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  • Aspirin: A Review On Analytical Method Development And Validation For Tablet Dosage Form By UV Visible Spectroscopy

  • Department of Pharmaceutical Chemistry, K. B. H. S. S. Trust’s Institute of Pharmacy & Research Centre, affiliated to Savitribai Phule Pune University, Bhayegaon, Malegaon, Nashik, Maharashtra, India.

Abstract

Aspirin is the efficacious as antipyretic, analgesic, and anti-inflammatory. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and pharmacodynamics and pharmacokinetic studies as well as stability study. The literature from numerous journals pertaining to analytical and pharmaceutical chemistry has been thoroughly reviewed, and instrumental analytical methods that were developed and used for determining the presence of a drug alone or in combination with other drugs in bulk drugs, formulations, and biological fluids have been examined. This review covers the most recent many analytical methods including spectrophotometric methods, chromatographic method including HPLC, HPTLC and RP HPLC, liquid chromatography were reported.

Keywords

Aspirin, Method development, validation

Reference

  1. Suresh Kumar S, Jamadar LD, Bhat K, Musmade PB, Vasantharaju SG, Udupa N. Analytical method development and validation for aspirin. International Journal of ChemTechResearch. 2010;2(1):389-99.
  2. Kokot Z, Burda K. Simultaneous determination of salicylic acid and acetylsalicylic acid in aspirin delayed-release tablet formulations by second-derivative UV spectrophotometry. Journal of pharmaceutical and biomedical analysis. 1998 Dec 1;18(4-5):871-5.
  3. Franeta JT, Agbaba D, Eric S, Pavkov S, Aleksic M, Vladimirov S. HPLC assay of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets. Il Farmaco. 2002 Sep 1;57(9):709-13.
  4. Hobl EL, Jilma B, Ebner J, Schmid RW. Simultaneous determination of acetylsalicylic acid and salicylic acid in human plasma by isocratic high?pressure liquid chromatography with post?column hydrolysis and fluorescence detection. Biomedical Chromatography. 2013 Jun;27(6):695-8.
  5. Ramos-Martos N, Aguirre-Gómez F, Molina-Díaz A, Capitán-Vallvey LF. Application of liquid chromatography to the simultaneous determination of acetylsalicylic acid, caffeine, codeine, paracetamol, pyridoxine, and thiamine in pharmaceutical preparations. Journal of AOAC International. 2001 May 1;84(3):676-83.
  6. Šatínský D, Neto I, Solich P, Sklená?ová H, Conceicao M, Montenegro BS, Araújo AN. Sequential injection chromatographic determination of paracetamol, caffeine, and acetylsalicylic acid in pharmaceutical tablets. Journal of Separation Science. 2004 May;27(7?8):529-36.
  7. Patel M ,Trivedi D,Shah U. Development and validation of UV visible Spectrophotometric method for simultaneous estimation of aspirin and 5-fluorouracilin bulk and dosage form..Nirmala university Journal of pharmaceutical science.2020;7(1):49-62
  8. Chaudhari S, Rane S.Development and validation of analytical methods for the simultaneous estimation of rosuvastatin and aspirin dosage in combine dosage form. Indo American Journal of Pharmaceutical Research.2020;10(1):580-7
  9. Raja Reddy, N.Divya, P.Pravalika, S. Hashika Keerthana, R.Kiran. Spectrophotometric Determination of Aspirin by Using FC Reagent. Int. J. of Res. in Pharmacology &Pharmacotherapeutics [Internet]. 2023Apr.28 [cited 2024Jan.19];12(2):93-7. Available from: https://ijrpp.com/ijrpp/article/view/473
  10. Emine A, Gül Gönül K, and Mine G. Development and Validation of a Novel Analytical Method for the Determination of Dissolution Rate of Acetylsalicylic Acid in Enteric-Coated Tablet Dosage Form by Liquid Chromatography. Glob J Pharmaceu Sci. 2020; 8(2): 555732. DOI: 10.19080/GJPPS.2021.08.555732.
