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  • A Review on Various Analytical Methodologies for Buspirone
  • 1Assistant Professor, Department of Pharmaceutical Chemistry, Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India.
    2Research Scholar, Department of Pharmacology, VYWS, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India.
    3Assistant Professor, Department of Pharmaceutics, Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India.
    4Assistant Professor, Department of Pharmacognosy, Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India.
    5Assistant Professor, Department of Pharmaceutical Chemistry, TSPM’s Trimurti Institute of Pharmacy, Paldhi, Jalgaon, Maharashtra, India
    6Research Scholar, Department of Pharmaceutical Chemistry, LTJSS, Priyadarshini J. L. College of Pharmacy, Nagpur, Maharashtra, India.
    7Student, TSPM’s Trimurti Institute of Pharmacy, Paldhi, Jalgaon, Maharashtra, India.

Abstract

Buspirone is a psychotropic drug which belongs to the class of compounds known as azaspirodecanediones. Buspirone used primarily as an anxiolytic. It specifically used for generalized anxiety disorder. As an anxiolytic drug buspirone is as potent as benzodiazepines, but it does not cause the adverse side effects, for example sedation, anti-convulsion or muscle relaxation. Buspirone was first approved in 1986 by USFDA. Therefore, the main objective of this analysis of Buspirone in pharmaceutical and biological formulation is in both qualitative and quantitative terms. In this review article, we have summarized UV/Vis spectroscopy, high- performance liquid chromatography (HPLC), High-performance thin-layer chromatography (HPTLC), Liquid chromatography-mass spectroscopy-mass spectroscopy (LC-MS/MS) etc. based methods for estimation of Buspirone. In addition to that, we have discussed the bioanalytical methods for Buspirone analysis. In conclusion, this review article will help to research scholars for further method development for drug estimation in pharmaceutical dosage forms and biological fluids.

Keywords

Buspirone, Psychotropic, Anxiolytic drug, USFDA, Analytical method, High- performance liquid chromatography

