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Abstract

The majority of commercial soaps contain chemicals that might harm skin. Natural herbal soaps might be an effective option. Herbal products have achieved global relevance in medicine and trade, and their use has increased as a result of their effectiveness and safety. Bacteria cause the majority of skin infections in humans, needing careful treatment, enhanced skin preservation, and the maintenance of healthy, youthful-looking skin. Polyherbal soap was made using extracts of Azadirachta indica, aloe barbadensis , curcuma longa, Sapindus mukorossi, Prunus Amygdalus, Lamiaceae , citrus limon, and other herbs. Considering polyherbal soap has been found to be useful in treating a variety of skin disorders, its use continues to rise in popularity. When compared to traditional soap, polyherbal soap is a safer, more effective option. Due to its many therapeutic uses, neem, Tulsi, and lemon papaya trees have gained global acceptance. Neem leaves and their constituents have been shown to have anti-inflammatory, antiulcer, antimalarial, antifungal, antibacterial, and anticarcinogenic properties. The purpose of this study was to assess the effects of ethanolic, ethyl acetate, and aqueous plant leaf extract. Neem, Tulsi, and Reetha were used as ingredients in herbal soap . neem leaf and seed were shown to be beneficial against certain dermatophytes. Tulsi exhibits antiviral properties and Reetha functions as a detergent with cleaning and foaming properties

Keywords

Herbal extracts, Evaluation, Skin condition, Polyherbal soap

Introduction

These days One of the most prevalent dermatological conditions in the globe is fungal skin infection . According to research, 40 million people have fungal infections. Fungal infections that appear superficially on the nails, hair, and skin are widespread and typically challenging to treat. Dermatophytes are among the most frequent causes of tinea (capitis, manuum, pedis, cruris, corporis, barbae, and onychomycosis). (1)  Knowing the fundamentals of human skin structure and function is crucial for all medical practitioners. (2)  Ayurvedic literature mention plant-based medicines, which are becoming more and more popular in India as a result of their validation in comparison to their contemporary counter parts. Soap is one of the contemporary cosmetics used to preserve and improve skin health.(3) Therefore, Ayurvedic herbs listed under varnya are selected for formulation. Professor Galen was the one who brought up the use of soap for cleaning and maintaining the body. However, the current chemical soap commonly results in skin irritation and dryness. Interestingly, the effectiveness of herbal-based soaps for topical conditions is making them more and more popular.(4)

In Ayurveda, the plants giloy, neem, Tulsi, and besharam are listed under varnya herbs. Human skin, the body's outermost layer, serves as the body's first line of defence, protecting it from a variety of diseases.(5)  The skin is constantly exposed to many environmental stimuli because it is the interface with the environment. This increases the risk of skin injury. In an attempt to recover, severely damaged skin frequently forms scar tissue, which is frequently depigmented and decolorized.(6) Plants have long been used to cure illnesses and infections in humans. The plant's active ingredient can be made into lotion, cream, gel, ointment, soap, or crud/solvent extract.(7)  Plant extracts and the phytoconstituents they contain are expected to be used in the future to manage hyperpigmentation.

Skin Infections

An infection of the skin that can be caused by bacteria, fungus, viruses or parasites. Skin disease may cause:

  • Discoloured skin patches (abnormal pigmentation)
  • Open sores, lesions or ulcers.
  • Peeling skin
  • Rashes, possibly with itchiness or pain.
  • Red, white or pus-filled bumps.
  • Scaly or rough skin.(8)

Fungal Infection

The two primary categories of fungus are yeasts and molds. Yeasts are typically single, small, oval cells, whereas mold colonies are composed of fibrous strands called hyphae. Despite their increasing prevalence, invasive fungal infections remain difficult to diagnose, prevent, and treat because of their high rates of morbidity and mortality.(9) A fungal infection, also known as mycosis, is a skin ailment caused by a fungus. There are millions of different species of fungi. They can be found on surfaces in your house, on plants, in the soil, and on your skin. On rare occasions, they may cause skin problems like rashes or acne.

