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  • Advancements In Lipid Nanoparticles For Enhanced Drug Delivery: A Comprehensive Review
  • Centurion University of Technology and Management, Gopalpur, Balasore, Odisha, India-756044

Abstract

Lipid nanoparticles have emerged as promising carriers for drug delivery due to their biocompatibility, versatility, and ability to encapsulate a wide range of therapeutic agents. This review article explores the recent advancements in lipid nanoparticles and their applications in pharmaceutical formulations. The article discusses various types of lipid nanoparticles, including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and lipid-drug conjugates, highlighting their unique characteristics and advantages. The focus is on their potential to overcome challenges associated with traditional drug delivery systems, such as poor bioavailability, limited stability, and off-target effects.

Keywords

Lipid nanoparticles, Drug delivery, Biocompatible, Biodegradable, Safe, Targeted, Emerging, Novel Drug delivery System

Reference

  1. Swetha, K., Kotla, N. G., Tunki, L., Jayaraj, A., Bhargava, S. K., Hu, H., ... & Kurapati, R. (2023). Recent advances in the lipid nanoparticle-mediated delivery of mRNA vaccines. Vaccines, 11(3), 658.
  2. Atabakhshi-Kashi, M., Geranpayehvaghei, M., Wang, Y., Akhbariyoon, H., Taleb, M., Zhang, Y., ... & Nie, G. (2020). Recent Advances of Nanocarriers for Effective Delivery of Therapeutic Peptides. Precision Nanomedicine, 3(2), 549-576.
  3. Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021). Lipid nanoparticles for mRNA delivery. Nature Reviews Materials, 6(12), 1078-1094.
  4. Zhao, Y. Q., Li, L. J., Zhou, E. F., Wang, J. Y., Wang, Y., Guo, L. M., & Zhang, X. X. (2022). Lipid-Based Nanocarrier Systems for Drug Delivery: Advances and Applications. Pharmaceutical Fronts, 4(02), e43-e60.
  5. Mahmoud, K., Swidan, S., El-Nabarawi, M., & Teaima, M. (2022). Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: A comprehensive review on targeting and recent advances. Journal of Nanobiotechnology, 20(1), 109.
  6. Akombaetwa, N., Ilangala, A. B., Thom, L., Memvanga, P. B., Witika, B. A., & Buya, A. B. (2023). Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications. Pharmaceutics, 15(2), 656.
  7. Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021). Lipid nanoparticles? from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement. ACS nano, 15(11), 16982-17015.
  8. Ezike TC, Okpala US, Onoja UL, Nwike CP, Ezeako EC, Okpara OJ, Okoroafor CC, Eze SC, Kalu OL, Odoh EC, Nwadike UG, Ogbodo JO, Umeh BU, Ossai EC, Nwanguma BC. (2023). Advances in drug delivery systems, challenges and future directions. Heliyon. Jun;9(6): e17488.
  9. Abdellatif, A. A., Mohammed, H. A., Khan, R. A., Singh, V., Bouazzaoui, A., Yusuf, M., ... & Al-Omar, M. S. (2021). Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity. Nanotechnology Reviews, 10(1), 1493-1559.
  10. Duan, Y., Dhar, A., Patel, C., Khimani, M., Neogi, S., Sharma, P., ... & Vekariya, R. L. (2020). A brief review on solid lipid nanoparticles: Part and parcel of contemporary drug delivery systems. RSC advances, 10(45), 26777-26791.
  11. Guevara, M. L., Persano, F., & Persano, S. (2020). Advances in lipid nanoparticles for mRNA-based cancer immunotherapy. Frontiers in chemistry, 8, 589959.
