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Abstract

Digestive disorders such as indigestion, flatulence, bloating, and loss of appetite are common gastrointestinal problems affecting daily life. Herbal formulations have gained significant attention due to their safety, efficacy, and minimal side effects compared to synthetic medicines. The present review focuses on the formulation and evaluation of a polyherbal digestive syrup prepared using Fennel fruit, Ajwain, Ginger, and Coriander fruit. These herbs are traditionally known for their carminative, stomachic, digestive stimulant, and antispasmodic properties. The review highlights the rationale behind the selection of ingredients, methods of extraction, formulation aspects of herbal syrup, and various evaluation parameters including organoleptic, physicochemical, microbiological, and stability studies. The synergistic action of the selected herbal ingredients provides effective relief from digestive discomfort while improving appetite and gastrointestinal function. This review concludes that the polyherbal digestive syrup is a promising, patient-friendly, and natural formulation for the management of common digestive disorders and has potential for further pharmaceutical development.

Keywords

Digestive syrup; Polyherbal formulation; Fennel fruit; Ajwain; Ginger; Coriander fruit; Carminative; Herbal evaluation; Gastrointestinal disorders

Introduction

Digestive disorders such as indigestion, flatulence, bloating, acidity, and loss of appetite are among the most common gastrointestinal problems encountered in daily life. Irregular food habits, stress, sedentary lifestyle, and consumption of spicy or junk foods significantly contribute to impaired digestion. Although synthetic digestive medicines are widely used, their long-term use may be associated with adverse effects, leading to increased interest in herbal formulations as safer alternatives.Herbal digestive syrups are preferred due to their natural origin, better patient compliance, and minimal side effects. Traditional medicinal plants have been used for centuries to promote digestion and relieve gastrointestinal discomfort. Among these, Fennel fruit, Ajwain, Ginger, and Coriander fruit are well known for their carminative, stomachic, digestive stimulant, and antispasmodic properties.The combination of these herbs in a polyherbal digestive syrup offers a synergistic effect, improving digestion, reducing gas formation, enhancing appetite, and providing overall gastrointestinal comfort. Therefore, the present review emphasizes the formulation and evaluation of a herbal digestive syrup containing these selected medicinal plants as an effective and patient-friendly dosage form for the management of common digestive disorders.

Fennel (Foeniculum vulgare) Fruit

Fennel fruit is traditionally used as a carminative and stomachic agent. It contains volatile oils that relax smooth muscles, reduce gas formation, and improve digestion. These properties make it a core ingredient in digestive formulations.

Ajwain (Trachyspermum ammi)

Ajwain seeds contain thymol and other active constituents responsible for stimulating gastric secretions, carminative action, and relief of flatulence. Its inclusion enhances the synergistic carminative and digestive support when used alongside fennel.

Ginger (Zingiber officinale)

Ginger is widely known for its digestive stimulant and anti-nausea effects. It promotes gastrointestinal motility and reduces discomfort after meals. Its warming property enhances overall digestive activity.

Coriander (Coriandrum sativum) Fruit

Coriander fruit also acts as a stomachic and anti-flatulent herbal. It helps alleviate acidity and improves appetite, making it a good companion to other digestive botanicals.

 

 

Fig: Digestive Syrup

Uses

  • Relieves indigestion (dyspepsia)
  • Reduces flatulence and abdominal bloating
  • Improves appetite
  • Provides relief from gas and stomach discomfort
  • Helps in post-meal heaviness
  • Reduces abdominal cramps and spasms
  • Helps in acidity and heartburn
  • Improves gastrointestinal motility
  • Useful in irregular digestion due to stress or lifestyle
  • Acts as a natural carminative and stomachic agent

Materials and Methods

  • Ingredients
  •  

 

 

Table: List of Ingredients

 

