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  • A Comparative Evaluation Of Central Nervous System Acting Drugs By Screening Models
  • Department of Pharmacology, Sri Venkateshwara College of Pharmacy, Osmania University, Telangana, India

Abstract

Drugs that stimulate or depress CNS play an important role in human therapeutics. Undesirable side effects and ineffectiveness of currently available CNS stimulants or depressants in many situations call for development of novel drugs. This study was designed for screening the activity of drugs for central nervous system. More particularly to compare the efficay of marketed CNS drugs with herbal drugs. CNS stimulant drugs Unicontin, Armodafinil, Bacopa monnieri were choosen and their locomotor activity was screened using Actophotometer. Bacopa monnieri was found to be equally potent to Armodafinil by the end 2hrs with a M±Sem of 142.1±1.01. CNS depressant drugs Clonazepam, Zolpidem and Ashwagandha were selected. The depressant activity was also screened by actophotometer. The results showed Ashwagandha has a potent CNS depressant action upto 2hrs with a M±Sem of 58±1.78 which may be due to its antioxidant action. Hence plant derived drugs can replace the conventional CNS drugs for various ailments.

Keywords

Central Nervous System, Screening Models

Reference

  1. Tripathi, K. D. Essentials of Medical Pharmacology. 6th ed. New Delhi: Jaypee Brothers Medical Publishers(P) LTD. 2008.
  2. Rang HP, Dale MM, Ritter JM, Roore PK, Pharmacology 6th edition. Philadelphia: Churchill Livingstone:2007.
  3. Xueli Z, Yang Y, Zhou C, Shan L, Yunguo Z, Xiaoling Y, 2014. Antidepressant effect of chimonanthus salcifolicus essential oil in chronic stressed rats. J Medi. Plant Res. 8, 430-435.
  4. Rang HP, Dale MM, Ritter JM, Roore PK, Pharmacology 6th edition. Philadelphia: Churchill Livingstone:2007. 
  5. Ferrari AJ, Charlson FJ, Norman RE, Patten SB, Freedman G, et al. (2013) Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010. PLOS Medicine 10(11): e1001547.
  6. Jaya Preethi P, Padmini K, Srikanth J, Lohita M, Swetha K. Screening Models for CNS Stimulant Drugs: A Review. Asian J. Pharm. Res. 3(3): July-Sept. 2013; Page 151-155.
  7. Rey JA. CNS Stimulants. In: Lippinott Illustrated reviews: Pharmacology. 6th edition, Wolters K, Philadelphia 2015; PP 215-224.
  8. Ghani A. Medicinal plants of Bangladesh. The Asiatic Society of Bangladesh:Dhaka; 1998.
  9. Sri neeraja, P. (2017). CNS stimulant property of natural products. International journal of reviews and research; 6(7), 739-742.
  10. Ghedira K and Goetz P. (2017) Waterhygroscopic- Bacopa Monnieri (L.) Pennell (Plantaginaceae) Phytotherapies, 5(3), 164-168.
  11. Tantra S.(2019) National journal of research in ayurveda science. National journal of research in ayurveda science, 7(2), 1-9.
  12. Singh M, Bhalla M, Dejager P, and Eilia M. (2011). An overview on Ashwagandha : A rasayana of ayurveda. African journal of traditional , complementary and alternative medicines, 8(5 suppl), 208-213.
  13. Anju(2011) Bacopa Monnieri_ A preliminary study evaluating Its anti-stress activity in swiss albino mice. Research journal of pharmaceutical biological and chemical sciences bacopa, 2(4), 786.

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Sireesha Kalva
Corresponding author

Department of Pharmacology, Sri Venkateshwara College of Pharmacy, Osmania University, Telangana, India

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Ramya Yenni
Co-author

Department of Pharmacology, Sri Venkateshwara College of Pharmacy, Osmania University, Telangana, India

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Arravolu Madhu
Co-author

Department of Pharmacology, Sri Venkateshwara College of Pharmacy, Osmania University, Telangana, India

Sireesha Kalva*, Ramya Yenni, Arravolu Madhu, A Comparative Evaluation Of Central Nervous System Acting Drugs By Screening Models, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 165-169. https://doi.org/10.5281/zenodo.10017308

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