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Abstract

Nystatin is a widely used antifungal agent. The goal of this study was to create Nystatin liposomes for a long-term drug delivery system. It has the advantages of dose reduction, reduced dosing frequency, reduced side effects, prolonged drug action, and thus improved patient compliance. Physical dispersion and ether injection were used to create the liposomes. Encapsulating the drug with soya lecithin and cholesterol allows for sustained release of the medication. As a solvent, chloroform, ether, and methanol were used. As a hydration medium for loading the drug, phosphate buffer pH 6.8 was used. The final liposome was tested for drug entrapment efficiency, morphological analysis, particle size analysis, in-vitro drug release studies, and stability. When comparing the two methods of Nystatin liposome formulation, the physical dispersion method demonstrated longer action than the ether injection method. Physical dispersion method performed better in terms of drug entrapment and stability.

Keywords

Physical dispersion, ether injection, soya lecithin, cholesterol, morphological analysis, Nystatin

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Photo
Pratikeswar Panda
Corresponding author

Department of Pharmaceutics, Siksha 'O' Anusandhan University, Bhubaneswar, India

Photo
Sagarika Mohapatra
Co-author

Department of Pharmaceutics, Siksha 'O' Anusandhan University, Bhubaneswar, India

Photo
Rakesh Sahoo
Co-author

Department of Pharmaceutics, Siksha 'O' Anusandhan University, Bhubaneswar, India

Pratikeswar Panda*, Sagarika Mohapatra, Rakesh Sahoo, Formulation And In Vitro Evaluation Of Nystatin's In Liposomal Drug Delivery System, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 31-40. https://doi.org/10.5281/zenodo.8312639

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