Archive

Abstract

Many medicinal plants are claimed to be useful in skin diseases in all traditional systems of medicine and folklore. At the same time, these herbal remedies are used orally and by topical application. Looking at the scope of the herbal drug and the increasing demand, especially for liver disease, cancer, diabetes, hypertension, kidney disease, inflammation, infectious disease, skin disease, etc. Hibiscus rosa-sinensis grows as a green herb in tropical areas. It is a low shrub with large, glossy green leaves and showy tube-shaped flowers. The plant loses leaves for a short time during the winter. This study aims to determine phytochemical components using different solvents and to study the antibacterial effect of methanol extract to varying concentrations against these bacteria. Phytochemical analysis of Hibiscus rosa-sinensis. Leaves extracts indicate the presence of various medicinally valuable components, including alkaloids, glycosides, carbohydrates, phytosterols, phenolic compounds, tannins, saponins, flavonoids, proteins, and amino acids. Current findings indicate that methanol is a good solvent for extracting antibacterial agents. Further studies are needed to investigate the individual phytochemical compounds of the Hibiscus rosa-sinensis. Leaves can be considered as effective as the most effective artificial antibiotics.

Keywords

Antibiotics, Antibacterial activity, Hibiscus rosa-sinensis, Methanol extract, Phytochemical analysis, etc

