View Article

  • A Comprehensive Overview On Ruellia Patula
  • 1*Associate professor, Department of Pharmaceutical Chemistry, College of Pharmacy, Shree Venkateshwara College of Paramedical Sciences, Gobi.Tamilnadu-638455
    1Principal, Head of the Department of Pharmaceutics, College of Pharmacy, Shree Venkateshwara College of Paramedical Sciences, Gobi-Tamilnadu-638455
    2B. Pharm final year student, College of Pharmacy, Shree Venkateshwara College of Paramedical Sciences, Gobi-Tamilnadu-638455

Abstract

Ruellia patula (syn.Dipteracanthus patulus Nees) is commonly known as Chilanthinayagam, Sisodi, Kirandhinayagam and Tutadi. It is a small, hairy undershrub distributed in various regions like Sri Lanka, India, Pakisthan, Burma, Arabia and Africa. Phytochemical studies had revealed the presence of tannins, lignans, saponins, flavonoids and steroids. Pharmacological studies done by many researchers had proved the existence of Anti-bacterial, Anti-inflammatory, Anti-ulcer, Anti-mutagenic, Anti-oxidant, Wound healing and Hepatoprotective activity. It is also used to treat various diseases including gonorrhea, sore eyes, renal infection, kidney stones, dental problems, stomach ache, syphilis, tumors, Rheumatic complaints, itches, insect bites, cough, scalds, paranchia and act as cardiotonic and anti-ulcer agent. Still now, scientific validation of various traditional uses would be appreciated, particularly to explore and authenticate several novel biologically active compounds of this herb. This review article shows the comprehensive benefits of Ruellia patula in phytotherapy. It enables the scientists to discover the further potential of this herb in other biomedical applications.

Keywords

Diperacanthus patulus, n-Hexadecanoic acid; 9,12, Octadecanoic acid (Z, Z), prokaryotic, Linalool, Paranchia, ?-carotene, Cardiotonic