Symptoms of fungal infection

Irritation

Scratchy skin

Roughness

Itches

Elevation

Usually, bacterial skin infections begin as little red pimples that ultimately enlarge. Moderate bacterial infections can be treated with topical antibiotics; more serious illnesses require oral medicines. Bacterial skin infections include impetigo, boils, and leprosy.
Viral skin disorders are caused by viruses. These infections vary in severity. Among the several viral diseases are warts, chickenpox, and hand, foot, and mouth disease.(10)

HERBAL SOAP

Herbal soap has antibacterial, anti-aging, antioxidant, and antiseptic properties(11). Unlike commercial soap, herbal soap does not contain artificial color, flavor, fluorides, etc(12) . Due to their high medical value, affordability, accessibility, and compatibility, herbs are the natural products most frequently used to treat almost all illnesses and skin issues(13).

Neem, Tulsi, Vitamin E, Aloe Vera, Lemon Ipomea Carnea, Giloy, water, coconut, oil, stearic acid, sorbitol, hydroxide, glycerine, and color soap base are the primary ingredients in this soap recipe. Azadirachta indica, one of the greatest trees in India, is well-known for its therapeutic qualities, which include antifungal and antibacterial effects on a variety of skin conditions. Fruits and seeds contain neem oil. Most common problems that people encounter are treated with it(14).

For thousands of years, people have known and used aloe vera's health, cosmetic, medicinal, and skin care advantages. Nowadays, the realm of cosmetology is where aloe vera is most frequently used. Aloe vera has 75 potentially active compounds(14).
Curcuma longa possesses anti-aging, anti-wrinkle, moisturizing, anti-oxidant, astringent, anti-microbial, and anti-inflammatory properties. Recent studies have shown that curcumin is excellent for wrinkles and can lower inflammation and the generation of free radicals (15).

Almond oil has been used for hundreds of years to treat dry skin conditions including psoriasis and eczema. In recent years, oxidative stress has drawn more attention in biology and medicine due to its involvement in several diseases, such as cancer, aging, and arteriosclerosis. The oil may decrease the appearance of acne, promote cell development, and reverse UV damage(16).

Tulsi is also used in the soap-making process. Deep cleaning, acne treatment, and skin lightening are just a few of its many advantages. Tulsi also made use of certain acute respiratory conditions. Cough, bronchitis, fever, and colds are all relieved by tulsi leaf juice . Tulsi is also used to reduce blood glucose levels in diabetics. The main component of this herbal soap is tulsi, which also has other advantages including lowering stress and boosting endurance(17).

When making soap for moisturized skin, rose water is utilized. The main benefits of this soap are its antibacterial, antifungal, lightening, acne-removing, and moisturizing properties. the rose water is rich in antioxidants , volatile oil and mild astringent compound(18) .

 

 

     

 

Fig. 1 Polyherbal soap                         fig.2 polyherbal soap

 

Content of soap

Aloe vera (19)

Family: Liliaceae

Botanical name: Aloe barbadensis [miller]

Parts: Pulp

Chemical constituents: Aloe vera contains a rich mixture of phytochemicals, barbaloin, aloesin, vitamins,   minerals, enzymes, amino acids, and sugars c-glucosides, anthraquinones.

Aloe vera gel: It is obtained from the leaves of aloe vera

 

 

 

Fig. 3   ALOE VERA                                             barbaloin

 

 MEDICINAL USES OF ALOE VERA

 

s. no

Medicinal uses

An explanation

1

Wound healing

accelerates healing by encouraging tissue repair and collagen formation.

2

Burns treatment

Effective for small burns and sunburns, it has a cooling and calming effect.

3

Anti-inflammatory action

lessens skin or mucous membrane swelling, redness, and inflammation

4

Antibacterial & antifungal

aids in preventing the formation of dangerous bacteria and fungus on skin or wounds.

5

Moisturizer

Used in creams and gels, it hydrates dry skin without blocking pores.

