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Abstract

The aim of the present study was to develop model controlled release (CR) matrix tablet formulations for Verapamil hydrochloride and to study the influence of hydroxy propyl methyl cellulose (HPMC) ratio on drug release and also to assess the potential value of HPMC mixtures as gelling agents in matrix tablets. The release of verapamil hydrochloride CR matrix tablets based on hydrophilic matrices of hydroxy propyl methyl cellulose of different viscosity grades of HPMC 50cps, HPMC K4M and HPMC K100M was studied. The compressed matrix tablets were evaluated for various parameters like hardness, friability, uniformity of weight, uniformity of drug content, FTIR drug-polymer interaction, invitro drug release and short term stability studies. A faster drug release rate was observed for the tablets prepared with low viscosity grades of HPMC and slower drug release rate was observed for the tablets prepared with high viscosity grades of HPMC. Analysis of drug dissolution profiles on the basis of Higuchi’s model indicated that the drug release was in all cases diffusion limited.

Keywords

Verapamil hydrochloride, Hydroxypropyl methyl cellulose, FTIR, Higuchi’s model, Korsmeyer’s model

Reference

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Sunil Firangi
Corresponding author

Luqman College of Pharmacy, Gulbarga, Karnataka

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Ananth Rao Kulkarni
Co-author

K.C.T College of Pharmacy, Gulbarga, Karnataka

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R. B. Sangoligi
Co-author

Luqman College of Pharmacy, Gulbarga, Karnataka

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Dr. S. N. Hiremath
Co-author

Pravara Rural College of Pharmacy, Loni, Maharashtra

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Dr Syed Sanaullah
Co-author

Luqman College of Pharmacy, Gulbarga, Karnataka

Sunil Firangi*, Ananth Rao Kulkarni, R. B. Sangoligi, Dr. S. N. Hiremath, Dr Syed Sanaullah, Formulation and In-vitro Evaluation of Controlled Release Matrix Tablets of Anti-Hypertensive Drug: Verapamil Hydrochloride, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 1-12. https://doi.org/10.5281/zenodo.8396256

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