Sri Venkateswara University College of Pharmaceutical Sciences, S.V. University, Tirupathi
The oral route is now the industry standard for drug delivery as it is recognized as the safest, least expensive, and most convenient method of achieving patient compliance. Rapidly dissolving tablets, a new idea for oral administration, is widely used and now accepted. These are solid dosage forms that dissolve and release the active ingredient when placed in the mouth without water for a short period of time. Geriatric, paediatric and bedridden patients are particularly favoured for the use of these FDTs because of dysphagia. Rapid absorption, quick onset of action and less drug loss properties are the main advantages of FDTs. Since disintegration is a critical step for any solid dosage form to exert its pharmacological effects, FDTs use super disintegrants to accelerate disintegration and increase bioavailability. This overview focuses on the overall development of ODTs and mainly highlights super disintegrants: selection, advantages, modes of addition, mode of action and types.
Pommala Nagaveni*, A. Sreevalli, G. Syam Sundar, Fast Dissolving Tablets: An Overview, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 7, 235-245. https://doi.org/10.5281/zenodo.8155035