6

Anti-oxidant

Packed with polyphenols that shield tissues from harm and vitamins C and E.

7

Hair & scalp care

conditions hair, improves scalp health, and lessens dandruff.

8

Anti-itching

reduces irritation and itching caused by bug bites, psoriasis, and eczema.

 

NEEM (20)

Family: Meliaceae.

Botanical name: Azadirachta indica.

 Chemical constituents: Azadirachtin, Glycerides, polyphenols, flavonoids , alkaloid, nimbin, nimbidin, terpenoid, steroids.

 Neem oil: It is known as ‘’margosa oil’’. Pressed from fruits and seeds of neem. 

     

 

 

 

                                                        fig.4  neem                              Azadirachtin

 

 

 

MEDICINAL USES OF NEEM

 

S. no

Medicinal use

An explanation

1

Aantibacterial

helps eliminate dangerous bacteria; used to wounds, acne, and skin problems.

2

antifungal

effective against fungal illnesses such as dandruff, ringworm, and athlete's foot.

3

Antiviral

demonstrates effectiveness against specific viruses and strengthens immunity.

4

Anti-inflammatory

reduces inflammation and edema in the skin and joints.

5

Antiseptic

used to prevent infection and clean wounds.

6

Blood Purifier

enhances skin health and aids in blood detoxification.

7

Skin Care

used to treat skin allergies, psoriasis, eczema, and acne.

 

TULSI (21)

Synonyms- Ocimum tenuiflorum.

 Biological source:-Fresh and dried leaves of ocimum species like ocimum sanctum l.

Family:- Lamiaceae .

 Part use:- Leaf .

 Chemical constituents- Eugenol germacrceterpens

 

 

 

Fig. 6 tulsi                                        Eugenol germacrceterpens

 

MEDICAL USE OF TULSI

 

s.no.

Skin Benefit

 

Explanation

1

Anti-inflammatory

These substances are beneficial for acne, rashes, eczema, and insect bites because they lessen redness, swelling, and irritation.

2

Skin detoxification

Tulsi tightens pores, prevents blackheads, regulates oil secretion, and purifies the skin.

3

Antifungal effect

Athlete's foot, ringworm, and other fungal skin infections can be treated with tulsi.

4

Anti-psoriasis

minimizes scaling and irritation and helps soothe psoriasis spots.

5

Anti-acne

Tulsi leaves minimize pimples, stop fresh outbreaks, eliminate bacteria that cause acne, and aid in thorough pore cleaning.

6

Anti-scar action

Tulsi paste or mild extract can gradually reduce acne scars and flaws.

 

TURMERIC (22)

Family: Zingiberaceae.

 Botanical name: Curcuma longa.

 Parts: Rhizome

 Chemical constituents: Curcumin, Zingiberene, Demethoxycurcumin,  Bisdemethoxycurcumin Volatile ,Turmerone, Atlantone,  Zingiberene ,Proteins, Resins, Sugars, Starches.

 

 


                fig.6  TURMARIC                                              Curcumin

 

 

MEDICINAL USE OF TURMARIC FOR SKIN

 

S.no.

Medicinal uses

Explanation

1

Anti-inflammatory

 

reduces redness, swelling, irritation

1

Antibacterial

avoids new pimples and aids in the treatment of acne.

2

Antioxidant

minimizes wrinkles and fine lines while delaying the aging of the skin.

3

Anti-pigmentation

reduces hyperpigmentation, tan, and dark patches.

4

Antifungal

beneficial for ringworm and other fungal infections

5

Wound Healing

accelerates the healing of minor wounds, burns, and cuts

 

CITRUS LIMON (23)

Common name:- Lemon.

Biological name:-citrus limon.

Biological sources:-Citrus limon consists of the fresh fruit obtained from the plant citrus limon (L.)Burm. F.,

Family:- Rutaceae .

Chemical constituents- niacin, riboflavin, thiamine, choline, pantothenic acid, foliate, vitamin c, vitamin B6, and minerals (calcium, copper, iron, manganese, magnesium, phosphorus, potassium, zinc).

