci., 2021, Vol 1, Issue 2, 104-111. https://doi.org/10.5281/zenodo.6257256

More related articles
Brain Tumors: Signs, Detection, and Treatment...
V. A. Chavan, V. K. Gahal, S. S. Deokar, ...
Prenatal Fear Of Child Birth...
Sneha Bhoir, Saurabh Borde, Saloni Bhoir, Sidra Choudhary, ...
Biodegradable Sanitary Napkins An Innovative Appro...
Mounika K, Dr. K. B. Ilango, Baranitharan A. K., Dhivyatharshini ...
Formulation Development And Evaluation Of The Tinospora Crispa Ointment...
Savita Yadav, Dr Gaurav Dubey, Shailendra Singh Chandel, Aditi Omprakash Jyotishi, ...
A Comprehensive Review On: Exploring The Cytotoxic Activity And Metal Oxide Bind...
Mayur S. Tekade, Sayli A. Tekade, Poonam D. Awaghate, ...
Hand And Foot Syndrome With Hyperpigmentation By Capecitabine...
Asra Jabeen, Masrat Nabi, Sheikh H. Ismail, Zahid Akhtar, Sami Magray, Nasreen Chashoo, ...
Related Articles
Green Synthesis And Biological Evaluation Of A, B - Unsaturated Carbonyl Compoun...
Shaikh Sabiya khalil , Md.Rayees Ahmad, Vishweshwar Dharashive, Dachawar Saiprasad, Shaikh Ghafurunn...
Evaluation Of Anti-Parkinsonian Effect Of Ethanolic Leaf Extract Of Allium, Jacq...
Adiba Afreen, Shaik Mohd Khasim, Saniya Zainab, Shaik Shahnaz Begum, Aman Khan, Mohd Ajaz Kaiser, Ka...
Apigenin And Its Anticancer Activity By Using Molecular Docking ...
Vishal R. Thorat, Nayana P. Jain, Dnyaney Dhok, Poornima Surve, ...
Formulation And Evaluation Of Antiperspirant/Hyperhidrosis Solution...
Ang Solanki, Nripen Prakash Khare , Khushbu Pinjane, Satyaendra Shrivastava , ...
Brain Tumors: Signs, Detection, and Treatment...
V. A. Chavan, V. K. Gahal, S. S. Deokar, ...
More related articles
Brain Tumors: Signs, Detection, and Treatment...
V. A. Chavan, V. K. Gahal, S. S. Deokar, ...
Prenatal Fear Of Child Birth...
Sneha Bhoir, Saurabh Borde, Saloni Bhoir, Sidra Choudhary, ...
Biodegradable Sanitary Napkins An Innovative Approach Towards Menstrual Hygiene ...
Mounika K, Dr. K. B. Ilango, Baranitharan A. K., Dhivyatharshini S., Gowtham K., Swetha V., Vijaykum...
Brain Tumors: Signs, Detection, and Treatment...
V. A. Chavan, V. K. Gahal, S. S. Deokar, ...
Prenatal Fear Of Child Birth...
Sneha Bhoir, Saurabh Borde, Saloni Bhoir, Sidra Choudhary, ...
Biodegradable Sanitary Napkins An Innovative Approach Towards Menstrual Hygiene ...
Mounika K, Dr. K. B. Ilango, Baranitharan A. K., Dhivyatharshini S., Gowtham K., Swetha V., Vijaykum...