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  • A Short Review On Premature Ejaculation (PE): Symptoms, Causes, And Prevention
  • 1PhD Research Scholar, Department of Pharmacy,  JSS College of Pharmacy, Mysuru Karnataka, India
    2Head & Assistant Professor,  Department of Chemistry (PG), Sahibganj College Sahibganj,  Jharkhand, India
    3Assistant Professor, Department of Pharmaceutical Sciences, Veerayatan Institute of Pharmacy, Gujarat, India
    4Assistant Professor, Department of Pharmaceutical Science, Sir J.C Bose Technical Campus, Bhimtal, Kumaun University, Nainital, India 
    5Assistant Professor, Department of Pharmacology, Sri Sivani college of Pharmacy, Srikakulam, Andhra Pradesh, India
    6Professor, Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Koni, Bilaspur, India
    7Lecturer, Department of Pharmacy, Government Polytechnic for Women, Srikakulam, Andhra Pradesh, India
    8Professor, Department of Pharmacy Practice, Geethanjali College of Pharmacy, Cheeryal (V), Keesara (M), Medchal-Malkajgiri (D), Telangana, India
     

Abstract

Premature ejaculation is a prevalent sexual dysfunction that can significantly impact a man's sexual and emotional well-being. It is characterized by early or rapid ejaculation and can be classified into two types: lifelong and acquired. PE is thought to be caused by a confluence of biological, psychological, and environmental variables, while the precise etiology is yet unknown. However, with various prevention strategies, such as techniques to delay ejaculation, pelvic floor exercises, and addressing underlying psychological issues, PE can be effectively managed. Seeking professional help is crucial for individuals and couples struggling with PE, as it can lead to improved sexual satisfaction and overall quality of life.

Keywords

Premature ejaculation, orgasm, sexual desire, relationship satisfaction

Introduction

Premature ejaculation (PE) is a common sexual dysfunction affecting millions of men worldwide. It is described as the frequent or continuous ejaculation before, during, or soon after modest sexual excitement after penetration, causing distress or interpersonal difficulty. PE can significantly impact a man's sexual satisfaction, self-esteem, and overall quality of life. The goal of this paper is to give a brief overview of the symptoms, causes, and prevention strategies of premature ejaculation. The primary symptom of PE is the incapacity to manage ejaculation, resulting in premature or fast ejaculation during intercourse. This can occur in less than a minute after penetration, leaving both partners dissatisfied. PE can be classified into two types: lifelong (primary) and acquired (secondary) [1]. Lifelong PE is present from the first sexual experience, while acquired PE develops later in life due to psychological or physical factors. The exact cause of PE is not fully understood, but it is believed to be a combination of psychological, biological, and environmental factors. Psychological factors such as anxiety, guilt, and relationship issues can contribute to PE. Biological factors such as hormonal imbalances, genetic predisposition, and abnormal nerve reflexes may also play a role. Environmental factors such as performance pressure, stress, and certain medications can also contribute to PE [2]. Fortunately, there are several prevention strategies available for PE. One of the most effective ways to prevent PE is to practice techniques that help delay ejaculation, such as the stop-start and squeeze techniques. These involve stopping sexual activity before reaching the point of ejaculation and then resuming once the sensation has subsided. Another prevention strategy is to engage in regular pelvic floor exercises, which can help strengthen the muscles responsible for controlling ejaculation. It is also essential to address any underlying psychological or relationship issues that may be contributing to PE. Seeking therapy or counseling can help individuals and couples improve communication, reduce anxiety, and enhance sexual satisfaction. Additionally, avoiding alcohol and recreational drugs, which can affect sexual function, can also help prevent PE [3].


       
            Picture3.png
       

    Figure 1: Comparing early ejaculation with the normal male sexual response.


Effects on Personal and Sexual Relationships [4]

Premature ejaculation can have a significant impact on a man's personal and sexual relationships. It can lead to feelings of inadequacy, low self-esteem, and even depression. This condition can also cause strain and frustration in a couple's sexual relationship, as it may leave one partner feeling unsatisfied. Oftentimes, it can also lead to avoidance of sexual activity, which can further strain the relationship.