Part use:- fruits .

     

 

                        Fig. 7 CITRUS LIMON.

Medicinal Uses of Citrus limon

 

s.no.

Medicinal use

Explanation

1

Antioxidant activity

Packed with vitamin C and flavonoids that protect cells from oxidative damage and boost immunity.

2

Boosts immunity

Increased vitamin C strengthens immunity and protects against colds and infections.

3

Antimicrobial effect

The natural antiviral and antibacterial properties of lemons help fight harmful microbes.

4

Skin health

Collagen formation is stimulated, dark spots are lightened, and skin suppleness is increased by vitamin C.

 

Almond (24)

Family: Rosaceae.

Botanical name: Prunus Amygdalus  ,

Parts: Nuts ,

Chemical constituents: Proteins, lipids, tannins, amino acids, leic acid, stearic acid , linoleic acid, palmitoleic acid and palmitic acid.

 Almond oil: It is obtained from by pressing nuts or fruits. In order to acquire the oil.

Uses: assist in balancing moisture absorption and water loss. enhances skin tone and complexion, addresses dry skin, reduces puffiness and under-eye bags, and heals acne. helps cure sun damage and lessens the visibility of scars and stretch marks.

 

      Fig.8 Almond

 

CARICA PAPAYA (25)

Biological name: Caricapapaya L.

Comman name: papaya.

Chemical constituent: tannin, alkaloid, glycosides, saponin, papin etc.

Part tyupically used: fruits.

 

 

Fig. 9  Caric papaya

  Medicinal use of Caric papaya

 

S.no.

Medicinal uses

Explanation

1

Skin cleansing

keeps pores clean by eliminating pollutants, oil, and grime from the skin.

2

Sun damage repair

Papaya's antioxidants aid in repairing UV-induced damage.

3

Anti-inflammatory

minimizes redness and swelling and calms sensitive skin.

4

Wound healing

Because of its enzymatic effect, it expedites the healing of small cuts, burns, and skin irritation.

 

Reetha (26,27)

Synonyms:- Sapindus mukorossi

Biological source:- Scientifically known as sapindus mukorossi.   

Family;-Sapindaceae

Part typically used- The seeds

chemical constituent-Saponins, sugars and mucilage

Medicinal Uses Of Reetha

 

S.no.

Medicinal uses

Explanation

1

Anti-acne activity

Its antimicrobial qualities aid in preventing acne by lowering the microorganisms that cause it.

2

Oil control

is beneficial for oily and acne-prone skin since it aids in the removal of extra sebum from the skin.

3

Skin soothing

possesses modest anti-inflammatory qualities that soothe sensitive and inflamed skin.

4

Antimicrobial action

prevents skin diseases by preventing dangerous bacteria from growing.

 

 

 

 