Reference

  1. Harborne JB, Baxter H and Moss GP. A handbook of bioactive compounds from plants. Phytochemical dictionary. 1993; 35:36-7.
  2. Edema MO and Alaga TO. Comparative evaluation of bioactive compounds in Hibiscus sabdariffa and Syzygium samarangense juice extracts. African Crop Science Journal. 2012;20(3):179-88.
  3. Sobhy EA, Abd Elaleem KG and Abd Elaleem HG. Potential antibacterial activity of Hibiscus rosa-sinensis Linn flowers extracts. International Journal of Current Microbiology Applications. 2017;6(4):1066-72.
  4. Koehn FE and Carter GT. The evolving role of natural products in drug discovery. Nature Reviews Drug discovery. 2005 Mar 1;4(3):206-20.
  5. Newman DJ, Gragg GM and Sander KM. Medicinal plants and their benefits. Journal of Natural Products. 2003; 66:1022-45.
  6. Akinmoladun AC, Ibukun EO, Afor E, Obuotor EM and Farombi EO. Phytochemical constituent and antioxidant activity of extract from the leaves of Ocimum gratissimum. Scientific Research Essay. 2007 May 1;2(5):163-6.
  7. Edeoga HO, Okwu DE and Mbaebie BO. Phytochemical constituents of some Nigerian medicinal plants. African Journal of Biotechnology. 2005 Aug 19;4(7):685-8.
  8. Krishnaiah D, Sarbatly R and Bono A. Phytochemical antioxidants for health and medicine: A move towards nature. Biotechnology and Molecular Biology Reviews. 2007;1(4):97-104.
  9. Patel R, Patel A, Vaghasiya D and Nagee A. Antimicrobial evaluation of Hibiscus rosa-sinensis plant extracts against some pathogenic bacteria. Bulletin of Environmental and Scientific Research. 2012;1(3-4):14-7.
  10. Abate TA and Belay AN. Assessment of antibacterial and antioxidant activity of aqueous crude flower, leaf, and bark extracts of Ethiopian Hibiscus rosa-sinensis Linn: geographical effects and Co2Res2/Glassy carbon electrode. International Journal of Food Properties. 2022;25(1):1875-89.
  11. Shimizu N, Tomoda M, Suzuki I and Takada K. Plant mucilages. XLIII: A representative mucilage with biological activity from the leaves of Hibiscus rosa-sinensis. Biological and Pharmaceutical Bulletin. 1993;16(8):735–739. 
  12. Sachdewa A and Khemani LD. Effect of Hibiscus rosa-sinensis Linn ethanol extract on blood glucose and lipid profile in streptozotocin-induced diabetes in rats. Journal of Ethnopharmacology. 2003;89(1):61–66.
  13. Kurup PNV, Ramdas VNK and Joshi P. Handbook of Medicinal Plants. New Delhi: Oxford & IBH Publishing Co. Pvt. Ltd.; 1979. pp. 86–87.
  14. Fazlin AS, Ahmad Z and Lim HH. Compendium of Medicinal Plants Used in Malaysia, vol. 2, Herbal Medicine Research Centre. Institute for Medical Research, Aktif Bestari Sdn Bhd, Kuala Lumpur, Malaysia. 2002.
  15. Arullappan S, Zakaria Z and Basri DF. Preliminary screening of antibacterial activity using crude extracts of Hibiscus rosa sinensis. Tropical Life Sciences Research. 2009;20(2):109.
  16. Hammad I. Genetic variation among Hibiscus rosa-sinensis (Malvaceae) of different flower colors using ISSR and isozymes. Australian Journal of Basic and Applied Sciences. 2009;3(1):113-25.
  17. Kirtikar KR and Basu BD. Indian Medicinal Plants. International Book Distributors, Dehradun. Volume I-IV. 1987.
  18. Duke JA and Ayensu ES. Medicinal plants of China. Reference publications; 1985.
  19. Bhattacharjee I, Chatterjee SK, Chatterjee S and Chandra G. Antibacterial potentiality of Argemone mexicana solvent extracts against some pathogenic bacteria. Memórias do Instituto Oswaldo Cruz. 2006; 101:645-8.
  20. Nadkarni AK. Indian Materia Medica, Popular Prakashan Pvt. Ltd., Bombay. 1976; 1:799.
  21. Jonadet M, Bastide J, Bastide P, Boyer B, Carnat AP and Lamaison JL. In vitro enzyme inhibitory and in vivo cardioprotective activities of Hibiscus sabdariffa L. Journal de pharmacie de Belgique. 1990;45(2):120-4.
  22. Yamasaki H, Uefuji H and Sakihama Y. Stress proteins and myocardial protection. Archives of Biochemistry and Biophysics. 1996;332(1):183-6.
  23. Uddin B, Hossan T, Paul S, Ahmed T, Nahar T and Ahmed S. Antibacterial activity of the ethanol extracts of Hibiscus rosa-sinensis leaves and flowers against clinical bacteria isolates. Bangladesh Journal of Life Sciences; 2010. 22(2): 65-73.
  24. Kasture VS, Chopde CT and Deshmukh VK. Anticonvulsive activity of Albizzia lebbeck, Hibiscus rosa sinesis and Butea monosperma in experimental animals. Journal of Ethnopharmacology. 2000;71(1-2):65-75.
  25. Siddiqui AA, Wani SM, Rajesh R and Alagarsamy V. Phytochemical and pharmacological investigation of flowers of Hibiscus rosa-sinensis Linn. Indian Journal of Pharmaceutical Sciences. 2006;68(1):127.
  26. Riaz G and Chopra R. A Review on Phytochemistry and Therapeutic Uses of Hibiscus rosa-sinensis sabdariffa L. Biomedical Pharmacotherapy. 2018; 102:575-586.
  27. https://www.floridacolorsplumeria.com/plumeria-fertilization-nutrition/#:~:text=Nitrogen (N), phosphorus (,) and Chlorine (Ci).
  28. Nath P and Yadav AK. Acute and sub-acute oral toxicity assessment of the methanolic extract from leaves of Hibiscus rosa-sinensis L. in mice. Journal of Intercultural Ethnopharmacology. 2015; 4(1): 70-73.
  29. Pekamwar SS, Kalyankar TM and Jadhav AC. Hibiscus rosa-sinensis: A review on ornamental plant. World Journal of Pharmacy and Pharmaceutical Sciences. 2013; 2(6):4719-4727.
  30. Sharma K, Pareek A and Chauhan ES. Evaluation of the hyperglycemic and hyperlipidemic mitigating impact of Hibiscus rosa-sinensis (Gudhal) flower in type II diabetes mellitus subjects. International Journal of Applied Biology and Pharmaceutical Technology. 2016; 7(2): 223-228.
  31. Vasudeva N and Sharma SK. Post-coital antifertility activity of Hibiscus rosa-sinensis Linn roots. Evidence-Based Complement Alternative Method. 2008; 5(1):91-94.
  32. Kokate CK and Purohit AP. A text book of Practical Pharmacognosy. Vallabh Prakashan. 2005; 5:105-11.

image
Ganesh D. Barkade
Corresponding author

Assistant Professor, Department of Pharmaceutical Chemistry, Dr. Vitthalrao Vikhe Patil Foundation’s College of Pharmacy, Vilad Ghat, Ahmednagar – 414111.

