Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India.
Stones refer to solid mineral and crystalline deposits that form within the urinary system, including the kidneys, ureters, bladder, and urethra. These stones are composed of various minerals and can range in size from small particles to larger, more obstructive structures. These guidelines serve as a valuable resource for healthcare professionals in understanding the epidemiology and recommended management strategies for distal ureteric stones. The main etiological factors are Urinary tract infections, Certain medical conditions, Anatomical factors. Signs and symptoms are Flank pain , Hematuria Dysuria,Urinary urgency, frequency, Nausea and vomiting. Diagnostic tests like Non-contrast Computed Tomography (CT), Intravenous Pyelogram (IVP), Ultrasonography (US), Retrograde Ureterography, Management like Extracorporeal Shock Wave Lithotripsy (ESWL), Ureteroscopy, Percutaneous Nephrolithotomy (PCNL), Alpha-blockers, Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), Analgesics. Pharmacodynamics of tamsulosin is the relaxation of smooth muscle in the ureter, which is achieved through the blockade of alpha-1 adrenergic receptors. Tamsulosin is well absorbed, protein binding of approximately 99%, eliminated mainly via hepatic metabolism, with less than 1% of the dose excreted unchanged in the urine. Adverse effects of tamsulosin Intraoperative floppy iris syndrome (IFIS) , Abnormal ejaculation and retrograde ejaculation, Dizziness and postural hypotension. Pharmacodynamics of silodosin in ureteric stones is believed to involve the relaxation of smooth muscle in the ureter, which promotes stone passage. Silodosin is wellabsorbed, moderate volume of distribution eliminated mainly via hepatic metabolism, with less than 1% of the dose excreted unchanged in the urine.
Y. Bhavana*, T. Bhavana, S. D. Reshma, S. Balakrishna Reddy, Dr. M. Lakshmi Banusri, Tamsulosin Versus Silodosin for The Treatment of Distal Ureteric Stones: A Review, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 8, 96-103. https://doi.org/10.5281/zenodo.8246283