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  • Formulation And Evaluation Of Chewable Tablet Of Solanum Nigrum. L Leaf Extract
  • 1Final year Student, Department of Pharmaceutics, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, Affiliated to The Tamil Nadu Dr. M.G.R. Medical University Chennai -600 032, Tamilnadu. 
    2Associate Professor, Department of Pharmaceutics, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, Affiliated to The Tamil Nadu Dr. M.G.R. Medical University Chennai -600 032, Tamilnadu. 
    3Principal, Department of Pharmaceutics, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, Affiliated to The Tamil Nadu Dr. M.G.R. Medical University Chennai -600 032, Tamilnadu.
     

Abstract

The purpose of this research work is to formulate and evaluate chewable tablets by using Solanum nigrum L. leaf extract that disintegrates in the mouth and provide an effective treatment for glossitis. The present work is the phytochemical screening of the ethanolic extract the plant Solanum nigrum, followed by pre-formulation studies like organoleptic properties, solubility, compatibility studies by FTIR, and calibration studies using UV spectroscopy. These studies aimed to develop a chewable tablet formulation using the direct comparison method with various compositions. The studies of the chewable tablets are pre-compression parameters like angle of repose, bulk density, taped density, Carr’s index, and Hausner ratio, and post-compression parameters like appearance, thickness, hardness test, friability test, weight variation test, disintegration test, and stability studies. Finally, all parameters are within the limit. So, the stability study of Formulation F3 revealed that the plant extract of Solanum nigrum was stable under accelerated and intermediate stability conditions for 3 months. Hence, Formula F3, containing the plant extract of Solanum nigrum at 700 mg, has been formulated as a chewable tablet by the direct compression method, which satisfied all the criteria for chewable tablets. Hence, it may be summarized that the tablets prepared by the direct compression method might be a perfect and effective formulation to prevent the treatment of glossitis

Keywords

Solanum nigrum, Chewable tablets, Direct Comparsion method, Glossitis, Ethanol extract, Pre formulation, Pre- and Post-compression parameters

Introduction

  1. Chewable tablets are tablets that are required to be broken and chewed in between the teeth before ingestion. These tablets are given to children who have difficulty in swallowing and to the adults who dislike swallowing. Chewable tablets are chewed and broken into smaller pieces prior to swallowing and are not to be swallowed intact.  In this way, the time required for disintegration is reduced and the rate of absorption of the medicament may increase. For the preparation of chewable tablets, mannitol is used as the base.  These tablets should have acceptable taste and flavour. They should disintegrate in a short time and produce cool sweet taste. Solanum nigrum commonly known as “Black night shade” belongs to solanacae family. It is called as Manathakkali in Tamil. It shows medicinal properties like anti-microbial, anti-oxidant, cytotoxic properties, anti-ulcerogenic, and hepato-protective activity. The literature survey based on chewable tablets, solanum nigrum and experimental design, Yerukali Sudha Rani et al., A review on Solanum nigrum, Santosh Kumar Bhatt et al., An Overview of the Role of Chewable Tablets. The aim of the present study is to formulate and evaluate by using chewable tablets of solanum nigrum L. Leaf extract that disintegrates in mouth and provide an effective treatment for glossitis. To formulate the herbal extract into a solid dosage form by direct compression method. The chewable tablet is easily accessible for self-medication and safe. Hence it is well accepted by patients.

     

    MATERIALS AND METHODS

    MATERIALS:


    Table no: 1 List of Materials Used and Manufacturers


           
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    EQUIPMENT:

    The equipment used in the present work are as follows,


    Table no: 2 List of Instruments Used and Manufacturers


           
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    METHODS:

    PLANT COLLECTION AND AUTHENTICATION:

    Solanum nigrum.L leaves plant was collected from during NOV 2023 from Pennagaram, Dharmapuri District, Tamil Nadu and India. The Plant was authenticated by Jagadeesh Assistant Professor, PG and Research Department of Botany, Sri Vijay Vidyalaya College of Arts and Science, Nallampalli, Dharmapuri, Tamil Nadu-636 807.



