Chhatrapati Shivaji College of Pharmacy, Deori, Dist. Gondia (M.H.)
The anatomy of the human finger consists of three parts. The nail plate, nail bed and matrix start from the posterior structure. Nails and cuticles are special cuticles that protect delicate fingers and toes from trauma and serve as a tool or weapon. Nail problems occur in people of all ages. Unless a person suffers from malnutrition, diet is not usually responsible for abnormal nail changes. Some nail conditions require professional treatment by a doctor or dermatologist, while others respond to simple self-help techniques and simple lifestyle changes. If in doubt you should seek medical attention. Nail disease is a common reason for dermatological consultation. They are evaluated by clinical examination, Dermatoscopy, visual examination, microbiology (including mycology) and histopathological examination. Medicinal Herbs are a great way to care for and heal your body. Before doing anything, the doctor must first know the cause. The herb is available in dry alcohol, glycerin and other forms of alcohol.
Nails and cuticles are special cuticles that protect delicate fingers and toes from trauma and serve as a tool or weapon. The anatomy of the human finger consists of three parts. The nail plate, nail bed and matrix start from the posterior structure [1]. The nail plate serves as a protective layer on the dorsal surface of each distal phalanx of the hands and feet. Permanent matrix nails are nails. It is important for the integrity, appearance and growth of different parts of the nail apparatus, including the surrounding tissues and the phalanx bone [2]. Other duties include protection as well as defensive or striking, drawing, and cosmetic purposes. This review focuses on various nail diseases that occur due to physiological changes in the body [3]. Nail diseases account for 10% of dermatological disorders and affect a large number of older people [4].
Health Benefits of Nails
Did you know that your nails can tell you something about your overall health? Health or physical illness is shown as a family that penetrates to the nails. They vary in shape and size due to systemic problems that prevent their growth. A small white spot here, a slight tinge of pink there, or skin redness or swelling could be signs of an illness. Problems with your liver, lungs, or heart can be revealed by your nails. Read on to discover secrets that nails can hide.[5] Senile Changes In Nails. It is believed that senile changes in the nails are caused by peripheral degeneration, often caused by arteriosclerosis. Even if the nail plate is exposed to the sun[7,8], UV rays can contribute to such changes. Trauma, biological abnormalities, infections, dermatological or systemic diseases and their.
The calcium and iron content of older nails increases and decreases with age.
The size of nail plate keratinocytes increases with the number of 'pertinax bodies', which are remnants of keratinocyte nuclei. A blood clot is seen in the dermis of the nail bed damage to the ducts and elastic fibers, especially under the dark circles.
Fig.No.1 Change in Histology
Change in the growth of nails
Fingers and hands grow at an average rate of 0.1 mm/day (3.0 mm/month) and 0.03 mm/day (1.0 mm/month). In the elderly, nail growth rate decreases by approximately 0.5% per year between the ages of 25 and 100. As shown by Oreintreich and Scharp (1967), [6] nail growth decreases by an average of 38% over a ten-year period. and nine. In this study, the decline in nail growth in females was greatest by age six; then no change was observed fromto eight years, whereas in men the rate was more pronounced from six to eight years. [6]
Discoloration of nails
Senile nails can be light, dark and opaque; Its color varies from white (leukonychia) or yellow to black or grey. [11] Leukonychia can be true (due to matrix involvement), total, subtotal, transverse, punctate, or longitudinal; pseudoleukonychia (exogenous origin) observed in onychomycosis with keratin granulation after nail application; and visible leukonychia (due to background changes).
Fig.No.2 Discoloration of Nails
Finger problems and information [12,13,14,15]
Nails support and protect the sensitive tips of the fingers and toes. Fingers also help us grasp things, press buttons, or unfasten them. A toe grows three times faster than a finger. Nail problems occur in people of all ages. Unless a person suffers from malnutrition, diet is not usually responsible for abnormal nail changes. Some nail conditions require professional treatment by a doctor or dermatologist, while others respond to simple self-help techniques and simple lifestyle changes. If in doubt you should seek medical attention. Toe problems can affect people of all ages, but are more common in the elderly. Common causes of finger problems include injuries, infections, and skin conditions such as eczema and psoriasis. Common causes of foot problems include trauma, ill-fitting shoes, poor mobility, muscle weakness, and infection. Minor problems are best treated by a chiropractor. Nail Structure Nails are made of a protein called keratin. This is the same protein that makes up skin and hair. Nails grow from cells growing under the nail, and these cells then overlap and become stronger. This is called keratinization. The strength, thickness and growth speed of nails are characteristics we inherit from our parents.
