Department of Pharmacology, Sri Venkateshwara College of Pharmacy, Osmania University, Telangana, India
Drugs that stimulate or depress CNS play an important role in human therapeutics. Undesirable side effects and ineffectiveness of currently available CNS stimulants or depressants in many situations call for development of novel drugs. This study was designed for screening the activity of drugs for central nervous system. More particularly to compare the efficay of marketed CNS drugs with herbal drugs. CNS stimulant drugs Unicontin, Armodafinil, Bacopa monnieri were choosen and their locomotor activity was screened using Actophotometer. Bacopa monnieri was found to be equally potent to Armodafinil by the end 2hrs with a M±Sem of 142.1±1.01. CNS depressant drugs Clonazepam, Zolpidem and Ashwagandha were selected. The depressant activity was also screened by actophotometer. The results showed Ashwagandha has a potent CNS depressant action upto 2hrs with a M±Sem of 58±1.78 which may be due to its antioxidant action. Hence plant derived drugs can replace the conventional CNS drugs for various ailments.
Sireesha Kalva*, Ramya Yenni, Arravolu Madhu, A Comparative Evaluation Of Central Nervous System Acting Drugs By Screening Models, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 165-169. https://doi.org/10.5281/zenodo.10017308