Ingredient

Quantity

Role / Function

Fennel fruit extract

2.0 g

Carminative; relieves gas and bloating; improves digestion

Ajwain extract

1.0 g

Stimulates gastric secretion; relieves flatulence and indigestion

Ginger extract

1.0 g

Digestive stimulant; enhances gastric motility; anti-nausea

Coriander fruit extract

1.5 g

Stomachic; reduces acidity; improves appetite

Sucrose

60 g

Sweetening agent; syrup base; improves palatability

Sodium benzoate

0.1 g

Preservative

Citric acid

0.2 g

pH adjuster; flavor enhancer

Peppermint oil

0.05 mL

Flavoring agent; antispasmodic

Purified water

q.s. to 100 mL

Vehicle

 

Method of Preparation

Step 1: Collection and Preparation of Plant Materials

  • Collect good quality dried Fennel fruit, Ajwain, Ginger, and Coriander fruit.
  • Clean the crude drugs to remove dirt and foreign matter.
  • Dry them under shade and grind into coarse powder.

Step 2: Extraction of Herbal Ingredients

  • Weigh the required quantities of each powdered drug.
  • Transfer them into a clean container.
  • Add sufficient purified water (or hydro-alcoholic solvent).
  • Allow the mixture to macerate for 24 hours with occasional stirring.
  • Filter the extract using muslin cloth followed by Whatman filter paper.
  • Concentrate the filtrate on a water bath to obtain a thick herbal extract.

Step 3: Preparation of Syrup Base

  • Dissolve the required quantity of sucrose in purified water by gentle heating.
  • Cool the syrup to room temperature.
  • Add sodium benzoate and dissolve completely.
  • Adjust pH using citric acid.

Step 4: Incorporation of Herbal Extract

  • Slowly add the prepared herbal extract into the syrup base with continuous stirring.
  • Add peppermint oil (pre-dissolved in a small quantity of alcohol or glycerin).
  • Mix thoroughly to obtain a uniform solution.

Step 5: Make Up the Volume

  • Add purified water to make up the final volume (100 mL).
  • Stir well to ensure uniformity.

Step 6: Filtration and Packaging

  • Filter the final syrup to remove suspended particles.
  • Transfer into amber-colored bottles

Evaluation of Herbal Bio-Deodorant Cream

Organoleptic Evaluation

  • Color: Visual observation
  • Odor: Characteristic aromatic smell
  • Taste: Sweet with mild herbal flavor
  • Appearance: Clear and uniform syrup

pH Determination

  • Measure using a digital pH meter at room temperature.
  • Acceptable pH range: 4.5 – 6.5
  • Ensures stability and patient acceptability.

Viscosity

  • Determined using Ostwald viscometer / Brookfield viscometer.
  • Indicates pourability and consistency of syrup.

Total Solid Content

  • Determined by evaporating a known volume of syrup.
  • Indicates concentration of solids present in formulation.

Clarity Test

  • Syrup is examined against light and dark backgrounds.
  • Confirms absence of suspended particles.

Stability Studies

  • Syrup is stored at different conditions (room temperature, accelerated conditions).
  • Evaluated for changes in color, odor, pH, and viscosity over time.

Sedimentation Study

  • Observed visually during storage.
  • Confirms physical stability and homogeneity.

Compatibility Studies

  • Ensures no interaction between herbal extracts and excipients.

 

 

Fig : Evaluation of Syrup

DISCUSSION

The polyherbal digestive syrup formulated using Fennel fruit, Ajwain, Ginger, and Coriander fruit demonstrates a synergistic effect due to the combined carminative, stomachic, antispasmodic, and digestive stimulant properties of the selected herbs. The syrup dosage form improves patient compliance because of its palatability and ease of administration. Evaluation parameters reported in the literature indicate acceptable physicochemical properties, good stability, and microbial safety. Overall, the formulation provides an effective, safe, and economical herbal alternative for the management of common digestive disorders.

