View Article

  • A Review On Novel Drug Delivery Systems Used For Delivering Of Drugs Into Ophthalmic Region
  • 1Associate professor, Department of Pharmaceutics, CMR College of pharmacy-501401, Hyderabad. 
    2Department of Pharmaceutics, CMR college of pharmacy, Hyderabad-501401.                   
    3Professor and Principal CMR college of pharmacy, Hyderabad-501401.
     

Abstract

Eye is a very sensitive organ, the dosage forms to be administered are very peculiar. Design of ophthalmic drug delivery systems is a major challenge, as they are to be made to pass various ocular barriers and improve drug bioavailability for a prolong period of time. Conventional delivery systems are employed for administration of drug into the ocular region and find difficult to pass through the barriers of the eye, low bioavailability and potential drug side effects, hence the novel drug delivery systems are developed for effective release of drug and prolong release and more retention time of drug in the ophthalmic region. These novel drug delivery systems offer manifold advantages over conventional systems as they increase the efficiency of drug delivery by improving the release profile and also reduce drug toxicity. Development of novel therapeutic agents continue to provide ocular delivery systems with high therapeutic efficacy. Need to develop ocular drug delivery systems that provide controlled release for the treatment of chronic diseases in order to reduce dosing frequency. The current article gives a quality of information about novel drug delivery system employed in the delivery of drug to optical region.

Keywords

Contact lens, Iontophoresis, Micelles, Microemulsions, Dendrimers

Reference

  1. Paola Franco, Iolanda De Marco. Contact Lenses as Ophthalmic Drug Delivery Systems: A Review, Polymers (2021), 13: 1102.
  2. Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, and Ashim K Mitra. Ocular drug delivery systems: An overview, World J Pharmacol (2013) 2(2): 47–64.
  3. Thakur Raghu Raj Singh, Ismaiel Tekko, Kathryn McAvoy, Ryan F Donnelly, Hannah McMillian, David Jones. Minimally invasive microneedles for ocular drug delivery, Expert Opinion on Drug Delivery (2017)14(4): 1-7.
  4. Lianghui Zhao, Jike Song, Yongle Dua, Cong Ren, Bin Guoa, and Hongsheng B. Therapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases, Drug Delivery (2023), 30(1): 3-9.
  5. Hongyu Yang, Ming Zhao, Dandan Xing, Jian Zhang, Ting Fang, Faxing Zhang, Zhihao Nie, Yaming Liu, Lihua Yang, Ji Li, Dongkai Wang. Contact lens as an emerging platform for ophthalmic drug delivery: A systematic review, Asian Journal of Pharmaceutical Sciences (2023), 18: 1-3.
  6. Victor L. Perez, Barbara Wirostko, Michael Korenfeld, Stephen From, and Michael Raizman. Ophthalmic Drug Delivery Using Iontophoresis: Recent Clinical Applications, Journal Of Ocular Pharmacology and Therapeutics (2020), 36 (2): 3-6.
  7. Dong Weia, Ning Pu, Si-Yu Li, Yan-Ge Wanga and Ye Tao. Application of iontophoresis in ophthalmic practice: an innovative strategy to deliver drugs into the eye, Drug Delivery (2023), 30 (1): 2165736.
  8. Piotr Gadzinski, Anna Froelich, Monika Wojty?ko, Antoni Bia?ek, Julia Krysztofiak and Tomasz Osma?ek. Microneedle-based ocular drug delivery systems–recent advances and challenges, J Nanotechnol (2022), 13: 1167–1184.
  9. Zhiguo Li,a Minting Liu,a Lingjie Ke,a Li-Juan Wang,a Caisheng Wu, Cheng Li, Zibiao Li and Yun-Long Wu.  Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years, Nanoscale Adv (2021), 3.
  10. Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, and Ashim K Mitra. Ocular drug delivery systems: An overview, World J Pharmacol (2013), 2(2): 47–64.
  11. Shiding Li, Liangbo Chen and Yao Fu.  Nanotechnology-based ocular drug delivery systems: recent advances and future prospects, Journal of Nanobiotechnology (2023), 21:232.
  12. Sadek Ahmed, Maha M. Amin., Sinar Sayed. Ocular Drug Delivery: a Comprehensive Review, AAPS Pharm SciTech (2023), 24:66.
  13. Aminu musa Wada, Arsh Chanana, Ravindra Pal Singh, Saadatu Abdulhamid. A Review on Niosomes In Ocular Drug Delivery System (ODDS), International Journal of Pharmaceutical Research and Applications (2022), 7(6):2032-2044.
  14. Bincy William. S. A review on niosomes in ocular drug delivery system, International Journal of Research and Review (2020), 7(10): 13-17.
  15. S. Nagalakshmi, N. Damodharan, J. Thanka, S. Seethalakshmi. Niosomes in Ocular Drug Delivery System: A Review of Magic Targeted Drug Delivery, Int J Pharm Sci Rev Res (2015), 32(1): 61-66.
  16. Rahul Rama Hegde, Anurag Verma, Amitava Ghosh. Microemulsion: New Insights into the Ocular Drug Delivery, ISRN Pharmaceutics (2013), 826798.
  17. Preeti K. Suresh, Geeta Barsa, Abhishek K. Sah and Sanjay J. Daharwal, Ocular implants as drug delivery device in opthalmic therapeutics: An overview, Research J Pharm and Tech (2014), 7(6): 112-114.
  18. Yadav Tejpal, Jat R.K. Microspheres as an ocular drug delivery system-a review, Journal of Drug Delivery & Therapeutics (2013), 3(1): 114-123.
  19. Zimmer A, J & G Kreuter. Microspheres and nanoparticles used in ocular delivery Systems, Advanced Drug Delivery Reviews (1995), 16: 61-73.
  20. Yumei Wu, Yuanyuan Liu, Xinyue Li, Dereje Kebebe, Bing Zhang, Jing Ren, Jun Luf, Jiawei Li, Shouying Dud,Zhidong Liu. Research progress of in-situ gelling ophthalmic drug delivery system, Asian Journal of Pharmaceutical Sciences (2019), 4(1): 1-15.
  21. Asmat Majeed and Nisar Ahmad Khan. Ocular in situ gel: An overview, Journal of Drug Delivery and Therapeutics (2019), 9(1):337-347.

