• A Literature Review On Silk Maize Health Benefits And It’s Pharmacological Effects In Various Diseases
  • (1)Student, Rofel shri G.M. Bilakhia College of Pharmacy, Vapi, Gujarat (Rajju Shroff Rofel University)
    (2)Student, Rofel shri G.M. Bilakhia College of Pharmacy, Vapi, Gujarat (Rajju Shroff Rofel University)
    (3)Student, Rofel shri G.M. Bilakhia College of Pharmacy, Vapi, Gujarat (Rajju Shroff Rofel University)
    (4)Student, Drs. Kiran & Pallavi Patel Global University, Vadodara, Gujarat (Babria Institute of Technology)
    (5)Student, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat


Scientifically known as stigma maydis or Zea mays, Maize silk has significant importance as a traditional medicine for treating a broad range of illnesses. From centuries this plant has been potentially used as an Oral Anti Diabetic and Kidney stone treatment as well as in other like Diuretic, Antioxidant, Nephroprotective, Anti-inflammatory, and Anti-hypertensive. The composition of maize silk includes proteins, carbohydrates, vitamins, and certain salts of calcium, sodium, potassium, and magnesium ions. The phytoconstituents found in maize silk are Volatile Oils, Tannins, Saponins, Alkaloids, Flavonoids, and some Steroids like Stigmasterol and Sitosterol are all present in Cornsilk. Formic Acid, Oleic Acid, Palmitic Acid, Linoleic Acid, Stearic Acid, Succinic Acid, and Lactic Acid are among the organic acids included in maize silk. Numerous studies have claimed the Antioxidant potential of maize silk and its medical uses as Diuretic agents, for lowering blood sugar levels, as an Antifatigue agent, and as an Antidepressant. Urinary tract issues are treated with teas and Corn Silk supplements. This comprehensive Article on health potential of Corn Silk will be provide readers a throughout understanding of maize silk's potential benefits withs its pharmacological effects on health.


Silk Maize, Diuretic, Antioxidant, Nephroprotective, Anti-inflammatory, Anti-hypertensive, Anti Diabetic, Kidney stone