CONCLUSION        

The present review concludes that a polyherbal digestive syrup formulated with fennel fruit, ajwain, ginger, and coriander fruit is a promising natural remedy for the management of digestive ailments such as indigestion, flatulence, bloating, and loss of appetite. The synergistic action of the selected herbs, combined with an acceptable syrup formulation, offers improved therapeutic effectiveness with minimal side effects.Evaluation studies reported in the literature confirm that the formulation is stable, safe, and patient-friendly. Therefore, such a herbal digestive syrup holds significant potential for further development and commercialization as an alternative to synthetic digestive preparations. Future research may focus on clinical evaluation, optimization of formulation, and standardization of herbal extracts to enhance efficacy and consistency.

RESULTS

The results obtained from the reviewed studies indicate that the polyherbal digestive syrup formulated with Fennel fruit, Ajwain, Ginger, and Coriander fruit exhibited satisfactory pharmaceutical characteristics. The formulation showed acceptable organoleptic properties with a pleasant taste, characteristic aroma, and uniform appearance. The pH of the syrup was within the acceptable range for oral herbal preparations, indicating good stability. Viscosity and specific gravity values were found to be appropriate, ensuring easy pourability and accurate dosing. The syrup remained clear without any sedimentation during storage, and microbial load studies confirmed that the formulation was microbiologically safe. Stability studies further demonstrated that no significant changes occurred in physical or chemical parameters over the study period, suggesting good shelf stability and suitability for oral administration.

FUTURE SCOPE:

The polyherbal digestive syrup formulated using Fennel fruit, Ajwain, Ginger, and Coriander fruit has wide scope for further research and development. Future studies may focus on clinical evaluation to scientifically validate its efficacy and safety in human subjects. Standardization of herbal extracts using advanced analytical techniques can improve batch-to-batch consistency and quality. The formulation may also be optimized by incorporating digestive enzymes or probiotics to enhance therapeutic effectiveness. Development of sugar-free or diabetic-friendly formulations can expand patient acceptability. Additionally, long-term stability studies and scale-up manufacturing studies can support commercialization. Exploration of novel delivery systems, such as ready-to-drink sachets or pediatric formulations, may further increase market potential.

ACKNOWLEDGEMENTS            

The author expresses his sincere gratitude to the Department of Pharmaceutics, Samarth Institute Of Pharmacy, for providing the necessary laboratory facilities and materials to accomplish this research work. Special thanks to Dr Sachin Bhalekar Mahadu, Department of Quality Assurance, for her valuable guidance, motivation and continuous support during the project. The author is grateful to faculty members and laboratory assistants of the Department of Pharmacognosy for their help during herbal extraction and formulation studies. Finally, the author wishes to thank friends and family members for their continuous encouragement and moral support during the project.

