GHG Khalsa College of Pharmacy, Gurusar-Sadhar
This research is mainly focused on development of an Excellent Gradient method by reverse phase - high performance liquid chromatography (RP-HPLC) using UV Visible Detector. The main objective of method validation of Lurasidone HCl as a tablet dosage form is to validate the method as in-house method. As this tablet dosage form is not registered in any of Pharmacopeia, so the method is developed and validated for further studies. The sample is analyzed by RP-HPLC using octadecylsilane (C18) column (Inertsil LC-GC) as stationary phase with UV-Visible detector. The ‘Gradient Method’ is used as instrumental method. The Mobile phase (A) was prepared using potassium phosphate buffer by adjusting the pH of value 4.0 and mobile phase (B) was 100?etonitrile; the ratio used for gradient was buffer: acetonitrile (40:60) respectively. The wavelength for ? max was selected by UV-Visible detector on spectrophotometer at wavelength 254nm. This method complies with Linearity , Accuracy , Recovery , Specificity , precision , stability , LOD , LOQ and Robustness
estimation of lurasidone hydrochloride: a novel antipsychotic drug in bulk and pharmaceutical dosage form. IJPS., 2012; 3(4): 2643-2653.
Simranjeet Singh, Muskan Sood, Anu Jindal*, Rajmeet Singh, Satvinder Kaur, Jaswinder Singh, Shaveta Bhardwaj Analytical Method Validation of Tablet Dosage Form of Lurasidone HCl, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 240-245. https://doi.org/10.5281/zenodo.10113218