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  • A Review On Hydrotropy Technique Used In Solubility Enhancement
  • 1Student at Pratibhatai Pawar College Of Pharmacy Shrirampur
    2Assistant Professor at Pratibhatai Pawar College Of Pharmacy Shrirampur

Abstract

Oral route is the most desirable and preferred method of administering therapeutic agents for their systemic effects, but poorly solubility of drug is major challenge for formulation scientist. About 40% of orally administered drugs suffer from formulation difficulties related to their water insolubility. Dissolution rate, absorption, distribution and excretion of a moiety depend upon its solubility characteristics. On the basis of solubility, drugs are classified into four classes of the BCS classification. Solubility challenges are faced in the Class II and Class IV of the BCS system. To improve solubility and bioavailability of poorly soluble drug we use various methods or techniques. The methods like solid dispersion, complexation, liquisolid, hydrotropy, sonocrystallization, self-emulsifying method, are commonly referred for solubility enhancement. In this review we concentrated on the hydrotrophy method used in solubility enhancement of poorly soluble drugs.

Keywords

Hydrotropy, Solubility, techniques, bioavailability, solid dispersion

Reference

  1. Cholo, M.C., Steel, H.C., Fourie, P.B., Germishuizen, W.A. and Anderson, R., 2012. Clofazimine: current status and future prospects. Journal of antimicrobial chemotherapy, 67(2), pp.290-298.
  2. Khatri, H., Hussain, M.S. and Tyagi, S., 2022. SOLUBILITY ENHANCEMENT TECHNIQUES: AN OVERVIEW.
  3. Dangre, P.V., Sormare, V.B. and Godbole, M.D., 2017. Improvement in dissolution of bosentan monohydrate by solid dispersions using spray drying technique. Open Pharmaceutical Sciences Journal, 4(1).
  4. Ghanbarzadeh, S., Khalil, A., Jouyban, A., Emami, S., Javadzadeh, Y., Solhi, M. and Hamishehkar, H., 2016. Dramatic improvement in dissolution rate of albendazole by a simple, one-step, industrially scalable technique. Research in Pharmaceutical Sciences, 11(6), p.435.
  5. Jyoti, J., Nidhi, N.S. and Vikas, A.S., 2019. A review on hydrotropy: a potential approach for the solubility enhancement of poorly soluble drug. Asian J Pharm Clin Res, 12(10), pp.19-26.
  6. Agrawal S, Pancholi SS, Jain NK, Agrawal GP. Hydrotropic solubilization of nimesulide for parenteral administration. Int J Pharm 2004;274:149-55.
  7. Pande VV. Exploration of mixed hydrotropy strategy in formulation and development of etodolac injection. J Nanomed Res 2016;3:423
  8.  Chavda HV, Patel CN, Anand IS. Biopharmaceutics classification system. Syst Rev Pharm 2010;1:62-9.
  9. Cook J, Addicks W, Wu YH. Application of the Biopharmaceutical Classification System in Clinical Drug Development—An Industrial View. The AAPS Journal, 2008; 10(2): 306-310.
  10. Mohit, Hussain MS. A Brief Review on Buccal Drug Delivery System: Advantages, Limitations, and Impact on Healthcare system. World Journal of Pharmaceutical Research, 2021; 10(5): 558-576.
  11. Campardelli R, Baldino L, Reverchon E. Supercritical fluids applications in nanomedicine. J. Supercrit. Fluids, 2015; 101: 193–214.
  12. Rigter IM, Schipper HG, Koopmans RP, Van Kan HJM, Frijlink HW, Kager PA, Guchelaar HJ. Relative bioavailability of three newly developed albendazole formulations: a randomized crossover study with healthy volunteers. Antimicrobial agent and chemotherapy 2004; 48:1051-1054.
  13. Filipovic-Grcic J, Perissutti B, Moneghini M, Voinovich D, Martinac A , Jalsenjak I. Spray-dried carbamazepine-loaded chitosan and HPMC micro-shperes: preparation and characterization. J Pharm. Pharmacol. 2003, 55: 921-931.
  14. Wan LS, Heng PWS, Chia CGH. Spray drying as process of microencapsulation and the effect of different coating polymers. Drug Develop. Ind. Pharm. 1992, 18: 997-1011.
  15. Cook GC. Use of benzimidazole chemotherapy in human helminthiases: Indica [2] tions and efficacy. Parasitol. Today 1990; 6:133–136.
  16. Pensel PE, Castro S, Allemandi D, Bruni SS, Palma SD, Elissondo MC. Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis. Vet Parasitol. 2014;203(1-2):80-86
  17. Maghsoodi M, Hemati E, Qadermazi B, Yari Z. Hollow microspheres for gastroretentive floating-pulsatile drug delivery: preparation and in vitro evaluation. Adv Pharm Bull. 2011;1(2):55-61.
  18. Park JH, Choi HK. Enhancement of solubility and dissolution of cilostazol by solid dispersion technique. Arch Pharm Res. 2015;38(7):1336-1344.
  19. Nuzzo M, Millqvist-Fureby A, Sloth J, Bergenstahl B. Surface composition and morphology of particles dried individually and by spray drying. Drying Technol. 2015;33(6):757-767.
  20. Maghsoodi M, Hemati E, Qadermazi B, Yari Z. Hollow microspheres for gastro retentive floating-pulsatile drug delivery: preparation and in vitro evaluation. Adv Pharm Bull. 2011;1(2):55-61.
  21. Garc??a JJ, Bolás F, Torrado JJ. Bioavailability and efficacy characteristics of two different oral liquid formulations of albendazole. Int J Pharm. 2003;250(2):351-358.
  22. Limbachiya MI. Solubility enhancement techniques for poorly soluble drugs: A review. IJPRD, 2011; 4(4):71-86

Photo
Shinde Vishal
Corresponding author

Student at Pratibhatai Pawar College Of Pharmacy Shrirampur

Photo
Khandre Rajashree
Co-author

Assistant Professor at Pratibhatai Pawar College Of Pharmacy Shrirampur

Shinde Vishal*, Khandre Rajashree, A Review on Hydrotropy Technique Used In Solubility Enhancement, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 5, 226-235. https://doi.org/10.5281/zenodo.7949315

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