1* Research Scholar, Sunrise University, Alwar, Rajasthan, India.
2 Institude of pharmaceutical science and Research (For Girls) Swami-Chincholi (Bhigwan), Maharashtra, India
3 Research Scholar, Sunrise University, Alwar, Rajasthan, India.
A new, simple rapid and novel spectrophotometric method has been developed for simultaneous estimation and first order derivatives of Ramipril and Olmesartan Medoxomil. The method involved measurement of absorbance at two wavelength 208nm (RAM) 256 nm (OLM). The Beer’s law obeyed the concentration range of 5-50µg/ml for both OLM and RAM 5-50µg/mL for both drugs. The R2 values were found to be 0.996 and 0.994for Olmesartan and Ramipril respectively. Percentage Assay and Recovery were found to be 99.9-99.3% for Olmesartan and Ramipril. The method was validated statistically and by recovery studies. The method shows good linearity, accuracy, and precision, limit of detection and limit of quantification. Both these methods have been successively applied to pharmaceutical formulation and were validated according to ICH guidelines. This method can be successfully employed for the routine simultaneous estimation of OLM and RAM in pharmaceutical dosage forms
Priti R. Kale, Vishal B. Babar, Ashish B. Jadhav, Analytical Method Validated Techniques For The Simultaneous Estimation Of Olmesartan Medoxomil And Ramipril By RP-HPLC Method, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 23-31. https://doi.org/10.5281/zenodo.10450843
10.5281/zenodo.10450843