Reference

  1. J W Prakash, R D Anpin Raj, N Asbin Anderson, Christhudas William, G S Regini, K Bensar , R Rajeev , S Kiruba , S Jeeva & S S M Das , "Ethnomedicinal plants used by Kani tribes of Agasthiyarmalai biosphere reserve, southern Western Ghats" , Indian Journal of traditional knowledge vol. 7(3) , July 2008 , pp. 410-413.
  2. William A R & Thomson M D, Healing plants, (McMilan Ltd, LONDON), 1978.
  3. S. Gopalakrishnan, K. Saroja and J. Dulcy Elizabeth, "GC-MS analysis of the methanolic extract of the leaves of Dipteracanthus Patulus (Jacq.) Nees, Journal of Chemical and Pharmaceutical Research., 2011, 3(3):477-480.
  4. KC Murugasamudaliar. Guapadam (Siddha Material Medica - Vegetable section [in Tami] Prat 1,6th ed. Directorate of Siddha System of Medicine, Madaras.1988; p.361.
  5. VK Singh, A.M.Khan. Medicial plants and Publishers, New Delhi. 1990;250.
  6. JW Prakash, RDA Raja, NA Anderson, C Williams, GS Regini, K Bensar, R Rajeev, S Kiruba, S Jeeva, SSM Das. IJTK.2008, 7, 410-413.
  7. Mamdouh N. Samy, Hany E. Khalil, Sachiko Sugimoto, Katsuyoshi Matsunami, Hideaki Otsuka, Mohamed S. Kamel. "Biological studies on chemical constituents of Ruellia patula and Ruellia tubersa". Journal of pharmacognosy and phytochemical 2015; 4(1): 64-67.
  8. Willis, JC, "A Dictionary of the Flowering Plants and Ferns", 8th Ed., Cambridge University Press, London, New Rochelle, Melbourne Sydney, 1973, 5.
  9. Trease GE, Evans WC. Pharmacogosy". 15th Ed., Baillere and Tindall Press, Londo 2002; 35:471.
  10. Flora of Peninsular India, Indian Institute of Science.
  11. Gansh H (2017) Anti-ulcer and Wound Healing activities of Dipteracanthus patulus (Jacq) Leaf Extract. Master thesis, Arulmigu Kalasalingam College of  Pharmacy, Krishnankoil.
  12. Bailey LH."The standard Cyclopedia of Horticulture", Vol. I, the MacMillian Company, 1963, 73-74.
  13. Metcafe CR, Chalk L. "Anatomy of the Dicotyledons" Vol II, Clarendo Press, Oxford, 1972,1014.
  14. Karthika C, Yogeshwari G, Murugantham K, Manivannan S, ?Phytochemical analysis of Ruellia Patula using Gas Chromatography- Mass Spectrometry?, Asian Journal of Pharmaceutical and Clinical Research, vol 9, Issue 2, 2016.
  15. Bhuvaneswari S, Manivannan S, Anti-diabetic and anti-inflammatory activity of Carlluma adscendens war. Adscendens. Int J Pharm Bio Sci 2015, 5:42-9.
  16. S.Ramdevi , B. Kaleeswari , P.Natarajan , ?Phytochemical analysis and antimicrobial activity of Ruellia Patula  L. against pathogenic microorganisms? , South Indian Journal of Biological Sciences 2016 ; 2(2);319-326.
  17. Adegoke AA, Iberi PA, Akinpelu DA, Aiyegoro OA, Mboto Ci (2010). ?study on phytochemical screening and antimicrobal potentials of Phyllanthus amarus against multiple antibiotics resistant bacteria?. International Journal of Applied Research in National Produts, 3(3), 6-12.
  18. Ahmad I, Mohammed F (1998). ?screening some indian medical plants for their antimicrobial properties?. Journal of Ethnopharmacology, 62, 183-193.
  19. Shrinivas B Bumrela and suresh R Naik, ?Identification of ?-carotene and ?-sitosterol in methanolic extract of Dipteracanthus Patulus (Jacq) nees and their role in antimicrobial and antioxidant activity?, International Journal of Phytomedicine 3 (2011) 204-215.
  20. Chirangini P, Amit K, Pandey BN, Sharma GJ, Mishra KP. Herbal for human health and disease: prospects and challenges in 21st century. In: Sharma AK, Arora R, editiors. Herbal drugs - A Twenth first century Perspective. New delhi: Jaypee Brothers Medical Publishers; 2006, P. No :1-7.
  21. Mudiganti Ram Krishna Rao, Ayub Alam and Kumari Sangeeta Singh,’ ’Preliminary Phytochemical analysis of different extracts of Ruellia Patula, Luffa aegytiaca and Thunbergia alata’’, Journal of Chemical and Pharmaceutical Research, 2015, 7(10):315-320.
  22. KR Kirtikar, BD Basu. Indian Medicinal Plants. Vol. 3. Dehrabum: International Books Distributors; 2005. Pp. 1863-5.
  23. S Selva Kumar, M Ram Krishna Rao, Pavunraj, D B Hattacharya. J of pharmcy Research 2012, 5(8), 4271-4272.
  24. S Selva Kumar, M Ram Krishna Rao, Umar Mustaq Dar, Peerzadh Gh. Jeelai. J of pharmacy Research, 2012,5(7), 3734-3739.
  25. Kannika parameswari Nachimuthu, Chinnaswamy Palanisamy, Physiochemical analysis and HPLC-PDA METHOD for quantification of stigmasterol in Dipteracanthus patulus (Jacq.) Nees, Journal of Pharmacy Research 7 (2013) 741-746.
  26. Fazal Hina, Ahmad Nisar, Ajad Khan Mir. ?Physio-chemical, Phytochemical evaluation and DPPH-Scavenging antioxidant potential in medicinal plants used for herbal formulation in pakistan’’. Pak J Bot.2011, 43:63-67.