  12. Yousry, A., Hassan, T., Elaidy, S. M., & Gad, S. (2022). Nanocarriers as pulmonary drug delivery systems. Records of Pharmaceutical and Biomedical Sciences, 6(3), 113-119.
  13. Saez, V., Souza, I. D. L., & Mansur, C. R. E. (2018). Lipid nanoparticles (SLN & NLC) for delivery of vitamin E: a comprehensive review. In International Journal of Cosmetic Science, 40(2), 03–116. 
  14. Stefanov, S. R., & Andonova, V. Y. (2021). Lipid nanoparticulate drug delivery systems: recent advances in the treatment of skin disorders. Pharmaceuticals, 14(11), 1083.
  15. Pandey, S., Shaikh, F., Gupta, A., Tripathi, P., & Yadav, J. S. (2022). A Recent Update: Solid Lipid Nanoparticles for Effective Drug Delivery. In Advanced Pharmaceutical Bulletin, 12(1),17–33. 
  16. Dhankhar, R., Vyas, S. P., Jain, A. K., Arora, S., Rath, G., & Goyal, A. K. (2010). Advances in novel drug delivery strategies for breast cancer therapy. In Artificial Cells, Blood Substitutes, and Biotechnology, 38(5),230–249. 
  17. Sivadasan, D., Sultan, M. H., Madkhali, O., Almoshari, Y., & Thangavel, N. (2021). Polymeric lipid hybrid nanoparticles (plns) as emerging drug delivery platform—A comprehensive review of their properties, preparation methods, and therapeutic applications. Pharmaceutics, 13(8), 1291.
  18. Mahmoud, K., Swidan, S., El-Nabarawi, M., & Teaima, M. (2022). Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: A comprehensive review on targeting and recent advances. Journal of Nanobiotechnology, 20(1), 109.
  19. Sokkula, S. R., & Gande, S. (2020). A comprehensive review on self-nano emulsifying drug delivery systems: advancements & applications. Int. J. Pharm. Sci. Drug Res, 12(5), 576-583.
  20. Doktorovova, S., & Souto, E. B. (2009). Nanostructured lipid carrier-based hydrogel formulations for drug delivery: a comprehensive review. Expert opinion on drug delivery, 6(2), 165-176.
  21. Yoon, G., Park, J. W., & Yoon, I. S. (2013). Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery. Journal of Pharmaceutical Investigation, 43, 353-362.
  22. Singh, M., & Mazumder, B. (2022). Recent Advancements in Nanodiamond Mediated Brain Targeted Drug Delivery and Bioimaging of Brain Ailments: A Holistic Review. Pharmaceutical Nanotechnology, 10(1), 42-55.
  23. Narayan, R., Nayak, U. Y., Raichur, A. M., & Garg, S. (2018). Mesoporous silica nanoparticles: A comprehensive review on synthesis and recent advances. Pharmaceutics, 10(3), 118.
  24. Das, S., & Chaudhury, A. (2011). Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. Aaps Pharmscitech, 12, 62-76.
  25. Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021). Lipid nanoparticles? from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement. ACS nano, 15(11), 16982-17015.
  26. Severino, P., Andreani, T., Macedo, A. S., Fangueiro, J. F., Santana, M. H. A., Silva, A. M., & Souto, E. B. (2012). Current state-of-art and new trends on lipid nanoparticles (SLN and NLC) for oral drug delivery. Journal of drug delivery, 2012.
  27. Puglia, C., & Bonina, F. (2012). Lipid nanoparticles as novel delivery systems for cosmetics and dermal pharmaceuticals. Expert Opinion on Drug Delivery, 9(4), 429-441.
  28. Fathi-Karkan, S., Arshad, R., Rahdar, A., Ramezani, A., Behzadmehr, R., Ghotekar, S., & Pandey, S. (2023). Recent advancements in the targeted delivery of etoposide nanomedicine for cancer therapy: A comprehensive review. European Journal of Medicinal Chemistry, 115676.
