Archive

  • Emerging Frontiers In Sustained Release Drug Delivery Systems: Unveiling The Latest Innovations And Future Perspectives
  • IEC School of Pharmacy, IEC University Baddi, Solan-174103, Himachal Pradesh, India

Abstract

Sustained release drug delivery systems have emerged as a promising approach to improve therapeutic effectiveness and patient compliance. This review article aims to provide a comprehensive overview of the advancements in sustained release drug delivery systems, focusing on design principles, formulation strategies, and novel approaches. The introduction highlights the background and significance of sustained release drug delivery systems in optimizing therapy for chronic conditions. The objectives of the review article include exploring the factors influencing system design, considering patient-specific considerations and personalized therapy, understanding the duration of therapy and sustained release requirements, and discussing the role of drug characteristics in selecting appropriate delivery systems. The review delves into the design principles of sustained release drug delivery systems, emphasizing patient-specific considerations and personalized therapy in system design. It discusses the duration of therapy and sustained release requirements, as well as the role of drug characteristics in selecting appropriate delivery systems. Formulation strategies for sustained release are explored, with a focus on matrix-based formulations, the role of polymers in controlling drug release kinetics, the use of excipients and additives for improved sustained release profiles, and novel approaches and technologies in formulation design. The advantages and challenges of matrix-based formulations are discussed, along with the role of polymers in achieving controlled release profiles. Excipients and additives are explored for their role in enhancing sustained release profiles, and novel approaches such as nanotechnology and 3D printing are highlighted for their potential in personalized medicine. In conclusion, this review article provides a comprehensive overview of the advancements in sustained release drug delivery systems. By considering design principles, formulation strategies, and novel approaches, researchers and practitioners can enhance therapeutic effectiveness, improve patient compliance, and shape the future of sustained release drug delivery.

Keywords

Sustained release drug delivery systems; Design principles; Formulation strategies; Polymers; Novel approaches