  27. Chemmugil P, Lakshmi PTV, and Annamalai A,’’A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq, Avicenna Journal of Medical Biotechnology vol.11, No.1.
  28. Sanjay Yadav, Vedprya Arya, Sandeep Kumar, Jaya Parkash Yadav,’’Anti-inflammatory activity of roots, leaves and stem of Dipteracanthus patulus (Jacq) Nees (Acanthaceae )’’. Asian Pacific Journal of Tropical Biomedicine 2012;2(1): S187-S191.
  29. Ramadevi S, Kaleeswaran B, Natarajan P. Phytochemicals analysis and antimicrobial activity of Ruellia patula L. against pathogenic microorganisms. South Indian Journal of Biological Sciences 2016;2(2);319-326.
  30. Yuvaraja K R, Santhiagu A, Jasemine S, Gopalasatheeskumar K,’’Hepatoprotective activity of Chloroform and Ethyl acetate extract of Dipteracanthus Patulus against Paracetamol induced Hepatotoxicity in rats through Antioxidant mechanism’’ , 2020.
  31. Maninikandan A, Victor AD. Effect of 50% hydroethanolic leaf extracts of Ruellia tuberosa L. and Dipteracanthus patulus (Jacq.) on AST, ALT, ACP and ALP levels in serum, liver and kidney of alloxan induced diabetic rat. Annals of pharmacy and pharmaceutical sciences.210;1(2):142-146.
  32. Manikandan A, Victor AD, Evaluation of biochemical contents, nutritional value, trace                                            elements, SDS-PAGE and HPLC profiling in the laves of Ruellia tuberosa L. and Dipteracanthus patulus (Jacq.). J Chm. Pharm. Res2010;6(3):295-303
  33. Sanjay Yadav, Vedparaya Arya, Sandeep kumar, Jaya parkash Yadav,’’Anti-inflammatory activity of roots, leaves, and stem of Dipteracanthus Patulus (Jacq.) Nees (Acanthaceae)’’, Asian Pacific Journal of Tropical Biomedicine (2012) S187-S191
  34. Mamdouh Nabil samy, Sachiko Sugimoto, Katsuyoshi Masunami, Hideaki Otsuka, Mohamed salah kamel,’’Chemical Constituents and Biological Activites of GENUS RUELLIA’’, International Journal of Pharmacognosy samy et al., IJP, 2015; Vol. 2(6); 270-279.
  35. Chemmugil P, P T V Lakshmi and Annamalai, ’Exploring the phyto-constituents of Ruellia patula (Acanthaceae) as Antibacterial Agent’’, EC Microbiology 7.5(2017):133-148.
  36. Sanjay Yadav, Vedpriya Arya, Pawan Kumar and J. P. Yadav, Evaluation of genetic Variability Among Dipteracanthus Patulus (jacq) Nees. Assessions using RAPD Markers, society for environment and development, (India) 6 (2011) 145-153
  37. M.Farid Akhtar Shahid Rashid, Mansoor Ahmad k. Usmanghani,’’Cardiovascular Evaluation of Ruellia Patula and Ruellia Brittoniana’’, Journal of Islamic Academy of Sciences 5:1, 67-71, 1992.
  38. P. Muthumani, S. Venkatraman, R.Meera, P. Devi, V. Kameswari, B.Eswarapriya. “Phytochemical investigation of Ruellia patula, Luffa cylindrica and Llephantopus scaber”, Der Pharama Chemica; 2009.
  39. K. Saroja, J.Dulcy Elizabeth and S. Gopalakrishnan. “Wound Healing activity of Dipteracanthus patulus (Jacq.) Nees”, Pharmacologyonline 2: 462-469 (2009).
  40. Mamdouh Nabil Samy, Hany Ezzat Khalil, Sachiko Sugimoto, Katsuyoshi Matsunami, Otsuka and Mohamed Salah Kamel. Three New Flavonoid Glycosides, Byzantionoside B 6’-O-Sulfate and Xyloglucoside of (Z)-Hex-3-en-1-ol-from Ruellia patula. Chem. Pharm. Bull. 59(6) 725-729 (2011).
  41. N. Kannikaparameswari & P.Chinnaswamy. Exploration of Antimutagenic Properties of Methanolic Extract of Leaves of Dipteracanthus patulus (Jacq.) Nees. International Journal of Medicine and Pharamaceutical Science (IJMPS) ISSN(P): 2250-0049: ISSN(E): 2321-0095, Vol.4.
  42. Yuvaraja K R, Santhiagu A, Jasemine S, Gopalasathees kumar K, Antioxidant Potential of Medicinally Important Plants Ehretia microphylla, Dipteracanthus patulus and Hydnocarpus Laurifolia, International Journal of Biology, Pharmacy and Allied Sciences (IJBPAS),2020, 9(2):195-205.
  43. A Manikandan and D Victor Arokia Doss, Antiulcer Activity of 50% Hydroethanolic Leaf Extract of Ruellia tuberosa I. and Dipteracanthus patulus (Jacq) On Pylorus Ligated Gastric Ulcer Model. 
  44. Kaplanski G, Marin V, Montero-Julian F, Mantovani A, Farnarier C. IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends in Immunology. 2003;24(1): 25–29.
  45. Yung-Jia Chiu , Tai-Hung Huang, Chuan-Sung Chiu, Tsung-Chun Lu, Ya-Wen Chen, Wen-Huang Peng, Chiu-Yuan Chen. Analgesic and Anti-inflammatory Activities of the Aqueous Extract from Plectranthus amboinicus (Lour) Spreng: Both In-vitro and In- vivo. Evidence-Based Complementary and Alternative Medicine.2012
  46. Vermelho, A.B.; Bastos, M.C.F.; Branquinha, M.H.S. Bacteriologia Geral. Virtual Healthy Llibrary.2007. 
  47. Praveena Bhatt, Pradeep S. Negi.Antioxidant and Antibacterial Activities in the Leaf Extracts of Indian Borage (Plectranthus amboinicus).Food and Nutrition Sciences. 2012;3(2):146-152