SYMPTOMS [4-5]

The primary symptom of PE is the inability to control ejaculation, which occurs before or soon after penetration. However, other symptoms may accompany this condition, including:

  1. Ejaculating within one minute of penetration consistently.
  2. Inability to delay ejaculation during sexual intercourse.
  3. Feelings of frustration, guilt, or shame after sexual encounters.
  4. Avoidance of sexual intimacy due to fear of failure.
  5. Relationship problems due to unsatisfactory sexual experiences.     

Importantly, PE is relatively rare, and isolated episodes do not always signify a long-term issue. However, if the symptoms persist and cause distress, it is advisable to seek medical help.

CAUSES [5]

It's unclear exactly what causes premature ejaculation. However, several factors may contribute to this condition, including:

  1. Psychological factors:

Anxiety, stress, and depression can all contribute to PE. Performance anxiety, in particular, can lead to a fear of failure and a constant worry about ejaculating too quickly, creating a self-fulfilling cycle.

  1. Biological factors:

Certain medical conditions, such as diabetes, high blood pressure, and thyroid problems, can cause PE. Additionally, hormonal imbalances, abnormal levels of neurotransmitters, and genetic predispositions may also play a role.

  1. Relationship issues:

Problems in a relationship, such as lack of communication, unresolved conflicts, or sexual incompatibility, can lead to PE.

  1. Inexperience:

In some cases, PE may be due to a lack of sexual experience or inadequate knowledge about one's own body and sexual responses.

  1. Erectile dysfunction (ED):

Men with ED may develop a habit of ejaculating quickly to avoid losing their erections, leading to PE.

  1. Inflammation or infection:

Inflammation or infection of the prostate or urethra can cause PE, as these conditions can affect the nerves and muscles involved in ejaculation.


       
            Picture1.jpg
       

    Figure 2: Showing causes of the PE


PREVENTION [6-7]

Prevention methods for PE can be divided into psychological and behavioral interventions. Psychological interventions involve addressing any underlying psychological issues, such as anxiety or relationship problems, through therapy or counseling. Behavioral interventions focus on developing techniques to delay ejaculation, such as the start-stop technique, which involves stopping sexual activity when nearing ejaculation and then resuming once the sensation has passed. Other behavioral techniques include the squeeze technique, which involves squeezing the head of the penis to delay ejaculation, and the use of condoms to reduce sensitivity.PE can be prevented or managed effectively through various treatments and lifestyle changes. These include:

  1. Behavioral techniques:

Techniques such as the 'squeeze' and 'stop-start' methods involve temporarily halting sexual activity when the man feels he is about to ejaculate. This can help to delay ejaculation and increase control.

    1. Stop – Start:

The partner stimulates the penis until they are almost ready to ejaculate during the start-stop phase. The companion should then come to a stop and allow the male to regain control of his instincts. This procedure will be repeated twice more by the partner. He can then ejaculate on the fourth try. Experts advise doing this technique three times a week or more to improve control over ejaculation during intercourse[8]

    1. Squeeze:

To achieve the climax of the erection with the squeeze method, the partner stimulates the penis and then applies tight pressure until the erection begins to weaken. To gain control and delay ejaculation, this technique aids in improving the realization of the peak sense. It can take a few weeks for this approach to show results.

  1. Counselling:

Seeking therapy or counseling can help address any underlying psychological issues that may be contributing to PE. It can also improve communication and intimacy within a relationship.

  1. Medications:

Certain medications, such as selective serotonin reuptake inhibitors (SSRIs) and topical anesthetics, can delay ejaculation and improve control [9].

  1. Lifestyle changes:

Making healthy lifestyle choices, such as exercising regularly, reducing stress levels, and avoiding alcohol and drug use, can help manage PE.

  1. Communication and education:

Open communication with your partner about sexual needs and preferences can help alleviate performance anxiety and increase intimacy. Additionally, educating oneself about sexual responses and techniques can improve control and delay ejaculation.

  1. Topical Anesthetics:

Over-the-counter topical anesthetics, such as lidocaine, can be applied to the penis to reduce sensitivity and delay ejaculation. However, these should be used with caution, as they may also reduce sensitivity for the partner, leading to unsatisfactory sexual experiences [10].