Reference

  1. Prabhu P. Advancements in sustained release drug delivery systems: Design principles, formulation strategies, and novel approaches. Int J Pharm. 2020;587:119674.
  2. Gupta A, Aggarwal G, Singla S, Arora V. Matrix tablets: An overview. Int J Pharm Sci Drug Res. 2011;3(4):223-229.
  3. Pandey A. Polymers used for sustained release formulation: A review. Indo Am J Pharm Res. 2013;3(1):1-15.
  4. Maiti S. Excipients used in sustained release dosage forms: A review. Int J Appl Pharm. 2018;10(2):1-9.
  5. Wang S, Liu R, Fu Y, Kao WJ. Release mechanisms and applications of drug delivery systems for extended-release. Expert Opinion on Drug Delivery. 2020 Sep 1;17(9):1289-304.
  6. Geraili A, Xing M, Mequanint K. Design and fabrication of drug?delivery systems toward adjustable release profiles for personalized treatment. View. 2021 Oct;2(5):20200126.
  7. Borandeh S, van Bochove B, Teotia A, Seppälä J. Polymeric drug delivery systems by additive manufacturing. Advanced drug delivery reviews. 2021 Jun 1;173:349-73.
  8. Prakhar A, Akhtar S. A comprehensive review on sustained release matrix tablets: a promising dosage form. Universal Journal of Pharmaceutical Research. 2018;3(6):49- 54.
  9. Ghezzi M, Pescina S, Padula C, Santi P, Del Favero E, Cantù L, Nicoli S. Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions. Journal of Controlled Release. 2021 Apr 10;332:312-36.
  10. Kalaydina RV, Bajwa K, Qorri B, Decarlo A, Szewczuk MR. Recent advances in “smart” delivery systems for extended drug release in cancer therapy. International journal of nanomedicine. 2018 Aug 20:4727-45.
  11. Bodunde OP, Ikumapayi OM, Akinlabi ET, Oladapo BI, Adeoye AO, Fatoba SO. A futuristic insight into a “nano-doctor”: a clinical review on medical diagnosis and devices using nanotechnology. Materials Today: Proceedings. 2021 Jan 1;44:1144-53.
  12. Zaborenko N, Shi Z, Corredor CC, Smith-Goettler BM, Zhang L, Hermans A, Neu CM, Alam MA, Cohen MJ, Lu X, Xiong L. First-principles and empirical approaches to predicting in vitro dissolution for pharmaceutical formulation and process development and for product release testing. The AAPS journal. 2019 May;21:1-20.
  13. Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, Moher D, Tugwell P, Welch V, Kristjansson E, Henry DA. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. bmj. 2017 Sep 21;358.
  14. Griffith DA, Tamer Cavusgil S, Xu S. Emerging themes in international business research. Journal of international business studies. 2008 Oct 1;39:1220-35.
  15. Patra JK, Das G, Fraceto LF, Campos EV, Rodriguez-Torres MD, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S, Habtemariam S. Nano based drug delivery systems: recent developments and future prospects. Journal of nanobiotechnology. 2018 Dec;16(1):1-33.
  16. Jiskoot W, Randolph TW, Volkin DB, Middaugh CR, Schöneich C, Winter G, Friess W, Crommelin DJ, Carpenter JF. Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. Journal of pharmaceutical sciences. 2012 Mar 1;101(3):946-54.
  17. Thomas RL, Zubair MY, Hayes B, Ashby MA. Goals of care: a clinical framework for limitation of medical treatment. Medical Journal of Australia. 2014 Oct;201(8):452-5.
  18. Wang K, Zhao Y, Chang YH, Qian Z, Zhang C, Wang B, Vannan MA, Wang MJ. Controlling the mechanical behavior of dual-material 3D printed meta-materials for patient-specific tissue-mimicking phantoms. Materials & Design. 2016 Jan 15;90:704- 12.
  19. Baryakova TH, Pogostin BH, Langer R, McHugh KJ. Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems. Nature Reviews Drug Discovery. 2023 May;22(5):387-409.
  20. Jain KK. An overview of drug delivery systems. drug delivery systems. 2020:1-54.
  21. Bhowmik D, Gopinath H, Kumar BP, Duraivel S, Kumar KS. Controlled release drug delivery systems. The Pharma Innovation. 2012 Dec 1;1(10).
  22. Guo M, Sun X, Chen J, Cai T. Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications. Acta Pharmaceutica Sinica B. 2021 Aug 1;11(8):2537-64.
  23. Ratnaparkhi MP, Gupta Jyoti P. Sustained release oral drug delivery system-an overview. Terminology. 2013;3(4):10-22270.
  24. Virmani T, Gupta J. Pharmaceutical application of microspheres: an approach for the treatment of various diseases. Int J Pharm Sci Res. 2017;8(8):3253-60.
  25. Date AA, Hanes J, Ensign LM. Nanoparticles for oral delivery: Design, evaluation and state-of-the-art. Journal of Controlled Release. 2016 Oct 28;240:504-26.