           
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    Figure no: 1 Plant of Solanum nigrum.L


    EXTRACTION PROCEDURE:

    The leaves of Solanum nigrum were washed to remove dust and dried under shade for about 2 weeks at room temperature (25±2?). To get a constant weight, the dried plant materials were grinded to coarse powder separately by mechanical device, stored and used in this work throughout the study period. In this process, 100gm of the leaves of the Solanum nigrum was coarsely powdered crude drug is placed in an individual closed vessel with the Ethanol and allowed to stand at room temperature for a period of seven days with frequent agitation until the soluble matter has dissolved. The mixture then is strained, the marc the damp solid material is pressed and the liquids are clarified by filtration or decantation after standing. The filtrate was concentrated on the water bath. Finally dried form of powder was obtained and the dried extract was collected and stored in a dessicator.

    QUALITATIVE PHYTOCHEMICAL ANALYSIS:

    Phytochemical evaluation is used to determine the nature of phytoconstituents present in the plant. The chemical tests for various phytoconstituents in the extracts of Leaf of Solanum nigrum were carried out as described below:


    Table no: 3 Qualitative Phytochemical Analysis


           
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    PRE-FORMULATION STUDIES:

    ORGANOLEPTIC PROPERTIES:

    The organoleptic properties like color, odour and taste of plant extract were evaluated.

    COLOR AND NATURE:

    Transferred small quantity of the sample on a white piece of paper, spreader the powder and examined visually.

    TASTE AND ODOUR:

    Very less quantity of Plant extract was used to get taste with the help of tongue as well as smelled to get the odour.

    SOLUBILITY:

    The plant extract was dried in desiccators over CaO. Its solubility in water, methanol, ethanol, chloroform, petroleum ether, dil. NaOH, and dil. HCl was determined as follows: 1 mg of the dried extract was dissolved in 1 mL of the solvent at room temperature. Its solubility in each solvent was assessed qualitatively by visual observation.

    CALIBRATION CURVE USING UV- VISIBLE SPECTROSCOPY:

    The standard stock solution of solanum nigrum.L. Leaf extract was prepared by accurately weighing and transferring 10 mg of the extract to 100 ml of volumetric flask. Then 2ml of the solution was added to 10ml volumetric flask and final volume was made up with phosphate buffer (PH 6.8) to get final standard stock solution(20µg/ml) was further diluted water to obtain 05-25µg/ml Solanum nigrum L. Leaf extract These solutions were scanned in the range of 760nm. The calibration curve was plotted between absorbance values against concentration.

    COMPATIBILITY STUDIES USING FTIR SPECTROSCOPY:

    The plant extract and excipients mixture of 1:1 ratio was accurately weighed and compatibility of freshly prepared mixtures was determined by FT-IR spectroscopy. FT-IR spectra of the plant extract, excipient and the physical mixture of the plant extract and excipients were recorded on a Fourier-transform infrared spectrophotometer (Shimadzu FT-IR, Japan) in the range of 4000-400 cm-1 and observed for any interaction between the plant extract and excipients.


    Table no: 4 Plant extract - Excipients Compatibility Protocol


           
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    FORMULATION OF CHEWABLE TABLET BY DIRECT COMPRESSION METHOD:

    The chewable tablets containing 200 mg the plant extract of solanum nigrum were prepared with a total tablet weight of 700 mg. All the formulation were prepared by direct compression.