  1. Condoms:

Using condoms can also help delay ejaculation by reducing sensation. Some condoms are specially designed with thicker latex or numbing agents that can help prolong sexual activity.

  1. Pelvic Floor Exercises:

Exercises that strengthen the pelvic floor muscles, also known as Kegel exercises, can help improve control over ejaculation. These exercises involve contracting and relaxing the muscles used to control urination and can be done discreetly at any time.[11,12]


       
            Picture2.png
       

    Figure 3: Showing Preventions of the PE


Other prevention methods may include practicing relaxation techniques, such as deep breathing and meditation, to reduce anxiety and stress. Regular exercise and a healthy diet can also promote overall physical and mental well-being, which can have a positive impact on sexual function. Additionally, communicating openly and effectively with sexual partners can help to reduce performance anxiety and improve sexual satisfaction [13-14].

CONCLUSION

Premature ejaculation is a common sexual dysfunction that can cause distress and strain relationships. However, it is a treatable condition, and seeking medical help can lead to effective management and improved sexual experiences. By understanding the symptoms, causes, and prevention methods, men can take responsibility for their sexual health and strengthen their general well-being.                                                                                             

REFERENCES

  1. American Urological Association. (2018). Premature Ejaculation. Retrieved from https://www.auanet.org/guidelines/premature-ejaculation-guideline
  2. Akhondzadeh, S., Fallah-Pour, H., Afkham, K., & Jamshidi, A. H. (2002). Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial. BMC Complementary and Alternative Medicine, 2, 11. https://doi.org/10.1186/1472-6882-2-11
  3. Aldridge-Gerry, A., Zeleke, B. M., & Krest, M. (2019). Cognitive-behavioral therapy (CBT) for premature ejaculation: A systematic review. Journal of Sex and Marital Therapy, 45(1), 1–14. https://doi.org/10.1080/0092623X.2018.1433645
  4. Gur, S., & Sikka, S. C. (2016). Current perspectives on the role of selective serotonin reuptake inhibitors in the management of premature ejaculation. Therapeutic Advances in Urology, 8(3), 143–152. https://doi.org/10.1177/1756287216652542
  5. Althof, S. (2016). Psychological approaches to the treatment of rapid ejaculation. Journal of Sexual Medicine, 13(4), 591-609.
  6. McMahon, C. G. (2014). Management of premature ejaculation. Nature Reviews Urology, 11(12), 691–701.
  7. Shindel, A. W. (2016). Premature ejaculation in the United States: treatment practice and outcomes. Sexual Medicine, 4(4), e175–e184.
  8. Waldinger, M. D. (2016). Premature ejaculation: state of the art. Translational Andrology and Urology, 5(4), 416-423.
  9. World Health Organization. (2019). Premature Ejaculation: A Clinical Review for the General Physician. Retrieved from https://apps.who.int/iris/bitstream/handle/10665/329881/WHO-RHR-19.20-eng.pdf
  10. Zamar, A. (2020). Premature ejaculation: causes, mechanisms, and treatments. International Journal of Impotence Research, 32(3), 301-311.
  11. Hartmut Porst, Andrea Burri (2017). FortacinTM spray is for the treatment of premature ejaculation. Urologia,84 (Suppl 2): S1-S10, DOI: 10.5301/uj.5000275
  12. Mayo Clinic. (2019). Premature Ejaculation. Retrieved from https://www.mayoclinic.org/diseases-conditions/premature-ejaculation/diagnosis-treatment/drc-20354905
  13. National Institute of Diabetes and Digestive and Kidney Diseases. (2017). Premature Ejaculation. Retrieved from https://www.niddk.nih.gov/health-information/urologic-diseases/premature-ejaculation
  14. U.S. National Library of Medicine. (2020). Premature Ejaculation. Retrieved from https://medlineplus.gov/prematureejaculation.html

