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Abstract

Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder that affects many women. It's characterized by an imbalance of reproductive hormones, which can lead to a variety of symptoms. One of the main features of PCOS is the presence of cysts on the ovaries, which can affect their ability to release eggs regularly. This can result in irregular menstrual cycles or even a lack of periods. PCOS can also cause excess production of androgens, which are male hormones. This hormonal imbalance can lead to symptoms like acne, excessive hair growth, and hair loss .In addition to these physical symptoms, PCOS can also have an impact on fertility .Women with PCOS may have difficulty getting pregnant due to irregular ovulation. It's important to note that not all women with PCOS will experience all of these symptoms, and the severity can vary from person to person. While the exact cause of PCOS is unknown, it is believed to involve a combination of genetic and environmental factors .There is currently no cure for PCOS, but there are treatment options available to manage the symptoms. These can include lifestyle changes such as diet and exercise, as well as medications to regulate hormones and improve fertility. Medications, including 3-hydroxy-3-methyl-3-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors, thiazolidinediones, sodium-glucose cotransporter-2 inhibitors, dipeptidyl peptidase-4 inhibitors, glucose-like peptide-1 receptor agonists, mucolytic agents, and some supplements have supporting data for being repurposed in PCOS.It's important for women with PCOS to work closely with their healthcare provider to develop a personalized treatment plan. Regular check-ups and monitoring are crucial to manage the condition effectively . PCOS is an endocrine gynaecology disorder from childbearing age. If the PCOD/PCOS is not treat at the its critical stage it can be lead to permanent infertility. Clomifene and metformin are the drug of choice for this disease. some time PCOS shown glucose-induced hyperinsulinemia, insulin resistance and independent BMI. The insulin dependent glucose level can be decreases by 35-40%in case of PCOD affected women by comparing to normal healthy women. More than 2% of women are suffering to type 2 diabetes mellitus and almost 16% of women move from impaired glucose tolerance to type 2 diabetes mellitus. The incidence of PCOS with obesity is very complex although PCOS occurs both in obese and meta-analysis reveal that obesity more frequently.

Keywords

reproductive hormone , menstrual cycles , reductase inhibitors, (HMG-CoA), Polycystic, Clomifene, hyperinsulinemia

Reference

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Sanket Daud
Corresponding author

Nandkumar shinde college of pharmacy

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Sayali Shinde
Co-author

Nandkumar shinde college of pharmacy

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Sayali Petare
Co-author

Nandkumar shinde college of pharmacy

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Santosh Kande
Co-author

Nandkumar shinde college of pharmacy

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Anil B Jadhav
Co-author

Nandkumar shinde college of pharmacy

S. S. Daud*, S. S. Shinde, S.R. Petare, S. D. Kande ,A.B.Jadhav., Managing PCOS: Treatment options and lifestyle strategies, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 404-415. https://doi.org/10.5281/zenodo.10389767

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