    PR

    OCEDURE:

    Step: 1

    Solanum nigrum powder and all the other ingredients were individually passed through a sieve no.30

    Step: 2

    All the ingredients were mixed thoroughly by triturating up to 5 min by using poly bag

    Step: 3

    Magnesium Stearate is sifted through sieve no.40 added with Step: 2 mixing for 3 minutes. The tablets were prepared by using direct compression method according to the formulation table. Then the blend was compressed using caplet punch 16.50 x 8.50 mm



           
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    Flow chat no: 1 Procedure of formulation of chewable tablet by direct compression method


    Composition of the different formulation for chewable tablet by direct compression method


    Table no: 5 Formulation of Solanum nigrum Chewable Tablets


           
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    Figure no: 2 Powder of Granulation


           
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    Figure no:3 Solanum nigrum chewable tablet


           
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    EVALUATION STUDIES OF CHEWABLE TABLET:

    PRE-COMPRESSION PARAMETERS:

    ANGLE OF REPOSE

    Angle of repose is defined as the maximum angle possible between the surface of a pile of the powder and horizontal plane. The frictional force in a loose powder or granules can be measured by angle of repose.

    tan ? = h / r,

    ? = tan-1 (h/r)

    Where, ? is the angle of repose, h is height of pile, R is radius of the base of pile

    Relationship between Angle of Repose (?) and flow properties.


    Table no: 6 Flow Properties and Corresponding Angle of Repose


           
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    BULK DENSITY:

    Calculated amount of the model drug was introduced in a 100ml graduated cylinder. Powder level was noted without compacting shows in table-19, Bulk density was calculated using the following equation:

    Bulk density = M/Vo

    Where, M =Mass of the test sample,

    VO =Unsettled apparent volume

    TAPPED DENSITY:                       

    Calculated amount of the model drug was introduced in a 100ml graduated cylinder. Mechanically the cylinder was tapped using the tapped density apparatus by raising the cylinder and allowing it to drop under its own weight that provides a fixed drop of 14±2 mm at a normal rate of 250 drops per minute. The cylinder was tapped 1250 times initially and tapped volume measured. Tapped density was calculated using the following equation:

    Tapped Density = (M)/Vf

    Where M = Mass of test sample,

    Vf = Final tapped volume

    CARR’S INDEX:

    This parameter is the measure of propensity of powder to be compressed and reflect the relative importance of inters particulate interaction.

    Carr^' s Index=(100(TD-BD))/TD

    HAUSNER RATIO:

    The Hausner ratio is a number that is used to correlate the flow ability of drug substance.

    Hausner Ratio=(Tapped Density)/(Bulk Density)

    Flow ability of powder on the basis of Carr’s index and Hausner Ratio\


    Table no 7: Flow ability of powder on the basis of Carr’s index and Hausner Ratio


           
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    POST-COMPRESSION PARAMETERS:

    SHAPE AND COLOUR:

    Uncoated tablets were examined under a lens for the shape of the tablet and colour was observed by keeping the tablets in light.

    THICKNESS:

    The crown thickness of individual tablet may be measured with a Vernier caliper, which permits accurate measurements and provides information on the variation between tablets. Other technique employed in production control involves placing 5 or 10 tablets in a holding tray, where their total crown thickness may be measured with a sliding caliper scale. The tablet thickness was measured using Vernier caliper.

    HARDNESS TEST:

    Tablets require a certain amount of strength, or hardness and resistance to friability, to withstand mechanical shocks of handling in manufacture, packaging and shipping. The hardness of the tablets was determined using Monsanto Hardness tester. It is expressed in Kg/cm2. Three tablets were randomly picked from each formulation and the mean and standard deviation values were calculated.

    FRIABILITY TEST:

    It is the phenomenon where by tablet surfaces are damaged and show evidence of lamination or breakage when subjected to mechanical shock or attrition. The friability of tablets was determined by using Roche Friabilator. It is expressed in percentage (%). Ten tablets were initially weighed (W initial) and transferred into Friabilator. The Friabilator was operated at 25 rpm for 4 minutes or run up to 100 revolutions. The tablets were weighed again (W final). The percentage friability was then calculated by,

    F=(W(inital)-W(final))/(W(inital)) X 100

    % Friability of tablets less than 1% is considered acceptable.