Photo
N. Madhavi
Corresponding author

Associate professor, Department of Pharmaceutics, CMR College of pharmacy-501401, Hyderabad.

Photo
Ch. Sai Kiran
Co-author

Department of Pharmaceutics, CMR college of pharmacy, Hyderabad-501401.

Photo
B. Mounika
Co-author

Department of Pharmaceutics, CMR college of pharmacy, Hyderabad-501401.

Photo
B. Swetha
Co-author

Department of Pharmaceutics, CMR college of pharmacy, Hyderabad-501401.

Photo
T. Rama Rao
Co-author

Professor and Principal CMR college of pharmacy, Hyderabad-501401.

N. Madhavi, CH. Sai kiran, B. Mounika, B. Swetha, T. Rama rao , A Review On Novel Drug Delivery Systems Used For Delivering Of Drugs Into Ophthalmic Region, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 392-402. https://doi.org/10.5281/zenodo.10673356

More related articles
A Review On: Pharmacovigilance Important And Its F...
Supekar Amol V., Tagare Chetan B. , Girhe Akshay R. , Zirpe Pandh...
Formulation And Evaluation Of Herbal Soap For Anti...
Abhishek Y. Desale , Prerna Shirode , Mayur Nikam , ...
Tolvaptan : Vasopressin Antagonist for Hyponatremi...
Kondeti Venkata Surya Siva Kumar, Saripella Latha Sree, Saripella...
Exploring The Multifaceted Mechanisms Of Amphetamines And Their Impact On Neurot...
Arnab Roy, Mahesh Kumar Yadav, Abrarul Haque, Pratik Mondal, Gautam Mahto, Balraj Kumar, Nisha Kumar...
Formulation And Evaluation Of Face Scrub In Modern Pharmaceutics: An Herbal Form...
Kartikay Prakash , Polly Gupta, Shashank Tiwari , Trivid Shukla, Preeti Yadav, ...
A Review On Ultrasound in pharmaceutics ...
Dipti Muntode , Rajeshree Khandre, ...
Related Articles
To Study Relationship Between Body Mass Index And Hypercholesterolemia...
Janvi kachhia , Amee Upadhyay, Janvi Kachhia, Amee Upadhyay, Jignasa Mansuriya, ...
Comparative Analysis Of Drug Labeling Requirements In The USA And India: Regul...
Surbhi H. Makvana, Shrikalp Deshpande, Maitreyi Zaveri, ...
A Review on: Polyherbal Hand wash...
Pathan Shain Mahemood, N. S. Pendbhaje, Sonali D. More, Smeeta L. Chandre, ...
A Review On: Pharmacovigilance Important And Its Future Perspectives ...
Supekar Amol V., Tagare Chetan B. , Girhe Akshay R. , Zirpe Pandhari B. , Tanpure Sidharth S., ...
More related articles
A Review On: Pharmacovigilance Important And Its Future Perspectives ...
Supekar Amol V., Tagare Chetan B. , Girhe Akshay R. , Zirpe Pandhari B. , Tanpure Sidharth S., ...
Tolvaptan : Vasopressin Antagonist for Hyponatremia...
Kondeti Venkata Surya Siva Kumar, Saripella Latha Sree, Saripella Jaya Sree, ...
A Review On: Pharmacovigilance Important And Its Future Perspectives ...
Supekar Amol V., Tagare Chetan B. , Girhe Akshay R. , Zirpe Pandhari B. , Tanpure Sidharth S., ...
Tolvaptan : Vasopressin Antagonist for Hyponatremia...
Kondeti Venkata Surya Siva Kumar, Saripella Latha Sree, Saripella Jaya Sree, ...