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  • A Review On Omaveloxolone
  • 1Assistant Professor, Department of Pharmaceutics, Vivekanandha Pharmacy College for Women, Veerachipalayam, Sankagiri West, Sankagiri Taluk, Salem District-637303.
    2Vivekanandha Pharmacy College for Women, Veerachipalayam, Sankagiri West, Sankagiri Taluk, Salem District-637303

Abstract

Omaveloxolone is a semisynthetic triterpenoid used to treat friedreich’s ataxia. It is the second generation oleananetriterpenoid Nrf2 inducer with antioxidant and anti-inflammatory properties. It is currently used to test in medical trials for freidreich’s ataxia, a genetic, multi –organ disease involving mitochondrial dysfunction. It is a nuclear factor erythroid 2 related factor 2 (Nrf2) activator. It is reviewed under Food and Drug Administration and it has the potential to first approved treatment for friedreich’s ataxia. Omaveloxolone is not the cure for friedreich’s ataxia, it is the first agent targeting to reach NDA submission. It is the rational and potent therapy that is probably disease modifying in the treatment of friedreich’s ataxia. Omaveloxolone (RTA-408) is an Nrf2 activator, which decreases the susceptibility of cells through oxidative stress and it leads to cell death and tissue degradation. It is good tolerated not having any significant long term adverse effects. Treatment with RTA-408 remarkably improved in the neurological function, it is measured by modified Freidreich’s Ataxia Rating Scale.

Keywords

Omaveloxolone

Reference

  1. Michael S, Petrocine SV, Qian J, Lamarche JB, Knutson MD, Garrick MD, Koeppen AH. Iron and iron- responsive proteins in the cardiomyopathy of Friedreich’s ataxia. Cerebellum. 2006; 257 (5): 61–67.
  2. Harding AE. Friedreich’s ataxia: a clinical and genetic study of 90 families with an analysis of early diagnostic criteria and intrafamilial clustering of clinical features. Brain. 1981; 104: 589–620.
  3. Weidemann F, Rummey C, Bijnens B, Stork S, Jasaityte R, Dhooge J, Baltabaeva A, Sutherland G, Schulz JB, Meier T. Mitochondrial Protection with Idebenone in Cardiac or Neurological Outcome study: The heart in Friedreich ataxia: definition of cardiomyopathy, disease severity, and correlation with neurological symptoms. Circulation. 2012; 125: 1626–34.
  4. Alexeev V, Lash E, Aguillard A et al. (2014) Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound. Molecular cancer therapeutics 13, 2968-2977.
  5. Harding AE. Friedreich’s ataxia: a clinical and genetic study of 90 families with an analysis of early diagnostic criteria and intrafamilial clustering of clinical features. Brain 1981; 104 (3): 589–620.
  6. Babady NE, Carelle N, Wells RD, et al. Advancements in the pathophysiology of Friedreich’s ataxia and new prospects for treatments. Mol Genet Metab 2007; 92 (1–2): 23–35.
  7. Shan Y, Schoenfeld RA, Hayashi G, et al. Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich’s ataxia YG8R mouse model. Antioxid Redox Signal 2013; 19 (13):1481–1493.
  8. D’Oria V, Petrini S, Travaglini L, et al. Frataxin deficiency leads to reduced expression and impaired translocation of NF-E2-related factor (Nrf2) in cultured motor neurons. Int J Mol Sci 2013; 14(4): 7853–7865.
  9. Paupe V, Dassa EP, Goncalves S, et al. Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia. PLoS One 2009; 4 (1): 4253.
  10. Lynch DR, Chin MP, Delatycki MB, et al. Safety and efficacy of Omaveloxolone in Friedreich ataxia (MOXIe study). Ann Neurol 2021; 89 (2): 212–225.
  11. Abeti R, Baccaro A, Esteras N, et al. Novel Nrf2-inducer prevents mitochondrial defects and oxidative stress in Friedreich’s Ataxai models. Front Cell Neurosci 2018; 12:188.
  12. Harding AE. Friedreich’s ataxia: a clinical and genetic study of 90 families with an analysis of early diagnostic criteria and intrafamilial clustering of clinical features. Brain 1981; 104(3): 589–620.

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Lalitha A.
Corresponding author

Assistant Professor, Department of Pharmaceutics, Vivekanandha Pharmacy College for Women, Veerachipalayam, Sankagiri West, Sankagiri Taluk, Salem District-637303.

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Nanjundeshwari G.
Co-author

Vivekanandha Pharmacy College for Women, Veerachipalayam, Sankagiri West, Sankagiri Taluk, Salem District-637303

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Swetha M.
Co-author

Vivekanandha Pharmacy College for Women, Veerachipalayam, Sankagiri West, Sankagiri Taluk, Salem District-637303

Photo
Swetha R.
Co-author

Vivekanandha Pharmacy College for Women, Veerachipalayam, Sankagiri West, Sankagiri Taluk, Salem District-637303

Lalitha A., Nanjundeshwari G., Swetha M., Swetha R., A Review On Omaveloxolone, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 447-456. https://doi.org/10.5281/zenodo.8383431

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