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  • Ameliorative effect of Dhatryadi Ghrita on Letrozole induced Polycystic Ovarian Syndrome in female albino Wistar rats
  • 1Department of Pharmacology, Student of Pharmacy, Madras Medical College, Chennai, India.
    2Department of Pharmacology, Faculty of Pharmacy, Madras Medical College, Chennai, India.

Abstract

Objective: To investigate ameliorative effects of Dhatryadi ghrita on letrozole induced PCOD in female albino Wistar rats. Methods: Letrozole was given orally to rats every day for 21 days at a dose of 1 mg/kg body weight to induce PCOS. PCOS rats were then treated daily with metformin (70mg/Kg) and DG (200mg/Kg and 400mg/Kg) for 15 d. Rats which underwent none of these treatments were kept as control. Serum glucose, Lipid profile, insulin, estrogen, progesterone levels and superoxide dismutase levels were determined. Results: Rats treated with letrozole demonstrated a significant increase in body weight, serum triglycerides, cholesterol, LDL, glucose and insulin, and a significant decline in progesterone, Oestrogen, HDL and SOD levels compared to control. Rats treated with metformin, DG 200mg/Kg and DG 400mg/Kg showed a remarkable decrease in the elevated body weight, blood glucose, LDL, TC, TG and insulin levels and significant increase in the serum oestrogen, progesterone, SOD and HDL levels. Conclusion: Data indicate that DG exert potential ameliorative effects against PCOS through the modulation of hormonal and lipid profile as well as oxidative stress. These beneficial impacts of Dhatryadi ghrita make it a promising agent for the treatment and prevention of PCOS. Furthermore, these substances' beneficial effects are on par with those of metformin.

Keywords

Dhatryadi ghrita (DG); Metformin; Polycystic Ovarian Syndrome; hormone analysis; oxidative stress; hyperinsulinemia

Reference

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Sangeetha Venkatesan
Corresponding author

Department of Pharmacology, Student of Pharmacy, Madras Medical College, Chennai, India.

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Sakthi Abirami
Co-author

Department of Pharmacology, Faculty of Pharmacy, Madras Medical College, Chennai, India.

Sangeetha Venkatesan, Sakthi Abirami, Ameliorative effect of Dhatryadi Ghrita on Letrozole induced Polycystic Ovarian Syndrome in female albino Wistar rats, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 417-426. https://doi.org/10.5281/zenodo.8378350

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