    WEIGHT VARIATION TEST:

    The tablets were selected randomly from each formulation and weighed individually to check for weight variation. The U.S Pharmacopoeia allows a little variation in the weight of a tablet. The percentage deviation in weight variation is shown in table


    Table 8: Percentage deviation in weight variation


           
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    ASSAY:

    20 tablets were accurately weighed and crushed in a mortar, a quantity of powder equivalent to label claim was disperse in methanol, shake and diluted to 100ml with methanol and filtered. 20m1 of the filtrate was diluted to 100ml with methanol. Absorbance was measured at 760nm in UV spectrophotometer.

    Calculation = Drug content/label claim x 100

    IN-VITRO DISINTEGRATION TIME:

    The process of breakdown of a tablet into smaller particles is called as disintegration. The in-vitro disintegration time of a tablet was determined using disintegration apparatus as per I.P. specifications.

    Method

    For a drug to be absorbed from a solid dosage form after oral administration, it must first be in solution, and the first important step toward this condition is usually the break- up of the tablet, a process known as disintegration. The disintegration time of chewable tablets was determined in accordance with the official “United states of pharmacopoeia Chewable tablets” stating a maximum disintegration time of 5 minutes (USP 36). One tablet in each of the 6 tubes of the basket is to be placed and the apparatus subjected to run. The assembly should be raised and lowered between 50 cycles per minute. The time in seconds taken for complete disintegration of the tablet with no palpable mass remaining in the apparatus was measured and recorded. Disintegration or more specifically dispersion times were measured in 900 ml purified water according to the I.P. method without using disc at room temperature (25°C ± 2°C).

    STABILITY STUDIES:

    Stability of a drug has been defined as the ability of a particular formulation, in a specific container, to remain within its physical, chemical, therapeutic and toxicological specifications. The purpose of stability testing is to provide evidence on how the quality of a drug substance or drug product varies with time under the influence of a variety of environmental factors such as temperature, humidity and light and enables recommended storage conditions, re-test periods and shelf lives to be established. In the present study, the Chewable Tablets are packed in suitable packaging and stored under the following conditions for a period as prescribed by ICH guidelines for intermediate and accelerated studies.

    1. 25 ± 2°C/60±5% RH

    2. 40 ± 2°C/75±5% RH

    The tablets were withdrawn after period of 1, 2 and 3 Months and analyzed for physical characterization (Appearance, hardness, friability, disintegration etc.,) and drug content.

    RESULT AND DISCUSSION:

    EXTRACTION:

    Extraction with the ethanol solvent were performed, percentage yield and phytochemical analysis were done. The percentage yields of each extract are tabulated below.


    Table 9: Percentage yields of successive extracts of Leaf of solanum nigrum.L


           
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    DISCUSSION:

    The plant was extracted using ethanol in maceration method. The semisolid extract, so obtained was extractive value is 7.3.

    PHYTOCHEMICAL SCREENING:

    The Preliminary phytochemical analysis of various extracts was performed Note: + ve indicates positive result, - ve indicates negative result


    Table 10: Preliminary phytochemical analysis of Ethanol extracts


           
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    Discussion:

    The ethanol extracts of solanum nigrum.L are tested to find the presence of different class compounds. Various qualitative chemical tests for the preliminary phytochemical screening of the extract of ethanol were applied. The phytochemical test on an extract of the solanum nigrum.L revealed the presence of Tannins, Flavonoids, Alkaloid, Quinines, Glycosides and Phenol.

    PRE-FORMULATION STUDIES:

    ORGANOLEPTIC PROPERTIES:


    Table 11: Organoleptic Properties of solanum nigrum extract


           
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    Discussion:

    The organoleptic properties like color, odour and taste of the plant extract were evaluated. The color of the plant extract of solanum nigrum was found to be Granular powder appearance, Creamiest to off white colour, Herbal odour and Mint with Banana taste was observed in the study.

    SOLUBILITY TEST:


    Table 12: Solubility Analysis of Solanum nigrum extract


           
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    Discussion:

    The solubility analysis of the plant extract indicates that soluble in water, methanol, ethanol, dilute NaOH and Dilute Hcl.