  29. Narayana, S., Ahmed, M. G., Gowda, B. H., Shetty, P. K., Nasrine, A., Thriveni, M., ... & Sanjana, A. (2021). Recent advances in ocular drug delivery systems and targeting VEGF receptors for management of ocular angiogenesis: A comprehensive review. Future Journal of Pharmaceutical Sciences, 7(1), 1-21.
  30. Jacob, S., Nair, A.B., Shah, J., Gupta, S., Boddu, S.H., Sreeharsha, N., Joseph, A., Shinu, P. and Morsy, M.A. (2022). Lipid Nanoparticles as a Promising Drug Delivery Carrier for Topical Ocular Therapy—An Overview on Recent Advances. Pharmaceutics, 14(3), p.533.
  31. Kamble, P., & Singh, P. (2020). A critical review on potential advancements of nanostructured lipid carriers in drug delivery. Current Nanomedicine (Formerly: Recent Patents on Nanomedicine), 10(4), 298-325.
  32. Bai, X., Smith, Z. L., Wang, Y., Butterworth, S., & Tirella, A. (2022). Sustained drug release from smart nanoparticles in cancer therapy: A Comprehensive review. Micromachines, 13(10), 1623.
  33. Al-Sayadi, G. M., Verma, A., Choudhary, Y., Sandal, P., Patel, P., Singh, D., ... & Das Kurmi, B. (2023). Solid Lipid Nanoparticles (SLNs): Advancements in Modification Strategies Toward Drug Delivery Vehicle. Pharmaceutical Nanotechnology, 11(2), 138-154.
  34. Dolatabadi, J. E. N., Valizadeh, H., & Hamishehkar, H. (2015). Solid lipid nanoparticles as efficient drug and gene delivery systems: recent breakthroughs. Advanced pharmaceutical bulletin, 5(2), 151.
  35. Amoabediny, G., Haghiralsadat, F., Naderinezhad, S., Helder, M. N., Akhoundi Kharanaghi, E., Mohammadnejad Arough, J., & Zandieh-Doulabi, B. (2018). Overview of preparation methods of polymeric and lipid-based (niosome, solid lipid, liposome) nanoparticles: A comprehensive review. International Journal of Polymeric Materials and Polymeric Biomaterials, 67(6), 383-400.
  36. Jacob, S., Nair, A. B., Shah, J., Gupta, S., Boddu, S. H. S., Sreeharsha, N., ... & Morsy, M. A. (2022). Lipid nanoparticles as a promising drug delivery carrier for topical ocular therapy—an overview on recent advances. Pharmaceutics 2022; 14 (3): 533.
  37. Schäfer-Korting, M., Mehnert, W., & Korting, H. C. (2007). Lipid nanoparticles for improved topical application of drugs for skin diseases. Advanced drug delivery reviews, 59(6), 427-443.
  38. Gupta, P., Neupane, Y. R., Aqil, M., Kohli, K., & Sultana, Y. (2023). Lipid-based nanoparticle-mediated combination therapy for breast cancer management: a comprehensive review. Drug Delivery and Translational Research, 1-28.
  39. Wong, H. L., Bendayan, R., Rauth, A. M., Li, Y., & Wu, X. Y. (2007). Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Advanced drug delivery reviews, 59(6), 491-504.
  40. Naziris, N., & Demetzos, C. (2022). Lipid nanoparticles as platforms for theranostic purposes: recent advances in the field. Journal of Nanotheranostics, 3(2), 86-101.
  41. Andra, V. V. S. N. L., Pammi, S. V. N., Bhatraju, L. V. K. P., & Ruddaraju, L. K. (2022). A comprehensive review on novel liposomal methodologies, commercial formulations, clinical trials and patents. BioNanoScience, 12(1), 274-291.
  42. Almeida, A. J., & Souto, E. (2007). Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Advanced drug delivery reviews, 59(6), 478-490.
