View Article

Abstract

Sublingual dosage forms have gained significant attention in the field of pharmaceuticals due to their unique route of administration and rapid onset of action. This dosage form involves placing medication under the tongue, where it dissolves and is absorbed directly into the bloodstream through the highly vascularized sublingual mucosa. This route offers several advantages, including avoiding first-pass metabolism in the liver, enhancing bioavailability, and providing a non-invasive and convenient option for patients who have difficulty swallowing or require fast drug action. In this abstract, we explore the characteristics, advantages, and challenges associated with sublingual dosage forms. We discuss the principles of drug absorption through the sublingual route, highlighting the role of the sublingual mucosa in drug uptake. The factors influencing drug formulation and optimization for sublingual delivery are also examined, including the choice of excipients, drug solubility, and taste-masking techniques. Furthermore, we delve into the diverse range of therapeutic applications that can benefit from sublingual dosage forms, such as pain management, cardiovascular diseases, and hormone replacement therapy. Case studies and examples of commercially available sublingual products are provided to illustrate the practicality and effectiveness of this delivery route. While sublingual dosage forms offer numerous advantages, they are not without challenges, such as taste masking, stability issues, and dosage accuracy. We address these challenges and discuss potential strategies for overcoming them. In conclusion, sublingual dosage forms represent a promising avenue for drug delivery, offering rapid onset of action, improved bioavailability, and patient convenience. As pharmaceutical research continues to advance, the development and optimization of sublingual dosage forms are expected to play an increasingly important role in modern medicine.

Keywords

Sublingual dosage form, systemic circulation, salivary gland, Tongue, sublingual drug delivery

Reference

  1. Universal Journal of Pharmaceutical Research An International Peer Reviewed Journal Open access to Pharmaceutical research ©2018, publisher and licensee UJPR, This is an open access article which permits unrestricted non commercial use, provided the original work is properly cited Volume 3, Issue 4, 2018
  2. A Review on Sublingual Dosage Form Yadav Dimple Shyamkumar*^, Ms. Jimmy Limbachiya, Dr. Kinjal Solanki^, Dr. Vikram Pandhya Shankersinh Vaghela B apu Institute of Pharmacy, Gandhinagar, Gujarat, India
  3. https://pubmed.ncbi.nlm.nih.gov/19062634
  4. Patel KN, Pancholi SS, Sublingual route for systemic drug delivery: A pharmaceuitical review, International Journal of Research in Pharmaceutical and biomedical Sciences, 2012;3(2):913-923
  5. Lachman L, Liebermann HA, KanigJL.The Theory and Practice of Industrial Pharmacy, 3rd ed. Mumbai: Varghese  Publishing House1990. P. 479-488
  6. SomyaSah, AshutoshBadola, PreetiKothiyal, Sublingual tablets: an overview, Indian Journal of Pharmaceutical and Biological Research, 2016; 4(2): 20-26.
  7. Manisha Singh, Nitin Chitranshi, Ajay Pal Singh, Vandana Arora, Abdul WadoodSiddiqi, An Overview on fast Disintegrating Sublingual Tablets, InternationalJournal of Drug Deliverym, 2012; 4: 407-417
  8. Harris D, Robinson JR. Drug delivery via the mucous membranes of the oral cavity. Journal of pharmaceutical sciences, 1992 Jan 1; 81(1):1-10.
  9. Verma P, Thakur AS, Deshmukh K, Jha AK, S. Routes of drugadministration.International Journal of Pharmaceutical Studies and Research, 2010; 1(1):54-59.
  10. Dhangar RS, Patil ST, Pawar SP. Sublingual: A Route for Systemic Drug Delivery System. International Journal of Pharma and Chemical Research, 2017 Apr; 3(2): 301-307.
  11. Jaiswani R, Prakash A, Mishra DK, Jain DK. Sublingual Tablets: An Overview. Journal of Drug Delivery Research, 2014; 3(4):10-21.
  12. Narang N, Sharma J. Sublingual mucosa as a route for systemic drug delivery. International Journal Pharmaceutical Sciences, 2011; 3(2):18-22.
  13. Nibha KP, Pancholi SS. An overview on: Sublingual route for systemic drug delivery. International journal of research in pharmaceutical and biomedical sciences, 2012 Apr; 3(2):913-23.
  14. Gennaro A: Remington: The science and practice of pharmacy, Lippincott Williams and Wilkins; Philadelphia;20th edition; 1: 963-975 
  15. Bredenberg S, Duberg M, Lennernis B, Lennernäs H, Pettersson A, Westerberg M. Nystrom C. In vitro and in vivo evaluation of a new sublingual tablet system for rapid oromucosal absorption using fentanyl citrate as the active substance. EurJPharm Sci., Nov30,2003; 20(3): 327-34
  16. Doelker E. Pharmaceutical dosage forms: Tablets: HA Lieberman, L. Lachman and JB Schwartz (Eds.), in three volumes, 2ndedn.