    CALIBRATION CURVE OF SOLANUM NIGRUM IN 0.1 N PHOSPHATE BUFFER


    Table 13: Calibration curve of Solanum nigrum in 0.1 N phosphate buffer


           
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    Figure no: 4 Calibration curve of Solanum nigrum in 0.1 N phosphate buffer


           
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    COMPATIBILITY STUDIES USING FTIR SPECTROSCOPY



           
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    Comparative of the FT-IR Spectral Data of the plant extract :


    Table 14: Comparative of the FT-IR Spectral Data of the plant extract


           
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    Discussion:

    FT- IR spectral studies indicated that the plant extract is compatible with all the excipients. The FT-IR spectrum of physical mixture showed all the characteristic peaks of the plant extract of solanum nigrum, thus conforming that no interaction of plant extract occurred with the components of formulation.

    EVALUATION OF THE PLANT EXTRACT OF SOLANUM NIGRUM CHEWABLE TABLETS 

    PRE-COMPRESSION PARAMETERS 

    The powder blends were evaluated for the following parameters such as Angle of repose, Bulk density, Tapped density, Carr’s index and Hausner ratio. The results were given below in Table


    Table 15: Evaluation of the Pre compression Parameters


           
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    All the values are expressed as mean ± SD, n=3

    Discussion:

    The angle of repose of all formulations was found between 29.65-33.64 ? which indicates the flow type of powder blend was passable.  The bulk density was found between 0.42-0.46 g/cm3, tapped density was found between 0.56-0.59 g/cm3.  Carr’s index was found in the range of 13.88 to 21.94 % which indicates the flow type of powder blend was passable.  Hausner’s ratio ranges between 1.26 to 1.37. The above results in terms of micromeritic properties revealed that the flow property of all formulation was passable and within the acceptable limit.

    POST COMPRESSION PARAMETERS

    GENERAL APPEARANCE

    The general appearance of all formulations (F-1 to F-5) were examined and found as follows,

    Colour   - Creamiest to off white colour

    Shape           - Caplet Shape

    Surface - Smooth surface

    The prepared tablets were evaluated for various post compression parameters. The results are presented in Table


    Table 16: Evaluation of the post compression Parameters


           
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    All the values are expressed as mean ± SD, n=3

    Discussion:

    THICKNESS AND HARDNESS

    The thickness of tablets was measured and was found in the range between 5.16 to 5.34 mm. All the formulation possessed uniform thickness.  The hardness of the tablets was measured and the values were found in the range between 6.31 to 7.12 kg/cm2.

    WEIGHT VARIATION AND FRIABILITY

    Test all formulations of tablets passed the weight variation test since the values are within the acceptable variation limit (±20.0%) of the tablet. Similarly, percentage friability values of the prepared chewable tablets showed less than 1% weight loss that is highly within the acceptable limit. Hence all the tablets passed the friability test. Tablets were evaluated for various parameters and the results are given in Table

    DRUG CONTENT AND DISINTERGRATION TIME


    Table 17: Evaluation of Drug content and Disintegration Test


           
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    All the values are expressed as mean ± SD, n=3

    Discussion:

    The content of the chewable tablets was found in the range between 99.00 -101.00%. The results revealed that the content of Solanum Nigrum L extract was within the acceptable limits in all the formulations. Disintegration time of Solanum Nigrum L extract chewable tablets were found between 2.50±0.01 to 3.45±0.015 minutes. Specification limit of disintegration time for uncoated tablet from I.P is NMT 5 minutes.  Disintegration time of all formulations were found within the time as specified in the I.P and passed the disintegration test. The disintegration time of formulation III containing showed plant extract disintegration (3.15 ±0.01 min) compared with other formulations.

    STABILITY STUDIES

    The optimized formulation (F-3) was selected for the stability study and stored at 25±2°C/60%±5%RH and 40±2°C/75%±5%RH for a period of three months. The tablets were evaluated for various parameters like physical appearance, weight variation, thickness, hardness, friability, disintegration time and drug content at every month interval.