  26. Muralidhara BK, Wong M. Critical considerations in the formulation development of parenteral biologic drugs. Drug Discovery Today. 2020 Mar 1;25(3):574-81.
  27. Mostaghimi A, Antonini MJ, Plana D, Anderson PD, Beller B, Boyer EW, Fannin A, Freake J, Oakley R, Sinha MS, Smith L. Regulatory and safety considerations in deploying a locally fabricated, reusable face shield in a hospital responding to the COVID-19 pandemic. Med. 2020 Dec 18;1(1):139-51.
  28. Scheetz L, Park KS, Li Q, Lowenstein PR, Castro MG, Schwendeman A, Moon JJ. Engineering patient-specific cancer immunotherapies. Nature biomedical engineering. 2019 Oct;3(10):768-82.
  29. Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nature reviews drug discovery. 2021 Feb;20(2):101-24.
  30. Teixeira PJ, Silva MN, Coutinho SR, Palmeira AL, Mata J, Vieira PN, Carraça EV, Santos TC, Sardinha LB. Mediators of weight loss and weight loss maintenance in middle?aged women. Obesity. 2010 Apr;18(4):725-35.
  31. Zhang M, Hu W, Cai C, Wu Y, Li J, Dong S. Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment. Materials Today Bio. 2022 Mar 1;14:100223.
  32. Brunet M, Van Gelder T, Åsberg A, Haufroid V, Hesselink DA, Langman L, Lemaitre F, Marquet P, Seger C, Shipkova M, Vinks A. Therapeutic drug monitoring of tacrolimus-personalized therapy: second consensus report. Therapeutic drug monitoring. 2019 Jun 1;41(3):261-307.
  33. Wheeler HE, Maitland ML, Dolan ME, Cox NJ, Ratain MJ. Cancer pharmacogenomics: strategies and challenges. Nature Reviews Genetics. 2013 Jan;14(1):23-34.
  34. Varadarajulu S, Petruff C, Ramsey WH. Patient preferences for gender of endoscopists. Gastrointestinal endoscopy. 2002 Aug 1;56(2):170-3.
  35. Javierre E, García SJ, Mol JM, Vermolen FJ, Vuik C, Van Der Zwaag S. Tailoring the release of encapsulated corrosion inhibitors from damaged coatings: controlled release kinetics by overlapping diffusion fronts. Progress in Organic Coatings. 2012 Sep 1;75(1-2):20-7.
  36. Teymourian H, Parrilla M, Sempionatto JR, Montiel NF, Barfidokht A, Van Echelpoel R, De Wael K, Wang J. Wearable electrochemical sensors for the monitoring and screening of drugs. ACS sensors. 2020 Aug 21;5(9):2679-700.
  37. Tiwari G, Tiwari R, Sriwastawa B, Bhati L, Pandey S, Pandey P, Bannerjee SK. Drug delivery systems: An updated review. International journal of pharmaceutical investigation. 2012 Jan;2(1):2.
  38. Keek SA, Leijenaar RT, Jochems A, Woodruff HC. A review on radiomics and the future of theranostics for patient selection in precision medicine. The British journal of radiology. 2018 Nov;91(1091):20170926.
  39. Cao Y, Samy KE, Bernards DA, Desai TA. Recent advances in intraocular sustained- release drug delivery devices. Drug discovery today. 2019 Aug 1;24(8):1694-700.
  40. Graham CD, Gouick J, Krahé C, Gillanders D. A systematic review of the use of Acceptance and Commitment Therapy (ACT) in chronic disease and long-term conditions. Clinical psychology review. 2016 Jun 1;46:46-58.
  41. Sartor RB, Wu GD. Roles for intestinal bacteria, viruses, and fungi in pathogenesis of inflammatory bowel diseases and therapeutic approaches. Gastroenterology. 2017 Jan 1;152(2):327-39.
  42. Hastings IM, Watkins WM, White NJ. The evolution of drug–resistant malaria: the role of drug elimination half–life. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 2002 Apr 29;357(1420):505-19.
  43. Kumar KS, Bhowmik D, Srivastava S, Paswan S, Dutta AS. Sustained release drug delivery system potential. The pharma innovation. 2012 Apr 1;1(2).
  44. Lu CH, Petzold A, Kalmar B, Dick J, Malaspina A, Greensmith L. Plasma neurofilament heavy chain levels correlate to markers of late stage disease progression and treatment response in SOD1G93A mice that model ALS. PLoS One. 2012 Jul 16;7(7):e40998.
  45. Tottoli EM, Dorati R, Genta I, Chiesa E, Pisani S, Conti B. Skin wound healing process and new emerging technologies for skin wound care and regeneration. Pharmaceutics. 2020 Aug;12(8):735.
  46. Haney MJ, Klyachko NL, Zhao Y, Gupta R, Plotnikova EG, He Z, Patel T, Piroyan A, Sokolsky M, Kabanov AV, Batrakova EV. Exosomes as drug delivery vehicles for Parkinson's disease therapy. Journal of controlled release. 2015 Jun 10;207:18-30.
  47. Spring BQ, Bryan Sears R, Zheng LZ, Mai Z, Watanabe R, Sherwood ME, Schoenfeld DA, Pogue BW, Pereira SP, Villa E, Hasan T. A photoactivable multi-inhibitor nanoliposome for tumour control and simultaneous inhibition of treatment escape pathways. Nature nanotechnology. 2016 Apr;11(4):378-87.