  1. Poprac, P.; Jomova, K.; Simunkova, M.; Kollar, V.; Rhodes, C.; Valko, M. Targeting free radicals in oxidative stress-related human diseases. Trends Pharmacol. Sci. 2017, 38, 592–607.
  2. Sarepoua, E.; Tangwongchai, R.; Suriharn, B.; Lertrat, K. Influence of variety and harvest maturity on phytochemical content in Cornsilk. Food Chem. 2015, 169, 424–429
  3. Https://www.Newworldencyclopedia.Org/entry/maize
  4. Challenges and opportunities for traditional herbal medicine today with special reference to its status in India by Bushra Parveen,Abida Parveen,Rabea Parveen,Sayeed Ahmad,Minhaj Ahmad and Muhammad Iqbal,December 2020
  5. 032260
  6. Corn Silk (stigma maydis) in healthcare: A phytochemical and pharmacological review by khairunnisa hasanudin, puziah hashim and shuhaimi mustafa molecules 2012.
  7. Inglett, G.E. Corn: culture, processing, products; the AVI publishing company: westport, CT, USA,1970
  9. American Journal of Plant Sciences, Vol.5 No.18, August 7, 2014
  10. Pietta, P.G. (2000) Flavonoids as Antioxidants. Journal of Natural Products, 63, 1035-1042.
  11. Wan rosli,w.I.,Nurhanan,a.R., Farid, C.Ghazali & mohsin,s.S.J., Effect of sodium hydroxide(naoh) and sodium hypochlorite(nahclo) on morphology and mineral concentration of zea mays hairs(cornsilk),annals of microscopy,2010.
  12. Josephine miriam gwendin.V, indujata, jony blessing manojj, shivasamy MS, recent trends in effective utilization of by-product corn,indain journal of science,2015,22(76),18-26.
  13. Cornsilk- A medicinal boon vijitha T P*, saranya D department of biotechnology, sapthagiri college of engineering (affiliated to VTU, belgaum), bangalore-560057, india international journal of chemtech research
  17. Diabetes mellitus by Hossam A. Shouip Sinai University · researchgate faculty of pharmacy on 02 January 2015
  18. Ibrahim MA, Lawal S, Onojah A, Abdukadir A & Adamu A 2016. Modulation of sialic acid levels among some organs during insulin resistance or hyperglycemic states. Mol. Cell Biochem., 411(1-2): 235-239.
  19. Vijitha TP & Saranya D 2017. CornSilk- A Medicinal Boon. Int. J. Chem. Tech. Res., 10(10): 129-137
  20. Ghada M, Eltohami MS, Adurahman HN, Mahmoud ME & Mudawi 2014. In vitro study of the effect of Corn Silk on glucose uptake by isolated rat hemi-diaphragm. World J. Pharm. Res., 3: 1-2191.
  21. CornSilk- A Medicinal Boon Vijitha T P*, Saranya D Department of Biotechnology, Sapthagiri College of Engineering (Affiliated to VTU, Belgaum), Bangalore-560057, India International Journal of ChemTech Research
  22. Amjad, A., Rizwan, B., Jabeen, S.: The efect of methanolic extract of Corn Silk in gentamicin induced acute renal injury in rats model: methanolic extract of Corn Silk in gentamicin induced acute renal injury. Pak. BioMed J. 31, 308–312 (2022)
  24. Singh, A., Raghuvanshi, R.S.: Development and evaluation of value-added fber rich Laddoo supplemented with processed Corn Silk (2021)
  25. https://doi. Org/10.54393/pbmj.v5i1.259
  26. Corn Silk (Stigma Maydis) in Healthcare: A Phytochemical and Pharmacological Review an article  in  Molecules · December 2012 by Puziah Hashim Universiti Putra Malaysia
  27. Shihua S, Siming L, Weihao L. Corn silk tea for hypertension: A systematic review and meta-analysis of randomized controlled trials. evidencebased complementary and alternative medicine. 2019; 2019: 1-7. DOI: 10.1155/2019/2915498
  28. Liu, R.H.; Mohmoud and Tanabe, H. J. Nutri. 2019, 134: 3479-3485.
  29. Choi, D.J.; Kim, S.L.; Choi, J.W.; Park, W.I.; Neuroprotective effects of corn silk maysin via inhibition of H202- induced apoptotic cell death in SK-N-MC cells. Life Sci. 2014, 109: 57-64
  30. Pan YX, Wang C, Chen ZQ, Li WW, Yuan GQ & Chen HX 2019. Physicochemical prop erties and antidiabetic effects of a polysaccharide from Corn Silk in high-fat diet and streptozotocin-induced diabetic mice. Carbohydrate Polym., 164: 370–378
  31. Lee EY, Kim SL, Kang HJ, Kim MH, Ha AW & Kim WK 2016. High maysin Corn Silk extract reduces body weight and fat deposition in C57BL/6J mice fed high-fat diets. Nutr. Res. Pract., 10: 575-582.
  32. FUW Trends in Science & Technology Journal, e-ISSN: 24085162; p-ISSN: 20485170; December, 2020: Vol. 5 No. 3 pp. 816 – 820
  33. Sanusi Bello Mada*, Lawal Sani, Gloria Dada Chechet CORN SILK FROM WASTE MATERIAL TO POTENTIAL THERAPEUTIC AGENT: A MINI REVIEW Department of Biochemistry, Ahmadu Bello University Zaria, Nigeria *Corresponding author: Received: April 22, 2020 Accepted: September 15, 2020.