Photo
Namrata S. Revar
Corresponding author

Department of Pharmaceutical Chemistry, Mahavir Institute of Pharmacy, Mhasrul, Varvandi road, Nashik.

Photo
Samruddhi B. Sawant
Co-author

Department of Pharmaceutical Chemistry, Mahavir Institute of Pharmacy, Mhasrul, Varvandi road, Nashik.

Photo
Sanjeevani D. Rupwate
Co-author

Department of Pharmaceutical Chemistry, Mahavir Institute of Pharmacy, Mhasrul, Varvandi road, Nashik.

Namrata S. Revar*, Samruddhi B. Sawant, Sanjeevani D. Rupwate, Sublingual Dosage Form, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 397-403. https://doi.org/10.5281/zenodo.8371537

More related articles
Simultaneous Estimation Of Vildagliptin And Piogli...
Aishwarya Aijinath Ubale , Monika gopal Shinde, Punam Nivrutti Ba...
Greenness Assessment of Chromatographic Methods Us...
Shinde Vrushali, Bhabad Nikita, Shinde Sayli, Rakibe Vaishali, ...
Transfersomes: Pioneering Nanocarriers for Enhance...
Rutuja Kadam , Dr. Avinash Hosmanii , Sampada Potdar, Rutuja Sava...
Related Articles
A Simple Review of Analytical Techniques for Determination of Vildagliptin ...
Dinesh Gaikwad, Dr. Prasanna Datar, Dr. Rajkumar Shete, ...
Herbal Cosmetic: An Best Approach For Treating Skin Disorders...
Dhanashri B. Lakhe, Smita Aher, R. S. Bachhav, ...
Natural Plant Potential for Anticancer Activity...
Rutuja Mane, Dr. Dharashive Vishweshwar M., Vaishnavi Siral, Bhakare Mahesh, Charan Shinde, Sonal Do...
Simultaneous Estimation Of Vildagliptin And Pioglitazone In Bulk And Pharmaceuti...
Aishwarya Aijinath Ubale , Monika gopal Shinde, Punam Nivrutti Bandgar, Pradnya Prashant Shinde , Ba...
More related articles
Simultaneous Estimation Of Vildagliptin And Pioglitazone In Bulk And Pharmaceuti...
Aishwarya Aijinath Ubale , Monika gopal Shinde, Punam Nivrutti Bandgar, Pradnya Prashant Shinde , Ba...
Greenness Assessment of Chromatographic Methods Used for Analysis of Praziquante...
Shinde Vrushali, Bhabad Nikita, Shinde Sayli, Rakibe Vaishali, ...
Transfersomes: Pioneering Nanocarriers for Enhanced Drug Delivery ...
Rutuja Kadam , Dr. Avinash Hosmanii , Sampada Potdar, Rutuja Savakhande , Shweta Patil, ...
Simultaneous Estimation Of Vildagliptin And Pioglitazone In Bulk And Pharmaceuti...
Aishwarya Aijinath Ubale , Monika gopal Shinde, Punam Nivrutti Bandgar, Pradnya Prashant Shinde , Ba...
Greenness Assessment of Chromatographic Methods Used for Analysis of Praziquante...
Shinde Vrushali, Bhabad Nikita, Shinde Sayli, Rakibe Vaishali, ...
Transfersomes: Pioneering Nanocarriers for Enhanced Drug Delivery ...
Rutuja Kadam , Dr. Avinash Hosmanii , Sampada Potdar, Rutuja Savakhande , Shweta Patil, ...