Department of Quality Assurance, PRES College of Pharmacy (Women’s), Chincholi, Nashik-422102
A proper approach that enables the scientist to analyse the drug molecule in the most exact, precise, and simple manner is necessary for the process of developing new medications. Finding the optimum approach for method development is crucial for the quantitative and qualitative estimate of pharmaceuticals in analytical chemistry. This research aids the author in comprehending the many analytical methods that may be used in the drug development process, including spectroscopy, chromatography, electrochemical methods, electrophoretic analysis, flow injection, and hyphenated method. All of these strategies use several independent methodologies and distinct analytical processes. We also talk about the current, unwavering trends that may be applied to all of these procedures to enhance their analytical behaviour. The validation of the document in terms of accuracy, precision, specificity, limit of detection, linearity, and range is necessary during the method development phase. Thus, this review article includes a concise assessment of the analytical approaches that are now accessible as well as the most recent developments in method development, method validation, and method development. Several chemical and instrumental techniques that are used in drug estimation have been developed over time in order to make medications function as intended. These medications must be recognised and quantitated since contaminants can form in them at different points during production, transit, and storage, making administration dangerous. Analytical tools and techniques are crucial in this regard. In determining the quality of the medications, this study emphasises the importance of analytical procedures and equipment. The study covers many analytical methods that have been used in the examination of medicines, including titrimetric, chromatographic, spectroscopic, electrophoretic, and electrochemical.
Krutanjali Nikumbh*, Kiran Dhamak, A Comprehensive Review on Analytical Methods for The Estimation of Pharmaceuticals, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 6, 65-77. https://doi.org/10.5281/zenodo.8033494