Nail structures include:
Nail Condition
Many conditions can affect our nails, with different causes and treatments. A healthy nail plate is pink and the nail appears white as it emerges from the nail bed. Common causes of nail discoloration include:
Nail plate removed When the nail plate is removed from the nail bed, it appears white. Common causes include:
Ingrown nails older people are at greater risk. The causes are:
Fig.No.3 Fungal Infection
Ribbed nails
Ribs that run across the length or width of the nail plate can have many causes, including:
Fig.No.4 Ribbed Nails
Fig.no.5 Psoriasis
Ribbed nails
Ribs that run the length or width of the nail plate can have many causes, including:
Cracking of the nail
In this case, the lightened nail plate splits or bed. Common causes are:
Rough or broken nails
Nails may be thick or cracked. This is a normal aging process for the nails to harden. Trimming, shaping, and nail care by a podiatrist can improve the health of your nails and help diagnose and treat more serious nail problems. Ingrown or split toenails can benefit from regular professional attention. Trimming, shaping, and nail care by a podiatrist can improve the health of your nails and help diagnose and treat more serious nail problems.
Bacterial nail infections
Staphylococcus aureus bacteria is the cause of nail infections. The infection usually first settles in the skin under the nail (near the nail). If left untreated, the infection can develop further, causing inflammation and swelling. It is often associated with candida infection, especially if it is chronic. Activities that make a person more susceptible to bacterial nail infections include:
Fig.No.6 Bacterial Nail Infection
Inflammation of the skin around the nail - paronychia
The skin around the nail can become infected with bacteria, most commonly Staphylococcus aureus. This condition is called paronychia. Symptoms may include pain, redness and swelling around the fringe, as well as yellow-green discharge.
Treatment of paronychia includes:
Chronic paronychia (where the condition persists for a long time) is difficult to treat. With chronic paronychia, the nail may become crooked and discolored, and the skin in the affected area may blister. Sometimes the inflammation spreads from one nail to another. List of common microbes responsible for chronic paronychia.
Fig.no.7 Paronychia
Chronic paronychia (where the condition persists for a long time) is difficult to treat. With chronic paronychia, the nail may become crooked and discolored, and the skin in the affected area may blister. Sometimes the inflammation spreads from one nail to another. List of common microbes responsible for chronic paronychia.
Fungal infections
Fungal infections, such as tinea, are transmitted from person to person and can infect the fingers or toes. If left untreated, the nail bed itself can become infected. People with diabetes or compromised immune systems are at higher risk of developing fungal infections.
Symptoms of nail infection depend on the cause but may include:
Discolouration, usually in streaks
Treatment for fungal infection includes:
Trauma to the Nail
Nail biting or forceful nail biting can cause a variety of problems, including:
Fig.no.8 Trauma to the nail
Big toes
One of the most common problems treated by podiatrists is bunions.
Big toes are often affected by this painful condition. Possible causes are:
Improper nail cutting
The doctor's treatment depends on the severity of the injury, but he can also remove part of the ingrown nail with local anesthesia.
Suggestions to prevent ingrown nails are as follows:
Skin and nail diseases
Skin diseases such as psoriasis, eczema (dermatitis), lichen planus or lupus can affect the nails. Irregularities can be holes, indentations or nails.
Abnormal nail shapes
Abnormal nail shapes, such as brittle nails, may be caused by iron deficiency. Nail tumors. Nails can be infected with tumors, including cervical cancer, often caused by human papillomavirus (HPV) infection. Melanoma can also affect the nails. Varicose veins in the nail. These are thin lines of blood that run along the nail bed. Causes include trauma, anemia, infective endocarditis (inflammation of the heart lining) and some diseases such as rheumatoid arthritis. Other Diseases and Nails
Some diseases that can affect the shape, integrity and color of our nails are:
Congenital Nail Disease
Some nail problems are congenital (present at birth). This includes nail syndrome, in which nails become damaged or lost.
Aging and Nails
As our body ages, the growth rate of our fingers and toes tends to slow down. Protein changes in the nail plate cause nails to become thinner and more prone to breakage. Discoloration and swelling are also common.
Fig.No.9 Congenital Nail Disease
Diagnosis And Treatment of Nail Problems
Any unusual changes in your nails should be monitored by a doctor. Consult your doctor for treatment or possibly a referral to a dermatologist. If the cause of your nail problem is not immediately apparent, your doctor may take a sample of your nail and subnail for laboratory analysis. Hand ulcers usually respond to treatment rather than infection.
Depending on the cause, treatment may include:
• Antibiotics for bacterial infections • Antifungals, especially oral tablets, for nail fungal infections
• Treatment of all types of skin infections
• Advice on proper nail care.
