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  • Overview On The Novel Medication Of Liquisolid Technology For Improving Solubility And Bioavailability

  • 1Assistant Professor, Department of Pharmaceutics, Smt. B.N.B Swaminarayan Pharmacy, Salvav-Vapi
    2Assistant Professor, Department of Pharmaceutical Quality Assurance, Smt. B.N.B Swaminarayan Pharmacy, Salvav-Vapi
    3Assistant Professor, Department of Pharmaceutical Quality Assurance, Smt. B.N.B Swaminarayan Pharmacy, Salvav-Vapi
    4Assistant Professor, Department of Pharmaceutical Quality Assurance, Smt. B.N.B Swaminarayan Pharmacy, Salvav-Vapi

Abstract

The majority of the novel medication candidates are lipophilic and water-insoluble. The pharmaceutical industry has a tremendous difficulty in improving the solubility and bioavailability of these medications. The Liquisolid technique, which involves converting a liquid medicine into a seemingly dry, non-adherent, free-flowing, and compressible powder, is an innovative and sophisticated method for dealing with the problem. The purpose of this article is to provide an overview of the Liquisolid technology as well as a summary of its advancement in pharmaceutics. The key advantages of this technology are its low cost, easy processing, and large industrial production capacity. This approach is a relatively recent technique for efficiently retarding drug release, in addition to improving the dissolving rate of weakly water-soluble medicines. In addition, the Liquisolid approach has been examined as a tool for reducing the impact of pH variations on drug release and as a possible alternative to traditional coating for improving drug photostability in solid dosage forms. Overall, the Liquisolid approach is a new and promising tool for improving drug dissolving and extending drug release, and its pharmaceutics applications are currently being explored.

Keywords

Liquisolid, lipophilic, technology, dissolution enhancement, pH, solubility

Reference

  1. Timmermans, S. (2000) Technology and medical practice. In C. Bird, P. Conrad and A. Fremont (eds) Handbook of Medical Sociology (5th Edition). Upper Saddle River, New Jersey: Prentice Hall, Inc.
  2. Yadav V.B., Yadav A.V., “Liquisolid granulation technique for tablet manufacturing: An overview.”  J.  Of Pharmacy Research (JPR). 2009; 2(4): 670-674.
  3. Patel Chirag J, Tyagi Satyanand, Patel Jaimin, Chaudhari Bharat, Parashar Tarun, Soniya, “Enhancement of solubility by Liquisolid Technique: A review.” Pharmatutor - ART- 1513.
  4. Doijad R.C., Phatan A.B., Gaikwad S.S., Baraskar S.S., Pawar N.B., Maske V.D., “Liquisolid:  A novel Technique for dissolution enhancement of poorly soluble drugs.” Current Pharma Research (CPR). 2012; 3(1): 735-749.
  5. Burra Shashidher, Yamsani Madhusudhanrao, Vobalaboina Venkateswarlu. “The    Liquisolid technique:  An overview.” Brazilian j. of pharmaceutical sciences (BJPS).2011;47(3): 475-482.
  6.  Tayel SA, Soliman II, Louis D. Improvement of dissolution properties of carbamazepine through application of the liquisolid tablet technique. Eur J Pharm Biopharm 2008; 69:342–347. 
  7.  Gubbi SR, Jarag R. Formulation and characterization of atorvastatin calcium liquisolid compacts. Asian J Pharm Sci 2010; 5:50–60. 
  8.  Karmarkar AB, Gonjari ID, Hosmani AH, et al. Evaluation of in vitro dissolution profile comparison methods of sustained release tramadol hydrochloride liquisolid compact formulations with marketed sustained release tablets. Drug Discov Ther 2010; 4:26–32. 
  9.  Singh SK, Srinivasan KK, Gowthamarajan K, et al. Influence of formulation parameters on dissolution rate enhancement of glyburide using liquisolid technique. Drug Dev Ind Pharm 2012; 38:961–970. 
  10.  Javadzadeh Y, Jafari-Navimipour B, Nokhodchi A, et al. Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine). Int J Pharm 2007; 341:26–34. 
  11. Charman SA, Charman WN. Oral modified release delivery systems. In: Rathbone MJ, Hadgraftb J, Roberts MS, editors. Modified release drug delivery technology. New York: 2003. p. 1–9. 
  12.  Saeedi M, Akbari J, Morteza-Semnani K, et al. Enhancement of dissolution rate of indomethacin using liquisolid compacts. Iran J Pharm Res 2011; 10:25–34. 
  13.  Karmarkar AB, Gonjari ID, Hosmani AH, et al. Dissolution rate enhancement of fenofibrate using liquisolid tablet technique. Lat Am J Pharm 2009; 28:219–225

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Desai Avni P.
Corresponding author

Assistant Professor, Department of Pharmaceutics, Smt. B.N.B Swaminarayan Pharmacy, Salvav-Vapi

Photo
Krishna P. Vairagi
Co-author

Assistant Professor, Department of Pharmaceutical Quality Assurance, Smt. B.N.B Swaminarayan Pharmacy, Salvav-Vapi

Photo
Dhruvi B. Parmar
Co-author

Assistant Professor, Department of Pharmaceutical Quality Assurance, Smt. B.N.B Swaminarayan Pharmacy, Salvav-Vapi

Photo
Heli H. Desai
Co-author

Assistant Professor, Department of Pharmaceutical Quality Assurance, Smt. B.N.B Swaminarayan Pharmacy, Salvav-Vapi

Desai Avni P., Krishna P. Vairagi, Dhruvi B. Parmar, Heli H. Desai, Overview On The Novel Medication Of Liquisolid Technology For Improving Solubility And Bioavailability, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 8, 169-185. https://doi.org/10.5281/zenodo.8262407

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