  34. Mada, S.B., Sani, L., Chechet, G.D.: Corn Silk from waste material to potential therapeutic agent: a mini review. Fuw Trends Sci. Technol. J. 5(3), 816–820 (2020)
  36. Lee, J., Kim, S.L., Lee, S., Chung, M.J., Park, Y.I.: Immunostimulating activity of maysin isolated from Corn Silk in murine RAW 264.7 Macrophages. BMB Rep. 47(7), 382 (2014)
  39. Nguemfo, E.L.; Dimo, T.; Azebaze, A.G.B.; Asongalem, E.A.; Alaoui, K.; Dongmo, A.B.; Cherrah, Y.; Kamtchouing, P. Anti-inflammatory and anti-nociceptive activities of the stem bark extracts from Allanblackia monticola STANER L.C. (Guttiferae). J. Ethnopharmacol. 2007, 114, 417–424.
  40. Wang, G.Q.; Xu, T.; Bu, X.M.; Liu, B.Y. Anti-inflammation effects of corn silk in a rat model of carrageenin-induced pleurisy. Inflammation 2011, 35, 822–827
  41. Kan, A.; Orhan, I.; Coksari, G.; Sener, B. In-vitro neuroprotective properties of the maydis stigma extracts from four corn varieties. Int. J. Food Sci. Nutr. 2011, 63
  42. Molecules 2012,17,9697-9715;doi:10.3390/molecules17089697
  43. s11101-018-9591
  44. Abirami, S., Priyalakshmi, M., Soundariya, A., Samrot, A.V., Saigeetha, S., Emilin, R.R., Dhiva, S., Inbathamizh, L.: Antimicrobial activity, antiproliferative activity, amylase inhibitory activity and phytochemical analysis of ethanol extract of Corn(Zea mays L.) silk. Curr. Res. Green Sustain. Chem. 4, 100089 (2021).
  45. Górniak, I., Bartoszewski, R., Króliczewski, J.: Comprehensive review of antimicrobial activities of plant favonoids. Phytochem. Rev. 18(1), 241–272 (2019).
  47. Thompson MEH, Raizada MN. Fungal pathogens of maize gaining free passage along the silk road. Pathogens. 2018; 7: 81. DOI: 10.3390/pathogens70400818 Jianyou G, Tongjun L
  48. Ryuk,J.A.; Ko,B.S.;et al.; Protection against Neurological Symptoms by Consuming corn silk water in Artery-Occluded Gerbils with reducing Oxidative stress, Inflammation and Post -Stroke Hyperglycemia through the Gut-Brain Axis.Antioxidants.2022,11: 168.
  49. Khairunnisa, H,; Puziah, H.; Shuhaimi, M.; Corn silk (Stigma Maydis) in healthcare: A phytochemical and pharmacological review. Molecules. 2012, 17: 9697-9715.
  50. Zou, Z., Xi, W., Hu, Y., Nie, C., Zhou, Z.: Antioxidant activity of Citrus fruits. Food Chem. 196, 885–896 (2016).
  51. Bhuvaneshwari, K. and Sivakami Sridevi, P.L.; Analysis of Nutrients and phytochemicals content in Corn Silk (Zea.Mays). International journal of Science and Research. 2017, 6(1): 2319-7064.
  53. Kaur, D., Kaur, D., Bains, N.A., Chopra, A.N., Arora, P.O.: Antianxiety evaluation of extracts of stigma maydis (Cornsilk). Int. J. Pharm. Pharm. Sci. 8, 309–312 (2015)
  55. 3049/24/10/1886
  56. Choi, S.Y.; Lee, Y.; Kim, S.S.; et al.; Inhibitory Effect of Corn Silk on Skin Pigmentation. Molecules. 2014, 19: 2808
  58. 8158/12/11/2159
  59. A Physicochemical Study of the Antioxidant Activity of Corn Silk Extracts by Lubomír Lap?ík,David ?epka,Barbora Lap?íková,Daniela Sumczynski,Shweta Gautam,Peng Li,and Tomáš Valenta
  60. Stoecklin, G.; Lu, M.; Rattenbacher, B.; Moroni, C. A constitutive decay element promotes tumor necrosis factor alpha mRNA degradation via an AU-rich element-independent pathway. Mol. Cell. Biol. 2003, 23, 3506–3515.
  61. Corn Silk Tea for Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Review Article Evidence-Based Complementary and Alternative Medicine Volume 2019, Article ID 2915498, 7 pages by Shihua Shi, Siming Li , Weihao Li and Hao Xu 2
  63. Principles of Pharmacology by H. L. Sharma and K. K. Sharma First Edition, 2007,Publishers: Paras Medical Publishers, New Delhi
  64. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition Laurence Brunton, Bjorn Knollman, Randa Hilal-Dandan McGraw Hill Professional, 26-Oct-2017
  65. Anonymous. Maize. Available online: (accessed on 29 June 2011).
  66. . Anonymous. Corn Silk Tea Common Uses AND Benefits. Available online:  http://www.Corn
  67. All structure are referred from

Patel umangkumar Rajeshbhai
Corresponding author

Student B.pharm

Paswan Praveenkumar

Students M.pharm

Patel Priya


Patel Nidhi


Sinha Neeta


Patel Umangkumar Rajeshbhai(1)* Patel Priya Sureshbhai(2) Patel Nidhi Saswant(3) Paswan Praveen kumar(4) Sinha Neeta Dhananjay(5), A Literature Review On Silk Maize Health Benefits And It’s Pharmacological Effects In Various Diseases, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 385-397.

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