Gel‘s are the preparations used to enhance the human appearance. The aim of the present research was to formulate the gel for the purpose of whitening, Moistening, Nourishing, lightening & Treatment of various diseases of the skin. Different gelling agent; HPMC, CMC, AEROSIL. Active pharmaceutical ingredients TACROLIMUS taken. Different types of formulations gel namely F1 to F6 were formulated by incorporating different concentrations of ingredients. The evaluations of all formulations (F1 to F6) were done on different parameters like, irritancy, and consistency were examined. Formulations showed good consistency, homogeneity, appearance, spread ability, no evidence of phase separation and ease of removal. F2 showing 99.81±0.044 drug content. Thus gel formulation is safe to use was proved and it can be used as the provision of a barrier to protect skin.


Tacrolimus, Gels, Polymer


  1. Felsten LM, Alikhan A, Petronic-Rosic V. Vitiligo: a comprehensive overview. Part II: treatment options and approach to treatment. J Am Acad Dermatol. 2011;65:493-514.
  2. Lakshmi. D. M. and Deshpande, A. S.(2014), “Various Treatments For Vitiligo: Problems associated and Solutions”, Journal of Applied Pharmaceutical Science, Vol, 4(11), 101-105.
  3. Talia, K.,(2009), “Vitiligo in children: a review of classification, hypotheses of pathogenesis and treatment”, World J Pediatric, 4, 265-268.
  4. Craiglow, B. G. and King, B. A. (2015), “Tofacitinib citrate for treatment of vitiligo: a pathogenesis-directed therapy, JAMA Dermatology, 151(10), 1110-1112.
  5. Sharadha M, Gowda D V, Vishal Gupta N, Akhila A R. An overview on topical drug delivery system- updated review in international journal of research in pharmaceutical sciences. Wed,08 Jan 2020.
  6. Shah, V. P. Yacobi, A., S Radulescu, F., Miron, D. S., Lane, M. E. 2015. A science based approach to topical drug classification system(TCS). International journal of pharmaceutics, 491(1-2):21-25.
  7. Bhowmik, D., Gopinath, H., Kumar, B. P., Duraivel, S., Kumar, K. B. S. 2012. Recent Advances in Novel Topical Drug Delivery System. The Pharma Innovation Journal, 1:12-31.
  8. Soni,  P., (2010), “ A Review on Traditional and Alternative Treatment For Skin Disease Vitiligo “, International Journal of Pharmaceutical  & Biological Archive,1(3). 220-227.
  9. Bos JD, Meinardi MMHM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol. 2000; 9(3): 165- 169.
  10. Kikwai L, Babu RJ, Prado RA, Kolot A, Armstrong CA, Ansel JC et al. In vitro and in vivo evaluation of topical formulations of spantide II. AAPS PharmSciTech 2005; 6 (4):E562-72.
  11. Tas C, Ozkan Y, Savaser A, Baykara T. In vitro release studies of chlorpheniramine maleate from gels prepared by different cellulose derivatives. IL Farmaco 2003; 58:605-11.
  12. Kaur LP, Guleri TK. Topical Gel: A Recent Approach for Novel Drug delivery. Asian Journal of Biomedical and Pharmaceutical Sciences. 2013; 3(17):1-5. 
  13. Zatz JL. Kushla GP: Gels. In: Lieberman HA, Rieger MM, Banker GS. Pharmaceutical dosage form: Disperse system, New York: Marcel Dekker, 2005, 399-421.
  14. Kaur LP, Garg R, Gupta GD. Development and evaluation of topical gel of minoxidil from different polymer bases in application of alopecia. International Journal of Pharmacy and Pharmaceutical Sciences, 2010; 2(3):43-47.
  15. Goyal S, Sharma P, Ramchandani U, Shrivastava SK, Dubey PK. Novel Anti-Inflammatory Topical Herbal Gel Containing Withania somnifera and Boswellia serrata. International Journal of Pharmaceutical and Biological Archives. 2011; 2(4):1087-1094.
  16. Jani R, Jani K, Setty CM. Preperation and evaluation of topical gel Valdecoxib, Dipti Patel, Inter. Journal Pharm. Sci. Research. 2010; 2(1):51-54. 
  17. Dow DA., et al. ?Dow Pharmaceutical Sciences, Inc., assignee. Topical gel delivery systems for treating skin disorders?. European patent 1304992 B1. (2009): 29

L. Gopi
Corresponding author

Aadhibhagawan College Of Pharmacy, Rantham, T. V. malai, Tamilnadu.

R. Priyadharshini

Aadhibhagawan College Of Pharmacy, Rantham, T. V. malai, Tamilnadu.

M. Priya

Aadhibhagawan College Of Pharmacy, Rantham, T. V. malai, Tamilnadu.

B. Priyanka

Aadhibhagawan College Of Pharmacy, Rantham, T. V. malai, Tamilnadu.

D. Raja

Aadhibhagawan College Of Pharmacy, Rantham, T. V. malai, Tamilnadu.

L. Gopi*, R. Priyadharshini, M. Priya, B. Priyanka, D. Raja, K. Ramesh, Aadhibhagawan College Of Pharmacy, Rantham, T. V. malai, Tamilnadu, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 7, 162-169.

More related articles
Formulation And In vitro Evaluation Of Bilayer Tab...
Mayur Aware, Sheetal Gondkar, Rishikesh Bachhav, ...
Development And Validation Of UV HPLC Method For T...
Amol Amrutkar, Smita Aher, Rishikesh Bachhav, ...
Formulation Development and Evaluation Of Wax Inco...
Amol Ghare, Sheetal Gondkar, Rishikesh Bachhav, ...
A Comprehensive Review On Analytical Method Development And Validation...
Amol Amrutkar, Smita Aher, Rishikesh Bachhav, ...
Method Development and Validation of Indacaterol Maleate By RP HPLC In Bulk and ...
Manali Katkade, Anagha Baviskar, Kiran Kotade, Charushila Bhangale, ...
Related Articles
Ayurvedic Remedies of Bacterial Meningitis...
Komal Ushir, Dinesh Rishipathak, Pragati Bhosale, Manisha Raut, ...