Reference

  1. Zayed MA, Fahmey MA, Hawash MA and El-Habeeb AA. Mass spectrometric investigation of buspirone drug in comparison with thermal analyses and MO-calculations. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2007; 67(2): pp.522-530.
  2. Ary K, Rona K, Ondi S and Gachalyi B. 1998. High-performance liquid chromatographic method with coulometric detection for the determination of buspirone in human plasma by means of a column-switching technique. Journal of Chromatography A, 1998; 797(1-2): pp.221-226.
  3. Patil, V., Labade, S., Khilare, C. and Sawant, S. A Molecular Bridge-Like Binding Mode of Buspirone to BSA: Multispectroscopic and Molecular Docking Investigation. Chemical Data Collections 2022; 40: p.100892.
  4. Kartal M, Khedr A and Sakr A. Liquid chromatographic method for the analysis of buspirone HCl and its potential impurities. Journal of chromatographic science, 2000; 38(4): pp.151-156.
  5. https://pubchem.ncbi.nlm.nih.gov/compound/Buspirone#section=Pharmacology-and-Biochemistry
  6. https://go.drugbank.com/drugs/DB00490
  7. https://en.wikipedia.org/wiki/Buspirone#Pharmacology
  8. Spooner N. Dried blood spot sampling for quantitative bioanalysis, time for a revolution. Bioanalysis, 2010; 2: 1781.
  9. DU Q, SUN J, KANG LJ, & YAN GW. Determination of buspirone hydrochloride and its active metabolite in plasma by HPLC. Chinese Journal of Pharmaceutical Analysis, 2003; 23(1): 56-58.
  10. Foroutan SM, Zarghi A, Shafaati A R, & Khoddam A. Simple high-performance liquid chromatographic determination of buspirone in human plasma. Il Farmaco, 2004; 59(9): 739-742.
  11. Péhourcq F. Rapid high?performance liquid chromatographic measurement of buspirone in human plasma after overdose. Biomedical Chromatography, 2004; 18(9): 637-640.
  12. Odontiadis J, & Franklin M. Simultaneous quantitation of buspirone and its major metabolite 1-(2-pyrimidinyl) piperazine in human plasma by high-performance liquid chromatography with coulometric detection. Journal of pharmaceutical and biomedical analysis, 1996; 14(3): 347-351.
  13. Ary K, Rona K, Ondi S, & Gachalyi B. High-performance liquid chromatographic method with coulometric detection for the determination of buspirone in human plasma by means of a column-switching technique. Journal of Chromatography A, 1998; 797(1-2): 221-226.
  14. Kristjánsson F. Sensitive determination of buspirone in serum by solid-phase extraction and two-dimensional high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 1991; 566(1): 250-256.
  15. Gannu R, Yamsani SK, Palem CR, Yamsani VV, Kotagiri H, & Yamsani MR. Development of high performance liquid chromatography method for buspirone in rabbit serum: Application to pharmacokinetic study. Analytica chimica acta, 2009; 647(2): 226-230.
  16. Kim KT, Lee JY, Park JH, Kim MH, Kim JS, Shin HJ, ... & Kim DD. Development of HPLC method for the determination of buspirone in rat plasma using fluorescence detection and its application to a pharmacokinetic study. Chemical and Pharmaceutical Bulletin, 2016; 64(11): 1582-1588.
  17. Aparicio X, Campos A, Gras J, Fernandez E, & Gelpí E. Determination of a buspirone metabolite in plasma samples. Journal of Pharmaceutical and Biomedical Analysis, 1988; 6(6-8): 945-948.
  18. Franklin M. Determination of plasma buspirone by high-performance liquid chromatography with coulometric detection. Journal of Chromatography B: Biomedical Sciences and Applications, 1990; 526: 590-596.
  19. Diaz-Marot A, Puigdellivol E, Salvatella C, Comellas L, & Gassiot M. Determination of buspirone and 1-(2-pyrimidinyl) piperazine in plasma samples by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 1989; 490: 470-473.
  20. Chew WM, Xu MJ, Cordova CA, & Chow HS. Quantification of a cytochrome P450 3A4 substrate, buspirone, in human plasma by liquid chromatography–tandem mass spectrometry. Journal of Chromatography B, 2006; 844(2): 235-239.
  21. Green R, Houghton R, & Jacobs S. Determination of buspirone and its metabolite 1-(2- pyrimidinyl)-piperazine in human plasma by liquid chromatography tandem mass spectrometry. Chromatographia, 2004; 59 (Suppl 2): S197-S201.
  22. Kerns EH, Rourick RA, Volk KJ, & Lee MS. Buspirone metabolite structure profile using a standard liquid chromatographic-mass spectrometric protocol. Journal of Chromatography B: Biomedical Sciences and Applications, 1997; 698(1-2): 133-145.
  23. Joshi P, Rao S, Singh M, Vig N, Singh AK, Rajawat NS, & Gupta A. A sensitive LC-ESI- MS/MS method for the quantification of low concentrations of buspirone in human plasma. Analytical Methods, 2013; 5(24): 7014-7021.