Fig. 10 Reetha

REFERENCES

  1. Aparajita Verma, Mohan Singh Mehata. Controllable Synthesis of silver nanoparticles using neem leave and their antimicrobial activity. Journal of radiation research and applied sciences volume 9, Issue 1 January  2016, page 109-111
  2. Barkat Ali Khan et al., Review Article; Human Skin, ageing and anti-oxidant; Journal of medicinal plant Research, January, 2012; 6(1): 1-6.
  3. Eugene Sebastian John Nidiryl, Ganeshan2,  Ankanahalli  Narayana shetty Lokeshal, Nanjundagowada Ramachandran2. Additional studies on the antifungal activity of a methanol extract of Ipomea Carnea Subsp . Fistulosa and Octadecyl p- coumarates. Pharmacogen. Commn . 2016;6(3) 148-151.
  4. Antoni Femenia, Emma S . Sa Nchez, Susana Simal, carmen Rossellos. Antoni Femenia, Emma S . Sa Nchez, Susana Simal, carmen Rossellos. Carbohydrate polymers 39(1999) 109-117.
  5. Christopher A. Giuliano, and Michael j. rybak  . efficacy of triclosan as an antimicrobial hand soap its potential impact on antimicrobial resistance: A focused review. Pharmacotherapy volume 35 , number 3, 2015.
  6. Swarnlata saraf, Sunil M. Hargude, Chanchal Deep Kaur and Shailendra Saraf . formulation and evaluation of herbal shampoo containing extract of Allium sativum. Research J. topical and cosmetic sci.2(1):Jan. -June 2011.
  7. Ahmad Eidl , Nidal Jaradatl , Nagib Elmarzugi2. A review of chemical constituents and traditional usage of neem plant (Azadirachta indica ). Palestinian medical and pharmaceutical Journal (Palestinian medical and pharmaceutical journal (pmpj). 2017;2(2):75-81.
  8. Sarah Taylor, MaryAnn De Pietro. Skin Infection: Types, Causes, and Treatment, 2022.
  9. Kumar, Cortan, Robbins.Basic patgology, 7th edition, Elsevier publication, 2003; 310 311.
  10. Ki V, Rotstein C. Bacterial skin and soft tissue infections in adults: A review of their epidemiology, pathogenesis, diagnosis, treatment and site of care. Can J Infect Dis Med Microbiol, 2008; 19(2): 173-184
  11. Deepa G., Nikhil M. Research Article; Phytochemical, antioxidant, and antimicrobial activity of psidiumguajavaleaves against oral dental pathogens; Indian Journal of Applied Research, June, 2015; (5)6: 52-54.
  12. Saikia A.P., Ryakala V.K., Sharma P., Goswami P., Bora U; Ethnobotany of medicinal plants used by Assamese people for various skin ailments and cosmetics. Journal of Ethnopharmacology, June, 2006; 106(2): 149-157.
  13. Book of Neem Oil from Neem Seeds and Applications: Shovon Bhattacharjee, Muhammed Miah, 2013; 1-113.
  14. Amar Surjushe, Resham Vasani, and D G Saple; A Short Review; Aloe Vera; Indian Journal of Dermatology, February, 2008; 53(4): 163-166.
  15. Swarnlata Saraf, Gunjan Jeswani, Chanchal Deep Kaur and Shailendra Saraf; Research Article; Development of novel herbal cosmetic cream with Curcuma longa extract loaded transfersomes for Anti-wrinkle effect; African Journal of Pharmacy and Pharmacology, August, 2011; 5(8): 1054- 1062.
  16. Ouzir, M., et al. (2021). Comprehensive Reviews in Food Science and Food Safety, 20(4), 3344–3387.
  17. Cohen, M. M. (2014). Tulsi - Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and Integrative Medicine, 5(4), 251–259.
  18. Boskabady, M. H., Shafei, M. N., Saberi, Z., & Amini, S. (2011). Avicenna Journal of Phytomedicine, 1(1), 1–15.
  19. John M. Boyce Md. State of science review best product for skin antisepsis. J.M Boyce/American Journal of infection control 47 (2019) A17-A22.
  20. GARIMA PANDEY, KK VERMA, MUNNA SINGH; Research article; Evaluation of Phytochemical, Antibacterial and Free Radical Scavenging Properties of Azadirachta Indica (Neem) Leaves; International Journal of Pharmacy and Pharmaceutical Sciences, 2014; 6(2): 444-447.
  21. Deep Srivastava and  K. Shukla. Pharmaceutical efficacy of Ipomoea carnea. Biological forum-an international journal 7(1): 225-235(2015).
  22. Swarnlata Saraf, Gunjan Jeswani, Chanchal Deep Kaur and Shailendra Saraf; Research Article; Development of novel herbal cosmetic cream withCurcuma longa extract loaded transfersomes for Anti-wrinkle effect; African Journal of Pharmacy and Pharmacology, August, 2011; 5(8): 1054- 1062.
  23. González-Molina E, Domínguez-Perles R, Moreno DA, García-Viguera C.
    Natural bioactive compounds of Citrus limon for health and cosmetic applications.
    Journal of Functional Foods. 2010;2(4):241–250.
  24. Ali Jahanban Esfahlan, Rashid Jamei, Rana Jahanban Esfahlan; Review Article; The importance of almond (Prunus amygdalus L.) and its byproducts; Article in food chemistry, 2010; 349–360.
  25. Pedro Cha’Vez-Quintal Tania Gonza’Lez-Flores, Ingrid Rodri’Guez- Buenfil, Santiago Gallegos-Tintore. Antifungal activity in ethanolic extracts of carica papaya L. Cv. Maradol leaves and seed. Indian J Microbiol (Jan- mar 2011) 51(1):54-60.
  26. Gana Manjusha k, Balakrishnaiah  P. Syamala R, Mounik N, Ravi Chandra T. formulation and evaluation of herbal bath soap containing methanolic extracts of three Ayurvedic Varnya herbs. Asian J pharm clin res , volume 12 Issue 11, 2019, 213-215.
  27. Christopher A. Giuliano, and michlel J . Rybak . efficacy of triclosan as an antimicrobial hand shoap and its potential impact on antimicrobial resistance: A focused review . pharmacotherapy publication. 2015.

