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Abstract

Nanotechnology is the study of manipulating matter at the atomic and molecular levels and deals with matter at a scale of 1 billionth of a metre. The quality of human life recently been altered and improved physically using particulate systems like nanoparticles. They have been used in vivo to maintain the drug entity in systemic circulation, prevent drug access to the targeted sites, and transport the drug to the site of action at a controlled and steady rate. In general, nanoparticles have one or more dimensions and range in size from 1 to 100 nm. Nanoparticles are the preparations having size in nanometres. In this various polymer are used in the formulation of nanoparticles for the drug delivery research to increase therapeutic benefit. This review mainly focussed on types, preparation methods such as cross-linking technique, polymerization-based methods, polymer precipitation methods, and evaluation parameters such as particle size, zeta-potential, particle shape, drug entrapment efficiency, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, surface hydrophobicity, invitro drug release of nanoparticles.

Keywords

Nanotechnology, Nanoparticles, Types, Preparation and Evaluation

Reference

  1. Aarti P. Nikam, Mukesh. P. Ratnaparkhiand, Shilpa, P. Chaudhari: Nanoparticles, An Overview. International Journal of Research and Development in Pharmacy and Life Sciences2014; 3:1121-1127. 
  2. Hasan S: A Review on Nanoparticle, Their Synthesis and Types Biosynthesis and Mechanism. Research Journal of recent sciences2015; 4:1-3.
  3. Cho E J, Holback H, Liu K C, Abouelmagd S A, Park J and Yeo Y: Nanoparticle characterization, State of the art, challenges, and emerging technologies. HHS public access manuscript, vol 10(6), 2013: 2093-2110.
  4. Machado S, Pacheco J G, Nouws HPA, Albergaria J T and Delerue-Matos C: Characterization of green zero-valent iron nanoparticles produced with tree leaf extracts. Sci. Total Environ 2015; 533:76-81.
  5. M. Mohan Varma, K.T. Sunil Kumar and I. Durga Srivalli: A Review on Nanoparticles, Synthesis, Characterization and Applications. World Journal of Pharmaceutical and Medical Research 2021; 7:169-179.
  6. Vyas SP, Khar RK: Targeted and controlled drug delivery, Novel carrier systems. CBS Publishers, New Delhi, 2002.
  7. Bhardwaj V, Hariharan S, Bala I, Lamprecht A, Kumar N, Panchagnula R: Pharmaceutical aspects of polymeric nanoparticles for oral delivery. J. Biomed and Nanotech 2005; 1:1-23.
  8. Ananta Choudhury, Rahela Eyachmin Laskar, Debasish Deka, Kashmiri Sonowal, Suman Saha: A Review on Nanoparticle, types, preparation and its Characterization. Research journal of pharmacy and technology 2021; 14:1815-1822.
  9. Singh D, Harikumar SL, Nirmala: Nanoparticle, An overview. Journal of drug delivery & Therapeutics 2013; 3:169-75.
  10. M. Anto Godwin, K. Mahitha shri, M. Balaji: Nanoparticle and Their Applications, Mini Review. International Journal of Research in Engineering and Bioscience2015; 3:11-29.
  11. El-houshoudy AN: Emulsion polymerization Mechanism. Recent Research in a polymerization. Research Journal of Pharmacy and Technology 2018; 1.
  12. Kawaguchi S, Ito K, Springer, Berlin, Heidelberg: Dispersion Polymerization, In polymer particles. Research Journal of Pharmacy and Technology 2005; 299-328.
  13. Sugihara S, Blanazs A, Armes SP, Ryan AJ, Lewis AL: Aqueous dispersion polymerization, a new paradigm for in situ block copolymer self-assembly in concentrated solution. Journal of the American Chemical Society 2011; 133:15707-15713.
