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  • Acebrophylline Is A Better Choice Of Drug Over Theophylline For Patients With Asthma, COPD And Bronchitis Patients
  • 1M. Pharm, MBA (NMIMS), Business Development at BIBO HEALTH (Hilt Brands India Pvt Ltd), Bengaluru.
    2B. Pharmacy (PESCP), B2B Sales at BIBO HEALTH (Hilt Brands India Pvt Ltd), Bengaluru.
    3MBA (IIT), CEO and Co-Founder at BIBO HEALTH (Hilt Brands India Pvt Ltd), Bengaluru.

Abstract

The use of pharmacological treatment for COPD has increased over the past few decades and paints a positive image. In COPD, methylxanthines are frequently utilised. Theophylline is a well-known bronchodilator and anti-inflammatory drug, whilst Acebrophylline is a more recent addition in modern respiratory treatment, both are utilised as supplemental therapies for stable COPD patients using LAMA (long-acting muscarinic antagonists). Acebrophylline has anti-inflammatory properties and regulates airway mucus. The drug's strategy for treating obstructive airway disease incorporates numerous points of attack. Theophylline-7 acetic acid, whose carrier role elevates blood levels of Ambroxol, stimulates surfactant formation quickly and intensively. The molecule includes Ambroxol, which promotes several processes in the creation of pulmonary surfactants. Ciliary clearance is significantly improved as a result of the mucus' reduced viscosity and adhesivity. Acebrophylline also exerts an anti-inflammatory effect by diverting phosphatidylcholine toward the manufacture of surfactants, which prevents it from being used for the production of inflammatory mediators like leukotrienes.

Keywords

Acebrophylline, Ambroxol, alveolar surfactant, airway hyper-responsiveness, chronic bronchitis, asthma, chronic obstructive pulmonary disease (COPD), respiratory treatment

