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  • A Retrospective Study To Evaluate Appropriateness Of Antimicrobial Dosing In Renal Impairment In A Tertiary Care Hospital In Dakshina Kannada District
  • Student, PharmD, Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, India

Abstract

The effects of many drugs get altered in renal impairment. Drug doses should be modified in renal disease in accordance with creatinine clearance. The aim of the study was to analyze the antibiotics with inappropriate dosage based on patient`s renal function according to distinguished guidelines and to evaluate the number of prescribed antibiotics being appropriately adjusted. A retrospective study was conducted by screening the medical records of 100 patients who fulfilled the inclusion criteria. Extent of antimicrobial dosage adjustment was determined by calculating the creatinine clearance using Cockcroft and Gault equation and comparing with Stanford health care guidelines. The mean age of the study participant was 59.8 years with 67% male and 33?male. Out of 112 antimicrobials prescribed 49 antimicrobials were dosed appropriately, 63 required dosage adjustment. When the antibiotics for dosing error were evaluated Inj. Meropenem was associated with most number of dosing error (25.39%) followed by T.Amoxicillin + Clavulanic acid was associated with second most number of dosing error (14.28%). Approximately half of the antimicrobial dosing in renal impairment were inappropriate. Drug dosing should be emphasized in patients with renal impairment. Failure to do so could result in increased morbidity, mortality and therapeutic expenses. Awareness raising and monitoring system for inappropriate dosing is critical to improve the quality of care in patients with renal impairment..

Keywords

Renal impairment, dosage adjustment, creatinine clearance

Reference

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Suvidha
Corresponding author

Department of Pharmacy Practice, Srinivas College of Pharmacy

Viresh K. Chandur, Suvidha*, Ashitha Ephrem, Ramakrishna Shabaraya A., A Retrospective Study To Evaluate Appropriateness Of Antimicrobial Dosing In Renal Impairment In A Tertiary Care Hospital In Dakshina Kannada District, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 227-233. https://doi.org/10.5281/zenodo.10093206

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