    The results are presented in Table


    Table 18: Stability Data of Optimized Formulation (F-3) Stored at 25±2°C/60%±5%RH


           
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    All the values are expressed as mean ± SD, n=


    Table 19: Stability Data of Optimized Formulation (F-3) Stored at 40±2°C/75%±5%R


           
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    All the values are expressed as mean ± SD, n=3

    Discussion:

    Stability results revealed that there were no significant changes found in physical appearance, weight, thickness, hardness, friability, disintegration time, drug content a during the period of 3 months even after stored at 25±2°C/60%±5%RH and 40±2°C/75%±5%RH. The results revealed that the drug was stable even after stored at 25±2°C/60%±5%RH and 40±2°C/75%±5%RH for three months.

    CONCLUSION

The chewable tablets of taste masked the plant extract of solanum nigrum L were successfully prepared by direct compression method.

5 batches using various additives were prepared and evaluated with an aim of presenting the plant extract of Solanum Nigrum L taste masked by the chewable tablet.

Drug excipients compatibility study was performed by FTIR.

The physicochemical evaluation results for the powdered blend of all trials pass the official limits in the angle of repose, compressibility index, Bulk density, Tapped density, Hausner’s ratio.

After the compression of the chewable tablet to evaluate the Appearance, Thickness, Hardness test, Friability test, weight variation test and Disintegration test all the trials within the limits.

So, the plant extract of solanum nigrum was stability study of Formulation F3 revealed that the drug was stable under accelerated and long-term ability conditions for 3 months. Hence the Formula F3 containing the plant extract of Solanum Nigrum 700 mg has been formulated as a chewable tablet by direct compression method, which satisfied all the criteria for chewable tablets.

Hence it may be summarized that the tablets prepared by direct compression method might be a perfect and effective formulation to prevent the treatment of glossitis.

ACKNOWLEDGEMENT

The authors would like to acknowledge the contribution of the technical staff attached with this study. Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, Affiliated to The Tamil Nadu Dr. M.G.R. Medical University Chennai -600 032, Tamilnadu.

REFERENCE

 

  1. Santosh Kumar Bhatt et al., Role of Chewable Tablets: An Overview-Asian Journal of Pharmaceutical Research and Development. 2021; 9(4): 141-146
  2. Mendes RW. Chewable tablets Pharmaceutical dosage forms. Tablets. 2ndEd. New York: Marcel Dekker. Inc 1989:367-415
  3. Renu et al., Chewable Tablets: A comprehensive review. PharmaInnov 2015; 4(5):100-5
  4. Rani et al., a review on solanum nigrum, World Journal of Pharmacy and Pharmaceutical Sciences Vol 6, Issue 12, 2017:293-303
  5. Aneta Krakowska Sieprawska et al., Modern Methods of Pre-Treatment of Plant Material for the Extraction of Bioactive Compounds, Molecules. 2022 Feb; 27(3): 730.
  6. Abdullahi R. Abubakar et al., Preparation of Medicinal Plants: Basic Extraction and Fractionation Procedures for Experimental Purposes, J Pharm Bioallied Sci. 2020 Jan-Mar; 12(1): 1–10.
  7. Janorious Winka.J et al., A Comparison of Phytochemical Evaluation of Dendrophthoe Falcata (L.F) Ettingsh (Loranthaceae) Growing on The Host Plant Azadirachta Indica and Nerium Oleander, IAJPS 2022, 09 (2), 227-232.
  8. Bapan Banik et al., Development and Evaluation of Carminative Herbal Chewable Tablets Based on Turmeric, Fennel Seed, and Mango Ginger, Asian Pacific Journal of Health Sciences, July 2021:141-145
  9. Prasad V Kadam et al., Standardization and quantification of curcumin from Curcuma longa extract using UV visible spectroscopy and HPLC, Journal of Pharmacognosy and Phytochemistry 2018; 7(5): 1913-1918
  10. Adriana I. Segall et al., Preformulation: The use of FTIR in compatibility studies, JIAPS, Vol 4 (3), 01-06, 2019
  11. Jyoti Dahiya et al., Formulation and Evaluation of Chewable Tablets of Loratadine by Direct Compression Method, The Pharma Innovation Journal 2015; 4(5): 97-99
  12. Sathyaraj A, Palraja M. Preparation and Comparative Evaluation of Loratadine Solid dispersions with various binders by spray drying technique. International Journal of Research in pharmacy and Chemistry. 2012; 2(1):37-41.
  13. Wael Ali, Badawi A, Mahdy M, Nahas HE. Formulation and Evaluation of Carbamazepine 200 mg Chewable Tablet Using Cyclodextrins. International Journal of Pharmacy and Pharmaceutical Sciences. 2012; 4(2):472-80.
  14. Harbir K. Processing technologies for pharmaceutical tablet: A Review. International research Journal of Pharmacy. 2012; 3(7):20-23

