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Abstract

The term "cancer" encompasses a wide range of diseases that share the common feature of abnormal cell growth and uncontrolled spread within the body. In HER2- positive breast cancer, there is an amplification or overexpression of the HER2 gene, leading to increased production of the HER2 protein on the surface of cancer cells. By 2050, it is estimated that the number of breast cancer cases will reach 3.2 million. Breast cancer arises from a combination of genetic and environmental factors, making its etiology multifactorial in nature. BRCA1 and BRCA2, genes increase the risk. Hormonal factors, age, reproductive history, lifestyle choices, obesity, radiation exposure, and certain environmental factors contribute to the development of breast cancer. Possible signs and symptoms of breast cancer encompass a breast lump or thickening, alterations in breast size or shape, nipple discharge or inversion, skin dimpling or puckering, redness or scaliness of the breast skin, and enduring breast or nipple discomfort. Diagnostic tests for breast cancer include mammography, ultrasound, magnetic resonance imaging (MRI), and breast biopsy. The management of HER2-positive breast cancer involves a multimodal approach. It includes targeted therapies like trastuzumab, pertuzumab, and ado- trastuzumab emtansine, chemotherapy, surgery (lumpectomy or mastectomy), radiation therapy, and hormonal therapy.

Keywords

HER2-positive breast cancer, BRCA1, BRCA2 genes, mammography, ultrasound, magnetic resonance imaging (MRI), trastuzumab, pertuzumab, trastuzumab emtansine, chemotherapy, surgery, radiation therapy, and hormonal therapy

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K. Sireesha
Corresponding author

Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India.

Photo
P. Shivani Naidu
Co-author

Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India.

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P. Lakshmi Prasanna
Co-author

Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India.

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A. Renuka
Co-author

Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India.

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G. Manas Kumar
Co-author

Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India.

K. Sireesha*, P. Shivani Naidu, P. Lakshmi Prasanna, A. Renuka, G. Manas Kumar, An Overview of Her 2 Neu Positive Breast Cancer, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 8, 89-95. https://doi.org/10.5281/zenodo.8244932

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