  48. Patsalos PN, Berry DJ, Bourgeois BF, Cloyd JC, Glauser TA, Johannessen SI, Leppik IE, Tomson T, Perucca E. Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia. 2008 Jul;49(7):1239-76.
  49. El Aita I, Ponsar H, Quodbach J. A critical review on 3D-printed dosage forms. Current pharmaceutical design. 2018 Nov 1;24(42):4957-78.
  50. Karimi M, Brazier J. Health, health-related quality of life, and quality of life: what is the difference?. Pharmacoeconomics. 2016 Jul;34:645-9.
  51. Din FU, Aman W, Ullah I, Qureshi OS, Mustapha O, Shafique S, Zeb A. Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. International journal of nanomedicine. 2017 Oct 5:7291-309.
  52. Dahan A, Miller JM, Amidon GL. Prediction of solubility and permeability class membership: provisional BCS classification of the world’s top oral drugs. The AAPS journal. 2009 Dec;11:740-6.
  53. Polizzi KM, Bommarius AS, Broering JM, Chaparro-Riggers JF. Stability of biocatalysts. Current opinion in chemical biology. 2007 Apr 1;11(2):220-5.
  54. Kuhl H. Pharmacokinetics of oestrogens and progestogens. Maturitas. 1990 Sep 1;12(3):171-97.
  55. Gemzell-Danielsson K, Schellschmidt I, Apter D. A randomized, phase II study describing the efficacy, bleeding profile, and safety of two low-dose levonorgestrel- releasing intrauterine contraceptive systems and Mirena. Fertility and sterility. 2012 Mar 1;97(3):616-22.
  56. Jarray A, Gerbaud V, Hemati M. Polymer-plasticizer compatibility during coating formulation: A multi-scale investigation. Progress in Organic Coatings. 2016 Dec 1;101:195-206.
  57. Rowland M. Influence of route of administration on drug availability. Journal of pharmaceutical sciences. 1972 Jan 1;61(1):70-4.
  58. Li J, Wang Y, Zhu Y, Oupický D. Recent advances in delivery of drug–nucleic acid combinations for cancer treatment. Journal of controlled release. 2013 Dec 10;172(2):589-600.
  59. Banerjee S, Pillai J. Solid lipid matrix mediated nanoarchitectonics for improved oral bioavailability of drugs. Expert opinion on drug metabolism & toxicology. 2019 Jun 3;15(6):499-515.
  60. Molinos-Senante M, Hernández-Sancho F, Sala-Garrido R. Economic feasibility study for wastewater treatment: A cost–benefit analysis. Science of the Total Environment. 2010 Sep 15;408(20):4396-402.
  61. He Z, Wan X, Schulz A, Bludau H, Dobrovolskaia MA, Stern ST, Montgomery SA, Yuan H, Li Z, Alakhova D, Sokolsky M. A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity. Biomaterials. 2016 Sep 1;101:296-309.
  62. Jamaledin R, Makvandi P, Yiu CK, Agarwal T, Vecchione R, Sun W, Maiti TK, Tay FR, Netti PA. Engineered microneedle patches for controlled release of active compounds: recent advances in release profile tuning. Advanced Therapeutics. 2020 Dec;3(12):2000171.
  63. Watson DS, Endsley AN, Huang L. Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens. Vaccine. 2012 Mar 16;30(13):2256-72.
  64. Suraweera A, O’Byrne KJ, Richard DJ. Combination therapy with histone deacetylase inhibitors (HDACi) for the treatment of cancer: achieving the full therapeutic potential of HDACi. Frontiers in oncology. 2018 Mar 29;8:92.
  65. Abaci A, Guvendiren M. Designing decellularized extracellular matrix?based bioinks for 3D bioprinting. Advanced healthcare materials. 2020 Dec;9(24):2000734.
  66. Yoo J, Won YY. Phenomenology of the initial burst release of drugs from PLGA microparticles. ACS Biomaterials Science & Engineering. 2020 Oct 9;6(11):6053-62.
  67. Fu Y, Kao WJ. Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems. Expert opinion on drug delivery. 2010 Apr 1;7(4):429-44.
  68. Casson S, Gray JE. Influence of environmental factors on stomatal development. New phytologist. 2008 Apr;178(1):9-23.
  69. Huang WC, Hu SH, Liu KH, Chen SY, Liu DM. A flexible drug delivery chip for the magnetically-controlled release of anti-epileptic drugs. Journal of Controlled Release. 2009 Nov 3;139(3):221-8.
  70. Berkland C, Kipper MJ, Narasimhan B, Kim KK, Pack DW. Microsphere size, precipitation kinetics and drug distribution control drug release from biodegradable polyanhydride microspheres. Journal of Controlled Release. 2004 Jan 8;94(1):129-41.
  71. Siepmann J, Siepmann F. Modeling of diffusion controlled drug delivery. Journal of controlled release. 2012 Jul 20;161(2):351-62