Reference

  1. Aparajita Verma, Mohan Singh Mehata. Controllable Synthesis of silver nanoparticles using neem leave and their antimicrobial activity. Journal of radiation research and applied sciences volume 9, Issue 1 January  2016, page 109-111
  2. Barkat Ali Khan et al., Review Article; Human Skin, ageing and anti-oxidant; Journal of medicinal plant Research, January, 2012; 6(1): 1-6.
  3. Eugene Sebastian John Nidiryl, Ganeshan2,  Ankanahalli  Narayana shetty Lokeshal, Nanjundagowada Ramachandran2. Additional studies on the antifungal activity of a methanol extract of Ipomea Carnea Subsp . Fistulosa and Octadecyl p- coumarates. Pharmacogen. Commn . 2016;6(3) 148-151.
  4. Antoni Femenia, Emma S . Sa Nchez, Susana Simal, carmen Rossellos. Antoni Femenia, Emma S . Sa Nchez, Susana Simal, carmen Rossellos. Carbohydrate polymers 39(1999) 109-117.
  5. Christopher A. Giuliano, and Michael j. rybak  . efficacy of triclosan as an antimicrobial hand soap its potential impact on antimicrobial resistance: A focused review. Pharmacotherapy volume 35 , number 3, 2015.
  6. Swarnlata saraf, Sunil M. Hargude, Chanchal Deep Kaur and Shailendra Saraf . formulation and evaluation of herbal shampoo containing extract of Allium sativum. Research J. topical and cosmetic sci.2(1):Jan. -June 2011.
  7. Ahmad Eidl , Nidal Jaradatl , Nagib Elmarzugi2. A review of chemical constituents and traditional usage of neem plant (Azadirachta indica ). Palestinian medical and pharmaceutical Journal (Palestinian medical and pharmaceutical journal (pmpj). 2017;2(2):75-81.
  8. Sarah Taylor, MaryAnn De Pietro. Skin Infection: Types, Causes, and Treatment, 2022.
  9. Kumar, Cortan, Robbins.Basic patgology, 7th edition, Elsevier publication, 2003; 310 311.
  10. Ki V, Rotstein C. Bacterial skin and soft tissue infections in adults: A review of their epidemiology, pathogenesis, diagnosis, treatment and site of care. Can J Infect Dis Med Microbiol, 2008; 19(2): 173-184
  11. Deepa G., Nikhil M. Research Article; Phytochemical, antioxidant, and antimicrobial activity of psidiumguajavaleaves against oral dental pathogens; Indian Journal of Applied Research, June, 2015; (5)6: 52-54.
  12. Saikia A.P., Ryakala V.K., Sharma P., Goswami P., Bora U; Ethnobotany of medicinal plants used by Assamese people for various skin ailments and cosmetics. Journal of Ethnopharmacology, June, 2006; 106(2): 149-157.
  13. Book of Neem Oil from Neem Seeds and Applications: Shovon Bhattacharjee, Muhammed Miah, 2013; 1-113.
  14. Amar Surjushe, Resham Vasani, and D G Saple; A Short Review; Aloe Vera; Indian Journal of Dermatology, February, 2008; 53(4): 163-166.
  15. Swarnlata Saraf, Gunjan Jeswani, Chanchal Deep Kaur and Shailendra Saraf; Research Article; Development of novel herbal cosmetic cream with Curcuma longa extract loaded transfersomes for Anti-wrinkle effect; African Journal of Pharmacy and Pharmacology, August, 2011; 5(8): 1054- 1062.