  24. Kivistö KT, Laitila J, Mårtensson K, & Neuvonen PJ. Determination of buspirone and 1- (2-pyrimidinyl)-piperazine (1-PP) in human plasma by capillary gas chromatography. Therapeutic drug monitoring, 1999; 21(3): 317.
  25. Lai CT, Véronique AMT, Rauw GA, Bateson AN, Martin IL, & Baker GB. Rapid, sensitive procedure to determine buspirone levels in rat brains using gas chromatography with nitrogen–phosphorus detection. Journal of Chromatography B: Biomedical Sciences and Applications, 1997; 704(1-2): 175-179.
  26. Kurien J, Kurian T, & Mathew A. Simple spectrophotometric determination of buspirone hydrochloride in bulk drug and pharmaceutical dosage forms. Science & Society, 2012; 10: 147.
  27. Amanlou M, Keivani S, Sadri B, Gorban-Dadras O, & Souri E. Simple extractive colorimetric determination of buspirone by acid-dye complexation method in solid dosage form. Research in Pharmaceutical Sciences, 2009; 4(1): 11-18.
  28. Dhandapani H, Hemamrutha S, Lakshmi Sravanthi K, & Swetha J. Spectrophotometric estimation of buspirone hydrochloride in bulk and its pharmaceutical formulation. Int J of Pharma Sciences and Research, 2010; 1(4).
  29. Kurien J, & Kurian T. A sensitive spectrophotometric method for the quantitative determination of buspirone hydrochloride in pharmaceutical formulations. Hygeia JD Med, 2012; 4: 6-14.
  30. Azmi SNH, Al-Ghafri LT, Al-Ghafri SS, & Al-Haribi MM.  Determination of buspirone HCL in commercial dosage forms by extractive spectrophotometric method and comparison by HPLC method. Sci. J. Anal. Chem, 2015; 3: 91.
  31. Rao B, Nagendrakumar AVD, Maiti S, & Raja G. Validated RP-HPLC method for the determination of buspirone in pharmaceutical formulations. Chromatography Research International, 2011.
  32. Azeem A, Rizwan M, Ahmad FJ, Iqbal Z, Khar RK, Aqil M, & Talegaonkar S. Development and validation of a stability-indicating LC-UV method for rapid analysis of buspirone in pharmaceutical dosage forms. Acta Chromatographica, 2009; 21(2): 283-297.
  33. Zaxariou M, & Panderi I. Development and validation of a high-performance liquid chromatographic method for the determination of buspirone in pharmaceutical preparations. Journal of pharmaceutical and biomedical analysis, 2004; 35(1): 41-50.
  34. Khedr A, & Sakr A. Stability-indicating high-performance liquid chromatographic assay of Buspirone HCI. Journal of chromatographic science, 1999; 37(12): 462-468.
  35. Azmi SNH, Al-Ghafri LT, Al-Ghafri SS, & Al-Haribi MM. Determination of buspirone HCL in commercial dosage forms by extractive spectrophotometric method and comparison by HPLC method. Sci. J. Anal. Chem, 2015; 3: 91.
  36. Kartal M, Khedr A, & Sakr A. Liquid chromatographic method for the analysis of buspirone HCl and its potential impurities. Journal of chromatographic science, 2000; 38(4): 151-156.
  37. Pilvenyt? G, Kazlauskien? D, Marksa M, & Bezruk I. Determination of buspirone, fluoxetine, escitalopram and paroxetine by HPTLC after SPE extraction. In The 22nd annual international scientific-practical conference„ BaltPharm Forum 2019 “„Pharmacists as drug experts: their role in health care system“: April 13-14, 2019 Kaunas, Lithuania: book of abstracts/Lithuanian Pharmaceutical Association. Pharmacists ‘Society of Latvia. Pharmaceutical Society of; Edited by: Vilma Petrikait?. Kaunas: Lithuanian Pharmaceutical Association (LFS), 2019.

Photo
Vikas R. Patil
Corresponding author

Assistant Professor, Department of Pharmaceutical Chemistry, Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India.

Photo
Vinay V. Sarode
Co-author

Research Scholar, Department of Pharmacology, VYWS, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India

Photo
Samir B. Tadvi
Co-author

Assistant Professor, Department of Pharmaceutics, Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India

Photo
Bhushan P. Patil
Co-author

Assistant Professor, Department of Pharmacognosy, Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India

Photo
Vaishali Badgujar
Co-author

Assistant Professor, Department of Pharmaceutical Chemistry, TSPM’s Trimurti Institute of Pharmacy, Paldhi, Jalgaon, Maharashtra, India

Vikas R. Patil*, Vinay V. Sarode, Samir B. Tadvi, Bhushan P. Patil, Vaishali Badgujar, Shweta V. Rane, Kunal M. Jadhav, A Review on Various Analytical Methodologies for Buspirone, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 6, 56-64. https://doi.org/10.5281/zenodo.8033198

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