Reference

  1. Pauwels R. The effects of theophylline on airway inflammation. Chest. 1987 Jul;92(1 SUPPL.):32S-37S. 
  2. Sharma A, Adiga S, Chogtu B, Mohapatra AK, Magazine R. Comparing the efficacy and influence on the quality of life of three classes of drugs used in bronchial asthma - a prospective study. J Clin Diagn Res [Internet]. 2014 Sep [cited 2023 Sep 21];8(9):HC13-5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25386456
  3. Agliati G. Effects of a short course of treatment with acebrophylline on the mucus rheological characteristics and respiratory function parameters in patients suffering from chronic obstructive pulmonary disease. Journal of International Medical Research. 1996;24(3):302–10. 
  4. Pozzi E. Acebrophylline: an airway mucoregulator and anti-inflammatory agent. Monaldi Arch Chest Dis [Internet]. 2007 [cited 2023 Sep 21];67(2):106–15. Available from: https://pubmed.ncbi.nlm.nih.gov/17695695/
  5. Gildea TR, Khatri SB, Castro M. Bronchial thermoplasty: A new treatment for severe refractory asthma. Cleve Clin J Med. 2011 Jul;78(7):477–85. 
  6. Cox G, Thomson NC, Rubin AS, Niven RM, Corris PA, Siersted HC, et al. Asthma Control during the Year after Bronchial Thermoplasty. New England Journal of Medicine. 2007 Mar 29;356(13):1327–37. 
  7. Cazzola M, Donner CF. Long-acting ?2 agonists in the management of stable chronic obstructive pulmonary disease. Drugs. 2000;60(2):307–20. 
  8. Mangprayool T, Kupittayanant S, Chudapongse N. Participation of citral in the bronchodilatory effect of ginger oil and possible mechanism of action. Fitoterapia [Internet]. 2013 [cited 2023 Sep 21];89(1):68–73. Available from: https://pubmed.ncbi.nlm.nih.gov/23685048/
  9. Simons FER, Simons KJ. Histamine and H1-antihistamines: celebrating a century of progress. J Allergy Clin Immunol [Internet]. 2011 [cited 2023 Sep 21];128(6). Available from: https://pubmed.ncbi.nlm.nih.gov/22035879/
  10. Abril AG, Pazos M, Villa TG, Calo-Mata P, Barros-Velázquez J, Carrera M. Proteomics Characterization of Food-Derived Bioactive Peptides with Anti-Allergic and Anti-Inflammatory Properties. Nutrients [Internet]. 2022 Oct 1 [cited 2023 Sep 21];14(20). Available from: https://pubmed.ncbi.nlm.nih.gov/36297084/
  11. Kim S Il, Park CY, Fordjuor G, Lee JH, Lee JS, Lee JE. Comparison of cytotoxicities and anti-allergic effects of topical ocular dual-action anti-allergic agents. BMC Ophthalmol [Internet]. 2019 Nov 8 [cited 2023 Sep 21];19(1). Available from: https://pubmed.ncbi.nlm.nih.gov/31703568/
  12. Vasi? J, Dimi? D, Antonijevi? M, Avdovi? EH, Milenkovi? D, Nakarada ?, et al. The Electronic Effects of 3-Methoxycarbonylcoumarin Substituents on Spectral, Antioxidant, and Protein Binding Properties. Int J Mol Sci [Internet]. 2023 Jul 1 [cited 2023 Sep 21];24(14). Available from: https://pubmed.ncbi.nlm.nih.gov/37511579/
  13. S S, T O, S M, T A, M T, Y S, et al. Effect of expectorants on relaxation behavior of sputum viscoelasticity in vivo. Biorheology [Internet]. 1983 [cited 2023 Sep 21];20(5):677–83. Available from: https://pubmed.ncbi.nlm.nih.gov/6375756/
  14. Lhermitte M, Lamblin G, Lafitte JJ, Degand P, Roussel P, Mazzuca M. Human, bronchial-mucus glycoproteins: a comparison between chemical properties and affinity for lectins. Carbohydr Res. 1981 Jun 1;92(2):333–42. 
  15. Tapadar SR, Das M, Chaudhuri AD, Basak S, Mahapatra ABS. The Effect of Acebrophylline vs Sustained Release Theophylline in Patients of COPD- A Comparative Study. J Clin Diagn Res [Internet]. 2014 Sep 20 [cited 2023 Jun 2];8(9):MC11–4. Available from: https://pubmed.ncbi.nlm.nih.gov/25386474/
  16. Keam SJ, Keating GM. Tiotropium bromide. A review of its use as maintenance therapy in patients with COPD. Treat Respir Med [Internet]. 2004 [cited 2023 Jun 2];3(4):247–68. Available from: https://pubmed.ncbi.nlm.nih.gov/15350163/
  17. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med [Internet]. 2007 Sep 15 [cited 2023 Jun 2];176(6):532–55. Available from: https://pubmed.ncbi.nlm.nih.gov/17507545/
  18. Gupta PR. Ambroxol - Resurgence of an old molecule as an anti-inflammatory agent in chronic obstructive airway diseases. Lung India [Internet]. 2010 Apr 1 [cited 2023 Sep 21];27(2):46–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20616932
  19. Kuriachan S, Mohan Babu Amberkar V, Mohan MK, Shahul HA, Meena kumari K. Acebrophylline-induced angioedema. Indian J Pharmacol [Internet]. 2015 Mar 1 [cited 2023 Sep 21];47(2):219–20. Available from: https://pubmed.ncbi.nlm.nih.gov/25878387/
  20. Hull JD, Lyon RA. In vitro pharmacology of ambroxol: Potential serotonergic sites of action. Life Sci. 2018 Mar 15;197:67–72. 
  21. Sved S, McGilveray IJ, Beaudoin N. The assay and absorption kinetics of oral theophylline-7-acetic acid in the human. Biopharm Drug Dispos [Internet]. 1981 [cited 2023 Sep 21];2(2):177–84. Available from: https://pubmed.ncbi.nlm.nih.gov/7248481/
  22. Goldrub N, Soares VRZ, Hamoui A, et al. Therapeutic activity and tolerability profile of acebrophylline. Advan Ther 1992; 9: 107-11
  23. Milvio C, Borellini P, Benazzi, et al. Effetti clinici del teofillin-acetato di ambroxol. Giorn Ist Ric Clin Ter 1985; 4: 77-80
  24. Fracchia C, Della Torre M, Zanotti E, et al. Valutazione dell’attività di acebrofillina (P3011): studio controllato verso ambroxol. Rass Pat App Resp 1987; 1: 177-181
  25. Mak, G., and Hanania, NA. (2012). New bronchodilators. Current Opinion in Pharmacology. 12, 238-245
  26. Page, CP. (2010). Doxofylline: a “novofylline”. Pulmonary pharmacology & therapeutics, 23(4), 231-234.

Photo
Sourav Pattanayak
Corresponding author

M. Pharm, MBA (NMIMS), Business Development at BIBO HEALTH (Hilt Brands India Pvt Ltd), Bengaluru.

Photo
Sagar Sheel
Co-author

B. Pharmacy (PESCP), B2B Sales at BIBO HEALTH (Hilt Brands India Pvt Ltd), Bengaluru.

Photo
Vikash Kumar
Co-author

MBA (IIT), CEO and Co-Founder at BIBO HEALTH (Hilt Brands India Pvt Ltd), Bengaluru.

Sourav Pattanayak, Sagar Sheel, Vikash Kumar, Acebrophylline Is A Better Choice Of Drug Over Theophylline For Patients With Asthma, COPD And Bronchitis Patients, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 403-411. https://doi.org/10.5281/zenodo.8372371

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