View Article

Abstract

The aim of the present study was to develop model controlled release (CR) matrix tablet formulations for Verapamil hydrochloride and to study the influence of hydroxy propyl methyl cellulose (HPMC) ratio on drug release and also to assess the potential value of HPMC mixtures as gelling agents in matrix tablets. The release of verapamil hydrochloride CR matrix tablets based on hydrophilic matrices of hydroxy propyl methyl cellulose of different viscosity grades of HPMC 50cps, HPMC K4M and HPMC K100M was studied. The compressed matrix tablets were evaluated for various parameters like hardness, friability, uniformity of weight, uniformity of drug content, FTIR drug-polymer interaction, invitro drug release and short term stability studies. A faster drug release rate was observed for the tablets prepared with low viscosity grades of HPMC and slower drug release rate was observed for the tablets prepared with high viscosity grades of HPMC. Analysis of drug dissolution profiles on the basis of Higuchi’s model indicated that the drug release was in all cases diffusion limited.

Keywords

Verapamil hydrochloride, Hydroxypropyl methyl cellulose, FTIR, Higuchi’s model, Korsmeyer’s model

Reference

  1. Lachmann L, Lieberman HA, Kanig JL.  The Theory & Practice of Industrial Pharmacy, 3rd Edition, Varghese Publishing House, Bombay 1991: 430.
  2. Robinson JR, Lee HL (Ed).  Controlled Drug Delivery: Fundamentals & Applications. 2nd Edition, Marcel Dekker Inc., New York, 1987; 373.
  3. Gennaro AR (Ed.) Remington.  The Science & Practice of Pharmacy.  19th Edition, Vol. II; 1995: 1662.
  4. Shargel L and Andrew BC. Applied Biopharmaceutics and Pharmacokinetics (4th Edn.), 174.
  5. Remingtons; The science & practice of pharmacy, 20th Edn., Lippan cott, Williams & Wilkins, Baltimore, Marryland, 1995; 721-752.
  6. Martindale, The Complete Drug Reference, 33rd Edn, The Pharmaceutical Press, London, 2001: 332-33.
  7. Qiu. Y et al., Formulation development of sustained release hydrophilic matrix tablets of zileuton, Pharmaceutical Development and Technology, 2 (3): 197-204, 1997.
  8. Xu. G and Sunada. H., Influence of formulation change on drug release kinetics from hydroxypropyl methyl cellulose matrix tablets, Chem.Pharm.Bull., 43 (mar): 483-487, 1995.
  9. USP; The United States Pharmacopial Convention Inc., CD-2004; USP 27-NF-22.
  10. Lachmann L, Lieberman HA, Kanig JL.  The Theory & Practice of Industrial Pharmacy, 3rd Edn, Varghese Publishing House, Bombay 1991: 430.
  11. Higuchi.T., Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices, J. Pharm. Sci., 51: 1145-1149, 1963.
  12. Korsmeyer, R. W., Gurny. R.,  Doelker. E., Buri. P.,  Peppas. N.A., Mechanism of solute release from porous hydrophilic polymer, Int. J. Pharm, 15: 25-35, 1983.

Photo
Sunil Firangi
Corresponding author

Luqman College of Pharmacy, Gulbarga, Karnataka

Photo
Ananth Rao Kulkarni
Co-author

K.C.T College of Pharmacy, Gulbarga, Karnataka

Photo
R. B. Sangoligi
Co-author

Luqman College of Pharmacy, Gulbarga, Karnataka

Photo
Dr. S. N. Hiremath
Co-author

Pravara Rural College of Pharmacy, Loni, Maharashtra

Photo
Dr Syed Sanaullah
Co-author

Luqman College of Pharmacy, Gulbarga, Karnataka

Sunil Firangi*, Ananth Rao Kulkarni, R. B. Sangoligi, Dr. S. N. Hiremath, Dr Syed Sanaullah, Formulation and In-vitro Evaluation of Controlled Release Matrix Tablets of Anti-Hypertensive Drug: Verapamil Hydrochloride, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 1-12. https://doi.org/10.5281/zenodo.8396256

More related articles
A Review on Particle Size Reduction of Active Phar...
Saurabh Patara, Snehal Jadhav, Sneha Jankar, Shreya Tondlikar, Pr...
High-Fat Diet-Induced Obesity in Rodents: Dietary ...
Hajera Begum, Dr. Koppala R. V. S. Chaitanya, Mahadev Anitha, Bom...
Biosurfactants as Pharmaceutical Excipients: Emerg...
Shahil Ghadage, Tushar Shelke, Priya Daingade...
Development of Sugar-Free Herbal Syrup of Clerodendrum inerme Using Stevia for D...
Sarthak Nehe, Samiksha Bichave, Sagar Vaidya, Nikita Jadhav, Manish Ahire, Manas Vyavahare, Gaurav P...
A Review on the Safety of Two Single-Inhaler Triple Therapy Regimens: Fluticason...
Jerin. M., Sam Jeeva Kumar, Dr. Shaiju Dharan, Dr. Chintha Chandran, Krishna B....
Related Articles
DNA Barcoding and Molecular Techniques for Authentication of Aloe vera – Revie...
Sumit Kor, Shreyash Pardeshi, Aditya Jamghare, Sahil Shirose, Avadhoot Partole, Raj Dohole, Yash Mul...
Emerging Herbal Strategies for the Management of Hyperpigmentation : Comprehensi...
Shubhangi Kasture, Shrutika Patil, Dnyaneshwar Sutar, Divesh Gavit, Ancy Keerthika, Akash Jambhale...
Clitoria ternatea Flower and ITS Bioactive Compounds;Potential Use as Microencap...
Snehal Jadhav, Sneha Jankar, Shreya Tondlikar, Saurabh Patara, Aditi Bangar, Pratiksha Pandit...
Phytosomes: A NOVEL Approach for HERBAL Drug Delivery – Review Article...
Sahil Shirose, Suyog Vishe, Monika Vinchu, Harshali Shelar, Aditya Jamghare, Avadhoot Partole...
A Review on Particle Size Reduction of Active Pharmaceutical Ingredients (APIs) ...
Saurabh Patara, Snehal Jadhav, Sneha Jankar, Shreya Tondlikar, Pratiksha Pandit, Aditi Bangar...
More related articles
A Review on Particle Size Reduction of Active Pharmaceutical Ingredients (APIs) ...
Saurabh Patara, Snehal Jadhav, Sneha Jankar, Shreya Tondlikar, Pratiksha Pandit, Aditi Bangar...
High-Fat Diet-Induced Obesity in Rodents: Dietary Composition, Adipose Remodelin...
Hajera Begum, Dr. Koppala R. V. S. Chaitanya, Mahadev Anitha, Bommu Vaishnavi...
Biosurfactants as Pharmaceutical Excipients: Emerging Applications...
Shahil Ghadage, Tushar Shelke, Priya Daingade...
A Review on Particle Size Reduction of Active Pharmaceutical Ingredients (APIs) ...
Saurabh Patara, Snehal Jadhav, Sneha Jankar, Shreya Tondlikar, Pratiksha Pandit, Aditi Bangar...
High-Fat Diet-Induced Obesity in Rodents: Dietary Composition, Adipose Remodelin...
Hajera Begum, Dr. Koppala R. V. S. Chaitanya, Mahadev Anitha, Bommu Vaishnavi...
Biosurfactants as Pharmaceutical Excipients: Emerging Applications...
Shahil Ghadage, Tushar Shelke, Priya Daingade...