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Abstract

The leaves of Syzygium guineense have been founded useful for the control and cure of malaria, and performed antiplasmodial activity in vitro. Investigation of this plant was carried out to analyse antioxidant and antimicrobial properties of characterized essential oil of the leaf of Syzgium guineense (S. guineense). Essential oil obtained by hydrodistillation was identifyed by gas chromatography coupled with mass spectrometry (GC-MS). The antioxidant potential was discovered by measuring the inhibition of 2,2-diphenyl-1-picrylhydrazyl hydrate radical (DPPH). The essential oil were tested against five bacteriafor gives their inhibitory effects : “Mycobacterium bovis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Staphylococcus aureus” and one fungus: Candida albicans using broth microdilution method. The GC-MS analysis revealed the presence of 46 components accounting for 92.63% of the essential oil constituents. Sesquiterpenoids (73.15%) and monoterpenoids (14.17%) were the main classes of the essential oil. Aromadendrene (6.98%), germacrene B (5.52%) and ?-selinene (3.94%) were the predominant sesquiterpene hydrocarbons. The oxygenated sesquiterpenes were ?-cadinol (6.68%), ?-cadinol (6.64%) and caryophyllene oxide (5.44%). Butylated hydroxytoluene (BHT) exhibited higher antioxidant activity compare to the essential oil. The essential oil revealed strong antimicrobial activities against the tested microorganism with MIC ranging between 25- 100?g/mL. Results showed that the leaf essential oil of S. guineense had high amount of sesquiterpenoids (73.15%) with strong antioxidant and antimicrobial activities.

Keywords

Phytochemical, Pharmacological, Extract

Reference

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Kokate Rohit
Corresponding author

Saraswati Institute of Pharmacy Kurtadi , Hingoli

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Kharbe Vitthal
Co-author

Saraswati Institute of Pharmacy Kurtadi , Hingoli

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Kirtankar Tejaswini
Co-author

Saraswati Institute of Pharmacy Kurtadi , Hingoli

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Lashkar Priti
Co-author

Saraswati Institute of Pharmacy Kurtadi , Hingoli

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Sumit S. Bodkhe
Co-author

Assistant Professor Saraswati Institute of Pharmacy , Kurtadi Dist. Hingoli, Maharashtra , India (Pharmacognosy Department)

Kharbe vitthal, Kirtankar Tejaswini, Kokate Rohit, Lashkar Priti, Sumit S. Bodkhe, Review On Phytochemical And Pharmacological Investigation of Syzygium Guineense Extract, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 50-55. https://doi.org/10.5281/zenodo.10459289

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