Photo
MOUNIKA.K
Corresponding author

Associate professor, Department of pharmaceutical chemistry, Shree venkateshwara college of paramedical sciences, Gobi, Tamilnadu -638455

Photo
Dr. K. B. Ilango
Co-author

Principal, Head of the Department of Pharmaceutics, College of Pharmacy, Shree Venkateshwara College of Paramedical Sciences, Gobi-Tamilnadu-638455

Photo
Subashini V.
Co-author

B. Pharm final year student, College of Pharmacy, Shree Venkateshwara College of Paramedical Sciences, Gobi-Tamilnadu-638455

Mounika K1*, Dr K B Ilango1, Subashini V 2, A Comprehensive Overview On Ruellia Patula, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 365-377. https://doi.org/ 10.5281/zenodo.10149628

More related articles
Identify And Evaluate The Phytochemical Properties...
Suraj Dewangan, Victor Lal, Vasundhara Jaiswal, Shruti Rathore, D...
Studies On Effect Of Supplementation Of Ascorbic A...
Nagendra Singh , Akhil Patel , Suresh Kumar , Megha Pande , Vijay...
Approaching The Spectrum Of Coma: A Case Study On ...
Indranil Chatterjee, Sourav Mandal, Suchetan Sarkar, Sagarika Gho...
Formulation Development And Evaluation Of Gastroretentive Floating Tablets Of Cl...
Kajal A Choursiya, Sachin M Nikam, Khanderao R Jadhav, Rishikesh S Bachhav, ...
To Ensure Patient Safety In Bhaktivedanta Hospital & Research Institute By Conti...
Deepak Mali, Narendra Pande, Haripriya Tinani , Gajanan Ramtake, Ila Gosh , Kailas M., Sivaprasad G....
Phytochemical Analysis and Antidepressant activity of Ethanolic Extract of Amara...
Rimsha Parveen, Dilip Kumar Tiwari, Abhishek Sharma, Mehta Parulben D, Priyanka Namdeo, ...
Related Articles
Formulation And Evaluation Of Herbal Anti-Bacterial Crack Heel Ointment Using Th...
Ms.Priyanka Raut, Mrs.Manisha Mishra, Gayatri Bawane, Ayushi Ambade, Alshapha Anjum Khan, Abhilasha ...
Cyclodextrin Based Nanosponges: A Novel Approach For Targeted Drug Delivery...
Kanika, Chinu Kumari, Dev Prakash Dahiya, Nikhil Rana, Rahul Sharma, Abhilash Rai, Abhishek Soni, ...
Formulation and Evaluation Of Herbal Blood Purifier Syrup...
Garje Bajirao Baban, Katkar Vaishnavi , Garje Sanjay, Sayyed G. A., ...
Formulation and Evaluation of Herbal Hair Conditioner...
Kaveri H. Sonawane, Gauri S. Chaure, Balu T. Jagtap, ...
Identify And Evaluate The Phytochemical Properties Of Ashoka Bark In Fibroids...
Suraj Dewangan, Victor Lal, Vasundhara Jaiswal, Shruti Rathore, Divyani Soni, ...
More related articles
Identify And Evaluate The Phytochemical Properties Of Ashoka Bark In Fibroids...
Suraj Dewangan, Victor Lal, Vasundhara Jaiswal, Shruti Rathore, Divyani Soni, ...
Studies On Effect Of Supplementation Of Ascorbic Acid On Post Thaw Sperm Acrosom...
Nagendra Singh , Akhil Patel , Suresh Kumar , Megha Pande , Vijay Singh , R.A. Siddique , ...
Approaching The Spectrum Of Coma: A Case Study On Various Ways To Recover Patien...
Indranil Chatterjee, Sourav Mandal, Suchetan Sarkar, Sagarika Ghosh, ...
Identify And Evaluate The Phytochemical Properties Of Ashoka Bark In Fibroids...
Suraj Dewangan, Victor Lal, Vasundhara Jaiswal, Shruti Rathore, Divyani Soni, ...
Studies On Effect Of Supplementation Of Ascorbic Acid On Post Thaw Sperm Acrosom...
Nagendra Singh , Akhil Patel , Suresh Kumar , Megha Pande , Vijay Singh , R.A. Siddique , ...
Approaching The Spectrum Of Coma: A Case Study On Various Ways To Recover Patien...
Indranil Chatterjee, Sourav Mandal, Suchetan Sarkar, Sagarika Ghosh, ...