  72. Mönkäre J, Hakala RA, Vlasova MA, Huotari A, Kilpeläinen M, Kiviniemi A, Meretoja V, Herzig KH, Korhonen H, Seppälä JV, Järvinen K. Biocompatible photocrosslinked poly (ester anhydride) based on functionalized poly (?-caprolactone) prepolymer shows surface erosion controlled drug release in vitro and in vivo. Journal of controlled release. 2010 Sep 15;146(3):349-55.
  73. Colombo P. Swelling-controlled release in hydrogel matrices for oral route. Advanced Drug Delivery Reviews. 1993 Jul 1;11(1-2):37-57.
  74. Worthington RJ, Melander C. Combination approaches to combat multidrug-resistant bacteria. Trends in biotechnology. 2013 Mar 1;31(3):177-84.
  75. Wu W, Liu B. Modulating the optical properties and functions of organic molecules through polymerization. Materials Horizons. 2022;9(1):99-111.
  76. Liu J, Xiao Y, Allen C. Polymer–drug compatibility: a guide to the development of delivery systems for the anticancer agent, ellipticine. Journal of pharmaceutical sciences. 2004 Jan 1;93(1):132-43.
  77. Dürig T, Fassihi R. Guar-based monolithic matrix systems: effect of ionizable and non- ionizable substances and excipients on gel dynamics and release kinetics. Journal of controlled release. 2002 Apr 23;80(1-3):45-56.
  78. Maderuelo C, Zarzuelo A, Lanao JM. Critical factors in the release of drugs from sustained release hydrophilic matrices. Journal of controlled release. 2011 Aug 25;154(1):2-19.
  79. Rosiaux Y, Jannin V, Hughes S, Marchaud D. Solid lipid excipients—matrix agents for sustained drug delivery. Journal of Controlled Release. 2014 Aug 28;188:18-30.
  80. Taniguchi C, Kawabata Y, Wada K, Yamada S, Onoue S. Microenvironmental pH- modification to improve dissolution behavior and oral absorption for drugs with pH- dependent solubility. Expert opinion on drug delivery. 2014 Apr 1;11(4):505-16.
  81. Hirschler MM. Flame retardants and heat release: review of data on individual polymers. Fire and Materials. 2015 Apr;39(3):232-58.
  82. Ghosal K, Chandra A, Roy S, Agatemor C, Thomas S, Provaznik I. Electrospinning over solvent casting: tuning of mechanical properties of membranes. Scientific reports. 2018 Mar 22;8(1):5058.
  83. Wang S, Liu R, Fu Y, Kao WJ. Release mechanisms and applications of drug delivery systems for extended-release. Expert Opinion on Drug Delivery. 2020 Sep 1;17(9):1289-304.
  84. Rani M, Shim WJ, Han GM, Jang M, Song YK, Hong SH. Benzotriazole-type ultraviolet stabilizers and antioxidants in plastic marine debris and their new products. Science of The Total Environment. 2017 Feb 1;579:745-54.
  85. Pingali K, Mendez R, Lewis D, Michniak-Kohn B, Cuitino A, Muzzio F. Mixing order of glidant and lubricant–influence on powder and tablet properties. International journal of pharmaceutics. 2011 May 16;409(1-2):269-77.
  86. Chaerunisaa AY, Sriwidodo S, Abdassah M. Microcrystalline cellulose as pharmaceutical excipient. InPharmaceutical formulation design-recent practices 2019 Jul 19. IntechOpen.
  87. Yang B, Gomes Dos Santos A, Puri S, Bak A, Zhou L. The industrial design, translation, and development strategies for long-acting peptide delivery. Expert Opinion on Drug Delivery. 2022 Oct 3;19(10):1233-45.
  88. Yellepeddi VK, Joseph A, Nance E. Pharmacokinetics of nanotechnology-based formulations in pediatric populations. Advanced drug delivery reviews. 2019 Nov 1;151:44-55.
  89. Kleiner LW, Wright JC, Wang Y. Evolution of implantable and insertable drug delivery systems. Journal of controlled release. 2014 May 10;181:1-0.
  90. Kotta S, Nair A, Alsabeelah N. 3D printing technology in drug delivery: recent progress and application. Current pharmaceutical design. 2018 Nov 1;24(42):5039-48.
  91. Tegenfeldt JO, Prinz C, Cao H, Huang RL, Austin RH, Chou SY, Cox EC, Sturm JC. Micro-and nanofluidics for DNA analysis. Analytical and bioanalytical chemistry. 2004 Apr;378:1678-92.
  92. Kalia S, editor. Polymeric hydrogels as smart biomaterials. Cham: Springer; 2016.
  93. Saleh K, Guigon P. Coating and encapsulation processes in powder technology. InHandbook of powder technology 2007 Jan 1 (Vol. 11, pp. 323-375). Elsevier Science BV.
  94. Jha K, Kataria R, Verma J, Pradhan S. Potential biodegradable matrices and fiber treatment for green composites: A review. AIMS Materials Science. 2019;6(1):119-38.
  95. Yan LT, Xie XM. Computational modeling and simulation of nanoparticle self- assembly in polymeric systems: Structures, properties and external field effects. Progress in Polymer Science. 2013 Feb 1;38(2):369-405.