  16. Ouzir, M., et al. (2021). Comprehensive Reviews in Food Science and Food Safety, 20(4), 3344–3387.
  17. Cohen, M. M. (2014). Tulsi - Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and Integrative Medicine, 5(4), 251–259.
  18. Boskabady, M. H., Shafei, M. N., Saberi, Z., & Amini, S. (2011). Avicenna Journal of Phytomedicine, 1(1), 1–15.
  19. John M. Boyce Md. State of science review best product for skin antisepsis. J.M Boyce/American Journal of infection control 47 (2019) A17-A22.
  20. GARIMA PANDEY, KK VERMA, MUNNA SINGH; Research article; Evaluation of Phytochemical, Antibacterial and Free Radical Scavenging Properties of Azadirachta Indica (Neem) Leaves; International Journal of Pharmacy and Pharmaceutical Sciences, 2014; 6(2): 444-447.
  21. Deep Srivastava and  K. Shukla. Pharmaceutical efficacy of Ipomoea carnea. Biological forum-an international journal 7(1): 225-235(2015).
  22. Swarnlata Saraf, Gunjan Jeswani, Chanchal Deep Kaur and Shailendra Saraf; Research Article; Development of novel herbal cosmetic cream withCurcuma longa extract loaded transfersomes for Anti-wrinkle effect; African Journal of Pharmacy and Pharmacology, August, 2011; 5(8): 1054- 1062.
  23. González-Molina E, Domínguez-Perles R, Moreno DA, García-Viguera C.
    Natural bioactive compounds of Citrus limon for health and cosmetic applications.
    Journal of Functional Foods. 2010;2(4):241–250.
  24. Ali Jahanban Esfahlan, Rashid Jamei, Rana Jahanban Esfahlan; Review Article; The importance of almond (Prunus amygdalus L.) and its byproducts; Article in food chemistry, 2010; 349–360.
  25. Pedro Cha’Vez-Quintal Tania Gonza’Lez-Flores, Ingrid Rodri’Guez- Buenfil, Santiago Gallegos-Tintore. Antifungal activity in ethanolic extracts of carica papaya L. Cv. Maradol leaves and seed. Indian J Microbiol (Jan- mar 2011) 51(1):54-60.
  26. Gana Manjusha k, Balakrishnaiah  P. Syamala R, Mounik N, Ravi Chandra T. formulation and evaluation of herbal bath soap containing methanolic extracts of three Ayurvedic Varnya herbs. Asian J pharm clin res , volume 12 Issue 11, 2019, 213-215.
  27. Christopher A. Giuliano, and michlel J . Rybak . efficacy of triclosan as an antimicrobial hand shoap and its potential impact on antimicrobial resistance: A focused review . pharmacotherapy publication. 2015.

Photo
Vishal kumar
Corresponding author

Shree dev bhoomi institute of education science and technology, poundha, dehradun

Photo
Ajay kumar
Co-author

Shree dev bhoomi institute of education science and technology, poundha dehradun

Photo
Dr. Shivanand Patil
Co-author

Shree dev bhoomi institute of education science and technology, poundha dehradun

Vishal kumar, Ajay kumar, Dr. Shivanand Patil, Preparation And Evaluation of Polyherbal Soap, Int. J. of Pharm. Sci., 2026, Vol 4, Issue 4, 987-996 https://doi.org/10.5281/zenodo.19450027

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