image
Akshata B. Sinare
Co-author

Research Scholar, Dr Vitthalrao Vikhe Patil Foundation's College of Pharmacy, Vilad Ghat, Ahmednagar – 414111.

image
Mayur G. Tandale
Co-author

Research Scholar, Dr Vitthalrao Vikhe Patil Foundation's College of Pharmacy, Vilad Ghat, Ahmednagar – 414111.

image
Rutuja B. Sonawane
Co-author

Research Scholar, Dr Vitthalrao Vikhe Patil Foundation's College of Pharmacy, Vilad Ghat, Ahmednagar – 414111.

image
Rutuja R. Sumbe
Co-author

Research Scholar, Dr Vitthalrao Vikhe Patil Foundation's College of Pharmacy, Vilad Ghat, Ahmednagar – 414111.

Akshata B. Sinare, Mayur G. Tandale, Rutuja B. Sonawane, Rutuja R. Sumbe, Vaibhav D. Talekar, Ganesh D. Barkade*, Extraction, Phytochemical Investigation and Antimicrobial Activity of Hibiscus Rosa-Sinensis, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 6, 47-55. https://doi.org/10.5281/zenodo.8030089

More related articles
Pharmacogenomics...
Kajal Gorakhnath Korhale , Rahul S. Mohan, Rajendra M. Kawade , ...
A Novel Validated Stability Indicating QBD Based R...
Rashid Azeez, Vinod A. Bairagi, Ziyaurrahman Azeez , ...
Analytical Method Development And Validation Of Ch...
Nilesh G. Ahire, Nikhil Nikam, Sakshi Bhavsar, Rajendra Dighe, Ra...
Validation Of Neutraceuticals For Quality Assurance...
Ashwini Ashok Didore, Dr. D. K. Vir, Dr. Gajanan Sanap, ...
All Rounder Of Ayurveda Tinospora Cordifolia...
Shital Devkar , Suvarna Deshmukh , Sourabh Patil , Shreyash Koli , Prachi L. Khochage , Nilesh B. Ch...
Development Of Spanlastics: Nanovesicular Drug Delivery Of Oxiconazole Nitrate...
Krishnananda Kamath K., Vindhya V. S., Shripathy D., A. R. Shabaraya, ...
Related Articles
Formulation And Evaluation Of Montelukast Levocetirizine Tablet ...
Dipali Kakade, Shabnam khan, Ramakant Sharma, Jeevan Patel, Shivani Khoware, Rakesh Patel, ...
Nanoemulsion: An Emerging Approach For The Enhancement Of Solubility In Lipophil...
E. P. Punnya, Ranitha R., Megha P. M., Sreethu K. Sreedharan, ...
Evaluation Of Different Marketed Brands Of Aspirin Tablets Using Quality Contro...
T. Ethiraj, V. Ganesan, M. Amudha, S. Abirami, B. Govendhiran, S. Keerthiga, A. Pastin Manoj, G. San...
Regulating Artificial Intelligence: Developments And Challenges...
Durga Chavali, Biju Baburajan, Ashokkumar Gurusamy, Vinod Kumar Dhiman, Siri Chandana Katari, ...
Pharmacogenomics...
Kajal Gorakhnath Korhale , Rahul S. Mohan, Rajendra M. Kawade , ...
More related articles
Pharmacogenomics...
Kajal Gorakhnath Korhale , Rahul S. Mohan, Rajendra M. Kawade , ...
A Novel Validated Stability Indicating QBD Based RS Method By HPLC For The Estim...
Rashid Azeez, Vinod A. Bairagi, Ziyaurrahman Azeez , ...
Analytical Method Development And Validation Of Chloramphenicol Eye Ointment By ...
Nilesh G. Ahire, Nikhil Nikam, Sakshi Bhavsar, Rajendra Dighe, Rashid Azeez, Vinod A. Bairagi, ...
Pharmacogenomics...
Kajal Gorakhnath Korhale , Rahul S. Mohan, Rajendra M. Kawade , ...
A Novel Validated Stability Indicating QBD Based RS Method By HPLC For The Estim...
Rashid Azeez, Vinod A. Bairagi, Ziyaurrahman Azeez , ...
Analytical Method Development And Validation Of Chloramphenicol Eye Ointment By ...
Nilesh G. Ahire, Nikhil Nikam, Sakshi Bhavsar, Rajendra Dighe, Rashid Azeez, Vinod A. Bairagi, ...