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Abstract

The historical reliance of biological research on the use of animal models has sometimes made it challenging to address questions that are specific to the understanding of human biology and disease. But with the advent of human organoids - which are stem cell-derived 3D culture systems, it is now possible to re-create the architecture and physiology of human organs in remarkable detail. Human organoids provide unique opportunities for the study of human disease and complement animal models. It is been used to study infectious diseases, genetic disorders and cancers through the genetic engineering of human stem cells, as well as directly when organoids are generated from patient biopsy samples. This review discusses the types and various applications of human organoids as models and outlines the challenges that have to be overcome for organoids to be able to substantially reduce the need for animal experiments.

Keywords

Human organoids, stem cells, Drosophila melanogaster, E.coli, Caenorhabditis elegans

Reference

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Dr. Pittu Vishnu Priya
Corresponding author

Joginpally B.R Pharmacy College, Yenkapally, Moinabad, Hyderabad, Telangana-500 075.

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Keshineni Shravani
Co-author

Joginpally B.R Pharmacy College, Yenkapally, Moinabad, Hyderabad, Telangana-500 075.

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Pabbathi Sai Divya
Co-author

Joginpally B.R Pharmacy College, Yenkapally, Moinabad, Hyderabad, Telangana-500 075.

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AVSSS Gupta
Co-author

Joginpally B.R Pharmacy College, Yenkapally, Moinabad, Hyderabad, Telangana-500 075.

Keshineni Shravani, Pabbathi Sai Divya, Dr. Pittu Vishnu Priya, AVSSS Gupta, Organoids As Promising Tools In Therapy, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 8, 207-214. https://doi.org/10.5281/zenodo.8278936

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