Self-Help Measures for Healthy Nails Ways to reduce the risk of nail problems include:
Treatment
Drug Therapy
The diseased nail can be removed and the doctor may prescribe oral tablets or medications to be applied to the nail surface. Terbinafine (Lamisil), itraconazole (Sporanox), or oral fluconazole (Diflucan). Onychomycosis sinks into the nail and makes treatment difficult. Primary treatment methods are ineffective. Oral terbinafine (Lamisil) appears to be an effective treatment for fungal infections with fewer side effects than other oral medications. Terbinafine has also been shown to be an effective treatment for high-risk patients, such as those with type 2 diabetes or HIV infection. [17] Oral itraconazole (Sporanox) may be a suitable treatment for fungal or non-dermatophytic fungal onychomycosis. Oral fluconazole (Diflucan) is also an effective treatment for onchomycosis. The effects of oral medication may not be seen for up to 12 to 18 months. Long-term rates of oncomycosis are estimated to be between 20% and 50%. To provide appropriate treatment for patients with nail disease, the severity of nail disease, extent of skin disease, and/or presence of joint disease must be carefully evaluated. Behavioral approaches that reduce Koebner's condition, especially regarding shoe fitting, nail care, and manual labor, are also important components of the intervention. [19] Topical or intralesional corticosteroids, as well as vitaminand D3 analogs, are the most recommended treatment for nail fungus. Because of the low absorption rate in this area, studies show that using 0.05 percent clobetasol propionate as a gel or cream in the periungual area may have only a minor effect on a patient's symptoms. A 24-week study was conducted on 28 patients with hydroxypropyl chitosan and hydroxypropyl chitosan lacquer. The intervention was well received by all patients and resulted in a 72% reduction in perforation and a 60% reduction in leukonychia and onycholysis. Other effective treatments for nail psoriasis include tacrolimus, fluorouracil, topical cyclosporine, tazarotene, and anthralin. In severe cases, radiotherapy may be used. [21]
Further information [22]
• Removal or removal of sores
Supplements
Any form of malnutrition can impair the growth of nails. These dietary recommendations may help reduce symptoms. Avoid foods that may contain allergens, such as dairy, wheat (gluten), corn, preservatives and food additives. A doctor may recommend food intolerance testing. Avoid processed foods, use healthy fats in food, reduce excess fat, avoid unnecessary coffee and other toxins, alcohol and tobacco, drink 6-8 glasses of water a day and get minutes of physical activity, at least 30 minutes a day. Omega-3 fatty acids, probiotic supplements, L-glutamine, etc. Nutritional supplements such as can help with malnutrition. [24]
Medicinal Herbs
Medicinal Herbs are a great way to care for and heal your body. Before doing anything, the doctor must first know the cause. The herb is available in dry alcohol, glycerin and other forms of alcohol. A teaspoon of green tea can be added to a glass of hot water to make tea. It is recommended to drink 2-4 glasses of water a day. The tincture may be used alone or in combination as indicated. Tea tree oil, green tea and reishi mushroom are examples of
herbs that can be used. [25]
Homeopathy
Many studies have been conducted to determine the effectiveness of various homeopathic medicines. Professional homeopaths may recommend one or more of the following treatments for nail problems, based on their prior knowledge and medical knowledge. Homeopathy treats the body, mind and soul. Expert homeopaths take all these factors into consideration when choosing the best treatment for a particular individual. For example, marigold and
Sulfur water. [26]
Acupuncture
Acupuncture can help with body functioning, digestion, and resolving medical problems. [27] Preventing common nail problems [28,29,30] Apply nail oil regularly throughout the day. Make sure to press the oil into the nails and droops. Wear gloves when working in your garden or when the weather gets cold. Wear rubber gloves or disposable plastic pants to protect your hands from excess water, liquids, and other chemicals.
To prevent nail infections [31,32]
To avoid problems with artificial nails [33,34]
CONCLUSION
Nail disease can occur at any age. Approximately half of nail infections are due to infectious diseases, 15% are due to inflammatory or metabolic conditions, and 5% are due to deformities and disorders. Nail disease is a common reason for dermatological consultation. They are evaluated by clinical examination, dermatoscopy, visual examination, microbiology (including mycology) and histopathological examination. Bacterial nail infections are rarer than colonization. Groups at high risk for nail infections include diabetics, dialysis patients, organ transplant recipients, and cancer patients.
REFERENCES
Sanika Ladhaikar*, Sharvari Pande, Gagan Shendre, Dhammadip Nandgaye, The Factors, Identification and Management of Nail Disorders, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 5, 4150-4161. https://doi.org/10.5281/zenodo.15510102