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Abstract

Liquorice (Glycyrrhiza glabra) has been widely utilized in traditional medicine for various therapeutic benefits, including its roles in gastrointestinal and respiratory health. Recent research indicates that liquorice and its bioactive components may significantly influence neurological function. This review explores the neurologic effects of liquorice, focusing on its potential in neuroprotection, cognitive enhancement, and management of neurological disorders. Key mechanisms such as neurotransmitter modulation, anti-inflammatory properties, oxidative stress reduction, and regulation of the hypothalamic-pituitary-adrenal (HPA) axis are examined. While liquorice demonstrates potential for neurological applications, concerns regarding neurotoxicity and systemic side effects due to excessive consumption are highlighted. Future research directions and clinical recommendations are discussed to establish safe and effective therapeutic use.

Keywords

Liquorice, Glycyrrhiza glabra, Neuroprotection, Cognitive Function, Neurotransmitter Modulation, Oxidative Stress, Neurodegeneration, HPA Axis

Reference

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  4. Zhao, X., et al. (2022). Liquorice bioactives and neurodegeneration: Mechanistic insights. Neurochemical Research, 47(2), 345-362.
  5. Wang, Y., et al. (2018). The effects of liquorice on stress-induced neurological disorders. CNS Neuroscience & Therapeutics, 24(6), 547-560.
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  7. Kim, H., et al. (2020). Anti-inflammatory effects of Glycyrrhiza glabra on neuroinflammation. Inflammation Research, 69(5), 389-402.
  8. Li, Z., et al. (2019). Glycyrrhizin as a modulator of dopaminergic pathways in Parkinson’s disease. Journal of Neurology, 266(4), 927-940.

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Ashvini Dhurandhar
Corresponding author

Samarth Collage Of Pharmacy Deulgaon Raja

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Shubham Bundhe
Co-author

Samarth Collage Of Pharmacy Deulgaon Raja

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Dr Gopalkrishna
Co-author

Samarth Collage Of Pharmacy Deulgaon Raja

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R.Sithaphle
Co-author

Samarth Collage Of Pharmacy Deulgaon Raja

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Dr. Prafulla R.Tathe
Co-author

Samarth Collage Of Pharmacy Deulgaon Raja

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Dr. Nandu Kayande
Co-author

Samarth Collage of Pharmacy Deulgaon Raja

Ashvini Dhurandhar*, Shubham Bundhe, Dr. Gopalkrishna, R. Sithaphle, Dr. Prafulla R. Tathe, Dr. Nandu Kayande, Neurologic Effects of Liquorice: A Comprehensive Review, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 2, 2028-2032. https://doi.org/10.5281/zenodo.14933113

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