Department of Pharmacology, Surabhi Dayakar Rao College of pharmacy,Rimmanaguda, Gajwel, Siddipet, Telanagana, India, Pin code: 502311.
Liver is one of the main sites of metabolism and also has a significant role through its various roles. It can split fats and proteins into smaller substances so that the cells of other tissues can use them for energy or for synthesizing specially needed biomolecules. Liver also synthesizes particles needed for blood coagulation, transport of fats conferring immunity to infection and many other purposes. Liver is dexterous of storing large quantity of fats, carbohydrates and even proteins and later releasing these nutrients into the tissue, which needs them. Any liver disease can cause measure physiological problem with grave consequences. The liver synthesizes about 50 gm of protein each day, primarily in the form of albumin. Liver cells also chemically convert amino acids to produce keto acidosis and ammonia, from which urea is formed and excreted in the urine. Digestive fat is converted in the intestine to triglycerides, fat, phospholipids and lipoproteins. These substances are converted in the liver into glycerol and fatty acids, through a process known as ketogenesis. Lever failure is continuously associated with cellular necrosis cellular necrosis, increased tissue lipid peroxidation and depletion in the flesh GSH levels. In addition, serum levels of many biochemical markers like SGOT, SGPT, triglycerides, cholesterol, bilirubin, alkaline phosphatase are elevated. Hence in the present study, the best effort is made to evaluate the caring effect of methanolic extract of Ocimum sanctum leaves against various hepato toxic agents in validated rat models. Additional study is required on the bioactive elements of OS that give rise to its varied therapeutic characteristics and their molecular actions. Furthermore, pharmacological characteristics of the ethno pharmacological information of OS for pharmaceutical therapeutic applications must be supported by its bioactive components.
Narsapuram Bharathi, Suddagoni Santhosh, Thalla Likesh Goud, Gunisetti Sri Anjali, Pitla Maheshwari, Chintala Mayuri, Hepatoprotective Role of Flavonoids from Ocimum Sanctum Against Halothane-Induced Liver Toxicity in Rats, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 109-123. https://doi.org/10.5281/zenodo.10000416