REFERENCES

  1. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 55th ed. Pune: Nirali Prakashan; 2018.
  2. Trease GE, Evans WC. Pharmacognosy. 16th ed. London: Saunders Elsevier; 2009.
  3. Khandelwal KR. Practical Pharmacognosy. 25th ed. Pune: Nirali Prakashan; 2017.
  4. World Health Organization. WHO guidelines on good agricultural and collection practices (GACP) for medicinal plants. Geneva: WHO; 2003.
  5. Evans WC. Trease and Evans’ Pharmacognosy. 15th ed. Edinburgh: Saunders; 2002.
  6. Bisset NG. Herbal Drugs and Phytopharmaceuticals. Stuttgart: Medpharm Scientific Publishers; 1994.
  7. Sharma PV. Dravyaguna Vijnana. Vol 2. Varanasi: Chaukhambha Bharati Academy; 2001.
  8. Rang HP, Dale MM, Ritter JM, Flower RJ. Rang and Dale’s Pharmacology. 8th ed. London: Elsevier; 2015.
  9. Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd ed. Paris: Lavoisier Publishing; 1999.
  10. Kokate CK. Textbook of Pharmacognosy. 6th ed. Pune: Nirali Prakashan; 2006.
  11. Singh R, Jain A. Formulation and evaluation of herbal digestive syrup. Int J Pharm Sci Rev Res. 2019;56(2):120–125.
  12. Patil SB, Pawar SP. Development and evaluation of polyherbal digestive formulation. Asian J Pharm Clin Res. 2018;11(6):233–237.
  13. Bisen P, Sharma A. A review on formulation and evaluation of digestive syrup. Int J Pharm Sci. 2024;6(12):45–52.
  14. Joshi VK, Sharma S. Herbal remedies for digestive disorders. J Ethnopharmacol. 2016;194: 100–110.
  15. Shah B, Seth A. Herbal medicines used in gastrointestinal disorders. Pharmacogn Rev. 2010;4(8):145–154.
  16. Ahmed S, Hasan MM. Carminative and digestive activity of medicinal plants. J Pharm Res. 2017;11(3):250–256.
  17. Choudhary GP. Role of herbal drugs in digestion. Indian J Nat Prod Resour. 2014;5(3):236–243.
  18. Kumar D, Kumar S. Evaluation of herbal syrup dosage forms. Int J Pharm Tech Res. 2015;8(4):670–676.
  19. Pandey G. Ayurvedic Pharmacology and Therapeutic Uses of Medicinal Plants. Varanasi: Chaukhambha Orientalia; 2004.
  20. Mukherjee PK. Quality Control of Herbal Drugs. 2nd ed. New Delhi: Business Horizons; 2007.
  21. Gupta AK. Introduction to Pharmaceutics – I. 4th ed. New Delhi: CBS Publishers; 2016.
  22. Lachman L, Lieberman HA, Kanig JL. The Theory and Practice of Industrial Pharmacy. 3rd ed. Mumbai: Varghese Publishing House; 1991.
  23. Aulton ME. Pharmaceutics: The Science of Dosage Form Design. 3rd ed. London: Churchill Livingstone; 2007.
  24. Indian Pharmacopoeia Commission. Indian Pharmacopoeia. Ghaziabad: IPC; 2022.
  25. United States Pharmacopeia. USP–NF. Rockville: United States Pharmacopeial Convention; 2021.
  26. Khan IA, Abourashed EA. Leung’s Encyclopedia of Common Natural Ingredients. 3rd ed. New York: Wiley; 2010.
  27. Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. New Delhi: CSIR; 1956.
  28. Sofowora A. Medicinal Plants and Traditional Medicine in Africa. 2nd ed. Ibadan: Spectrum Books; 1993.
  29. Harborne JB. Phytochemical Methods. 3rd ed. London: Chapman and Hall; 1998.
  30. Kokate CK, Gokhale SB. Textbook of Pharmaceutical Analysis. Pune: Nirali Prakashan; 2015.