 

Reference

  1. Santosh Kumar Bhatt et al., Role of Chewable Tablets: An Overview-Asian Journal of Pharmaceutical Research and Development. 2021; 9(4): 141-146
  2. Mendes RW. Chewable tablets Pharmaceutical dosage forms. Tablets. 2ndEd. New York: Marcel Dekker. Inc 1989:367-415
  3. Renu et al., Chewable Tablets: A comprehensive review. PharmaInnov 2015; 4(5):100-5
  4. Rani et al., a review on solanum nigrum, World Journal of Pharmacy and Pharmaceutical Sciences Vol 6, Issue 12, 2017:293-303
  5. Aneta Krakowska Sieprawska et al., Modern Methods of Pre-Treatment of Plant Material for the Extraction of Bioactive Compounds, Molecules. 2022 Feb; 27(3): 730.
  6. Abdullahi R. Abubakar et al., Preparation of Medicinal Plants: Basic Extraction and Fractionation Procedures for Experimental Purposes, J Pharm Bioallied Sci. 2020 Jan-Mar; 12(1): 1–10.
  7. Janorious Winka.J et al., A Comparison of Phytochemical Evaluation of Dendrophthoe Falcata (L.F) Ettingsh (Loranthaceae) Growing on The Host Plant Azadirachta Indica and Nerium Oleander, IAJPS 2022, 09 (2), 227-232.
  8. Bapan Banik et al., Development and Evaluation of Carminative Herbal Chewable Tablets Based on Turmeric, Fennel Seed, and Mango Ginger, Asian Pacific Journal of Health Sciences, July 2021:141-145
  9. Prasad V Kadam et al., Standardization and quantification of curcumin from Curcuma longa extract using UV visible spectroscopy and HPLC, Journal of Pharmacognosy and Phytochemistry 2018; 7(5): 1913-1918
  10. Adriana I. Segall et al., Preformulation: The use of FTIR in compatibility studies, JIAPS, Vol 4 (3), 01-06, 2019
  11. Jyoti Dahiya et al., Formulation and Evaluation of Chewable Tablets of Loratadine by Direct Compression Method, The Pharma Innovation Journal 2015; 4(5): 97-99
  12. Sathyaraj A, Palraja M. Preparation and Comparative Evaluation of Loratadine Solid dispersions with various binders by spray drying technique. International Journal of Research in pharmacy and Chemistry. 2012; 2(1):37-41.
  13. Wael Ali, Badawi A, Mahdy M, Nahas HE. Formulation and Evaluation of Carbamazepine 200 mg Chewable Tablet Using Cyclodextrins. International Journal of Pharmacy and Pharmaceutical Sciences. 2012; 4(2):472-80.
  14. Harbir K. Processing technologies for pharmaceutical tablet: A Review. International research Journal of Pharmacy. 2012; 3(7):20-23

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Karthick . S
Corresponding author

Karthick . S

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Vasanthan. A
Co-author

Vasanthan

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Dr.Senthil Kumar K L
Co-author

Dr. Senthil Kumar KL

Karthick S., A. Vasanthan, Senthilkumar K. L., Formulation And Evaluation Of Chewable Tablet Of Solanum Nigrum. L Leaf Extract, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 4, 1265-1280. https://doi.org/10.5281/zenodo.11092173

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