Late Laxmibai Phadtare college of pharmacy Kalamb Walchandnagar.
A rising global health concern, obesity is linked to a number of metabolic diseases, including as type 2 diabetes, heart disease, and some types of cancer. Natural and functional foods with therapeutic potential for weight management are gaining popularity. The tropical fruit Pithecellobium dulce, often called Manila tamarind, is high in flavonoids, dietary fiber, antioxidants, and other bioactive substances. This study investigates the possible anti-obesity effects of a nutritional juice made from Pithecellobium dulce as well as its formulation and assessment. High concentrations of polyphenols and saponins, which are known to encourage lipid metabolism and lessen fat storage, were found in the preliminary phytochemical investigation. In vitro tests and animal model studies showed that subjects who consistently drank the juice had improved lipid profiles, increased antioxidant activity, and significantly decreased body weight growth. According to these results, Pithecellobium dulce juice shows promise as a natural supplement for the treatment of obesity and its associated problems. It is advised to conduct additional clinical research to confirm its effectiveness in human beings.
In the recent years, there is an increasing interest in researchers for the production of biologically active compounds from natural sources. Bioactive compounds are important due to prevention/treatment of diseases like many types of cancers and other human diseases. These protective abilities of bioactive materials are mostly attributed to plant polyphenols and their antioxidant, antimicrobial, antiviral and anti-carcinogenic effects. Also, plant polyphenols are preferred as protective ingredients in pharmaceutical, food and cosmetic industries as food additives, preservatives and dietary supplements instead of synthetic chemicals. Worldwide about 1.9million adults are overweight and 600million of them are clinically obese4. Only drug named Orlistat is currently approved by USFDA for long term obesity treatment. But it has unwanted side effects like, dyspepsia, nephrotoxicity, flatulence, respiratory infection oily stools, abdominal pain, menstrual and psychiatric disorders5. Natural products recognized from conventional medicinal plants encompass constantly existing a thrilling chance for the expansion of newer remedial agents. A big amount of Indigenous plants have been claimed to have anti-obesity effect in the Indian system of medicine. Many medicinal plants like Camellia sinensis, Allium sativum, Nelumbo nucifera, Argyreia nervosa and Sida rhomboidea, were reported to have anti-obesity effect in different animal models. Therefore, basically our project is based on the purpose of finding every biological and physiochemical properties of the leave plant and its impact on the human body against diseases or disorders. According to some local sources and also after digging some research works some of the benefits of leave’s properties are:
The active compound of the plant includes flavonoid, sterols, tannin and triterpenoid and health promoting properties like protein, carbohydrates, steroids and disease preventing properties Some preliminary studies have shown that p. dulce leaves contain flavonoids glycosides that is beta D glucoside of a alpha spinosterol, octocosanol, kaempaferol 3-rhamnoside and kaemaferol which might exert an antiobesity effect.(6]
1.2About the sample:-
Pithecellobium dulce
Pithecellobium dulce (benth) belonging to the family of a leguiminosae .it is a small to medium sized evergreen,spiny legume tree the crown is a broad spreading with a irregular branches.)all plant part of p. dulce elaborates a vast array of biologically active compounds and have been demonstrated to exhibit antibacterial, antidiabetic, locomotor, antivenom, free radical scavenging, protease inhibitor, anti-inflammatory, antimycobacterial, abortifacient, spermicidal, anticonvulsant,antiulcer,antidiarrheal,antifungal, antitubercular, antitumor, antioxidative and antiobesity properties
1.2.1Biologicalsource
Pithecellobium ducle:
Botanical name-pithecellobium dulce
Family- leguiminosae
Part used- leaves
1.2.2Common name:
Hindi- vilayati imali, jungali jalebi,
Marathi- engraji chinch
Tamil-kodukkapuli
English-manila tamarind,money pod, madras thorn.
Nowdays, obesity is one of the serious health concern in the world and has been connected with the increased morbidity, mortality rate and reduced life span .] it has become and eventual outcome after certaim age of the human due to their lifestyle and food habits. Obesity increases the risk of many diseases such as hyperlipidemia, diabetic atherosclerosis, liver damage and cancer Moreover obesity inceases financial burden on the individual and eventually on the government alsothe major concern with the western food is either it consist of to much of enerdized material or higher fat compounds.this induces the free radical generation with increased possibility of cardiac related complication
1.3Superb health benefits of the jungle jalebi-
1.3.1Promote weight loss-
Drinking a glass of lemon juice, infused with the jungle jalebi pod extracts works wouder in shedding those extra kilos and maintaining a healthy body weight
1.3.2.Cures gut problem-
Jangle jalebi pods are a storehouse of powerful antioxidants such as flavonoids and quercetin these functions effectively in scavenging the harmful free radicals and toxins in the stomach and intestines, thereby curing diarrhea and dysentery
1.3.3. Manage diabetic symptoms-
The juice of jungali jalebi pod extract is known to exhibit anti hypoglycemic attributes.
1.3.4.Fortifies bones and muscles-
p.dulce pods are bestowed with extensive amount of calcium and phosphorous two minerals vital for maintaining strong bones.
1.3.5.Boosts immune function
The expansive qualities of vitamin c , a beneficial antioxidant,confer augmented immunity in those consuming a glass of jungle jalebi juice.
1.3.6. Promote oral health
The tiny pods of p. dulce are packed with calcium, magnesium, phosphorous, the trio of bone fortifying minerals, that vastly strengthen teeth enamel.
1.3.7. Relieves anxiety and depression
p.dulce leaves are loaded with tannin, flavonoid, alkaloid antioxidant. these enhance memory, cognition, brain power, besides ameliorating symptoms of anxiety, depression and influencing positive moods.
Aim: To Prepare and Evaluate the Herbal juice.
Objectives:
Plan of Work:
2.Formulation-
The herbal juice was formulation as per general method of formulation in which extracted Pithecellobium dulce leaves With water by heating upto 6 hours at 70 degree celcius.then add lemon juice,honey and rose water blended with turmeric colouring agent. Then add methyl paraben, propyl paraben.dilute with distilled water also add propylene glycol.to make uniform mixture.and stored in refrigerater.
3.Methods of preparation of juice –
Method – 1:
Method -2:
Drug profile:
1.API-
Pithecellobium Dulce Leaves
It is also known as jangle jalebi has vitamin c, which is an excellent antioxidant which helps our body to fight against many harmful free radicals. Dulce contains vital vitamins like ascorbic acid, thiamine, riboflavin and some essential amino acids.
2.Lemon Juice
Lemon contains a high amount of vitamin c, soluble fiber, that give them number of health benefits. Lemon may aid weight loss and reduce risk of heart disease, anemia, kidney stones, digestive issues, and cance
3.Turmeric
Turmeric is promoted as a dietary supplement for a variety of conditions, including arthritis, digestive disorder,respiratory tract,joints,and digestive system.
4.Honey
In addition to its use as a natural sweetener, honey is used as an anti-inflammatory, antioxidant and antibacterial agent
Harshada Gore*
Vaishnavi Patharkar
Ulka Mote