Reference

  1. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 55th ed. Pune: Nirali Prakashan; 2018.
  2. Trease GE, Evans WC. Pharmacognosy. 16th ed. London: Saunders Elsevier; 2009.
  3. Khandelwal KR. Practical Pharmacognosy. 25th ed. Pune: Nirali Prakashan; 2017.
  4. World Health Organization. WHO guidelines on good agricultural and collection practices (GACP) for medicinal plants. Geneva: WHO; 2003.
  5. Evans WC. Trease and Evans’ Pharmacognosy. 15th ed. Edinburgh: Saunders; 2002.
  6. Bisset NG. Herbal Drugs and Phytopharmaceuticals. Stuttgart: Medpharm Scientific Publishers; 1994.
  7. Sharma PV. Dravyaguna Vijnana. Vol 2. Varanasi: Chaukhambha Bharati Academy; 2001.
  8. Rang HP, Dale MM, Ritter JM, Flower RJ. Rang and Dale’s Pharmacology. 8th ed. London: Elsevier; 2015.
  9. Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd ed. Paris: Lavoisier Publishing; 1999.
  10. Kokate CK. Textbook of Pharmacognosy. 6th ed. Pune: Nirali Prakashan; 2006.
  11. Singh R, Jain A. Formulation and evaluation of herbal digestive syrup. Int J Pharm Sci Rev Res. 2019;56(2):120–125.
  12. Patil SB, Pawar SP. Development and evaluation of polyherbal digestive formulation. Asian J Pharm Clin Res. 2018;11(6):233–237.
  13. Bisen P, Sharma A. A review on formulation and evaluation of digestive syrup. Int J Pharm Sci. 2024;6(12):45–52.
  14. Joshi VK, Sharma S. Herbal remedies for digestive disorders. J Ethnopharmacol. 2016;194: 100–110.
  15. Shah B, Seth A. Herbal medicines used in gastrointestinal disorders. Pharmacogn Rev. 2010;4(8):145–154.
  16. Ahmed S, Hasan MM. Carminative and digestive activity of medicinal plants. J Pharm Res. 2017;11(3):250–256.
  17. Choudhary GP. Role of herbal drugs in digestion. Indian J Nat Prod Resour. 2014;5(3):236–243.
  18. Kumar D, Kumar S. Evaluation of herbal syrup dosage forms. Int J Pharm Tech Res. 2015;8(4):670–676.
  19. Pandey G. Ayurvedic Pharmacology and Therapeutic Uses of Medicinal Plants. Varanasi: Chaukhambha Orientalia; 2004.
  20. Mukherjee PK. Quality Control of Herbal Drugs. 2nd ed. New Delhi: Business Horizons; 2007.
  21. Gupta AK. Introduction to Pharmaceutics – I. 4th ed. New Delhi: CBS Publishers; 2016.
  22. Lachman L, Lieberman HA, Kanig JL. The Theory and Practice of Industrial Pharmacy. 3rd ed. Mumbai: Varghese Publishing House; 1991.
  23. Aulton ME. Pharmaceutics: The Science of Dosage Form Design. 3rd ed. London: Churchill Livingstone; 2007.
  24. Indian Pharmacopoeia Commission. Indian Pharmacopoeia. Ghaziabad: IPC; 2022.
  25. United States Pharmacopeia. USP–NF. Rockville: United States Pharmacopeial Convention; 2021.
  26. Khan IA, Abourashed EA. Leung’s Encyclopedia of Common Natural Ingredients. 3rd ed. New York: Wiley; 2010.
  27. Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. New Delhi: CSIR; 1956.
  28. Sofowora A. Medicinal Plants and Traditional Medicine in Africa. 2nd ed. Ibadan: Spectrum Books; 1993.
  29. Harborne JB. Phytochemical Methods. 3rd ed. London: Chapman and Hall; 1998.
  30. Kokate CK, Gokhale SB. Textbook of Pharmaceutical Analysis. Pune: Nirali Prakashan; 2015.

Photo
Sahil Sonlal Janwale
Corresponding author

Student of Samarth Institute of Pharmacy, Belhe, Pune, Maharashtra.

Photo
Sujal Anil Jagnade
Co-author

Student of Samarth Institute of Pharmacy, Belhe, Pune, Maharashtra.

Photo
Pratham Yogesh Bangar
Co-author

Student of Samarth Institute of Pharmacy, Belhe, Pune, Maharashtra.

Photo
Jayesh Gangadhar Jadhav
Co-author

Student of Samarth Institute of Pharmacy, Belhe, Pune, Maharashtra.

Photo
Avishkar Suresh Kad
Co-author

Student of Samarth Institute of Pharmacy, Belhe, Pune, Maharashtra.

Photo
Dr Sachin Mahadu Bhalekar
Co-author

Assistant Professor, Department of Quality Assurance Technique, Samarth Institute of Pharmacy, Belhe,Pune, Maharashtra

Sahil Janwale*, Dr Sachin Bhalekar2, Pratham Bangar, Sujal Jagnade, Jayesh Jadhav, Avishkar Kad, Formulation and Evaluation of Herbal Digestive Syrup Using Fennel Fruit, Ajwain, Ginger & Coriander Fruit, Int. J. of Pharm. Sci., 2026, Vol 4, Issue 1, 2879-2884. https://doi.org/10.5281/zenodo.18365571

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