  14. Song y, Fan JB, Wang S: Recent progress in interfacial polymerization, Materials Chemistry Frontiers. Research Journal of Pharmacy and Technology2017; 1:28-40.
  15. Raajimakers MJ, Benes NE: Current trends in interfacial polymerization chemistry. Progress in Polymer Science 2016; 1:86-142.
  16. Murthy SK: Nanoparticles in modern medicine, state of the art and future challenges. International Journal of nanomedicine2007; 2:129.
  17. Eid AG, Uddin N, Girgis S: Formulation and optimization of biodegradable insulin loaded nanoparticles. Research Journal of Pharmacy and Technology.
  18. Sezer AD editor: Application of nanotechnology in drug delivery. BOD-Books on Demand :2014.
  19. Kwon Hy, Lee Jy, Choi SW, Jang y, Kim JH: Preparation of PLGA nanoparticles containing estrogen by emulsification-diffusion method, colloids and surfaces.
  20. Gazi AS, Sailaja AK: Preparation and Characterization of paracetamol Loaded Eudragit S100 Nanoparticles by Salting out Technique. J Develop Drugs 2018; 7:2.
  21. Tiruwa R: A Review on nanoparticles, preparation and evaluation parameters. Indian Journal of Pharmaceutical and biological Research2016;4(2)27-31. 
  22. Redhead HM, Davis SS, Illum L: Drug delivery in poly(lactide-coglycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908, invitro characterisation and in-vivo evaluation. Journal of control Release2001; 70:353-363.
  23. Couvreur P, Barrat G, Fattal E, Legrand P, Vanthier C: Nanocapsule Technology- A Review. Critical Reviews in Therapeutic Drug Carrier Systems 2002; 19:99-134.
  24. Champeau Rachel: Assessing Safety Health of Nanomaterial.2006;15.
  25. Delvecchio Rick: Berkeley Considering Need for Nano Safety. Sfgate.com, 2006. 
  26. Jores K, Mehnert W, Drecusler M, Bunyes H, Johan C, Mader K: Investigation on the stricter of solid lipid nanoparticles and oil-loaded solid nanoparticles by photon correlation spectroscopy, field flow fractionasition and transmission electron microscopy. Journal of Control Release 2004; 17:217-227. 
  27. Molpeceres J, Aberturas MR, Guzman M: Biodegradable nanoparticles as a delivery system for cyclosporine, preparation and characterization. Journal of Microencapsulation2000; 17:599-614.
  28. Schroeder U, Sommerfeld P, Ulrich S, Sabel BA: Nanoparticle technology for delivery of drugs across the blood-brain barrier. Journal pharma sci 1998; 87:1305-1307.
  29. Jiang B, Hu L, Gao C, Shen J: Ibuprofen loaded nanoparticles prepared by a co-precipitation method and their release properties. Int J Pharm 2005; 304:220-230.
  30. Scholes PD, Coombes AG, Illum L, Daviss SS, Wats JF, Ustariz C, Vert M, Davies MC: Detection and determination of surfaces levels of poloxamer and PVA surfactant on biodegradable nanospheres using SSIMS and XPS. Journal of Control Release 1999; 59:261-278. 
  31. Kreuter J: physicochemical characterization of polyacrylic nanoparticles. International Journal of Pharmaceutics 1983; 14:43-58.

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Muni Raja Lakshmi K
Corresponding author

Sri Venkateswara College of Pharmaceutical Sciences, S V University, Tirupati

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Lavanya E
Co-author

Sri Venkateswara College of Pharmaceutical Sciences, S V University, Tirupati

Photo
Naseema Shaik
Co-author

Sri Venkateswara College of Pharmaceutical Sciences, S V University, Tirupati

Photo
Vankata Rao Gadde
Co-author

Sri Venkateswara College of Pharmaceutical Sciences, S V University, Tirupati

Muni Raja Lakshmi K*, Lavanya E, Naseema Shaik, Vankata Rao Gadde, Formulation And Evaluation of Nanoparticles-A Review, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 7, 196-204. https://doi.org/10.5281/zenodo.8127920

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