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Abstract

Liver is one of the main sites of metabolism and also has a significant role through its various roles. It can split fats and proteins into smaller substances so that the cells of other tissues can use them for energy or for synthesizing specially needed biomolecules. Liver also synthesizes particles needed for blood coagulation, transport of fats conferring immunity to infection and many other purposes. Liver is dexterous of storing large quantity of fats, carbohydrates and even proteins and later releasing these nutrients into the tissue, which needs them. Any liver disease can cause measure physiological problem with grave consequences. The liver synthesizes about 50 gm of protein each day, primarily in the form of albumin. Liver cells also chemically convert amino acids to produce keto acidosis and ammonia, from which urea is formed and excreted in the urine. Digestive fat is converted in the intestine to triglycerides, fat, phospholipids and lipoproteins. These substances are converted in the liver into glycerol and fatty acids, through a process known as ketogenesis. Lever failure is continuously associated with cellular necrosis cellular necrosis, increased tissue lipid peroxidation and depletion in the flesh GSH levels. In addition, serum levels of many biochemical markers like SGOT, SGPT, triglycerides, cholesterol, bilirubin, alkaline phosphatase are elevated. Hence in the present study, the best effort is made to evaluate the caring effect of methanolic extract of Ocimum sanctum leaves against various hepato toxic agents in validated rat models. Additional study is required on the bioactive elements of OS that give rise to its varied therapeutic characteristics and their molecular actions. Furthermore, pharmacological characteristics of the ethno pharmacological information of OS for pharmaceutical therapeutic applications must be supported by its bioactive components.

Keywords

Ocimum sanctum, Anti-inflammatory, Malaria, Flavonoids, SGOT, SGPT, Alkaline phosphatase

Reference

  1. James LS. The World Health Organization’s definition of health. Social against spiritual health. Social Indicator Research 1996; 38: 181-192.
  2. Edwin Jerald. Text book of Pharmacognosy. AcademicsPress, California 2007:1-3.
  3. Munge B, Sreedhar G, Mounika Y, Suddagoni S. Anthelmintic activity of seaweed extract of Padina boergesenii and Padina tetrastromatica acute subacute level in naturally infected sheep. Natl J Physiol Pharm Pharmacol 2022;12(02):115-120
  4. Koakate CK. Text book of Pharmacognosy. Nirali Publications, New Delhi 2007:1-73.
  5. Herbal medicine. WHO Drug Information, 2000; 4.
  6. Mate GS, NaikwadeNS, Magdum CS, Chowki AA, and Patil SB. Evaluation of anti-noiceceptive activity of Cissus Quadragularis on albino mice. Int J Green Pharm 2008; 2:118-21.
  7. Davidson. “Principle and Practice of Medicine”, Churchill Livingstone Elsevier Science Ltd 1999; 19: 838-878.
  8. Kumar, Cotran, Saunders, Robbins. “Basic Pathology”, The Curtis center, Philadelphia. Pennsylvania 2004; 7: 594-627.
  9. DamjanovI. “Histopathology a Color Atlas and Text Book”. Baltimore: Williams and Wilkins 1996; 2:211-217.
  10. Zimmerman HJ, Ishak KG. “Hepatotoxic injury due to drugs and toxins” London Churchill Livingstone 2002; 4: 622-24.
  11. Ishak KG. The liver Chapter 17th in “Pathology of Drug Induced and Toxic Disease. Riddell RH, New York: Churchill Livingstone, 1982; 459.
  12. Kirchain WR, Gill MA. “Drug – induced Liver Disease” chapter 36 in Pharmaco therapy a pathophysiological approach. London Appleton and Lange 1999; 4:628-636.
  13. Shashi K, Ramaiah, Apte U, Mehendale HM. Cytochrome P4502E1  induction increases ethanol liver injury in diet restricted rats, Drug Meta & Dispo 2001; 29(8):1088-1095.
  14. Habibollahi P, Mahboobi N, Esmaeili S, Safari S, Dabbagh A, Alavian SM. Halothane-induced hepatitis: A forgotten issue in developing countries: Halothane-induced hepatitis. Hepat Mon. 2011 Jan;11(1):3-6. PMID: 22087107; PMCID: PMC3206652.
  15. Saraswat B, Visen PKS, Dayal R, Agarwal DP and Patnaik GK. Protective action of ursolic acid against chemical induced hepatotoxicity in rats, Ind. J. Pharmacol. 1996; 28: 232-39.
  16. Klaassen CD and Plaa GL. Effect of CCl 4 on the Metabolism, Storage and Excretion of Sulfobromophthalein. Toxicol. Appl. Pharmacol1968; 12: 132-9.
  17. Harshmohan. The liver, biliary tract and exocrine pancreas. In: Text book of pathology, 4 th Ed, Jaypee Brothers Medical Publishers (P) Ltd. New Delhi. 2002; 22-4 and 569-630. M., S., KR, S., B., S., G., V. S., S., R., K., S. R., & K, M. (2016). 
  18. Ocimum sanctum: a review on the pharmacological properties. International Journal of Basic & Clinical Pharmacology, 5(3), 558–565.https://doi.org/10.18203/2319-2003.ijbcp20161491.
  19. Cohen MM. Tulsi - Ocimum sanctum: A herb for all reasons. J Ayurveda Integr Med. 2014 Oct-Dec;5(4):251-9. doi: 10.4103/0975-9476.146554. PMID: 25624701; PMCID: PMC4296439.
  20. Preeti et al: Tulsi (Ocimum Sanctum Linn.): An Ayurvedic And Contemporary Review. International Ayurvedic Medical Journal {online} 2021 {cited December 2021} Available from: http://www.iamj.in/posts/images/upload/3134_3138.pdf.

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Suddagoni Santhosh
Corresponding author

Department of Pharmacology, Surabhi Dayakar Rao College of pharmacy,Rimmanaguda, Gajwel, Siddipet, Telanagana, India, Pin code: 502311.

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Narsapuram Bharathi
Co-author

Department of Pharmacology, Surabhi Dayakar Rao College of pharmacy,Rimmanaguda, Gajwel, Siddipet, Telanagana, India, Pin code: 502311.

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Thalla Likesh Goud
Co-author

Department of Pharmacology, Surabhi Dayakar Rao College of pharmacy,Rimmanaguda, Gajwel, Siddipet, Telanagana, India, Pin code: 502311.

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Gunisetti Sri Anjali
Co-author

Department of Pharmacology, Surabhi Dayakar Rao College of pharmacy,Rimmanaguda, Gajwel, Siddipet, Telanagana, India, Pin code: 502311.

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Pitla Maheshwari
Co-author

Department of Pharmacology, Surabhi Dayakar Rao College of pharmacy,Rimmanaguda, Gajwel, Siddipet, Telanagana, India, Pin code: 502311.

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Chintala Mayuri
Co-author

Department of Pharmacology, Surabhi Dayakar Rao College of pharmacy,Rimmanaguda, Gajwel, Siddipet, Telanagana, India, Pin code: 502311.

Narsapuram Bharathi, Suddagoni Santhosh, Thalla Likesh Goud, Gunisetti Sri Anjali, Pitla Maheshwari, Chintala Mayuri, Hepatoprotective Role of Flavonoids from Ocimum Sanctum Against Halothane-Induced Liver Toxicity in Rats, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 109-123. https://doi.org/10.5281/zenodo.10000416

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