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  • Hepatoprotective Effect of Curcumin Microsponges against Paracetamol Induced Liver Toxicity in Rats
  • aDepartment of Pharmacology, SNJB’s Shriman Sureshdada Jain College of Pharmacy, Chandwad Dist: Nashik, India.
    bDepartment of Pharmacy, VADP’s VPD Institute of Pharmacy, Shirsondi Tal. Malegoan Dist. Nashik, India.
    cDepartment of Pharmacology, JES's SND College of Pharmacy, Babulgaon, Tal. Yeola, Dist. Nashik, India.
    dDepartment of Pharmaceutical Quality Assurance, Aldel St. John Institute of Pharmacy and Research, Palghar Dist: Thane, India.
    eDepartment of Pharmacy, SMES’s Mahavir Institute of Pharmacy, Nashik, India.
    fDepartment of Pharmaceutical Chemistry, SNJB’s Shriman Sureshdada Jain College of Pharmacy, Chandwad Dist: Nashik, India.

Abstract

There are currently numerous pharmacological effects associated with curcumin, but its use in clinical settings is constrained by its poor bioavailability. In this research, we created a formulation for curcumin microsponges and assessed their ability to protect rats livers from damage brought on by paracetamol. Paracetamol (2 g/kg/day) was used to produce toxicity over the course of 10 days. Paracetamol causes marked hepatotoxicity in rats by raising the standard of ALT, AST, ALP, and total bilirubin, which are liver function indicators along with reducing total protein level. Animal were treated orally including Curcumin microsponges (100 mg/kg) and plain curcumin (P-CUR) (100 mg/kg) daily for 10 days. Rats were sacrificed on the last day of treatment and the liver was excised for histopathological analysis. According to our findings, microsponges have a greater hepatoprotective impact than regular plain curcumin. When curcumin microsponges were administered, paracetamol-induced liver damage was successfully reduced, as seen by a decrease in liver function indicators. Our study suggests that curcumin microsponges have strong potential hepatoprotective effects.

Keywords

Curcumin, microsponges, paracetamol, biomarkers, liver, hepatoprotective

Reference

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Gaurav Kasar
Corresponding author

Department of Pharmacology, SNJB’s Shriman Sureshdada Jain College of Pharmacy, Chandwad Dist: Nashik, India.

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Pooja Rasal
Co-author

Department of Pharmacology, SNJB’s Shriman Sureshdada Jain College of Pharmacy, Chandwad Dist: Nashik, India.

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Ritesh Khairnar
Co-author

Department of Pharmaceutical Quality Assurance, Aldel St. John Institute of Pharmacy and Research, Palghar Dist: Thane, India.

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Revati Khairnar
Co-author

Department of Pharmacy, SMES’s Mahavir Institute of Pharmacy, Nashik, India.

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Shubham Khaire
Co-author

Department of Pharmacology, SNJB’s Shriman Sureshdada Jain College of Pharmacy, Chandwad Dist: Nashik, India.

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Yunus Ansari
Co-author

Department of Pharmaceutical Chemistry, SNJB’s Shriman Sureshdada Jain College of Pharmacy, Chandwad Dist: Nashik, India.

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Manoj Mahajan
Co-author

Department of Pharmacology, SNJB’s Shriman Sureshdada Jain College of Pharmacy, Chandwad Dist: Nashik, India.

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Aman Upaganlawar
Co-author

Department of Pharmacology, SNJB’s Shriman Sureshdada Jain College of Pharmacy, Chandwad Dist: Nashik, India.

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Amol Thakare
Co-author

Department of Pharmacy, VADP’s VPD Institute of Pharmacy, Shirsondi Tal. Malegoan Dist. Nashik, India.

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Chandrashekhar Upasani
Co-author

Department of Pharmacology, SNJB’s Shriman Sureshdada Jain College of Pharmacy, Chandwad Dist: Nashik, India.

Gaurav Kasarab, Pooja Rasal, Ritesh Khairnar, Revati Khairnar, Shubham Khaire, Yunus Ansari, Manoj Mahajan, Aman Upaganlawar, Amol Thakare, Chandrashekhar Upasani, Hepatoprotective Effect of Curcumin Microsponges against Paracetamol-Induced Liver Toxicity in Rats, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 841-856. https://doi.org/10.5281/zenodo.10590649

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