Reference

  1. American Urological Association. (2018). Premature Ejaculation. Retrieved from https://www.auanet.org/guidelines/premature-ejaculation-guideline
  2. Akhondzadeh, S., Fallah-Pour, H., Afkham, K., & Jamshidi, A. H. (2002). Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial. BMC Complementary and Alternative Medicine, 2, 11. https://doi.org/10.1186/1472-6882-2-11
  3. Aldridge-Gerry, A., Zeleke, B. M., & Krest, M. (2019). Cognitive-behavioral therapy (CBT) for premature ejaculation: A systematic review. Journal of Sex and Marital Therapy, 45(1), 1–14. https://doi.org/10.1080/0092623X.2018.1433645
  4. Gur, S., & Sikka, S. C. (2016). Current perspectives on the role of selective serotonin reuptake inhibitors in the management of premature ejaculation. Therapeutic Advances in Urology, 8(3), 143–152. https://doi.org/10.1177/1756287216652542
  5. Althof, S. (2016). Psychological approaches to the treatment of rapid ejaculation. Journal of Sexual Medicine, 13(4), 591-609.
  6. McMahon, C. G. (2014). Management of premature ejaculation. Nature Reviews Urology, 11(12), 691–701.
  7. Shindel, A. W. (2016). Premature ejaculation in the United States: treatment practice and outcomes. Sexual Medicine, 4(4), e175–e184.
  8. Waldinger, M. D. (2016). Premature ejaculation: state of the art. Translational Andrology and Urology, 5(4), 416-423.
  9. World Health Organization. (2019). Premature Ejaculation: A Clinical Review for the General Physician. Retrieved from https://apps.who.int/iris/bitstream/handle/10665/329881/WHO-RHR-19.20-eng.pdf
  10. Zamar, A. (2020). Premature ejaculation: causes, mechanisms, and treatments. International Journal of Impotence Research, 32(3), 301-311.
  11. Hartmut Porst, Andrea Burri (2017). FortacinTM spray is for the treatment of premature ejaculation. Urologia,84 (Suppl 2): S1-S10, DOI: 10.5301/uj.5000275
  12. Mayo Clinic. (2019). Premature Ejaculation. Retrieved from https://www.mayoclinic.org/diseases-conditions/premature-ejaculation/diagnosis-treatment/drc-20354905
  13. National Institute of Diabetes and Digestive and Kidney Diseases. (2017). Premature Ejaculation. Retrieved from https://www.niddk.nih.gov/health-information/urologic-diseases/premature-ejaculation
  14. U.S. National Library of Medicine. (2020). Premature Ejaculation. Retrieved from https://medlineplus.gov/prematureejaculation.html

Photo
Abdul Nazer Ali
Corresponding author

Department of Pharmacy Practice, Geethanjali College of Pharmacy, Cheeryal (V), Keesara (M), MedchalMalkajgiri (D), Telangana, India

Photo
Krishnalekha Bandyopadhyay
Co-author

PhD Research Scholar, Department of Pharmacy, JSS College of Pharmacy, Mysuru Karnataka, India

Photo
Anil Kumar
Co-author

Head & Assistant Professor, Department of Chemistry (PG), Sahibganj College Sahibganj, Jharkhand, India

Photo
Vishal Pathak
Co-author

Assistant Professor, Department of Pharmaceutical Sciences, Veerayatan Institute of Pharmacy, Gujarat, India

Photo
Mohammad Rizwan
Co-author

Assistant Professor, Department of Pharmaceutical Science, Sir J.C Bose Technical Campus, Bhimtal, Kumaun University, Nainital, India

Photo
Uriti Sri Venkatesh
Co-author

Assistant Professor, Department of Pharmacology, Sri Sivani college of Pharmacy, Srikakulam, Andhra Pradesh, India

Photo
Sanmati Kumar Jain
Co-author

Professor, Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Koni, Bilaspur, India

Photo
Konda V V S Krishna
Co-author

Lecturer, Department of Pharmacy, Government Polytechnic for Women, Srikakulam, Andhra Pradesh, India

Photo
Abdul Nazer Al
Co-author

Department of Pharmacy Practice, Geethanjali College of Pharmacy, Cheeryal (V), Keesara (M), Medchal-Malkajgiri (D), Telangana, India

Krishnalekha Bandyopadhyay , Anil Kumar , Vishal Pathak , Mohammad Rizwan , XYZ , Uriti Sri Venkatesh , Sanmati Kumar Jain , Konda V V S Krishna , Abdul Nazer Ali , A Short Review On Premature Ejaculation (PE): Symptoms, Causes, And Prevention, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 9, 344-349. https://doi.org/10.5281/zenodo.13712818

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