  11. Kirchhoefer RD. Simultaneous determination of aspirin and salicylic acid in bulk aspirin and in plain, buffered, and enteric-coated tablets by high-pressure liquid chromatography with UV and fluorescence detectors. Journal of pharmaceutical sciences. 1980 Oct 1;69(10):1188-91.
  12. Sinha PK, Damle MC, Bothara KG. A validated stability indicating HPTLC method for determination of aspirin and clopidogrel bisulphate in combined dosage form. Eurasian journal of analytical chemistry. 2009 Jul 1;4(2):152-60.
  13. Kitamura k, Takagi m, Hozumi k. Determination of aspirin and salicylic acid in aspirin tablets by second derivative ultraviolet spectrometry. Chemical and pharmaceutical bulletin. 1984 Apr 25;32(4):1484-90.
  14. Anthony O, Moh’d HS, Mataka MA, Juma A, Odalo OJ. A Comparative Anaylsis of Aspirin from Various Analgesic Formulations Using Titrimetry, Spectroscopic and Hypenated Chromatographic Techniques. J Mol Imaging Dynamic. 2017;7(134):2.
  15. Villari A, Micali N, Fresta M, Puglisi G. Spectrofluorimetry at zero angle: determination of salicylic acid in an acetylsalicylic acid pharmaceutical formulation. Analyst. 1994 Jan 1;119(7):1561-5.
  16. Drugbank. Aspirin [Internet]. go.drugbank.com. 2023. Available from: https://go.drugbank.com/drugs/DB00945
  17. Indian Pharmacopeia-2010, Indian Government Health and Welfare Society, Ghaziabad, pp843
  18. British Pharmacopoeia-2009, Official Monograph of Aspirin, pp1-5.
  19. USP30-NF25, Pharmacopeia Forum: Volume No. 29(6) pp 1446.
  20. Kumar SS, Jamadar LD, Bhat K, Musmade PB, Vasanthrsju SG, “Analytical Method Development and Validation for Aspirin” Int. J. Chem. tech. Res., 2010, 2(1), 389-399.
  21. Tstvetkova BG, Pancheva IP, Peikov PT, “Development and validation of RP-HPLC method for simultaneous determination of metoprolol and aspirin in fixed dose combinations” Der pharma chemical, 2012, 4(4), 1512- 1516.
  22. Yadav S, Rao JR, “RP-HPLC Method for Simultaneous Estimation Of Aspirin, Ramipril, Hydrochlorothiazide, Simvastatin And Atenolol From Pharmaceutical Dosage Form” Int. J. Pharm and pharm. Sci., 2014, 6(9), 443-448.
  23. Jain DK, Jain N, Verma J, “RP-HPLC Method for Simultaneous Estimation of Aspirin and Prasugrel in Binary Combination” Int. J. Pharm. Sci. And drug res., 2012, 4(3), 218-221
  24. Patel SM, Patel CN, Patel VB, “Stability indicating HPLC Method for Simultaneous Determination of Aspirin and Prasugrel” Int. J. Pharm. Sci., 2013, 75(4), 413-419.
  25. Leandro KC, Abrantes MB, “Development of a new analytical method for determination of acetylsalicylic and salicylic acids in tablets by reversed phase liquid chromatography” Braz. J. Pharm.sci., 2009, 45(4), 723-727.
  26. Bhusari VK, Dhaneswar SR, “Validated HPLC Method for Simultaneous Quantitation of Amlodipine Besylate, Atenolol and Aspirin in Bulk Drug and Formulation” J. Pharm. And biomed sci., 2012, 17(9), 1-6.
  27. Ramjith US, Sunith DK, Radhakrishnan S, Sameer PA, “HPLC Study Of Aspirin And Aspirin Derivatives” Int. J. Res. In pharm. And chem.., 2013, 3(1), 1-5.
  28. Pai SP, Gaude S, Palekar A, “RP-HPLC Method Development and Validation for Simultaneous Estimation of Aspirin, Caffeine and Orphenadrine citrate in Tablet Formulation” Int. J. Sci. and res., 2013, 5(1), 1170-1173.
  29. Prakash K, Kalakunta RR, Sama SR, “Rapid and simultaneous determination of aspirin and dipyridamole in pharmaceutical formulations by reversed-phase high performance liquid chromatography (RP-HPLC) method” African j.pharm and pharmacology, 2011, 5(2), 244-251
  30. Patel D, Patel N, Vishy R, Patel V, “Development and Validation of RP-HPLC Method for Simultaneous Estimation of Aspirin and Esomeprazole Magnesium in Tablet Dosage Form” Hindawi Pub. Corp., 2013, 5
  31. Kapugandi AN, Gandhi BM, Raju VB, “Development and Validation of Stability Indicating RP-HPLC Method for Simultaneous Estimation of Ramipril, Aspirin and Simvastatin in Bulk and Pharmaceutical Dosage Form” Asian J. Biomed and pharm sci., 2016, 6(53), 14-20.
