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  • A Novel Simultaneous Estimation Of Ramipril And Olmesartan Medoxomil By First Derivative UV Spectrophotometric Method In Solid Dosage Forms
  • 1* Research Scholar, Sunrise University, Alwar, Rajasthan, India.
    2 Institude of pharmaceutical science and Research (For Girls) Swami-Chincholi (Bhigwan), Maharashtra, India
    3 Research Scholar, Sunrise University, Alwar, Rajasthan, India.  
     

Abstract

A new, simple rapid and novel spectrophotometric method has been developed for simultaneous estimation and first order derivatives of Ramipril and Olmesartan Medoxomil. The method involved measurement of absorbance at two wavelength 208nm (RAM) 256 nm (OLM). The Beer’s law obeyed the concentration range of 5-50µg/ml for both OLM and RAM 5-50µg/mL for both drugs. The R2 values were found to be 0.996 and 0.994for Olmesartan and Ramipril respectively. Percentage Assay and Recovery were found to be 99.9-99.3% for Olmesartan and Ramipril. The method was validated statistically and by recovery studies. The method shows good linearity, accuracy, and precision, limit of detection and limit of quantification. Both these methods have been successively applied to pharmaceutical formulation and were validated according to ICH guidelines. This method can be successfully employed for the routine simultaneous estimation of OLM and RAM in pharmaceutical dosage forms

Keywords

Olmesartan Medoxomil, Ramipril, Estimation, Spectrophotometry, Dosage form.

Reference

  1. Raman N. Kachave, Rajendra N. Bhadane, Rajendra Wagh, Deepti Jain. Simultaneous Estimation of Olmesartan Medoxomil and Hydrochlorothiazide by Spectrophotometry in Tablet Formulation. Research J. Pharm. and Tech.2010; 3 (4): 1047-1049.
  2. SK Shah, AJ Asnani Spectrophotometric Method for Simultaneous Estimation of Olmesartan Medoxomil and Amlodipine Besylate in Pharmaceutical Preparations Research J. Pharm. and Tech. 2012; 5(7): 955-957
  3. Nirmal M. Thakke, Dr. Vishnu P. Choudahri Development and validation of a stability indicating RP-HPLC method for simultaneous estimation of Olmesartan Medoxomil and Metoprolol Succinate in pharmaceutical dosage form PharmaceuticalMethods 2012  3(2): 84-89
  4. M. Prasada Rao,  M.Srikanth , K. Umamaheswari Simultaneous estimation of Ramipril and Olmesartan Medoximil by RP-HPLC method International Journal of Pharmaceutical Chemistry and Analysis 2017; 4(4):106-111
  5. Gandla Kumaraswamy, Repudi Lalitha, K. Vijaypraksh Method development and validation for estimation of rufinamide in tablet dosage forms by RP-HPLC International Journal of Pharmaceutical Chemistry and Analysis 2016; 3(2) :99-103
  6. Mithun Rudrapal, Madhavi Usharani Oduri, Nageswara Rao Samidala Development and Validation of RP-HPLC Method for Simultaneous Estimation of Olmesartan and Hydrochlorothiazide in Tablet Dosage Form Oriental Journal of Chemistry An International Open Free Access, Peer Reviewed Research Journal 2015,  31(2):921-926
  7. A. D. MALI,  U. B. MORE Development And Validation Of Rp-Hplc Method For Simultaneous Estimation Of Impurities From Olmesartan Medoximil And Hydrochlorothiazide Tablet International  Journal of Pharmaceutical and science  2016, 8( 5) 45-48
  8. Suryadevara V, Reddyvalam L, Ballipalli V, Koduri T, Marupudi R. Method development and validation for simultaneous estimation of Olmesartan Medoxomil and Hydrochlorothiazide by Rp-Hplc. Oriental J Chem 2004;30:195-201.
  9. Patel U, Chokshi A, Desai P. Development and validation of rp-hplc method for determination of hydrochlorothiazide, Olmesartan medoxomil and their related substances in combined tablet dosage form. Int J Pharm Pharm Sci 2014;6:9.
  10. Laeis P, Puchler K, Kirch W. The pharmacokinetic and metabolic profile of olmesartan medoximil limits the risk of clinically relevant drug interaction. J Hypertension 2001;19:21-32.
  11. Rai M, Kawde PB. Simultaneous determination of olmesartan amlodipine besylate and hydrochlorothiazide in tablet dosage form by using stability-indicating HPLC method. Res J Pharm Biol Chem Sci 2013;4:560-7.
  12. Raj ND, Anbazhagan S, Kunapareddy A, Sunkara N, Chusena N. Validated stability indicating gradient RP-HPLC method for the estimation of antihypertensive drugs in bulk and pharmaceutical dosage. Int Curr Pharm J 2012;1:336-40.
  13. Dongyang L, Hua Pei B, Nobuka A, Xiaoming Ji. Quantitative determination of Olmesartan in human plasma and urine by liquid chromatography coupled to tandem mass spectrometry. J Chromatography B: Biomed Sci Appl 2007;856:190-7.
  14. Mehulkumar P, Ramesh V, VinaykumarSrinivas R, Diwan PV, Simultaneous spectroscopic estimation of Amlodipine besylate and Olmesartan Medoximil in tablet dosage form, Asian J Res Chem. 2009;2:127-130.
  15. Popat B.Mohite, Ramdas B.Pandharea , Vaidhun H.Bhaskar Simultaneous Estimation of Ramipril and Telmisartan in Tablet Dosage Form by Spectrophotometry Eurasian J. Anal. Chem.2010, 5(1): 89-94

Photo
Priti R. Kale
Corresponding author

Sunrise University Alwar Rajsthan

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Vishal Babar
Co-author

Institute of pharmaceutical sciences and research for girls Swami chincholi bhigwan

Photo
Ashish B. jadhav
Co-author

Sunrise University Alwar Rajsthan

Priti R. Kale, Vishal B. Babar, Ashish B. Jadhav, Analytical Method Validated Techniques For The Simultaneous Estimation Of Olmesartan Medoxomil And Ramipril By RP-HPLC Method, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 23-31. https://doi.org/10.5281/zenodo.10450843

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