1Department of Pharmaceutics, R. G, Sapkal College of Pharmacy, Anjaneri, Nashik-422212
2Department of Pharmacology, R. G, Sapkal College of Pharmacy, Anjaneri, Nashik-422212
In this study, the Dalfampridine multi-unit sustained release gastric drug delivery system was developed from a purely aqueous medium, avoiding the use of any organic solvents, thereby releasing the drug over a short period of time. time. The emulsion gelation technique is used to prepare the beads. Edible oil pearls are made by mixing and homogenizing olive oil and water containing pectin and molten wax, then extruding them into a solution of calcium chloride. The effects of carnauba wax on smoking efficacy, variation in delay, morphology, and drug release have been studied. Carnauba wax was found to be sufficient to promote drug release at gastric pH. The results show that these particles can trap drugs in large enough quantities and can also successfully deliver drugs to the stomach for a long time without the use of organic solvents.
Amol Ghare, Sheetal Gondkar, Rishikesh Bachhav, Formulation Development and Evaluation Of Wax Incorporated Floating Beads Of Dalfampridine, Int. J. in Pharm. Sci., 2021, Vol 1, Issue 2, 104-111. https://doi.org/10.5281/zenodo.6257256