  32. Sawyer M, Kumar V, “A Rapid High-Performance Liquid Chromatographic Method for the Simultaneous Quantitation of Aspirin, Salicylic Acid, and Caffeine in Effervescent Tablets” J. Chrom. Sci., 2003, 41, 393-397.
  33. Gousuddin MD, Sengupta P, Tripathi VD, Das A, “Stability Indicating RP-HPLC Method For Simultaneous Determination Of Aspirin And Clopidogrel In Dosage Form” Mal. J. Anal. Sci., 2016, 20(2), 247-257.
  34. Shrivastava PK, Basniwal PK, Jain D, Srivastava SK, “Concurrent Estimation of Clopidogrel Bisulfate and Aspirin in Tablets by Validated RP-HPLC Method” Ind. J. Pharm. Sci., 2008, 70(5), 667-669.
  35. Mahesh HR, Sudhakar KB, “A Novel Stability Indicating HPLC Assay Method for Simultaneous Estimation of Clopidogrel and Aspirin in Tablet dosage form by Using Core shell Technology column” Res. J. Pharm. And tech., 2015, 8(2)
  36. Panda SS, “Ion-Pairing RP-HPLC Method for Simultaneous determination of Aspirin and Clopidogrel bisulphate in Tablet and Capsule Dosage Form” Int. J. Pharm. Tech. Res., 2010, 2(1), 269-273.
  37. Londhe SV, Deshmukh RS, Malqund SV, Jain KS, “Development and Validation of a Reversed phase HPLC Method for Simultaneous Determination of Aspirin, Atorvastatin Calcium and Clopidogrel Bisulphate in Capsules” Ind. J. Pharm. Sci., 2011, 73(1), 23-29.
  38. Devika GS, Sudhakar M, Venkateshwara RJ, “A New Simple RP-HPLC Method for Simultaneous Estimation of Aspirin, Atorvastatin and Clopidogrel in Capsule Dosage Form” Asian. J. Res. In chem.., 2011, 4(5), 795-799.
  39. Gandala K, Lalitha R, Kishore K, Gopikrishna R, “A Validated RP-HPLC Method for Simultaneous Estimation of Aspirin and Rosuvastatin in Tablet Dosage Form” Int. J. Pharm. And chem. res., 2015, 1(3), 128-133.
  40. Godavariya VD, Prajapati PB, Marolia BP, Shah SA, “Development and Validation Of RP-HPLC Method For The Simultaneous Estimation Of Rosuvastatin Calcium And Aspirin In Marketed Formulation” Int. Res. J. Pharm., 2012, 3(8), 173-175.
  41. Solanki C, Patel N, “Development and Validation of RP-HPLC Method for Simultaneous Estimation of Rosuvastatin Calcium and Aspirin in Capsule Dosage Form” Int. J. Pharm. And bio. Sci., 2012, 3(3), 577-585.
  42. Sharma S, Goyal S, Chauhan K. A review on analytical method development and validation. International Journal of Applied Pharmaceutics. 2018 Nov  7;10(6):8-15
  43. Kachave R. Method development and validation of Aspirin and Ticlopidine Hydrochloride in bulk drug and tablet formulation by RP-HPLC. International Journal of Pharmaceutical Research. 2013;5(3):19-22.
  44. Jeffery, G. H. Vogel's text book of Quantitative chemical analysis, (5th edn., pp. 10) Congmon scientific and technical. 1999

Photo
Roshani R Deore
Corresponding author

Department of Pharmaceutical Chemistry, K. B. H. S. S. Trust’s Institute of Pharmacy & Research Centre, affiliated to Savitribai Phule Pune University, Bhayegaon, Malegaon, Nashik, Maharashtra, India.

Photo
Rushikesh
Co-author

Department of Pharmaceutical Chemistry, K. B. H. S. S. Trust’s Institute of Pharmacy & Research Centre, affiliated to Savitribai Phule Pune University, Bhayegaon, Malegaon, Nashik, Maharashtra, India.

Photo
Mayur Unde
Co-author

Department of Pharmaceutical Chemistry, K. B. H. S. S. Trust’s Institute of Pharmacy & Research Centre, affiliated to Savitribai Phule Pune University, Bhayegaon, Malegaon, Nashik, Maharashtra, India.

Roshani R. Deore, Rushikesh Bachhav, Mayur Unde, Aspirin: A Review on Analytical method development and validation for tablet dosage form by UV visible spectroscopy, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 47-60. https://doi.org/10.5281/zenodo.10610890

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