  43. Böttger, R., Pauli, G., Chao, P. H., Fayez, N. A., Hohenwarter, L., & Li, S. D. (2020). Lipid-based nanoparticle technologies for liver targeting. Advanced drug delivery reviews, 154, 79-101.
  44. Charron, D. M., Chen, J., & Zheng, G. (2015). Theranostic lipid nanoparticles for cancer medicine. Nanotechnology-based precision tools for the detection and treatment of cancer, 103-127.
  45. Geszke-Moritz, M., & Moritz, M. (2016). Solid lipid nanoparticles as attractive drug vehicles: Composition, properties and therapeutic strategies. Materials Science and Engineering: C, 68, 982-994.
  46. Fan, Y., Marioli, M., & Zhang, K. (2021). Analytical characterization of liposomes and other lipid nanoparticles for drug delivery. Journal of pharmaceutical and biomedical analysis, 192, 113642.
  47. Harde, H., Das, M., & Jain, S. (2011). Solid lipid nanoparticles: an oral bioavailability enhancer vehicle. Expert opinion on drug delivery, 8(11), 1407-1424.
  48. Iqbal, M. A., Md, S., Sahni, J. K., Baboota, S., Dang, S., & Ali, J. (2012). Nanostructured lipid carriers system: recent advances in drug delivery. Journal of drug targeting, 20(10), 813-830.
  49. Patra, J. K., Das, G., Fraceto, L. F., Campos, E. V. R., Rodriguez-Torres, M. D. P., Acosta-Torres, L. S., ... & Shin, H. S. (2018). Nano based drug delivery systems: recent developments and future prospects. Journal of nanobiotechnology, 16(1), 1-33.
  50. Handa, M., Beg, S., Shukla, R., Barkat, M. A., Choudhry, H., & Singh, K. K. (2021). Recent advances in lipid-engineered multifunctional nanophytomedicines for cancer targeting. Journal of Controlled Release, 340, 48-59.
  51. Müller, R. H., Mäder, K., & Gohla, S. (2000). Solid lipid nanoparticles (SLN) for controlled drug delivery–a review of the state of the art. European journal of pharmaceutics and biopharmaceutics, 50(1), 161-177.
  52. Scioli Montoto, S., Muraca, G., & Ruiz, M. E. (2020). Solid lipid nanoparticles for drug delivery: pharmacological and biopharmaceutical aspects. Frontiers in molecular biosciences, 7, 319.
  53. Has, C., & Sunthar, P. (2020). A comprehensive review on recent preparation techniques of liposomes. Journal of liposome research, 30(4), 336-365.
  54. Tom, S., Gowda, D. V., Manjunath, M., Koshy, T. M., Karunakar, G., & Srivastava, A. (2016). Solid Lipid Nanoparticles-A Breakthrough In Novel Drug Delivery System. Amer J Pharm Res, 6, 131-146.
  55. Ghan, R. C. (2020). Nanoparticulate treatments for oral delivery. Drug Delivery Trends, 103-122.
  56. Seyfoddin, A., Shaw, J., & Al-Kassas, R. (2010). Solid lipid nanoparticles for ocular drug delivery. Drug delivery, 17(7), 467-489.
  57. Blasi, P., Giovagnoli, S., Schoubben, A., Ricci, M., & Rossi, C. (2007). Solid lipid nanoparticles for targeted brain drug delivery. Advanced drug delivery reviews, 59(6), 454-477.
  58. Allen, T. M., & Cullis, P. R. (2013). Liposomal drug delivery systems: from concept to clinical applications. Advanced drug delivery reviews, 65(1), 36-48.
  59. Beloqui, A., Solinís, M. Á., Rodríguez-Gascón, A., Almeida, A. J., & Préat, V. (2016). Nanostructured lipid carriers: Promising drug delivery systems for future clinics. Nanomedicine: Nanotechnology, biology and medicine, 12(1), 143-161.
  60. Sujeevan, O. (2023). Comprehensive review on nano drug delivery systems bioanalysis. GSC Advanced Research and Reviews, 14(1), 127-140.