image
Hans Raj
Corresponding author

IEC School of Pharmacy, IEC University Baddi, Solan-174103, Himachal Pradesh, India

image
Jyoti Gupta
Co-author

IEC School of Pharmacy, IEC University Baddi, Solan-174103, Himachal Pradesh, India

image
Divya
Co-author

IEC School of Pharmacy, IEC University Baddi, Solan-174103, Himachal Pradesh, India

Jyoti Gupta, Hans Raj*, Divya, Emerging Frontiers In Sustained Release Drug Delivery Systems: Unveiling The Latest Innovations And Future Perspectives, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 8, 186-206. https://doi.org/10.5281/zenodo.8267084

More related articles
Medicinal And Toilet Preparations Act: An In-Depth...
Balamuralidhara V., Deeksha K. S., Spoorthi S., ...
Therapeutic Potentials of Guggulu Formulations: A ...
Dr. Manasi D. Chunchuwar, Dr.Bharat Rathi, Dr.Piyush Chaudhary, D...
Safety And Efficacy Of Diuretics With Reduced Ejec...
G. Anjani Tejaswi, P. Shaheera, A. Navya Sree, M. Bala Tripura Su...
A Review Formulation And Evaluation Of Antimicrobial Cream...
Shinde Avinash B., Tagare Chetan B., Tahakik Rutvik N., Mahalkar Ram B., Sarukh Vikram, ...
Sublingual Dosage Form...
Namrata S. Revar, Samruddhi B. Sawant, Sanjeevani D. Rupwate, ...
Formulation And Evaluation Of Herbal Anti-Aging Cream...
Prerana Sahu, Ayush Dubey, Divyansh Sahu, Tanuj Pandey, Gyanesh Sahu, Harish Sharma, ...
Related Articles
Lifestyle Medicine Encompassing Scientific Exercises and Right Diet The Key To P...
J.C Balachandar, S. Irshad Ahamed, Amit Kumar Agrawal, Baani Khanna, Dilsher Khanna, M. Jayachandran...
Hepatoprotective Effect of Curcumin Microsponges against Paracetamol Induced Liv...
Gaurav Kasar, Pooja Rasal, Ritesh Khairnar, Revati Khairnar, Shubham Khaire, Yunus Ansari, Manoj Mah...
Development And Validation of New RP HPLC Method For the Simultaneous Estimation...
P. Seetharamaiah, Nagaraju Pappula, JVLN. Seshagiri Rao, D. Gowrisankar, ...
More related articles
Therapeutic Potentials of Guggulu Formulations: A Review Through Medieval Centur...
Dr. Manasi D. Chunchuwar, Dr.Bharat Rathi, Dr.Piyush Chaudhary, Dr.Aditi R. Shinde, ...
Safety And Efficacy Of Diuretics With Reduced Ejection Fraction In Heart Failure...
G. Anjani Tejaswi, P. Shaheera, A. Navya Sree, M. Bala Tripura Sundari, P. Seetaramayya, Velaga Mahe...
Therapeutic Potentials of Guggulu Formulations: A Review Through Medieval Centur...
Dr. Manasi D. Chunchuwar, Dr.Bharat Rathi, Dr.Piyush Chaudhary, Dr.Aditi R. Shinde, ...
Safety And Efficacy Of Diuretics With Reduced Ejection Fraction In Heart Failure...
G. Anjani Tejaswi, P. Shaheera, A. Navya Sree, M. Bala Tripura Sundari, P. Seetaramayya, Velaga Mahe...