Sublingual dosage forms have gained significant attention in the field of pharmaceuticals due to their unique route of administration and rapid onset of action. This dosage form involves placing medication under the tongue, where it dissolves and is absorbed directly into the bloodstream through the highly vascularized sublingual mucosa. This route offers several advantages, including avoiding first-pass metabolism in the liver, enhancing bioavailability, and providing a non-invasive and convenient option for patients who have difficulty swallowing or require fast drug action. In this abstract, we explore the characteristics, advantages, and challenges associated with sublingual dosage forms. We discuss the principles of drug absorption through the sublingual route, highlighting the role of the sublingual mucosa in drug uptake. The factors influencing drug formulation and optimization for sublingual delivery are also examined, including the choice of excipients, drug solubility, and taste-masking techniques. Furthermore, we delve into the diverse range of therapeutic applications that can benefit from sublingual dosage forms, such as pain management, cardiovascular diseases, and hormone replacement therapy. Case studies and examples of commercially available sublingual products are provided to illustrate the practicality and effectiveness of this delivery route. While sublingual dosage forms offer numerous advantages, they are not without challenges, such as taste masking, stability issues, and dosage accuracy. We address these challenges and discuss potential strategies for overcoming them. In conclusion, sublingual dosage forms represent a promising avenue for drug delivery, offering rapid onset of action, improved bioavailability, and patient convenience. As pharmaceutical research continues to advance, the development and optimization of sublingual dosage forms are expected to play an increasingly important role in modern medicine.


Sublingual dosage form, systemic circulation, salivary gland, Tongue, sublingual drug delivery


  1. Universal Journal of Pharmaceutical Research An International Peer Reviewed Journal Open access to Pharmaceutical research ©2018, publisher and licensee UJPR, This is an open access article which permits unrestricted non commercial use, provided the original work is properly cited Volume 3, Issue 4, 2018
  2. A Review on Sublingual Dosage Form Yadav Dimple Shyamkumar*^, Ms. Jimmy Limbachiya, Dr. Kinjal Solanki^, Dr. Vikram Pandhya Shankersinh Vaghela B apu Institute of Pharmacy, Gandhinagar, Gujarat, India
  4. Patel KN, Pancholi SS, Sublingual route for systemic drug delivery: A pharmaceuitical review, International Journal of Research in Pharmaceutical and biomedical Sciences, 2012;3(2):913-923
  5. Lachman L, Liebermann HA, KanigJL.The Theory and Practice of Industrial Pharmacy, 3rd ed. Mumbai: Varghese  Publishing House1990. P. 479-488
  6. SomyaSah, AshutoshBadola, PreetiKothiyal, Sublingual tablets: an overview, Indian Journal of Pharmaceutical and Biological Research, 2016; 4(2): 20-26.
  7. Manisha Singh, Nitin Chitranshi, Ajay Pal Singh, Vandana Arora, Abdul WadoodSiddiqi, An Overview on fast Disintegrating Sublingual Tablets, InternationalJournal of Drug Deliverym, 2012; 4: 407-417
  8. Harris D, Robinson JR. Drug delivery via the mucous membranes of the oral cavity. Journal of pharmaceutical sciences, 1992 Jan 1; 81(1):1-10.
  9. Verma P, Thakur AS, Deshmukh K, Jha AK, S. Routes of drugadministration.International Journal of Pharmaceutical Studies and Research, 2010; 1(1):54-59.
  10. Dhangar RS, Patil ST, Pawar SP. Sublingual: A Route for Systemic Drug Delivery System. International Journal of Pharma and Chemical Research, 2017 Apr; 3(2): 301-307.
  11. Jaiswani R, Prakash A, Mishra DK, Jain DK. Sublingual Tablets: An Overview. Journal of Drug Delivery Research, 2014; 3(4):10-21.
  12. Narang N, Sharma J. Sublingual mucosa as a route for systemic drug delivery. International Journal Pharmaceutical Sciences, 2011; 3(2):18-22.
  13. Nibha KP, Pancholi SS. An overview on: Sublingual route for systemic drug delivery. International journal of research in pharmaceutical and biomedical sciences, 2012 Apr; 3(2):913-23.
  14. Gennaro A: Remington: The science and practice of pharmacy, Lippincott Williams and Wilkins; Philadelphia;20th edition; 1: 963-975 
  15. Bredenberg S, Duberg M, Lennernis B, Lennernäs H, Pettersson A, Westerberg M. Nystrom C. In vitro and in vivo evaluation of a new sublingual tablet system for rapid oromucosal absorption using fentanyl citrate as the active substance. EurJPharm Sci., Nov30,2003; 20(3): 327-34
  16. Doelker E. Pharmaceutical dosage forms: Tablets: HA Lieberman, L. Lachman and JB Schwartz (Eds.), in three volumes, 2ndedn.

Namrata S. Revar
Corresponding author

Department of Pharmaceutical Chemistry, Mahavir Institute of Pharmacy, Mhasrul, Varvandi road, Nashik.

Samruddhi B. Sawant

Department of Pharmaceutical Chemistry, Mahavir Institute of Pharmacy, Mhasrul, Varvandi road, Nashik.

Sanjeevani D. Rupwate

Department of Pharmaceutical Chemistry, Mahavir Institute of Pharmacy, Mhasrul, Varvandi road, Nashik.

Namrata S. Revar*, Samruddhi B. Sawant, Sanjeevani D. Rupwate, Sublingual Dosage Form, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 397-403.

More related articles
Development And Validation Of UV HPLC Method For T...
Amol Amrutkar, Smita Aher, Rishikesh Bachhav, ...
Formulation Development and Evaluation Of Wax Inco...
Amol Ghare, Sheetal Gondkar, Rishikesh Bachhav, ...
Method Development and Validation of Indacaterol M...
Manali Katkade, Anagha Baviskar, Kiran Kotade, Charushila Bhangal...
Bioanalytical Method Development And Validation For The Estimation Of Active Pha...
Neha Gaikwad, Kanchan Shinde, Varsha Pangale, Charushila Bhangale, ...
Related Articles
Gastroretentive Drug Delivery System : A Review...
Suraj Kothule, Smita Aher, Rishikesh Bachhav, ...
Bilayer Floating Tablet : A Novel Floating Tablet...
Mayur Aware, Sheetal Gondkar, Rishikesh Bachhav, ...
More related articles
Method Development and Validation of Indacaterol Maleate By RP HPLC In Bulk and ...
Manali Katkade, Anagha Baviskar, Kiran Kotade, Charushila Bhangale, ...