  61. Birajdar, G. O., Kadam, V. S., Chintale, A. G., Halle, P. D., Nabde, M. K., & Maske, K. S. (2013). A Comprehensive review on nanotechnology. Research Journal of Pharmacy and Technology, 6(5), 486-495.
  62. Fang, C. L., A Al-Suwayeh, S., & Fang, J. Y. (2013). Nanostructured lipid carriers (NLCs) for drug delivery and targeting. Recent patents on nanotechnology, 7(1), 41-55.
  63. Muchow, M., Maincent, P., & Müller, R. H. (2008). Lipid nanoparticles with a solid matrix (SLN®, NLC®, LDC®) for oral drug delivery. Drug development and industrial pharmacy, 34(12), 1394-1405.
  64. Filipczak, N., Pan, J., Yalamarty, S. S. K., & Torchilin, V. P. (2020). Recent advancements in liposome technology. Advanced drug delivery reviews, 156, 4-22.
  65. Yeh, Y. C., Huang, T. H., Yang, S. C., Chen, C. C., & Fang, J. Y. (2020). Nano-based drug delivery or targeting to eradicate bacteria for infection mitigation: a review of recent advances. Frontiers in chemistry, 8, 286.
  66. Kalhapure, R. S., Suleman, N., Mocktar, C., Seedat, N., & Govender, T. (2015). Nanoengineered drug delivery systems for enhancing antibiotic therapy. Journal of pharmaceutical sciences, 104(3), 872-905.
  67. Poonia, M., Ramalingam, K., Goyal, S., & Sidhu, S. K. (2017). Nanotechnology in oral cancer: A comprehensive review. Journal of oral and maxillofacial pathology: JOMFP, 21(3), 407.
  68. Namiki, Y., Fuchigami, T., Tada, N., Kawamura, R., Matsunuma, S., Kitamoto, Y., & Nakagawa, M. (2011). Nanomedicine for cancer: lipid-based nanostructures for drug delivery and monitoring. Accounts of chemical research, 44(10), 1080-1093.
  69. Paliwal, R., Paliwal, S. R., Kenwat, R., Kurmi, B. D., & Sahu, M. K. (2020). Solid lipid nanoparticles: A review on recent perspectives and patents. Expert opinion on therapeutic patents, 30(3), 179-194.
  70. Pearce, T. R., Shroff, K., & Kokkoli, E. (2012). Peptide targeted lipid nanoparticles for anticancer drug delivery. Advanced materials, 24(28), 3803-3822.
  71. Ensign, L. M., Cone, R., & Hanes, J. (2012). Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers. Advanced drug delivery reviews, 64(6), 557-570.
  72. Agrawal, S., Garg, A., & Varshney, V. (2022). Recent updates on applications of Lipid-based nanoparticles for site-specific drug delivery. Pharmaceutical Nanotechnology, 10(1), 24-41.
  73. Müller, R. H., Petersen, R. D., Hommoss, A., & Pardeike, J. (2007). Nanostructured lipid carriers (NLC) in cosmetic dermal products. Advanced drug delivery reviews, 59(6), 522-530.
  74. Gordillo-Galeano, A., & Mora-Huertas, C. E. (2018). Solid lipid nanoparticles and nanostructured lipid carriers: A review emphasizing on particle structure and drug release. European Journal of Pharmaceutics and Biopharmaceutics, 133, 285-308.
  75. Ghasemiyeh, P., & Mohammadi-Samani, S. (2018). Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: Applications, advantages and disadvantages. Research in pharmaceutical sciences, 13(4), 288.

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Nihar Ranjan Kar
Corresponding author

Centurion University of Technology and Management, Gopalpur, Balasore, Odisha, India-756044

Nihar Ranjan Kar, Advancements In Lipid Nanoparticles For Enhanced Drug Delivery: A Comprehensive Review, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 95-115. https://doi.org/10.5281/zenodo.8328533

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